The South China Sea is rich in wind and wave energy resources,and the wind-wave combined power generation device is currently in the concept research and development stage.In recent years,extreme sea conditions such a...The South China Sea is rich in wind and wave energy resources,and the wind-wave combined power generation device is currently in the concept research and development stage.In recent years,extreme sea conditions such as super typhoons have frequently occurred,which poses a serious challenge to the safety of offshore floating platforms.In view of the lack of safety analysis of wind-wave combined power generation devices in extreme sea conditions at present,this paper takes the OC4-WEC combined with semi-submersible wind turbine(Semi-OC4)and the oscillating buoy wave energy converter as the research object,and establishes a mesoscale WRF-SWANFVCOM(W-S-F)real-time coupling platform based on the model coupling Toolkit(MCT)to analyze the spatial and temporal evolution of wind-wave-current in offshore wind farms during the whole process of super typhoon“Rammasun”transit.Combined with the medium/small scale nested method,the flow field characteristics of OC4-WEC platform are analyzed.The results show that the simulation accuracy of the established W-S-F platform for typhoon track is 42.51%higher than that of the single WRF model.Under the action of typhoon-wave-current,the heave motion amplitude of OC4-WEC platform is reduced by 38.1%,the surge motion amplitude is reduced by 26.7%,and the pitch motion amplitude is reduced by 23.4%.展开更多
Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess sign...Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess significant immunomodulatory properties in addition to their established direct tumoricidal effects.Emerging immunotherapies have revolutionized the clinical management of various cancer types.Conventional therapy and immunotherapy have demonstrated remarkable clinical efficacy,leading to numerous ongoing clinical investiga-tions exploring their potential synergistic effects.However,trials investigating the combination of conventional therapy and immunotherapy have shown limited synergistic therapeutic efficacy.This unsatisfactory clinical outcome may be attributed to the suboptimal design of the combination approach and the inadequate understanding of the mechanisms and impacts of radiotherapy,chemotherapy,targeted ther-apy regimens(including dosing,timing,and administration route),and surgery on both cancer cells and the host immune system.Here,we comprehensively review preclinical and clinical investigations exploring the therapeutic effects and mechanisms of conventional therapy alone or in combination with immunotherapy.We proposed that optimizing the dosing,timing,and route of administration of conventional therapies can enhance the synergistic efficacy of combination therapies,thus offering significant clinical advantages.展开更多
BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for ...BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.AIM To investigate the analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.METHODS In this retrospective study,94 patients scheduled for laparoscopic minimally invasive surgery for inguinal hernia,admitted to Yiwu Central Hospital between May 2022 and May 2023,were divided into a control group(inhalation combined general anesthesia)and a treatment group(dexmedetomidine-assisted intrave-nous-inhalation combined general anesthesia).Perioperative indicators,analgesic effect,preoperative and postoperative 24-hours blood pressure(BP)and heart rate(HR),stress indicators,immune function levels,and adverse reactions were com-pared between the two groups.RESULTS Baseline data,including age,hernia location,place of residence,weight,monthly income,education level,and underlying diseases,were not significantly different between the two groups,indicating comparability(P>0.05).No significant difference was found in operation time and anesthesia time between the two groups(P>0.05).However,the treatment group exhibited a shorter postoperative urinary catheter removal time and hospital stay than the control group(P<0.05).Preoperatively,no significant differences were found in the visual analog scale(VAS)scores between the two groups(P>0.05).However,at 12,18,and 24 hours postoper-atively,the treatment group had significantly lower VAS scores than the control group(P<0.05).Although no significant differences in preoperative hemodynamic indicators were found between the two groups(P>0.05),both groups experienced some extent of changes in postoperative HR,diastolic BP(DBP),and systolic BP(SBP).Nevertheless,the treatment group showed smaller changes in HR,DBP,and SBP than the control group(P<0.05).Preoperative immune function indicators showed no significant differences between the two groups(P>0.05).However,postoperatively,the treatment group demonstrated higher levels of CD3+,CD4+,and CD4+/CD8+and lower levels of CD8+than the control group(P<0.05).The rates of adverse reactions were 6.38%and 23.40%in the treatment and control groups,respectively,revealing a significant difference(χ2=5.371,P=0.020).CONCLUSION Dexmedetomidine-assisted intravenous-inhalation combined general anesthesia can promote early recovery of patients undergoing laparoscopic minimally invasive surgery for inguinal hernia.It ensures stable blood flow,improves postoperative analgesic effects,reduces postoperative pain intensity,alleviates stress response,improves immune function,facilitates anesthesia recovery,and enhances safety.展开更多
