This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The inp...This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The input circuit of a conventional inverter consists of a thick-gate-oxide n-type MOSFET(NMOS).These conventional drivers can tolerate a total ionizing dose(TID)of up to 100 krad(Si).In contrast,the proposed comparator input circuit uses both a thick-gate-oxide p-type MOSFET(PMOS)and thin-gate-oxide NMOS to offer a high input voltage and higher TID tolerance.Because the thick-gate-oxide PMOS and thin-gate-oxide NMOS collectively provide better TID tolerance than the thick-gate-oxide NMOS,the circuit exhibits enhanced TID tolerance of>300 krad(Si).Simulations and experimental date indicate that the DSS structure reduces the probability of unwanted parasitic bipolar junction transistor activation,yielding a better single-event effect tolerance of over 81.8 MeVcm^(2)mg^(-1).The innovative strategy proposed in this study involves circuit and layout design optimization,and does not require any specialized process flow.Hence,the proposed circuit can be manufactured using common commercial 0.35μm BCD processes.展开更多
Objective: We aim to analyze the surgical nursery of abdominal wall hernias in adults between two poorly fitted medical environments, the Regional Hospital Center of Tsévié (RHC-T) and the Prefectural Hospit...Objective: We aim to analyze the surgical nursery of abdominal wall hernias in adults between two poorly fitted medical environments, the Regional Hospital Center of Tsévié (RHC-T) and the Prefectural Hospital Center of Kpalimé (PHC-K) in Togo. Methodology: It was a retrospective, descriptive and comparative study carried out over five years (2018-2022) focusing on abdominal wall hernias in adults. Information was gathered from the patients’clinical notes and registers on the frequency of hernias, the anatomo-clinical forms of hernias, the type of anesthesia, the hernia repair technique and the postoperative evolution. Results: Of the 1022 and 1026 operations performed, 312 and 412 were hernial repairs, representing 30.5% and 41.2% of operations at RHC-T and PHC-K respectively (p = 0.001). The inguinal hernia was the most often found in 83.7% (n = 261) at RHC-T versus 76.6% (n = 324) at PHC-K. Herniorrhaphy was the most frequently used repair method, in 93.6% (n = 292) of patients at RHC-T and in 91.3% (n = 376) at PHC-K (p = 0.11). Postoperative complications were noted in 5.1% of cases (n = 16) at RHC-T versus 3.5% of cases (n = 15) at PHC-K (p = 0.307). These complications included scrotal hematomas, surgical areas infections, and orchitis. We recorded 1.3% (n = 4) and 0.8% (n = 3) deaths at RHC-T and PHC-K respectively (p = 0.496). Conclusion: There is homogeneity in the treatment of hernia in these two hospitals in Togo.展开更多
The plastid genome(plastome)represents an indispensable molecular resource for studying plant phylogeny and evolution.Although plastome size is much smaller than that of nuclear genomes,accurately and efficientlyannot...The plastid genome(plastome)represents an indispensable molecular resource for studying plant phylogeny and evolution.Although plastome size is much smaller than that of nuclear genomes,accurately and efficientlyannotating and utilizing plastome sequences remain challenging.Therefore,a streamlined phylogenomic pipeline spanning plastome annotation,phylogenetic reconstruction and comparative genomics would greatly facilitate research utilizing this important organellar genome.Here,we develop PlastidHub,a novel web application employing innovative tools to analyze plastome sequences.In comparison with existing tools,key novel functionalities in PlastidHub include:(1)standardization of quadripartite structure;(2)improvement of annotation flexibility and consistency;(3)quantitative assessment of annotation completeness;(4)diverse extraction modes for canonical and specialized sequences;(5)intelligent screening of molecular markers for biodiversity studies;(6)genelevel visual comparison of structural variations and annotation completeness.PlastidHub features cloud-based web applications that do not require users to install,update,or maintain tools;detailed help documents including user guides,test examples,a static pop-up prompt box,and dynamic pop-up warning prompts when entering unreasonable parameter values;batch processing capabilities for all tools;intermediate results for secondary use;and easy-to-operate task flows between fileupload and download.A key feature of PlastidHub is its interrelated task-based user interface design.Give that PlastidHub is easy to use without specialized computational skills or resources,this new platform should be widely used among botanists and evolutionary biologists,improving and expediting research employing the plastome.PlastidHub is available at https://www.plastidhub.cn.展开更多
Bathymodiolus mussels distribute in both deep-sea cold seep and hydrothermal vent environments,whose endosymbiotic gill tissue is a prominent character for the adaptation of extreme habitats.However,few studies explor...Bathymodiolus mussels distribute in both deep-sea cold seep and hydrothermal vent environments,whose endosymbiotic gill tissue is a prominent character for the adaptation of extreme habitats.However,few studies explored the adaptation mechanisms through comparative transcriptome sequencing and analysis of different tissues between seep mussels and vent mussels.We performed the comparative transcriptome sequencing and analysis for three tissue types(gill,mantle,and adductor muscle)of Bathymodiolus mussels collected from a cold seeping site Station S 11 and the 50-km away hydrothermal field Minami-Ensei Knoll in the Okinawa Trough.Results show that gene expression patterns had distinct tissue specificity.Compared with the non-endosymbiotic tissues(mantle and adductor muscle),the significantly strengthened gene functions in endosymbiotic gill included microbial recognition(fibrinogen C domain-containing protein 1-B-like(fibcd),fibrinogen-related protein 8(frp),peptidoglycan recognition proteins(pgrp),and C-type lectin(clec)),cell