This paper investigates the common due-window assignment scheduling problem with deteriorating jobs on a single machine in which the processing time of a job is a proportional function of its starting time.The goal is...This paper investigates the common due-window assignment scheduling problem with deteriorating jobs on a single machine in which the processing time of a job is a proportional function of its starting time.The goal is to minimize the maximum value of earliness and tardiness penalties,as well as due-window location cost,and size cost.Depending on whether the location and size of due-window are known,this paper studies three relevant cases,all of which are solvable in polynomial time.展开更多
BACKGROUND Common bile duct stones pose a high risk of recurrence or disease progression if not promptly treated.However,there is still no optimal treatment approach.AIM To investigate the clinical efficacy of modifie...BACKGROUND Common bile duct stones pose a high risk of recurrence or disease progression if not promptly treated.However,there is still no optimal treatment approach.AIM To investigate the clinical efficacy of modified pancreatic duct stent drainage in endoscopic retrograde cholangiopancreatography(ERCP)for treating common bile duct stones.METHODS This retrospective study included 175 patients with common bile duct stones treated at Taizhou Fourth People’s Hospital between January 1,2021,and November 30,2023.The patients were divided into three groups-the modified pancreatic duct stent drainage group(59 cases),the nasobiliary drainage group(58 cases),and the standard biliary drainage group(58 cases).Preoperative general clinical data,laboratory indicators,and the visual analog scale(VAS)at two time points(24 hours before and after surgery)were compared,along with postoperative complications across the three groups.RESULTS Serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,gamma-glutamyltransferase,total bilirubin,direct bilirubin,Creactive protein,and amylase were significantly lower in the modified pancreatic duct stent drainage group and the standard biliary drainage group than those in the nasobiliary drainage group(P<0.05).However,no statistically significant differences were observed in white blood cells,hemoglobin,or neutrophil levels among the three groups(P>0.05).The standard biliary drainage group had significantly lower VAS scores[(4.36±1.18)points]than those for the modified pancreatic duct stent drainage group[(4.92±1.68)points](P=0.033),and the nasobiliary drainage group[(5.54±1.24)points](P=0.017).There were no statistically significant differences in complication rates across the three groups(P>0.05).CONCLUSION Compared to standard biliary drainage and nasobiliary drainage,the modified pancreatic duct stent used during ERCP for patients with bile duct stones significantly reduced hepatocyte injury,improved liver function parameters,alleviated inflammation and pain,enhanced patient comfort,and demonstrated superior safety.展开更多
BACKGROUND Pancreaticobiliary maljunction(PBM)is a rare congenital abnormality in pancreaticobiliary duct development.PBM is commonly found in children,and it often leads to acute pancreatitis and other diseases as a ...BACKGROUND Pancreaticobiliary maljunction(PBM)is a rare congenital abnormality in pancreaticobiliary duct development.PBM is commonly found in children,and it often leads to acute pancreatitis and other diseases as a result of pancreaticobiliary reflux.Roux-en-Y choledochojejunostomy is a common surgical method for the treatment of PBM,but there are several associated complications that may occur after this operation.CASE SUMMARY The patient,a 12-year-old female,was hospitalized nearly 20 times in 2021 for recurrent acute pancreatitis.In 2022,she was diagnosed with PBM and underwent laparoscopic common bile duct resection and Roux-en-Y choledochojejunostomy in a tertiary hospital.In the first year after surgery,the patient had more than 10 recurrent acute pancreatitis episodes.After undergoing abdominal computed tomography and other examinations,she was diagnosed with“residual bile duct stones and recurrent acute pancreatitis”.On January 30,2024,the patient was admitted to our hospital due to recurrent upper abdominal pain and was cured through endoscopic retrograde cholangiopancreatography.CONCLUSION This article reports a case of a child with distal residual common bile duct stones and recurrent acute pancreatitis after Roux-en-Y choledochojejunostomy for PBM.The patient was cured through endoscopic retrograde cholangiopancreatography.展开更多
Synthetic fertilizers are widely used to address the urgent challenge of ensuring food supplies for a growing world population in the context of climate change. However, their industrial production and use in agricult...Synthetic fertilizers are widely used to address the urgent challenge of ensuring food supplies for a growing world population in the context of climate change. However, their industrial production and use in agriculture have a negative impact on the environment and consequently on human health. While chemical fertilizers may not have to be abandoned in agricultural production systems, limiting their use could help to make agriculture sustainable and resilient to climate change. In Senegal, the level of mineral fertilizers used in market gardening has become alarming in the Niayes area. As a result, microbial biotechnologies have been promoted for biofertilizer production of common bean (Phaseolus vulgaris L.) cultivation. Rhizobial inoculums have thus been used to reduce the rate of chemical nitrogen fertilizers being applied in cropping systems. Several investigations in the laboratory, on experimental stations and in the field have shown a possibility of a significant reduction in the use of nitrogen fertilizers in common bean production. Conventional mineral fertilization use can be reduced from over 120 kg N/ha to 20 kg N/ha. This contributes both to a very significant reduction in the application rate with the same level of yield and to an improvement in the standard of living. In addition, the environmental impact of using chemical fertilizers can be mitigated. This study is a contribution to the promotion of biofertilizers adoption in agricultural systems.展开更多
In this paper,we establish common fixed point theorems for expansive map?pings on b-metric-like space and coincidence point for f-weakly isotone increasing mappings in partially ordered b-metric-like space.The main re...In this paper,we establish common fixed point theorems for expansive map?pings on b-metric-like space and coincidence point for f-weakly isotone increasing mappings in partially ordered b-metric-like space.The main results generalize and extend several well-known comparable results from the existing literature.Moreover,some examples are provided to illustrate the main results.展开更多