Prepulse combined hydraulic fracturing facilitates the development of fracture networks by integrating prepulse hydraulic loading with conventional hydraulic fracturing.The formation mechanisms of fracture networks be...Prepulse combined hydraulic fracturing facilitates the development of fracture networks by integrating prepulse hydraulic loading with conventional hydraulic fracturing.The formation mechanisms of fracture networks between hydraulic and pre-existing fractures under different prepulse loading parameters remain unclear.This research investigates the impact of prepulse loading parameters,including the prepulse loading number ratio(C),prepulse loading stress ratio(S),and prepulse loading frequency(f),on the formation of fracture networks between hydraulic and pre-existing fractures,using both experimental and numerical methods.The results suggest that low prepulse loading stress ratios and high prepulse loading number ratios are advantageous loading modes.Multiple hydraulic fractures are generated in the specimen under the advantageous loading modes,facilitating the development of a complex fracture network.Fatigue damage occurs in the specimen at the prepulse loading stage.The high water pressure at the secondary conventional hydraulic fracturing promotes the growth of hydraulic fractures along the damage zones.This allows the hydraulic fractures to propagate deeply and interact with pre-existing fractures.Under advantageous loading conditions,multiple hydraulic fractures can extend to pre-existing fractures,and these hydraulic fractures penetrate or propagate along pre-existing fractures.Especially when the approach angle is large,the damage range in the specimen during the prepulse loading stage increases,resulting in the formation of more hydraulic fractures.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM),a chronic metabolic disease with a high global incidence,has become a serious public health challenge.China has the largest number of T2DM patients worldwide,imposing a signif...BACKGROUND Type 2 diabetes mellitus(T2DM),a chronic metabolic disease with a high global incidence,has become a serious public health challenge.China has the largest number of T2DM patients worldwide,imposing a significant economic burden on the healthcare system.T2DM is closely associated with insulin resistance,impaired pancreatic B cell function,and disordered glucose and lipid metabolism,which can lead to various complications,reducing patients'quality of life and increasing the risk of disability and death.Thus,finding effective preventive and intervention measures is crucial.Exercise therapy,a key part of diabetes management,has gained attention in recent years,with many studies indicating its benefits for blood glucose control and other aspects in diabetic patients.AIM To assess the effectiveness of combined resistance and aerobic exercise interventions on blood glucose control and metabolic indicators in patients with T2DM and to explore their application in diabetes management.METHODS Systematic searches were conducted using PubMed,EMBASE,Cochrane Library,and Chinese databases for relevant randomized controlled trials(RCTs).The inclusion criteria were participants aged≥18 years with T2DM and the intervention involved combined resistance and aerobic exercise for≥8 weeks.The primary outcome indicators were fasting blood glucose,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),glycated hemoglobin A1c(HbA1c),and total cholesterol(TC)levels.Data analysis was performed using RevMan software,and the interventional effects were assessed using weighted mean differences or standardized mean differences(SMD).RESULTS Six RCTs meeting the inclusion criteria were included,with a total sample size of 366 participants.The meta-analysis results showed that combined resistance and aerobic exercise significantly improved several metabolic indicators in patients with T2DM.Specific results were as follows:(1)For fasting blood glucose,combined exercise was more effective than aerobic exercise alone[SMD=1.22;95%confidence interval(95%CI):0.70,1.74;P<0.00001];(2)LDL-C levels were significantly reduced by the combined intervention(SMD=1.45;95%CI:1.18-1.72;P<0.00001);(3)The combined intervention significantly increased HDL-C levels(SMD=1.42;95%CI:0.98-1.87;P<0.00001);(4)The