apoptosis and immunity(interferon regulatory factor 1/2-like 1(ir f),cathepsin D(ctsd),caspase 2(casp 2)),and antioxidant capacity(copper/zinc superoxide dismutase(czsod),glutathione peroxidase(gpx),selenoprotein(sel)),in both seep and vent individuals.Consistent with metal accumulation,high expression levels of genes related to heavy metal detoxification(cytochrome P 450(cyp),ferritin-like(ftl),metallothionein(mt),glutathione S-transferase(gst))were also observed in gill.Moreover,to adapt to high hydrostatic pressure in the deep sea,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways associated with cellular community were significantly enriched in all three tissues,suggesting the regulation of cell structure and cell adhesion at transcriptional level.This study obtained gene expression profiles of deep-sea mussels subsisting at cold seep and hydrothermal vent sites,which could lay foundations for comprehensive investigations of molecular basis in adaptation of deep-sea mussels to the two extreme ecosystems.展开更多
The exchange and mutual appreciation of different cultures is an important topic in the context of globalization,and traditional patterns are the crystallization of the national cultures of various countries.The study...The exchange and mutual appreciation of different cultures is an important topic in the context of globalization,and traditional patterns are the crystallization of the national cultures of various countries.The study focuses on the Ming Dynasty Mandarin square in ancient China and the Tudor Dynasty coat of arms during the same period in England.By using comparative research,case studies,and combining historical documents and images,the origins of the two types of decorations are traced,and their social connotations and influencing factors are analyzed.Research has shown that under the influence of the historical backgrounds of politics,economy,and culture,the two types of decorative patterns exhibit a realistic aesthetic trend.The cultural connotations not only demonstrate social narrative functions such as customs and rituals,but also reflect political system functions such as hierarchy and honor.The different historical origins give rise to cultural differences in the selection of decorative elements between the two.The comparative study of the two is not only beneficial for conducting decorative design research from a global perspective,but also can promote the modern inheritance of traditional patterns while seeking common ground and reserving differences.展开更多
Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy live...Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.展开更多
The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strateg...The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strategy,the industry predominantly employs a semi-activated control strategy in existing tidal current energy converters.It is essential to identify the differences in predicted energy-harvesting performance between these two controlling strategies through experimental modeling or numerical studies.Furthermore,the suitability of the fully activated control strategy in predicting the energy-harvesting capabilities of oscillating hydrofoils is evaluated.The 2D numerical models of hydrofoil based on fully activated and semi-activated control strategies have been developed and validated.The amplitudes of heaving and pitching movements for the fully activated hydrofoil are determined to match those of the semi-activated hydrofoil.The results show that the main difference between the two control strategies lies in the phase shift occurring between the pitching and heaving motions.This phase shift affects the lift force and its coordination with the heaving velocity,which in turn affects the power output.Notably,the maximum relative efficiency difference obtained between the fully activated and semi-activated control strategies can reach 191%.展开更多
Herpes simplex virus(HSV)types 1 and 2 pose significant health risks during pregnancy,impacting both maternal and neonatal outcomes.The 2024 joint guideline from the British Association for Sexual Health and HIV(BASHH...Herpes simplex virus(HSV)types 1 and 2 pose significant health risks during pregnancy,impacting both maternal and neonatal outcomes.The 2024 joint guideline from the British Association for Sexual Health and HIV(BASHH)and the Royal College of Obstetricians and Gynaecologists(RCOG)in the United Kingdom introduces updated recommendations to reduce maternal-to-neonatal transmission.Key recommendations include initiating antiviral therapy earlier—at 32 weeks for standard pregnancies or as early as 22 weeks in high-risk cases—to minimize viral shedding.The guideline emphasizes polymerase chain reaction(PCR)testing for accurate diagnosis and advocates a multidisciplinary team(MDT)approach,involving genitourinary medicine(GUM)specialists,obstetricians,and neonatologists for delivery planning and neonatal care.However,the Chinese guidelines offer greater flexibility in the timing of antiviral treatment,tailored to regional resources and specific circumstances.PCR testing is also recommended,particularly in urban hospitals and tertiary care settings.The UK′s MDT model aligns with China′s integrative healthcare approach,presenting opportunities for mutual learning and collaboration.This comparative analysis highlights areas for cross-adaptation in clinical practices,with potential to enhance maternal and neonatal health outcomes globally.展开更多