Almost 400 years ago,Americas early European colonists voted to tax each household in Boston about$70 in todays money.The money was used to buy a local farm.The plan was to use it as a common area for the public.That ...Almost 400 years ago,Americas early European colonists voted to tax each household in Boston about$70 in todays money.The money was used to buy a local farm.The plan was to use it as a common area for the public.That is how Boston Common,in the state of Massachusetts,became Americas first public park.展开更多
BACKGROUND At present,there are few studies on the risk factors for bile leakage after laparoscopic common bile duct exploration(LCBDE)for older patients with choledocholithiasis.AIM To identify the potential risk fac...BACKGROUND At present,there are few studies on the risk factors for bile leakage after laparoscopic common bile duct exploration(LCBDE)for older patients with choledocholithiasis.AIM To identify the potential risk factors for bile leakage after LCBDE in older patients.METHODS A retrospective,single-center observational analysis was performed on patients aged≥70 years with choledocholithiasis treated by LCBDE who were admitted to our center between January 2011 and August 2022.The included patients were divided into non-bile leakage and bile leakage groups.Risk factors were determined by analyzing the observation indicators.RESULTS Seventy older patients with choledocholithiasis who underwent LCBDE were included.Univariate analysis showed that positive culture of bile bacteria was a risk factor for bile leakage after LCBDE(P<0.05).We further analyzed the bile bacteria,and univariate analysis showed that Enterococcus faecalis(E.faecalis)(P<0.05)and Pseudomonas aeruginosa(P<0.05)were associated with an increased risk of postoperative bile leakage in older patients(P<0.05).Multivariate analysis showed that E. faecalis was an independent risk factor for postoperative bile leakage in older patients (P < 0.05). Theresults of antibiotic sensitivity analysis showed that E. faecalis had 100% susceptibility to penicillin, ampicillin,linezolid, vancomycin, and furantoin.CONCLUSIONE. faecalis-associated biliary tract infection is an independent risk factor for bile leakage after LCBDE in olderpatients with choledocholithiasis. We suggest coverage with antibiotics to which E. faecalis is sensitive.展开更多
Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidne...Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidney beans,a subcategory of dry common beans,are highly valued for their rich protein,dietary fiber,low fat content,and various trace elements(Garcia-Cordero et al.,2021).Despite the release of several de novo genome assemblies(Goodstein et al.,2012;Schmutz et al.,2014;Vlasova et al.,2016;Cortinovis et al.,2024),existing common bean genomes remain incomplete,particularly in complex regions such as centromeres and telomeres,limiting a comprehensive understanding of the genomic landscape.展开更多
Based on Marxist theory of social reproduction and the dual dimensions of“wealth”and“common prosperity,”this study examines the impact of the digital economy in promoting common prosperity across the four key stag...Based on Marxist theory of social reproduction and the dual dimensions of“wealth”and“common prosperity,”this study examines the impact of the digital economy in promoting common prosperity across the four key stages:production,distribution,exchange,and consumption.The findings indicate that the digital economy fosters productivity growth and plays significant regulatory roles in primary distribution,redistribution,and third distribution.Moreover,the digital economy overcomes the spatiotemporal constraints of exchange and enhances consumption equality,thereby generating both“wealth”and“common prosperity”effects.However,there are still persistent challenges,including the displacement of traditional outputs,monopolization by digital platforms,the impact on employment,and income disparities arising from the digital divide.To address these challenges,we recommend optimizing the development policies of the digital economy,accelerating the growth of digital productivity,strengthening regulation of the digital platforms,building new talent supply systems,actively addressing the digital divide,and advancing market-oriented reform of data elements to better promote common prosperity.展开更多
The Rural Revitalization Investment Fund serves as a crucial financial instrument for advancing rural revitalization and promoting common prosperity.It aims to address financing and land-use challenges faced by rural ...The Rural Revitalization Investment Fund serves as a crucial financial instrument for advancing rural revitalization and promoting common prosperity.It aims to address financing and land-use challenges faced by rural industries through financial support while fostering coordinated industrial development.The fund primarily operates through equity direct investment and the“mother fund+direct investment”model,with an increasing emphasis on combining government guidance with social capital participation.However,challenges persist,including a shortage of professional talent,insufficient institutional innovation,and weak industrial foundations in rural areas.To enhance the fund’s effectiveness,it is recommended to strengthen professional team management,clearly define its strategic positioning,implement strict supervision,innovate operational mechanisms,and prioritize environmental and social responsibility.These measures will ensure that the fund contributes to rural revitalization while promoting sustainable development and common prosperity.展开更多
BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0....BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0.9 cm stone located in the lower and middle segments of the CBD,identified 30 days after T-tube cholangiography,accompanied by multiple microstones.Magnetic resonance cholangiopancreatography revealed dilation of both intrahepatic and extrahepatic bile ducts,with the widest segment of the CBD measuring approximately 2 cm.The patient underwent laparoscopic choledochal exploration followed by choledochojejunostomy using the Roux-en-Y technique.CONCLUSION Although recurrence of choledocholithiasis within such a short postoperative period is exceedingly uncommon,this case underscores the necessity for clinicians to remain vigilant regarding the potential for early postoperative recurrence.展开更多
