Energy-saving in China's iron and steel industry still relies on the development and improvement of short-term energy saving technologies.Therefore,a special converter smelting technology incorporating energy savi...Energy-saving in China's iron and steel industry still relies on the development and improvement of short-term energy saving technologies.Therefore,a special converter smelting technology incorporating energy saving was proposed.To evaluate the energy-saving potential of the CO_(2)–O_(2)mixed injection(COMI)technology,collected production data were used to develop an improved techno-economic model.Calculations reveal that the technology can save energy through auxiliary material consumption,sensible heat of solid by-product,iron loss reduction,and energy recovery.The application of COMI technology in an enterprise is cost effective,involving the energy saving potential of 0.206 GJ/t,the cost of conserved energy of−48.83 yuan/GJ,and a simple payback period of 0.35 year for a 60-million-yuan investment.Sensitivity analysis shows that the investment cost and discount rate primarily influence the cost of conserved energy of the technology.As the discount rate increased,the cost of conserved energy also gradually increased.Overall,the COMI technology is an energy-saving technology with good development prospects.展开更多
Previous studies have shown that 5-hydroxymethylfurfural, a compound extracted from wine- processed Fructus corni, has a protective effect on hippocampal neurons. The present study was designed to explore the related ...Previous studies have shown that 5-hydroxymethylfurfural, a compound extracted from wine- processed Fructus corni, has a protective effect on hippocampal neurons. The present study was designed to explore the related mechanisms. Our study revealed that high and medium doses （10, 1 μmol/L） of 5-hydroxymethylfurfural could improve the morphology of H2O2-treated rat hippocampal neurons as revealed by inverted phase-contrast microscopy and transmission electron microscopy. MTT results showed that incubation with high and medium doses of 5-hydroxymethylfurfural caused a significant increase in the viability of neuronal cells injured by H2O2. Flow cytometry assays con- firmed that H2O2 could induce cell apoptosis, while high and medium doses of 5-hydroxymethylfurfural had a visible protective effect on apoptotic rat hippocampal neurons. Real-time PCR and western blot analysis showed that high and medium doses of 5-hydroxymethylfurfural prevented H2O2-induced up-regulation of p53, Bax and caspase-3 and an- tagonized the down-regulation of Bcl-2 induced by H2O2 treatment. These results suggested that 5-hydroxymethylfurfural could inhibit apoptosis of cultured rat hippocampal neurons injured by H2O2 via increase in Bcl-2 levels and decrease in p53, Bax and caspase-3 protein expression levels.展开更多
基金the National Natural Science Foundation of China(Nos.52204342 and 52201073)Natural Science Foundation of Hebei Province(No.E2022208019)+1 种基金Natural Science Foundation of Hebei Education Department(Nos.BJK2024194 and BJK2024024)Natural Science Foundation of Hebei Education Department(No.QN2021058)for financial support.
文摘Energy-saving in China's iron and steel industry still relies on the development and improvement of short-term energy saving technologies.Therefore,a special converter smelting technology incorporating energy saving was proposed.To evaluate the energy-saving potential of the CO_(2)–O_(2)mixed injection(COMI)technology,collected production data were used to develop an improved techno-economic model.Calculations reveal that the technology can save energy through auxiliary material consumption,sensible heat of solid by-product,iron loss reduction,and energy recovery.The application of COMI technology in an enterprise is cost effective,involving the energy saving potential of 0.206 GJ/t,the cost of conserved energy of−48.83 yuan/GJ,and a simple payback period of 0.35 year for a 60-million-yuan investment.Sensitivity analysis shows that the investment cost and discount rate primarily influence the cost of conserved energy of the technology.As the discount rate increased,the cost of conserved energy also gradually increased.Overall,the COMI technology is an energy-saving technology with good development prospects.
基金financially supported by the National Natural Science Foundation of China,No.30772851a grant from the Six Talents Peaks Program of Jiangsu Province,Chinaa grant from the Priority Academic Program Development of Jiangsu Higher Education Institutions,PAPD(Traditional Chinese medicine combined with Western Medicine
文摘Previous studies have shown that 5-hydroxymethylfurfural, a compound extracted from wine- processed Fructus corni, has a protective effect on hippocampal neurons. The present study was designed to explore the related mechanisms. Our study revealed that high and medium doses （10, 1 μmol/L） of 5-hydroxymethylfurfural could improve the morphology of H2O2-treated rat hippocampal neurons as revealed by inverted phase-contrast microscopy and transmission electron microscopy. MTT results showed that incubation with high and medium doses of 5-hydroxymethylfurfural caused a significant increase in the viability of neuronal cells injured by H2O2. Flow cytometry assays con- firmed that H2O2 could induce cell apoptosis, while high and medium doses of 5-hydroxymethylfurfural had a visible protective effect on apoptotic rat hippocampal neurons. Real-time PCR and western blot analysis showed that high and medium doses of 5-hydroxymethylfurfural prevented H2O2-induced up-regulation of p53, Bax and caspase-3 and an- tagonized the down-regulation of Bcl-2 induced by H2O2 treatment. These results suggested that 5-hydroxymethylfurfural could inhibit apoptosis of cultured rat hippocampal neurons injured by H2O2 via increase in Bcl-2 levels and decrease in p53, Bax and caspase-3 protein expression levels.