Although previous studies have analyzed the unique structural characteristics of the polar vortices on Earth,Venus,Mars,and Titan,the understanding of the polar vortices on Venus and Titan is primarily based on small-...Although previous studies have analyzed the unique structural characteristics of the polar vortices on Earth,Venus,Mars,and Titan,the understanding of the polar vortices on Venus and Titan is primarily based on small-scale case studies due to the limited resolution and coverage of observational data.Conducting a detailed comparison of the polar vortex characteristics between the major terrestrial planets and Titan in the solar system is more challenging.In order to more finely compare the polar vortex characteristics of the main terrestrial planets in the solar system with Titan,we have achieved the optimal estimation of the polar vortices of Venus and Titan under existing conditions based on the advanced VCD2.3 and TitanWRF model.At the same time,combining ERA5 and EMARS databases,a detailed spatiotemporal comparison of polar vortex characteristics between terrestrial planets with atmospheres in the solar system and the most Earth-like Titan satellite was conducted for the first time.Here,we demonstrate that:(1)The circulation characteristics of Mars above the 1 mbar level are very similar to those at 1000 mbar in the lower layers of Titan,with seasonal variations of the same height.(2)In contrast to the vortex structure that is stably maintained in the lead direction in the polar regions of Mars and Earth during the winter,the time of occurrence of the peak vortex intensity at Titan and Venus is gradually shifted forward with increasing altitude.(3)When Venus undergoes vortex instability drift,the polar vortex at an altitude of 1 mbar breaks up into banded structures,a phenomenon that closely resembles the twisting deformation of PV structures during weak stratospheric polar vortex events on Earth.展开更多
Based on the Etihad Railway Station Project,this study selects a single-span frame bridge with a clear span of 7.3 meters as the research object.A comprehensive structural design process was conducted following the AR...Based on the Etihad Railway Station Project,this study selects a single-span frame bridge with a clear span of 7.3 meters as the research object.A comprehensive structural design process was conducted following the AREMA(2023),Manual for Railway Engineering-Volume 2-Structures,with systematic comparisons of techno-economic differences between the Chinese and American codes through recalculation verification and equivalent-precision design methods.The findings reveal:Recalculation using the Chinese code for identical structural dimensions and reinforcement layouts demonstrates that AREMA code exhibits greater conservatism in both strength requirements and crack control;Under equivalent precision design principles,the Chinese code solution reduces reinforcement by 4.128 t tons and a 19.5%reduction in reinforcement at critical sections compared to the AREMA code,indicating slightly reduced economic efficiency of the AREMA code.This research provides quantitative references for standardized design and specification integration in cross-border railway engineering projects.展开更多
Objective To discuss the flexible supervision and communication mode in the post-approval change(PAC)of drugs,to explore how to ensure the quality and availability of drugs during the changes,and to provide some sugge...Objective To discuss the flexible supervision and communication mode in the post-approval change(PAC)of drugs,to explore how to ensure the quality and availability of drugs during the changes,and to provide some suggestions and reference for promoting the timely marketing of drugs.Methods Based on the comparability protocol guidelines issued by the US FDA in October 2022,the regulatory status quo of PAC between China and the US was compared to explore the feasibility of implementing comparability protocols in China.Results and Conclusion According to the specific situation of post-approval of drug change supervision,some suggestions were put forward to optimize the PAC management procedure,such as establishing the communication pathways between holders and health authorities,publishing relevant guidance and strengthening training,so as to provide reference for the implementation of comparability protocols in China.展开更多
The rapid development and application of emerging information technologies,such as big data and artificial intelligence,facilitates the development of intelligent urban rail vehicles.Architecture is an important compo...The rapid development and application of emerging information technologies,such as big data and artificial intelligence,facilitates the development of intelligent urban rail vehicles.Architecture is an important component of intelligent urban rail vehicles and a key factor in ensuring their reliable and safe operation on various routes.In this context,it is very important to select appropriate architecture design standards.The paper reviews the relevant design standards for architecture at home and abroad,comprehensively analyzes the standards that need to be compared and analyzed,and conducts comprehensive comparative analysis in the aspects of the scope of application,load conditions,vertical static load,lateral load,and evaluation methods of the standards.Finally,it draws a conclusion that the standard JIS E 4207:2019,Rolling stock—Bogie—General rules for design of bogie frame strength,can meet the requirements of strength design of welded bogie frame in intelligent urban rail vehicles.It proposes the suggestions on better validating this design method in future bench and line tests of products,in order to improve the design concept of bogie frame strength and provide reference and inspiration for promoting the development of intelligent urban rail vehicles in China.展开更多