Based on micro-survey data from 894 farmers in Sichuan Province,this study employs the Ordinary Least Squares(OLS),Two-Stage Least Squares(2SLS),mediating effect,and moderating effect models to comprehensively analyze...Based on micro-survey data from 894 farmers in Sichuan Province,this study employs the Ordinary Least Squares(OLS),Two-Stage Least Squares(2SLS),mediating effect,and moderating effect models to comprehensively analyze the mechanisms and effects of digital literacy in empowering farmers’common prosperity.Endogeneity and robustness are addressed using the Sobel test,the Bootstrap,and moderating effect plots.The findings indicate that first,after controlling for variables such as age,gender,and planting years,digital literacy significantly and positively influences the common prosperity of farmers at the 5%level;second,enhanced digital literacy promotes higher levels of technology adoption and information accumulation among farmers,thereby increasing the probability of achieving common prosperity.The mediating effects of technology adoption and information sharing account for 21.10%and 33.94%of the total effect,respectively;and third,the information environment and financial empowerment play positive moderation roles in the effect of digital literacy on farmers’common prosperity,with the moderation effects significant at the 1%and 10%levels,respectively.Therefore,we recommend policies that enhance the access of farmers to digital literacy training,strengthen rural digital infrastructure,establish integrated rural information-sharing platforms,and create an enabling environment for the adoption of digital technologies.展开更多
Management innovation is a key driver of total factor productivity and plays a crucial role in developing new quality productive forces.As China’s capital market continues to develop,the prevalence of common ownershi...Management innovation is a key driver of total factor productivity and plays a crucial role in developing new quality productive forces.As China’s capital market continues to develop,the prevalence of common ownership—investors who hold significant stakes in multiple firms—has grown,raising the question of how it influences corporate management innovation.This study empirically investigates this issue using panel data from A-share listed companies in China between 2014 and 2022.The findings reveal an inverted U-shaped relationship between common ownership and management innovation.Specifically,institutional common ownership exerts no significant effect,while non-institutional common ownership exhibits a significant inverted U-shaped influence.Mechanism analysis suggests that common ownership often appoints shared directors,supervisors,and senior executives across firms,which in turn significantly impacts corporate management innovation.Further analysis indicates that common ownership in the primary and tertiary industries significantly influences management innovation,whereas that in the secondary industry does not show such an effect.This study offers valuable insights for corporate governance,business management,and investor decision-making and provides important references for policymakers in formulating governance-related regulations.展开更多
[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP datab...[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP database and HIT2.0 database.The collected targets were intersected with antibacterial/bacteriostatic targets obtained from the GeneCards database and OMIM database to identify the antibacterial/bacteriostatic targets of Common Cnidium Fruit.The active component-target network diagram of Common Cnidium Fruit was constructed using Cytoscape software and topological analysis was performed.GO enrichment analysis was performed on the target genes using the DAVID database.[Results]Screening yielded 25 active components of Common Cnidium Fruit,corresponding to 77 targets.Analysis identified 25 core antibacterial/bacteriostatic targets for Common Cnidium Fruit.Network analysis indicated that Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through active components such asβ-sitosterol,stigmasterol,and xanthoxylin,while activating the body's immune regulatory functions by acting on targets including CASP3,PTGS2,BCL2,JUN,and ESR1.[Conclusions]Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through multiple pathways via a mechanism involving multiple components,multiple targets,and multiple pathways.展开更多
Illegal hunting and trafficking of wildlife and their derivatives extort unprecedented population decline of relatively many species pushing them towards extinction.Notwithstanding contemporary counteracting intervent...Illegal hunting and trafficking of wildlife and their derivatives extort unprecedented population decline of relatively many species pushing them towards extinction.Notwithstanding contemporary counteracting interventions at international,regional,national and local levels,wildlife farming is advocated as an alternative approach to minimize pressure on wild populations.For wildlife farming to be an effective conservation tool,the integration of wildlife forensics is inevitable to allow distinction between captive-bred and wild-caught species.To this end,we analyzed methylation rates of skeletal muscle samples(pectoralis major,triceps brachii,gastrocnemius,biceps femoris,and neck muscles)from 60 captive-bred and 30 wild-caught Common Pheasant.A total of 13,507 differentially methylated regions were identified between five wild-caught and five captive-bred individuals through whole-genome methylation sequencing(WGBS).Based on the selected five methylation sites,LOC116231076,LOC116242223,ATAD2B,EGFL6,and HS2ST,quantitative detection technique was developed using methylation-sensitive high-resolution melting curve(MS-HRM)to measure methylation rates.The results showed significant differences in methylation rates at all differential sites between wild-caught and captive-bred individuals(|t|=0.67–33.10,P=0.000–0.042).The discrimination accuracy rate of each locus was highest in the gastrocnemius muscle and lowest in the neck muscle.The discrimination accuracy rate on LOC116231076,LOC116242223,ATAD2B,EGFL6,and HS2ST methylation sites for gastrocnemius muscle was 64.98%,100.00%,68.54%,63.79%,and 63.70%,respectively;and for neck muscle it was 67.42%,68.06%,83.61%,65.04%,and68.85%,respectively.The united discrimination accuracy rate of the five loci were 100.00%for gastrocnemius muscle,99.78%for biceps femoris muscle,97.52%for pectoralis major muscle,93.96%for triceps brachii muscle,and 91.63%for neck muscle,respectively.The panel also revealed excellent repeatability,reproducibility,sensitivity and universality to mammals and avian species.This study establishes an effective,accurate and low-cost identification technology for the identification of wild and farmed Common Pheasant,and also provides a reference for the development of identification methods for other species.展开更多
BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP...BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP)to clear the bile duct,followed by laparoscopic cholecystectomy.Alternatively,the single-stage laparoendoscopic rendezvous(LERV)procedure combines ERCP and laparoscopic cholecystectomy in the same surgical session.AIM To evaluate the efficacy,safety,and logistical considerations of these two approaches,emphasizing their implications for different healthcare settings.METHODS A literature search was conducted through a PubMed search(2010-2024)using the terms“laparoendoscopic rendezvous”,“endoscopic retrograde cholangiopancreatography”,and“cholecystocholedocholithiasis”.Only English-language studies were included.RESULTS In our analysis,LERV significantly reduced the incidence of post-ERCP pancreatitis by 67%(2.4%vs 8.8%)and shortened hospital stay by a mean of up to 6 days.Stone clearance rates were comparable between LERV(97%)and the two-stage approach(96%).Although LERV was associated with a longer operative time(139.8 minutes vs 107.7 minutes),it demonstrated lower overall costs,largely due to reduced hospitalization.Rates of postoperative bleeding,cholangitis,and bile leak were low and did not differ significantly between groups.CONCLUSION The single-stage LERV approach is safe,effective,and associated with lower pancreatitis rates,shorter hospital stays,and reduced costs compared to the two-stage strategy.Its implementation,however,requires coordinated surgical-endoscopic expertise,making it most suitable for well-equipped centers and carefully selected patients.展开更多
To illustrate the mechanisms of exosomal microRNAs(miRNAs)in common mental disorders,and explore their potential as diagnostic biomarkers and therapeutic targets,a systematic literature review of relevant studies on e...To illustrate the mechanisms of exosomal microRNAs(miRNAs)in common mental disorders,and explore their potential as diagnostic biomarkers and therapeutic targets,a systematic literature review of relevant studies on exosomal miRNAs in mental disorders was conducted.Data from cell experiments,animal models,and clinical studies were analyzed and combined to study the mechanisms and roles of exosomal miRNAs in various mental disorders.Research has shown that exosomal miRNAs,such as miR-146a,miR-223,miR-125b,and miR-451a,affect Alzheimer’s disease(AD)formation by regulating key pathways such as toll-like receptor 4(TLR4)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),respectively.MiR-146a-5p regulates the occurrence of schizophrenia through the Notch pathway.TLR4 regulates miR-146a and miR-155 in major depressive disorder(MDD),and miR-144-5p regulates the disease through PI3K/Akt.Exosomal miR-484,miR-652-3p,miR-142-3p,miR-21a-3p,and miR-21-5p regulate key pathways in bipolar disorder,autism spectrum disorder,and Rett syndrome(e.g.,TLR4,PI3K/Akt,and Epha4/TEK)and have an influence on mental disorders.Exosomal miRNAs are involved in the occurrence of mental disorders through TLR4,PI3K/Akt,and Epha4/TEK pathways,which provides a clearer understanding of disease cognition.Of these pathways,the TLR4 and PI3K/Akt pathways play a role in AD,MDD,and neurodevelopmental disorders,which can be used as an effective breakthrough in the study of mental disorders.Exosomal miRNAs could also serve as diagnostic biomarkers and therapeutic targets,providing new insights into precise interventions for mental disorders.展开更多
Background:The endoscopic appearance of the major duodenal papilla influences biliary cannulation and complications.This study aimed to investigate the role of major duodenal papillae in the endoscopic treatment of co...Background:The endoscopic appearance of the major duodenal papilla influences biliary cannulation and complications.This study aimed to investigate the role of major duodenal papillae in the endoscopic treatment of common bile duct(CBD)stones.Methods:This retrospective study was conducted at Bishan Hospital of Chongqing Medical University between January 2018 and August 2022.Patients with native papillae who underwent endoscopic treatment for CBD stones were recruited and divided into four groups according to Haraldsson's classification of papillae(typesⅠ-Ⅳ).Univariate and multivariate logistic regression analyses were used to identify risk factors for difficult cannulation and post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP).Results:A total of 596 patients with CBD stones were enrolled.The proportion of patients with typeⅠpapilla was the highest(n=231,38.8%),followed by typeⅢpapilla(n=175,29.4%),typeⅣpapilla(n=101,16.9%)and typeⅡpapilla(n=89,14.9%).Difficult cannulation occurred in 188 of 596 patients(31.5%),with most cases occurring in those with typeⅢpapilla(71/175,40.6%,P=0.020).Multivariate logistic analysis revealed that age[odds ratio(OR)=1.034,95%confidence interval(CI):1.021–1.047,P<0.001],typeⅢpapilla(OR=2.255,95%CI:1.439–3.535,P<0.001),gallbladder in situ(OR=2.486,95%CI:1.346–4.590,P=0.004),and CBD diameter<10 mm(OR=1.600,95%CI:1.049–2.441,P=0.029)were risk factors for difficult cannulation.The total incidence of PEP was 10.9%.Compared with the other types of papillae,the rate of PEP was the highest in those with typeⅠpapilla(15.2%,P=0.030).Multivariate analysis demonstrated that PEP was associated with difficult cannulation(OR=1.811,95%CI:1.044–3.143,P=0.035)and white blood cells(WBCs)<10×10~9/L(OR=2.199,95%CI:1.051–4.600,P=0.036).Conclusions:The endoscopic appearance of the major papilla is an important factor that influences both biliary cannulation and outcomes.TypeⅢpapilla is more frequently difficult to cannulate in the endoscopic treatment of CBD stones.展开更多
Herbicide safeners alleviate herbicide toxicity while preserving weed-control efficacy in common buckwheat.A three-year field experiment was performed to measure the effects of quizalofop-P-ethyl(QPE)alone or in combi...Herbicide safeners alleviate herbicide toxicity while preserving weed-control efficacy in common buckwheat.A three-year field experiment was performed to measure the effects of quizalofop-P-ethyl(QPE)alone or in combination with gibberellin or brassinolide on soil enzyme activity and yield components in common buckwheat.The herbicide-brassinolide application yielded the greatest increases in soil enzyme activity and yield components without sacrificing weed control efficacy.It is recommended for use in common buckwheat cultivation in the Loess Plateau.展开更多
[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(A...[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.展开更多
基金supported by LiaoNing Revitalization Talents Program(No.XLYC2002017).