combined intervention significantly reduced TG levels(SMD=1.12;95%CI:0.85-1.39;P<0.00001;(5)No statistically significant difference was observed in HbA1c between the combined and the aerobic exercise group(SMD=-0.03;95%CI:-1.09 to 1.04;P<0.00001);and(6)The combined exercise intervention group significantly reduced TC levels(SMD=2.66;95%CI:1.93-3.38;P<0.00001).The subgroup analysis results suggest that the effect of exercise interventions may be influenced by various factors,including the patient's age,baseline blood glucose levels,and exercise intensity.CONCLUSION Combined resistance and aerobic exercise intervention significantly improved fasting blood glucose,LDL-C,HDL-C,TG,and TC levels in patients with T2DM,especially in terms of blood glucose control and cardiovascular risk,demonstrating better outcomes than aerobic exercise alone.展开更多
With the continuous escalation of modern war,soldiers need to transport more combat materials to the combat area.The limited load-bearing capacity of soldiers seriously restricts their carrying capacity and mobility.I...With the continuous escalation of modern war,soldiers need to transport more combat materials to the combat area.The limited load-bearing capacity of soldiers seriously restricts their carrying capacity and mobility.It is urgent to develop a power-assisted exoskeleton robot suitable for individual combat.In the past,most power-assisted exoskeleton robots were driven by motors.This driving method has an excellent power-assisted effect,but the endurance is often insufficient.In view of this shortcoming,this study designed an ankle exoskeleton robot based on an active-passive combined drive through simulation analysis of human motion.It used OpenSim software to simulate and verify that the addition of spring could achieve a good effect.At the same time,according to the gait characteristics of the human body,the gait planning of an exoskeleton robot was carried out.Afterwards,theoretical analysis explained that the cooperation among spring,motor and wearer could be realized in this gait.Finally,the assisting ability and driving coordination of the active-passive combination driven ankle exoskeleton robot were verified through experiments.展开更多
Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micr...Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.展开更多
The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta po...The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta potential,contact angle,X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and atomic force microscopy(AFM)analyses.The microflotation experiments showed that the effective inhibition of chalcopyrite can be obtained through combined oxidation pretreatments with low microwave power and H_(2)O_(2)consumption.The zeta potential,contact angle and XPS analyses indicated that the surface hydrophobicity of molybdenite changed minimally after different treatments,whereas significant amounts of hydrophilic oxidation species were formed on the surface of chalcopyrite,thus decreasing its surface hydrophobicity and floatability.Moreover,the SEM and AFM analyses indicated that more uniform oxidative products were formed on the chalcopyrite surface,further significantly increasing the surface roughness.展开更多
Nanoplastics are emerging contaminants that may co-exist with organochlorine pesticides and adversely affect invertebrates in the environment.However,the impact of environmental aging on the combined toxicity of nanop...Nanoplastics are emerging contaminants that may co-exist with organochlorine pesticides and adversely affect invertebrates in the environment.However,the impact of environmental aging on the combined toxicity of nanoplastics and organochlorine pesticides remains unclear.This study investigated the effects of aging on the combined toxicity of polystyrene nanoplastics(PS NPs)and chlordane against Caenorhabditis elegans.The results showed that photo-aging altered the physicochemical properties of PS NPs and promoted the combined toxicity of PS NPs and chlordane to nematodes by reducing survival rate,body length and enhancing germline apoptosis.Additionally,combined exposure of nematodes to aged PS NPs and chlordane significantly increased reactive oxygen species production and intestinal permeability,suggesting that aging enhances combined toxicity through oxidative stress and intestinal damage.Moreover,aging increased chlordane contents in nematodes without promoting PS NPs accumulation,potentially leading to increased combined toxicity of PS NPs and chlordane.Notably,aging significantly increased the accumulation of PS NPs in the posterior intestine of the nematode during co-exposure,which may be responsible for the most sensitive and highest degree of change in germline apoptosis.These observations emphasize the significance of accounting for environmental aging as well as the accumulation and distribution of nanoplastics in organisms when assessing the combined effects of nanoplastics and coexisting pollutants.展开更多