This study explores the cultural and value foundations of the educational goals of higher education in Kazakhstan and China.Based on the historical development and cultural traditions of the two countries,this study c...This study explores the cultural and value foundations of the educational goals of higher education in Kazakhstan and China.Based on the historical development and cultural traditions of the two countries,this study compares the similarities and differences of the educational goals of the two countries through qualitative literature content analysis.Both countries have taken“modernization and internationalization”as one of the core development directions of higher education development,but China’s educational philosophy is rooted in Confucianism and socialist core values,emphasizing country and collectivism;while Kazakhstan,based on neoliberal orientation,draws on the European education framework,gradually integrates multicultural concepts,emphasizes national identity and attaches importance to students’individual development.This study uses Hofstede’s cultural dimensions and postcolonial education theory to explore how different nation-building narratives affect the educational goals of higher education.By comparing value systems,institutional logics,and student training models,it helps to understand how the educational systems of the“Global South”countries seek a balance between international standards and local cultural identity.It provides inspiration for the development of education based on culture and mutual reference under the global education trend,and provides a comparative education perspective for reform localization.展开更多
Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’p...Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.展开更多
This paper conducts clustering,potential semantic indexing,comparison,and inductive analysis of research papers on marketing between China and the UK from January 2020 to September 2024.The study found that the Chines...This paper conducts clustering,potential semantic indexing,comparison,and inductive analysis of research papers on marketing between China and the UK from January 2020 to September 2024.The study found that the Chinese marketing research focuses on digital transformation,policy impact,value co-creation,and emerging e-commerce models.In contrast,the UK marketing research focuses more on sustainability,technology integration,real-time research,and personalized marketing strategies.The study also found that there were few marketing articles published in Chinese and CSSCI journals in China,while the SSCI journals published in English were 62 times more than in Chinese.According to the research,digital marketing and data-driven decision-making,diversified marketing channels,sustainability and circular economy,technological innovation and cutting-edge technology application,meta-universe and blockchain technology,AI+marketing development,brand building,and international market expansion will become the research hotspots in the field of marketing in the future.The research suggests that China should strengthen the construction of an academic marketing platform,and China and the UK should strengthen cooperation in marketing research,learn from each other's strengths,and jointly give full play to their advantages in technology application,market and economy,strategy and innovation,and social media,to contribute to global economic development and marketing research.展开更多
This paper conducted a more comprehensive review and comparative analysis of the two heavy to blizzard processes that occurred in the Beijing area during December 13-15,2023,and February 20-21,2024,in terms of compreh...This paper conducted a more comprehensive review and comparative analysis of the two heavy to blizzard processes that occurred in the Beijing area during December 13-15,2023,and February 20-21,2024,in terms of comprehensive weather situation diagnosis,forecasting,and decision-making services,and summarized the meteorological service support experience of such heavy snow weather processes.It was found that both blizzard processes were jointly influenced by the 700 hPa southwesterly warm and humid jet stream and the near-surface easterly backflow;the numerical forecast was relatively accurate in the overall description of the snowfall process,and the forecast bias of the position of the 700 hPa southwesterly warm and humid jet stream determined the bias of the snowfall magnitude forecast at a certain point;when a deviation was found between the actual snowfall and the forecast,the cause should be analyzed in a timely manner,and the warning and forecast conclusions should be updated.With the full cooperation of relevant departments,it can greatly make up for the deviation of the early forecast snowfall amount,and ensure the safety and efficiency of people's travel.展开更多
Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in m...Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).展开更多
BACKGROUND Anxiety is a common comorbidity in patients with Crohn’s disease(CD).Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited.AIM To compare the ima...BACKGROUND Anxiety is a common comorbidity in patients with Crohn’s disease(CD).Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited.AIM To compare the imaging characteristics of brain microstructure and cerebral perfusion among CD patients with or without anxiety and healthy individuals.METHODS This prospective comparative study enrolled consecutive patients with active CD and healthy individuals who visited the study hospital between January 2022 and January 2023.Anxiety was measured using the Hospital Anxiety and Depression Scale-Anxiety.The imaging characteristics of brain microstructure and cerebral perfusion were measured by diffusion kurtosis imaging and intravoxel incoherent motion.RESULTSA total of 57 participants were enrolled. Among the patients with active CD, 16 had anxiety. Compared withhealthy individuals, patients with active CD demonstrated significantly lower radial kurtosis values in the rightcerebellar region 6, lower axial kurtosis (AK) values in the right insula, left superior temporal gyrus, and rightthalamus, and higher slow and fast apparent diffusion coefficients (ADCslow and ADCfast) in the bilateral frontal lobe,bilateral temporal lobe, and bilateral insular lobe (all P < 0.05). Compared with patients with CD without anxiety,patients with CD and anxiety exhibited significantly higher ADCslow values in the left insular lobe and lower AKvalues in the right insula and right anterior cuneus (all P < 0.05).CONCLUSIONThere are variations in brain microstructure and perfusion among CD patients with/without anxiety and healthyindividuals, suggesting potential use in assessing anxiety-related changes in active CD.展开更多
基金supported by the National Natural Science Foundation of China(U2241221).