文摘This paper investigates the common due-window assignment scheduling problem with deteriorating jobs on a single machine in which the processing time of a job is a proportional function of its starting time.The goal is to minimize the maximum value of earliness and tardiness penalties,as well as due-window location cost,and size cost.Depending on whether the location and size of due-window are known,this paper studies three relevant cases,all of which are solvable in polynomial time.
文摘BACKGROUND Common bile duct stones pose a high risk of recurrence or disease progression if not promptly treated.However,there is still no optimal treatment approach.AIM To investigate the clinical efficacy of modified pancreatic duct stent drainage in endoscopic retrograde cholangiopancreatography(ERCP)for treating common bile duct stones.METHODS This retrospective study included 175 patients with common bile duct stones treated at Taizhou Fourth People’s Hospital between January 1,2021,and November 30,2023.The patients were divided into three groups-the modified pancreatic duct stent drainage group(59 cases),the nasobiliary drainage group(58 cases),and the standard biliary drainage group(58 cases).Preoperative general clinical data,laboratory indicators,and the visual analog scale(VAS)at two time points(24 hours before and after surgery)were compared,along with postoperative complications across the three groups.RESULTS Serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,gamma-glutamyltransferase,total bilirubin,direct bilirubin,Creactive protein,and amylase were significantly lower in the modified pancreatic duct stent drainage group and the standard biliary drainage group than those in the nasobiliary drainage group(P<0.05).However,no statistically significant differences were observed in white blood cells,hemoglobin,or neutrophil levels among the three groups(P>0.05).The standard biliary drainage group had significantly lower VAS scores[(4.36±1.18)points]than those for the modified pancreatic duct stent drainage group[(4.92±1.68)points](P=0.033),and the nasobiliary drainage group[(5.54±1.24)points](P=0.017).There were no statistically significant differences in complication rates across the three groups(P>0.05).CONCLUSION Compared to standard biliary drainage and nasobiliary drainage,the modified pancreatic duct stent used during ERCP for patients with bile duct stones significantly reduced hepatocyte injury,improved liver function parameters,alleviated inflammation and pain,enhanced patient comfort,and demonstrated superior safety.
文摘BACKGROUND Pancreaticobiliary maljunction(PBM)is a rare congenital abnormality in pancreaticobiliary duct development.PBM is commonly found in children,and it often leads to acute pancreatitis and other diseases as a result of pancreaticobiliary reflux.Roux-en-Y choledochojejunostomy is a common surgical method for the treatment of PBM,but there are several associated complications that may occur after this operation.CASE SUMMARY The patient,a 12-year-old female,was hospitalized nearly 20 times in 2021 for recurrent acute pancreatitis.In 2022,she was diagnosed with PBM and underwent laparoscopic common bile duct resection and Roux-en-Y choledochojejunostomy in a tertiary hospital.In the first year after surgery,the patient had more than 10 recurrent acute pancreatitis episodes.After undergoing abdominal computed tomography and other examinations,she was diagnosed with“residual bile duct stones and recurrent acute pancreatitis”.On January 30,2024,the patient was admitted to our hospital due to recurrent upper abdominal pain and was cured through endoscopic retrograde cholangiopancreatography.CONCLUSION This article reports a case of a child with distal residual common bile duct stones and recurrent acute pancreatitis after Roux-en-Y choledochojejunostomy for PBM.The patient was cured through endoscopic retrograde cholangiopancreatography.
文摘Synthetic fertilizers are widely used to address the urgent challenge of ensuring food supplies for a growing world population in the context of climate change. However, their industrial production and use in agriculture have a negative impact on the environment and consequently on human health. While chemical fertilizers may not have to be abandoned in agricultural production systems, limiting their use could help to make agriculture sustainable and resilient to climate change. In Senegal, the level of mineral fertilizers used in market gardening has become alarming in the Niayes area. As a result, microbial biotechnologies have been promoted for biofertilizer production of common bean (Phaseolus vulgaris L.) cultivation. Rhizobial inoculums have thus been used to reduce the rate of chemical nitrogen fertilizers being applied in cropping systems. Several investigations in the laboratory, on experimental stations and in the field have shown a possibility of a significant reduction in the use of nitrogen fertilizers in common bean production. Conventional mineral fertilization use can be reduced from over 120 kg N/ha to 20 kg N/ha. This contributes both to a very significant reduction in the application rate with the same level of yield and to an improvement in the standard of living. In addition, the environmental impact of using chemical fertilizers can be mitigated. This study is a contribution to the promotion of biofertilizers adoption in agricultural systems.
基金Supported by the National Natural Science Foundation of China(12001249)the Natural Science Foundation of Jiangxi Province(20232BAB211004)the Educational Commission Science Programm of Jiangxi Province(GJJ2200523)。
文摘In this paper,we establish common fixed point theorems for expansive map?pings on b-metric-like space and coincidence point for f-weakly isotone increasing mappings in partially ordered b-metric-like space.The main results generalize and extend several well-known comparable results from the existing literature.Moreover,some examples are provided to illustrate the main results.
文摘Almost 400 years ago,Americas early European colonists voted to tax each household in Boston about$70 in todays money.The money was used to buy a local farm.The plan was to use it as a common area for the public.That is how Boston Common,in the state of Massachusetts,became Americas first public park.
基金Supported by the Ke Qiao Science and Technology Plan Projects,No.2022KZ70.
