Good compatibility between waterborne epoxy resin(WER)modifier and styrene-butadiene rubber(SBR)latex modified asphalt emulsion(SBRE)is an essential premise for good pavement performance of WER and SBR latex composite...Good compatibility between waterborne epoxy resin(WER)modifier and styrene-butadiene rubber(SBR)latex modified asphalt emulsion(SBRE)is an essential premise for good pavement performance of WER and SBR latex compositely modified asphalt emulsion(WSAE).This study aims to explore the compatibility between WER modifier and SBRE.To achieve the goal,several WER modifiers produced by two methods were first selected to modify SBRE,thus the WSAEs were prepared.Next,storage stability and workability of the WSAEs themselves,and high-temperature performance,rheological behavior and temperature sensitivity of their evaporated residues were compared and evaluated via performing a series of experiments,respectively,thus the WER modifier possessing an optimal modification effect was recommended.Results show that the storage stability of WSAEs is sensitive to the amount of WERs.The incorporation of 1%WERs by the mass of SBRE improves the storage stability of SBRE,while WERs that exceed 1%weaken its storage stability.When the WERs reach 3%and 4%,the 5 d storage stability of prepared WSAEs will be beyond the limitation of specification.Incorporating WERs into SBRE negatively affects the workability of SBRE,and the workability of WSAEs is adversely influenced by the WERs content and the storage time.To ensure the construction,the WSAEs with 3%and 4%WERs should not be stored for more than 36 h and 48 h,respectively.The WERs effectively improve the high-temperature performance of SBRE residue,especially the 3%WERs.Besides,the WERs notably enhance the rheological property and thermal stability of SBRE residue.In contrast,the WER modifier produced by chemically modified method has a smaller adverse impact on the storage stability and workability of WSAE,and a larger enhancement on the high-temperature performance,rheological property and thermal stability of SBRE residue,which is thus recommended to modify SBRE.展开更多
Objective:Compound traditional Chinese medicine(CTCM)with the application of compatibility from multiple active ingredients with multiple-specific targets can achieve a synergistic effect on cancer therapy.This study ...Objective:Compound traditional Chinese medicine(CTCM)with the application of compatibility from multiple active ingredients with multiple-specific targets can achieve a synergistic effect on cancer therapy.This study is aimed to observe the compatibility effects of Aidi injection on the treatment of hepatocellular carcinoma and to explore the mechanism of CTCM.Methods:Aidi injection is a clinical compound prescription containing Mylabris,Ginseng,Astragalus,and Acanthopanax,which can inhibit tumor growth and induce apoptosis.In this study,the anticancer activity of Aidi injection,as well as its disassembled and combined compositions,had been evaluated by varying levels of polyamine biomarkers on human hepatoma Hep-G2 cells detected using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Results:According to the different variations in polyamine levels,it was revealed that Mylabris and Ginseng had an antitumor effect,while Astragalus acted as an assistant and Acanthopanax had weak anticancer activity.The increased level of polyamines in Hep-G2 cells had been found in HL-7702 cells.On combining Mylabris and Ginseng,polyamine levels went close to the normal level,which was even more marked when Astragalus was added.Aidi injection acted like the combination of Mylabris,Ginseng,and Astragalus.Conclusions:This study established a quantitative evaluation of the compatibility effects of Aidi injection based on polyamine biomarkers and evaluated the consistency of its anticancer effect,providing a manner to research the efficacy evaluation of CTCM.Moreover,the correlation between polyamine metabolism and anticancer activity can be used in anticancer drug screening.展开更多
基金funded by the National Natural Science Foundation of China(NSFC)under Grant No.211021180360the Transportation Science and Technology in Shaanxi Province under Grant No.KY17-02.
文摘Good compatibility between waterborne epoxy resin(WER)modifier and styrene-butadiene rubber(SBR)latex modified asphalt emulsion(SBRE)is an essential premise for good pavement performance of WER and SBR latex compositely modified asphalt emulsion(WSAE).This study aims to explore the compatibility between WER modifier and SBRE.To achieve the goal,several WER modifiers produced by two methods were first selected to modify SBRE,thus the WSAEs were prepared.Next,storage stability and workability of the WSAEs themselves,and high-temperature performance,rheological behavior and temperature sensitivity of their evaporated residues were compared and evaluated via performing a series of experiments,respectively,thus the WER modifier possessing an optimal modification effect was recommended.Results show that the storage stability of WSAEs is sensitive to the amount of WERs.The incorporation of 1%WERs by the mass of SBRE improves the storage stability of SBRE,while WERs that exceed 1%weaken its storage stability.When the WERs reach 3%and 4%,the 5 d storage stability of prepared WSAEs will be beyond the limitation of specification.Incorporating WERs into SBRE negatively affects the workability of SBRE,and the workability of WSAEs is adversely influenced by the WERs content and the storage time.To ensure the construction,the WSAEs with 3%and 4%WERs should not be stored for more than 36 h and 48 h,respectively.The WERs effectively improve the high-temperature performance of SBRE residue,especially the 3%WERs.Besides,the WERs notably enhance the rheological property and thermal stability of SBRE residue.In contrast,the WER modifier produced by chemically modified method has a smaller adverse impact on the storage stability and workability of WSAE,and a larger enhancement on the high-temperature performance,rheological property and thermal stability of SBRE residue,which is thus recommended to modify SBRE.
基金performed in the National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica QC and financially supported by the National Natural Science Funds of China(grant nos.81603277/H2803 and 81102784/H2803)National Key Research and Development Project(2018YFC1707900)as well as the Liaoning Distinguished Professor Project for Qing Li。
文摘Objective:Compound traditional Chinese medicine(CTCM)with the application of compatibility from multiple active ingredients with multiple-specific targets can achieve a synergistic effect on cancer therapy.This study is aimed to observe the compatibility effects of Aidi injection on the treatment of hepatocellular carcinoma and to explore the mechanism of CTCM.Methods:Aidi injection is a clinical compound prescription containing Mylabris,Ginseng,Astragalus,and Acanthopanax,which can inhibit tumor growth and induce apoptosis.In this study,the anticancer activity of Aidi injection,as well as its disassembled and combined compositions,had been evaluated by varying levels of polyamine biomarkers on human hepatoma Hep-G2 cells detected using ultrahigh-performance liquid chromatography-tandem mass spectrometry.Results:According to the different variations in polyamine levels,it was revealed that Mylabris and Ginseng had an antitumor effect,while Astragalus acted as an assistant and Acanthopanax had weak anticancer activity.The increased level of polyamines in Hep-G2 cells had been found in HL-7702 cells.On combining Mylabris and Ginseng,polyamine levels went close to the normal level,which was even more marked when Astragalus was added.Aidi injection acted like the combination of Mylabris,Ginseng,and Astragalus.Conclusions:This study established a quantitative evaluation of the compatibility effects of Aidi injection based on polyamine biomarkers and evaluated the consistency of its anticancer effect,providing a manner to research the efficacy evaluation of CTCM.Moreover,the correlation between polyamine metabolism and anticancer activity can be used in anticancer drug screening.