文摘This article introduces a novel 20 V radiation-hardened high-voltage metal-oxide-semiconductor field-effect transistor(MOSFET)driver with an optimized input circuit and a drain-surrounding-source(DSS)structure.The input circuit of a conventional inverter consists of a thick-gate-oxide n-type MOSFET(NMOS).These conventional drivers can tolerate a total ionizing dose(TID)of up to 100 krad(Si).In contrast,the proposed comparator input circuit uses both a thick-gate-oxide p-type MOSFET(PMOS)and thin-gate-oxide NMOS to offer a high input voltage and higher TID tolerance.Because the thick-gate-oxide PMOS and thin-gate-oxide NMOS collectively provide better TID tolerance than the thick-gate-oxide NMOS,the circuit exhibits enhanced TID tolerance of>300 krad(Si).Simulations and experimental date indicate that the DSS structure reduces the probability of unwanted parasitic bipolar junction transistor activation,yielding a better single-event effect tolerance of over 81.8 MeVcm^(2)mg^(-1).The innovative strategy proposed in this study involves circuit and layout design optimization,and does not require any specialized process flow.Hence,the proposed circuit can be manufactured using common commercial 0.35μm BCD processes.
文摘Objective: We aim to analyze the surgical nursery of abdominal wall hernias in adults between two poorly fitted medical environments, the Regional Hospital Center of Tsévié (RHC-T) and the Prefectural Hospital Center of Kpalimé (PHC-K) in Togo. Methodology: It was a retrospective, descriptive and comparative study carried out over five years (2018-2022) focusing on abdominal wall hernias in adults. Information was gathered from the patients’clinical notes and registers on the frequency of hernias, the anatomo-clinical forms of hernias, the type of anesthesia, the hernia repair technique and the postoperative evolution. Results: Of the 1022 and 1026 operations performed, 312 and 412 were hernial repairs, representing 30.5% and 41.2% of operations at RHC-T and PHC-K respectively (p = 0.001). The inguinal hernia was the most often found in 83.7% (n = 261) at RHC-T versus 76.6% (n = 324) at PHC-K. Herniorrhaphy was the most frequently used repair method, in 93.6% (n = 292) of patients at RHC-T and in 91.3% (n = 376) at PHC-K (p = 0.11). Postoperative complications were noted in 5.1% of cases (n = 16) at RHC-T versus 3.5% of cases (n = 15) at PHC-K (p = 0.307). These complications included scrotal hematomas, surgical areas infections, and orchitis. We recorded 1.3% (n = 4) and 0.8% (n = 3) deaths at RHC-T and PHC-K respectively (p = 0.496). Conclusion: There is homogeneity in the treatment of hernia in these two hospitals in Togo.
基金the Natural Science Foundation of Shandong Province(ZR2020QC022)the Science and Technology Basic Resources Investigation Program of China(No.2019FY100900)+2 种基金the Major Program for Basic Research Project of Yunnan Province(202401BC070001)Yunnan Revitalization Talent Support Program:Yunling Scholar Project to Tingshuang Yithe open research project of“Cross Cooperative Team”of the Germplasm Bank of Wild Species,Kunming Institute of Botany,Chinese Academy of Sciences.
文摘The plastid genome(plastome)represents an indispensable molecular resource for studying plant phylogeny and evolution.Although plastome size is much smaller than that of nuclear genomes,accurately and efficientlyannotating and utilizing plastome sequences remain challenging.Therefore,a streamlined phylogenomic pipeline spanning plastome annotation,phylogenetic reconstruction and comparative genomics would greatly facilitate research utilizing this important organellar genome.Here,we develop PlastidHub,a novel web application employing innovative tools to analyze plastome sequences.In comparison with existing tools,key novel functionalities in PlastidHub include:(1)standardization of quadripartite structure;(2)improvement of annotation flexibility and consistency;(3)quantitative assessment of annotation completeness;(4)diverse extraction modes for canonical and specialized sequences;(5)intelligent screening of molecular markers for biodiversity studies;(6)genelevel visual comparison of structural variations and annotation completeness.PlastidHub features cloud-based web applications that do not require users to install,update,or maintain tools;detailed help documents including user guides,test examples,a static pop-up prompt box,and dynamic pop-up warning prompts when entering unreasonable parameter values;batch processing capabilities for all tools;intermediate results for secondary use;and easy-to-operate task flows between fileupload and download.A key feature of PlastidHub is its interrelated task-based user interface design.Give that PlastidHub is easy to use without specialized computational skills or resources,this new platform should be widely used among botanists and evolutionary biologists,improving and expediting research employing the plastome.PlastidHub is available at https://www.plastidhub.cn.