文摘BACKGROUND At present,there are few studies on the risk factors for bile leakage after laparoscopic common bile duct exploration(LCBDE)for older patients with choledocholithiasis.AIM To identify the potential risk factors for bile leakage after LCBDE in older patients.METHODS A retrospective,single-center observational analysis was performed on patients aged≥70 years with choledocholithiasis treated by LCBDE who were admitted to our center between January 2011 and August 2022.The included patients were divided into non-bile leakage and bile leakage groups.Risk factors were determined by analyzing the observation indicators.RESULTS Seventy older patients with choledocholithiasis who underwent LCBDE were included.Univariate analysis showed that positive culture of bile bacteria was a risk factor for bile leakage after LCBDE(P<0.05).We further analyzed the bile bacteria,and univariate analysis showed that Enterococcus faecalis(E.faecalis)(P<0.05)and Pseudomonas aeruginosa(P<0.05)were associated with an increased risk of postoperative bile leakage in older patients(P<0.05).Multivariate analysis showed that E. faecalis was an independent risk factor for postoperative bile leakage in older patients (P < 0.05). Theresults of antibiotic sensitivity analysis showed that E. faecalis had 100% susceptibility to penicillin, ampicillin,linezolid, vancomycin, and furantoin.CONCLUSIONE. faecalis-associated biliary tract infection is an independent risk factor for bile leakage after LCBDE in olderpatients with choledocholithiasis. We suggest coverage with antibiotics to which E. faecalis is sensitive.
基金supported by the National Natural Science Foundation of China(32241045,32241046,32241038)the Major Special Science and Technology Projects in Shanxi Province(202101140601027)+3 种基金Shanxi Provincial Agricultural Key Technologies Breakthrough Project(NYGG01)Doctoral Research Starting Project at Shanxi Agricultural University(2024BQ77)the National Key Research and Development Program of China(2023YFD1202705/2023YFD120270503,2023YFD1202703/2023YFD1202703-4)Shanxi HouJi Laboratory Self-proposed Research Project(202304010930003/202304010930003-03).
文摘Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidney beans,a subcategory of dry common beans,are highly valued for their rich protein,dietary fiber,low fat content,and various trace elements(Garcia-Cordero et al.,2021).Despite the release of several de novo genome assemblies(Goodstein et al.,2012;Schmutz et al.,2014;Vlasova et al.,2016;Cortinovis et al.,2024),existing common bean genomes remain incomplete,particularly in complex regions such as centromeres and telomeres,limiting a comprehensive understanding of the genomic landscape.
文摘Based on Marxist theory of social reproduction and the dual dimensions of“wealth”and“common prosperity,”this study examines the impact of the digital economy in promoting common prosperity across the four key stages:production,distribution,exchange,and consumption.The findings indicate that the digital economy fosters productivity growth and plays significant regulatory roles in primary distribution,redistribution,and third distribution.Moreover,the digital economy overcomes the spatiotemporal constraints of exchange and enhances consumption equality,thereby generating both“wealth”and“common prosperity”effects.However,there are still persistent challenges,including the displacement of traditional outputs,monopolization by digital platforms,the impact on employment,and income disparities arising from the digital divide.To address these challenges,we recommend optimizing the development policies of the digital economy,accelerating the growth of digital productivity,strengthening regulation of the digital platforms,building new talent supply systems,actively addressing the digital divide,and advancing market-oriented reform of data elements to better promote common prosperity.
文摘The Rural Revitalization Investment Fund serves as a crucial financial instrument for advancing rural revitalization and promoting common prosperity.It aims to address financing and land-use challenges faced by rural industries through financial support while fostering coordinated industrial development.The fund primarily operates through equity direct investment and the“mother fund+direct investment”model,with an increasing emphasis on combining government guidance with social capital participation.However,challenges persist,including a shortage of professional talent,insufficient institutional innovation,and weak industrial foundations in rural areas.To enhance the fund’s effectiveness,it is recommended to strengthen professional team management,clearly define its strategic positioning,implement strict supervision,innovate operational mechanisms,and prioritize environmental and social responsibility.These measures will ensure that the fund contributes to rural revitalization while promoting sustainable development and common prosperity.
基金Supported by the Key Research and Development Program of Shaanxi Province,China,No.2021GXLH-Z-100.
文摘BACKGROUND Recurrence of common bile duct(CBD)calculi within 30 days following T-tube cholangiography is exceedingly rare.CASE SUMMARY This article details an instance of choledocholithiasis involving a 1.2 cm×0.9 cm stone located in the lower and middle segments of the CBD,identified 30 days after T-tube cholangiography,accompanied by multiple microstones.Magnetic resonance cholangiopancreatography revealed dilation of both intrahepatic and extrahepatic bile ducts,with the widest segment of the CBD measuring approximately 2 cm.The patient underwent laparoscopic choledochal exploration followed by choledochojejunostomy using the Roux-en-Y technique.CONCLUSION Although recurrence of choledocholithiasis within such a short postoperative period is exceedingly uncommon,this case underscores the necessity for clinicians to remain vigilant regarding the potential for early postoperative recurrence.
基金a phased achievement of“Research on the Digital Transformation Mechanism and Policies of the Agricultural Industry in the Chengdu-Chongqing Economic Circle”(Ref.:24YBCY03),a project funded by the Sichuan Academy of Social Sciences。
文摘Based on micro-survey data from 894 farmers in Sichuan Province,this study employs the Ordinary Least Squares(OLS),Two-Stage Least Squares(2SLS),mediating effect,and moderating effect models to comprehensively analyze the mechanisms and effects of digital literacy in empowering farmers’common prosperity.Endogeneity and robustness are addressed using the Sobel test,the Bootstrap,and moderating effect plots.The findings indicate that first,after controlling for variables such as age,gender,and planting years,digital literacy significantly and positively influences the common prosperity of farmers at the 5%level;second,enhanced digital literacy promotes higher levels of technology adoption and information accumulation among farmers,thereby increasing the probability of achieving common prosperity.The mediating effects of technology adoption and information sharing account for 21.10%and 33.94%of the total effect,respectively;and third,the information environment and financial empowerment play positive moderation roles in the effect of digital literacy on farmers’common prosperity,with the moderation effects significant at the 1%and 10%levels,respectively.Therefore,we recommend policies that enhance the access of farmers to digital literacy training,strengthen rural digital infrastructure,establish integrated rural information-sharing platforms,and create an enabling environment for the adoption of digital technologies.
基金supported by the Humanities and Social Sciences Research Planning Project of the Ministry of Education:“A Study on Private Capital and Bank Stability”(No.19YJC790162).
文摘Management innovation is a key driver of total factor productivity and plays a crucial role in developing new quality productive forces.As China’s capital market continues to develop,the prevalence of common ownership—investors who hold significant stakes in multiple firms—has grown,raising the question of how it influences corporate management innovation.This study empirically investigates this issue using panel data from A-share listed companies in China between 2014 and 2022.The findings reveal an inverted U-shaped relationship between common ownership and management innovation.Specifically,institutional common ownership exerts no significant effect,while non-institutional common ownership exhibits a significant inverted U-shaped influence.Mechanism analysis suggests that common ownership often appoints shared directors,supervisors,and senior executives across firms,which in turn significantly impacts corporate management innovation.Further analysis indicates that common ownership in the primary and tertiary industries significantly influences management innovation,whereas that in the secondary industry does not show such an effect.This study offers valuable insights for corporate governance,business management,and investor decision-making and provides important references for policymakers in formulating governance-related regulations.
基金Supported by Scientific Research Platform Project of Putuo District,Shanghai(2024QX04).
文摘[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP database and HIT2.0 database.The collected targets were intersected with antibacterial/bacteriostatic targets obtained from the GeneCards database and OMIM database to identify the antibacterial/bacteriostatic targets of Common Cnidium Fruit.The active component-target network diagram of Common Cnidium Fruit was constructed using Cytoscape software and topological analysis was performed.GO enrichment analysis was performed on the target genes using the DAVID database.[Results]Screening yielded 25 active components of Common Cnidium Fruit,corresponding to 77 targets.Analysis identified 25 core antibacterial/bacteriostatic targets for Common Cnidium Fruit.Network analysis indicated that Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through active components such asβ-sitosterol,stigmasterol,and xanthoxylin,while activating the body's immune regulatory functions by acting on targets including CASP3,PTGS2,BCL2,JUN,and ESR1.[Conclusions]Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through multiple pathways via a mechanism involving multiple components,multiple targets,and multiple pathways.
基金supported by the Fundamental Research Funds for the Central Universities(2572020DR10)Project on the Investigation,Supervision and Industry Regulation of Rare and Endangered Species(2024)。
文摘Illegal hunting and trafficking of wildlife and their derivatives extort unprecedented population decline of relatively many species pushing them towards extinction.Notwithstanding contemporary counteracting interventions at international,regional,national and local levels,wildlife farming is advocated as an alternative approach to minimize pressure on wild populations.For wildlife farming to be an effective conservation tool,the integration of wildlife forensics is inevitable to allow distinction between captive-bred and wild-caught species.To this end,we analyzed methylation rates of skeletal muscle samples(pectoralis major,triceps brachii,gastrocnemius,biceps femoris,and neck muscles)from 60 captive-bred and 30 wild-caught Common Pheasant.A total of 13,507 differentially methylated regions were identified between five wild-caught and five captive-bred individuals through whole-genome methylation sequencing(WGBS).Based on the selected five methylation sites,LOC116231076,LOC116242223,ATAD2B,EGFL6,and HS2ST,quantitative detection technique was developed using methylation-sensitive high-resolution melting curve(MS-HRM)to measure methylation rates.The results showed significant differences in methylation rates at all differential sites between wild-caught and captive-bred individuals(|t|=0.67–33.10,P=0.000–0.042).The discrimination accuracy rate of each locus was highest in the gastrocnemius muscle and lowest in the neck muscle.The discrimination accuracy rate on LOC116231076,LOC116242223,ATAD2B,EGFL6,and HS2ST methylation sites for gastrocnemius muscle was 64.98%,100.00%,68.54%,63.79%,and 63.70%,respectively;and for neck muscle it was 67.42%,68.06%,83.61%,65.04%,and68.85%,respectively.The united discrimination accuracy rate of the five loci were 100.00%for gastrocnemius muscle,99.78%for biceps femoris muscle,97.52%for pectoralis major muscle,93.96%for triceps brachii muscle,and 91.63%for neck muscle,respectively.The panel also revealed excellent repeatability,reproducibility,sensitivity and universality to mammals and avian species.This study establishes an effective,accurate and low-cost identification technology for the identification of wild and farmed Common Pheasant,and also provides a reference for the development of identification methods for other species.