基金Supported by the National Natural Science Foundation of China(Nos.91858208,92358301)the Laoshan Laboratory(No.LSKJ 202203500),the China Postdoctoral Science Foundation of China(No.2019M663209)the Fundamental Research Funds for the Central Universities in China(No.19lGPY100)。
文摘Bathymodiolus mussels distribute in both deep-sea cold seep and hydrothermal vent environments,whose endosymbiotic gill tissue is a prominent character for the adaptation of extreme habitats.However,few studies explored the adaptation mechanisms through comparative transcriptome sequencing and analysis of different tissues between seep mussels and vent mussels.We performed the comparative transcriptome sequencing and analysis for three tissue types(gill,mantle,and adductor muscle)of Bathymodiolus mussels collected from a cold seeping site Station S 11 and the 50-km away hydrothermal field Minami-Ensei Knoll in the Okinawa Trough.Results show that gene expression patterns had distinct tissue specificity.Compared with the non-endosymbiotic tissues(mantle and adductor muscle),the significantly strengthened gene functions in endosymbiotic gill included microbial recognition(fibrinogen C domain-containing protein 1-B-like(fibcd),fibrinogen-related protein 8(frp),peptidoglycan recognition proteins(pgrp),and C-type lectin(clec)),cell apoptosis and immunity(interferon regulatory factor 1/2-like 1(ir f),cathepsin D(ctsd),caspase 2(casp 2)),and antioxidant capacity(copper/zinc superoxide dismutase(czsod),glutathione peroxidase(gpx),selenoprotein(sel)),in both seep and vent individuals.Consistent with metal accumulation,high expression levels of genes related to heavy metal detoxification(cytochrome P 450(cyp),ferritin-like(ftl),metallothionein(mt),glutathione S-transferase(gst))were also observed in gill.Moreover,to adapt to high hydrostatic pressure in the deep sea,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways associated with cellular community were significantly enriched in all three tissues,suggesting the regulation of cell structure and cell adhesion at transcriptional level.This study obtained gene expression profiles of deep-sea mussels subsisting at cold seep and hydrothermal vent sites,which could lay foundations for comprehensive investigations of molecular basis in adaptation of deep-sea mussels to the two extreme ecosystems.
文摘The exchange and mutual appreciation of different cultures is an important topic in the context of globalization,and traditional patterns are the crystallization of the national cultures of various countries.The study focuses on the Ming Dynasty Mandarin square in ancient China and the Tudor Dynasty coat of arms during the same period in England.By using comparative research,case studies,and combining historical documents and images,the origins of the two types of decorations are traced,and their social connotations and influencing factors are analyzed.Research has shown that under the influence of the historical backgrounds of politics,economy,and culture,the two types of decorative patterns exhibit a realistic aesthetic trend.The cultural connotations not only demonstrate social narrative functions such as customs and rituals,but also reflect political system functions such as hierarchy and honor.The different historical origins give rise to cultural differences in the selection of decorative elements between the two.The comparative study of the two is not only beneficial for conducting decorative design research from a global perspective,but also can promote the modern inheritance of traditional patterns while seeking common ground and reserving differences.
文摘Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.
基金supported by the Shandong Natural Science Foundation Youth Project(No.ZR2023QE075)the Open Project Program of Shandong Marine Aerospace Equipment Technological Innovation Center(No.MAETIC202210)the Shandong Natural Science Foundation Project(No.ZR2022ME145)。
文摘The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strategy,the industry predominantly employs a semi-activated control strategy in existing tidal current energy converters.It is essential to identify the differences in predicted energy-harvesting performance between these two controlling strategies through experimental modeling or numerical studies.Furthermore,the suitability of the fully activated control strategy in predicting the energy-harvesting capabilities of oscillating hydrofoils is evaluated.The 2D numerical models of hydrofoil based on fully activated and semi-activated control strategies have been developed and validated.The amplitudes of heaving and pitching movements for the fully activated hydrofoil are determined to match those of the semi-activated hydrofoil.The results show that the main difference between the two control strategies lies in the phase shift occurring between the pitching and heaving motions.This phase shift affects the lift force and its coordination with the heaving velocity,which in turn affects the power output.Notably,the maximum relative efficiency difference obtained between the fully activated and semi-activated control strategies can reach 191%.
文摘Herpes simplex virus(HSV)types 1 and 2 pose significant health risks during pregnancy,impacting both maternal and neonatal outcomes.The 2024 joint guideline from the British Association for Sexual Health and HIV(BASHH)and the Royal College of Obstetricians and Gynaecologists(RCOG)in the United Kingdom introduces updated recommendations to reduce maternal-to-neonatal transmission.Key recommendations include initiating antiviral therapy earlier—at 32 weeks for standard pregnancies or as early as 22 weeks in high-risk cases—to minimize viral shedding.The guideline emphasizes polymerase chain reaction(PCR)testing for accurate diagnosis and advocates a multidisciplinary team(MDT)approach,involving genitourinary medicine(GUM)specialists,obstetricians,and neonatologists for delivery planning and neonatal care.However,the Chinese guidelines offer greater flexibility in the timing of antiviral treatment,tailored to regional resources and specific circumstances.PCR testing is also recommended,particularly in urban hospitals and tertiary care settings.The UK′s MDT model aligns with China′s integrative healthcare approach,presenting opportunities for mutual learning and collaboration.This comparative analysis highlights areas for cross-adaptation in clinical practices,with potential to enhance maternal and neonatal health outcomes globally.