文摘BACKGROUND The optimal management of gallstones and common bile duct stones remains a subject of ongoing debate.The conventional two-stage treatment involves initial endoscopic retrograde cholangiopancreatography(ERCP)to clear the bile duct,followed by laparoscopic cholecystectomy.Alternatively,the single-stage laparoendoscopic rendezvous(LERV)procedure combines ERCP and laparoscopic cholecystectomy in the same surgical session.AIM To evaluate the efficacy,safety,and logistical considerations of these two approaches,emphasizing their implications for different healthcare settings.METHODS A literature search was conducted through a PubMed search(2010-2024)using the terms“laparoendoscopic rendezvous”,“endoscopic retrograde cholangiopancreatography”,and“cholecystocholedocholithiasis”.Only English-language studies were included.RESULTS In our analysis,LERV significantly reduced the incidence of post-ERCP pancreatitis by 67%(2.4%vs 8.8%)and shortened hospital stay by a mean of up to 6 days.Stone clearance rates were comparable between LERV(97%)and the two-stage approach(96%).Although LERV was associated with a longer operative time(139.8 minutes vs 107.7 minutes),it demonstrated lower overall costs,largely due to reduced hospitalization.Rates of postoperative bleeding,cholangitis,and bile leak were low and did not differ significantly between groups.CONCLUSION The single-stage LERV approach is safe,effective,and associated with lower pancreatitis rates,shorter hospital stays,and reduced costs compared to the two-stage strategy.Its implementation,however,requires coordinated surgical-endoscopic expertise,making it most suitable for well-equipped centers and carefully selected patients.
文摘To illustrate the mechanisms of exosomal microRNAs(miRNAs)in common mental disorders,and explore their potential as diagnostic biomarkers and therapeutic targets,a systematic literature review of relevant studies on exosomal miRNAs in mental disorders was conducted.Data from cell experiments,animal models,and clinical studies were analyzed and combined to study the mechanisms and roles of exosomal miRNAs in various mental disorders.Research has shown that exosomal miRNAs,such as miR-146a,miR-223,miR-125b,and miR-451a,affect Alzheimer’s disease(AD)formation by regulating key pathways such as toll-like receptor 4(TLR4)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),respectively.MiR-146a-5p regulates the occurrence of schizophrenia through the Notch pathway.TLR4 regulates miR-146a and miR-155 in major depressive disorder(MDD),and miR-144-5p regulates the disease through PI3K/Akt.Exosomal miR-484,miR-652-3p,miR-142-3p,miR-21a-3p,and miR-21-5p regulate key pathways in bipolar disorder,autism spectrum disorder,and Rett syndrome(e.g.,TLR4,PI3K/Akt,and Epha4/TEK)and have an influence on mental disorders.Exosomal miRNAs are involved in the occurrence of mental disorders through TLR4,PI3K/Akt,and Epha4/TEK pathways,which provides a clearer understanding of disease cognition.Of these pathways,the TLR4 and PI3K/Akt pathways play a role in AD,MDD,and neurodevelopmental disorders,which can be used as an effective breakthrough in the study of mental disorders.Exosomal miRNAs could also serve as diagnostic biomarkers and therapeutic targets,providing new insights into precise interventions for mental disorders.
文摘Background:The endoscopic appearance of the major duodenal papilla influences biliary cannulation and complications.This study aimed to investigate the role of major duodenal papillae in the endoscopic treatment of common bile duct(CBD)stones.Methods:This retrospective study was conducted at Bishan Hospital of Chongqing Medical University between January 2018 and August 2022.Patients with native papillae who underwent endoscopic treatment for CBD stones were recruited and divided into four groups according to Haraldsson's classification of papillae(typesⅠ-Ⅳ).Univariate and multivariate logistic regression analyses were used to identify risk factors for difficult cannulation and post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP).Results:A total of 596 patients with CBD stones were enrolled.The proportion of patients with typeⅠpapilla was the highest(n=231,38.8%),followed by typeⅢpapilla(n=175,29.4%),typeⅣpapilla(n=101,16.9%)and typeⅡpapilla(n=89,14.9%).Difficult cannulation occurred in 188 of 596 patients(31.5%),with most cases occurring in those with typeⅢpapilla(71/175,40.6%,P=0.020).Multivariate logistic analysis revealed that age[odds ratio(OR)=1.034,95%confidence interval(CI):1.021–1.047,P<0.001],typeⅢpapilla(OR=2.255,95%CI:1.439–3.535,P<0.001),gallbladder in situ(OR=2.486,95%CI:1.346–4.590,P=0.004),and CBD diameter<10 mm(OR=1.600,95%CI:1.049–2.441,P=0.029)were risk factors for difficult cannulation.The total incidence of PEP was 10.9%.Compared with the other types of papillae,the rate of PEP was the highest in those with typeⅠpapilla(15.2%,P=0.030).Multivariate analysis demonstrated that PEP was associated with difficult cannulation(OR=1.811,95%CI:1.044–3.143,P=0.035)and white blood cells(WBCs)<10×10~9/L(OR=2.199,95%CI:1.051–4.600,P=0.036).Conclusions:The endoscopic appearance of the major papilla is an important factor that influences both biliary cannulation and outcomes.TypeⅢpapilla is more frequently difficult to cannulate in the endoscopic treatment of CBD stones.
基金supported by the Science and Technology Key Research&Development Project of Shaanxi Province(2022NY-178)the Technical System of Minor Cereals Industry in Shaanxi Province(NYKJ-2022-YL(XN)28)the Special Fund for Seed Industrial Development in Shaanxi Province(K3031223130).
文摘Herbicide safeners alleviate herbicide toxicity while preserving weed-control efficacy in common buckwheat.A three-year field experiment was performed to measure the effects of quizalofop-P-ethyl(QPE)alone or in combination with gibberellin or brassinolide on soil enzyme activity and yield components in common buckwheat.The herbicide-brassinolide application yielded the greatest increases in soil enzyme activity and yield components without sacrificing weed control efficacy.It is recommended for use in common buckwheat cultivation in the Loess Plateau.
基金Supported by Philosophy and Social Sciences Research Project of Hubei Provincial Department of Education(22Q149,19Y090).
文摘[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.