文摘Although previous studies have analyzed the unique structural characteristics of the polar vortices on Earth,Venus,Mars,and Titan,the understanding of the polar vortices on Venus and Titan is primarily based on small-scale case studies due to the limited resolution and coverage of observational data.Conducting a detailed comparison of the polar vortex characteristics between the major terrestrial planets and Titan in the solar system is more challenging.In order to more finely compare the polar vortex characteristics of the main terrestrial planets in the solar system with Titan,we have achieved the optimal estimation of the polar vortices of Venus and Titan under existing conditions based on the advanced VCD2.3 and TitanWRF model.At the same time,combining ERA5 and EMARS databases,a detailed spatiotemporal comparison of polar vortex characteristics between terrestrial planets with atmospheres in the solar system and the most Earth-like Titan satellite was conducted for the first time.Here,we demonstrate that:(1)The circulation characteristics of Mars above the 1 mbar level are very similar to those at 1000 mbar in the lower layers of Titan,with seasonal variations of the same height.(2)In contrast to the vortex structure that is stably maintained in the lead direction in the polar regions of Mars and Earth during the winter,the time of occurrence of the peak vortex intensity at Titan and Venus is gradually shifted forward with increasing altitude.(3)When Venus undergoes vortex instability drift,the polar vortex at an altitude of 1 mbar breaks up into banded structures,a phenomenon that closely resembles the twisting deformation of PV structures during weak stratospheric polar vortex events on Earth.
文摘Based on the Etihad Railway Station Project,this study selects a single-span frame bridge with a clear span of 7.3 meters as the research object.A comprehensive structural design process was conducted following the AREMA(2023),Manual for Railway Engineering-Volume 2-Structures,with systematic comparisons of techno-economic differences between the Chinese and American codes through recalculation verification and equivalent-precision design methods.The findings reveal:Recalculation using the Chinese code for identical structural dimensions and reinforcement layouts demonstrates that AREMA code exhibits greater conservatism in both strength requirements and crack control;Under equivalent precision design principles,the Chinese code solution reduces reinforcement by 4.128 t tons and a 19.5%reduction in reinforcement at critical sections compared to the AREMA code,indicating slightly reduced economic efficiency of the AREMA code.This research provides quantitative references for standardized design and specification integration in cross-border railway engineering projects.
文摘Objective To discuss the flexible supervision and communication mode in the post-approval change(PAC)of drugs,to explore how to ensure the quality and availability of drugs during the changes,and to provide some suggestions and reference for promoting the timely marketing of drugs.Methods Based on the comparability protocol guidelines issued by the US FDA in October 2022,the regulatory status quo of PAC between China and the US was compared to explore the feasibility of implementing comparability protocols in China.Results and Conclusion According to the specific situation of post-approval of drug change supervision,some suggestions were put forward to optimize the PAC management procedure,such as establishing the communication pathways between holders and health authorities,publishing relevant guidance and strengthening training,so as to provide reference for the implementation of comparability protocols in China.
文摘The rapid development and application of emerging information technologies,such as big data and artificial intelligence,facilitates the development of intelligent urban rail vehicles.Architecture is an important component of intelligent urban rail vehicles and a key factor in ensuring their reliable and safe operation on various routes.In this context,it is very important to select appropriate architecture design standards.The paper reviews the relevant design standards for architecture at home and abroad,comprehensively analyzes the standards that need to be compared and analyzed,and conducts comprehensive comparative analysis in the aspects of the scope of application,load conditions,vertical static load,lateral load,and evaluation methods of the standards.Finally,it draws a conclusion that the standard JIS E 4207:2019,Rolling stock—Bogie—General rules for design of bogie frame strength,can meet the requirements of strength design of welded bogie frame in intelligent urban rail vehicles.It proposes the suggestions on better validating this design method in future bench and line tests of products,in order to improve the design concept of bogie frame strength and provide reference and inspiration for promoting the development of intelligent urban rail vehicles in China.
文摘This study explores the cultural and value foundations of the educational goals of higher education in Kazakhstan and China.Based on the historical development and cultural traditions of the two countries,this study compares the similarities and differences of the educational goals of the two countries through qualitative literature content analysis.Both countries have taken“modernization and internationalization”as one of the core development directions of higher education development,but China’s educational philosophy is rooted in Confucianism and socialist core values,emphasizing country and collectivism;while Kazakhstan,based on neoliberal orientation,draws on the European education framework,gradually integrates multicultural concepts,emphasizes national identity and attaches importance to students’individual development.This study uses Hofstede’s cultural dimensions and postcolonial education theory to explore how different nation-building narratives affect the educational goals of higher education.By comparing value systems,institutional logics,and student training models,it helps to understand how the educational systems of the“Global South”countries seek a balance between international standards and local cultural identity.It provides inspiration for the development of education based on culture and mutual reference under the global education trend,and provides a comparative education perspective for reform localization.
文摘Teacher professional identity is a comprehensive reflection of teachers’role perception,emotional experiences,and behavioral tendencies towards their profession.It serves as an intrinsic driving force for teachers’professional development and is also a crucial issue in teacher education research.From a global perspective,this study systematically reviews and examines relevant research on the professional identity of international Chinese language teachers(ICLTs).A comparative analysis is conducted between Chinese and foreign scholars’research in terms of theoretical foundations,research subjects,research content,and research methodologies.This comprehensive overview of the current research landscape in this field,along with a summary of existing achievements and identified problems,facilitates the transformation of fragmented research findings on ICLTs’professional identity into a systematic understanding and reveals research gaps.Building upon this foundation,the study proposes future research prospects for the professional identity of ICLTs from aspects such as the construction of a cross-cultural perspective-based teacher professional identity system,the transformation of teacher professional identity in the context of digital transformation,and case studies on ICLTs’professional identity.The aim is to promote high-quality development in both theory and practice of international Chinese language education.
文摘This paper conducts clustering,potential semantic indexing,comparison,and inductive analysis of research papers on marketing between China and the UK from January 2020 to September 2024.The study found that the Chinese marketing research focuses on digital transformation,policy impact,value co-creation,and emerging e-commerce models.In contrast,the UK marketing research focuses more on sustainability,technology integration,real-time research,and personalized marketing strategies.The study also found that there were few marketing articles published in Chinese and CSSCI journals in China,while the SSCI journals published in English were 62 times more than in Chinese.According to the research,digital marketing and data-driven decision-making,diversified marketing channels,sustainability and circular economy,technological innovation and cutting-edge technology application,meta-universe and blockchain technology,AI+marketing development,brand building,and international market expansion will become the research hotspots in the field of marketing in the future.The research suggests that China should strengthen the construction of an academic marketing platform,and China and the UK should strengthen cooperation in marketing research,learn from each other's strengths,and jointly give full play to their advantages in technology application,market and economy,strategy and innovation,and social media,to contribute to global economic development and marketing research.
文摘This paper conducted a more comprehensive review and comparative analysis of the two heavy to blizzard processes that occurred in the Beijing area during December 13-15,2023,and February 20-21,2024,in terms of comprehensive weather situation diagnosis,forecasting,and decision-making services,and summarized the meteorological service support experience of such heavy snow weather processes.It was found that both blizzard processes were jointly influenced by the 700 hPa southwesterly warm and humid jet stream and the near-surface easterly backflow;the numerical forecast was relatively accurate in the overall description of the snowfall process,and the forecast bias of the position of the 700 hPa southwesterly warm and humid jet stream determined the bias of the snowfall magnitude forecast at a certain point;when a deviation was found between the actual snowfall and the forecast,the cause should be analyzed in a timely manner,and the warning and forecast conclusions should be updated.With the full cooperation of relevant departments,it can greatly make up for the deviation of the early forecast snowfall amount,and ensure the safety and efficiency of people's travel.
文摘Iread with great interest the recent article by Shin,et al.[1]the authors present an important exploration into the use of drug-coated balloon(DCB)in patients aged≥75 years,a demographic increasingly encountered in modern cardiovascular practice.The authors conducted a retrospective analysis involving 2050 elderly patients(aged≥75 years)undergoing successful percutaneous coronary intervention(PCI).
基金Ethics Committee of Affiliated Changzhou Second People’s Hospital of Nanjing Medical University(approval number KY039-01).
文摘BACKGROUND Anxiety is a common comorbidity in patients with Crohn’s disease(CD).Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited.AIM To compare the imaging characteristics of brain microstructure and cerebral perfusion among CD patients with or without anxiety and healthy individuals.METHODS This prospective comparative study enrolled consecutive patients with active CD and healthy individuals who visited the study hospital between January 2022 and January 2023.Anxiety was measured using the Hospital Anxiety and Depression Scale-Anxiety.The imaging characteristics of brain microstructure and cerebral perfusion were measured by diffusion kurtosis imaging and intravoxel incoherent motion.RESULTSA total of 57 participants were enrolled. Among the patients with active CD, 16 had anxiety. Compared withhealthy individuals, patients with active CD demonstrated significantly lower radial kurtosis values in the rightcerebellar region 6, lower axial kurtosis (AK) values in the right insula, left superior temporal gyrus, and rightthalamus, and higher slow and fast apparent diffusion coefficients (ADCslow and ADCfast) in the bilateral frontal lobe,bilateral temporal lobe, and bilateral insular lobe (all P < 0.05). Compared with patients with CD without anxiety,patients with CD and anxiety exhibited significantly higher ADCslow values in the left insular lobe and lower AKvalues in the right insula and right anterior cuneus (all P < 0.05).CONCLUSIONThere are variations in brain microstructure and perfusion among CD patients with/without anxiety and healthyindividuals, suggesting potential use in assessing anxiety-related changes in active CD.