China boasts abundant heavy oil resources,which is vital for its energy security.However,its heavy oil typically exhibits high viscosity,which severely hinders its flow and extraction.Enhancing heavy oil flowability i...China boasts abundant heavy oil resources,which is vital for its energy security.However,its heavy oil typically exhibits high viscosity,which severely hinders its flow and extraction.Enhancing heavy oil flowability is vital for its effective exploitation.This study independently developed a visualization experimental system and explored the mechanisms through which combined thermal flooding(a combination of heat,chemical agents and gas)enhances heavy oil flowability.Results indicate that combined thermal flooding,that is,synergistically integrating heat,chemical agents,and gas,can effectively enhance the recovery of heavy oil by improving its flowability.Its working mechanisms were explored from the aspects of thermal effects,emulsification,precursor film,profile control capacity,and CO_(2) solution and extraction effects.The emulsification was observed using a confocal laser scanning fluorescence microscope(CLSFM).Findings reveal that steam flooding can boost crude oil flowability by augmenting temperature,while a chemical system tends to produce low-viscosity oil-in-water emul-sions,thus further aiding the flow of crude oil.During CO_(2) flooding,the solvent initially reduced crude oil viscosity and formed foamy oil,followed by the pronounced component separation of the produced fluids in the later stage.This demonstrates the effectiveness of CO_(2) in viscosity reduction and component extraction.Additionally,the results of interfacial tension experiments indicate that surfactants can reduce the heavy oil's interfacial tension,fostering the formation of nano-scale precursor films.They can also thicken these films and diminish their spreading resistance,thus accelerating residual oil removal and promoting heavy oil production.This study further elaborated the mechanisms behind the combined thermal flooding's efficiency in enhancing heavy oil recovery,offering a theoretical foundation for its broader application.展开更多
This paper presents a numerical investigation of nonlinear sloshing in a prismatic tank.A three-dimensional,twophase flow model based on Cartesian grid is developed to simulate the phenomenon.The model solves incompre...This paper presents a numerical investigation of nonlinear sloshing in a prismatic tank.A three-dimensional,twophase flow model based on Cartesian grid is developed to simulate the phenomenon.The model solves incompressible Navier-Stokes equations,utilizing the fractional step method for velocity-pressure decoupling.The finite difference method discretizes spatial derivatives,with specific schemes implemented to enhance model robustness.Model validation involves simulating benchmark cases,and comparing wave profiles and pressure results with published experimental data and numerical findings.The model demonstrates robustness and accuracy in simulating violent sloshing.The validated model examines sloshing in a partially filled prismatic tank under combined surge and roll excitations.The study employs eight frequencies encompassing the natural frequencies of tank roll and surge motions.Roll motion excitation is fixed at 2°,while surge motion considers three excitation amplitudes(0.0 m,0.01 m,and 0.02m).Analysis reveals the effects of surge amplitude and excitation frequency on wave patterns,amplitudes,and pressure peaks.Results indicate the presence of multi-component waves,including transverse,diagonal,and longitudinal waves.Furthermore,the findings demonstrate a reduction in the natural frequency for surge motion through pressure peak analysis.展开更多
Objective:To analyze the effects of combined spinal-epidural anesthesia and epidural anesthesia in patients undergoing appendicitis surgery.Methods:Seventy-eight patients who underwent surgical treatment for appendici...Objective:To analyze the effects of combined spinal-epidural anesthesia and epidural anesthesia in patients undergoing appendicitis surgery.Methods:Seventy-eight patients who underwent surgical treatment for appendicitis from February 2022 to February 2025 were selected as samples and randomly divided into two groups.The study group received combined spinal-epidural anesthesia,while the control group received epidural anesthesia.Anesthesia indicators,vital signs,and complication indicators were compared between the two groups.Results:The onset time of anesthesia in the study group was shorter than that in the control group,the visual analog scale(VAS)score was lower than that in the control group,and the highest plane of anesthesia block was lower than that in the control group(P<0.05).At 15 minutes after anesthesia induction and at the end of surgery,the heart rate(HR),mean arterial pressure(MAP),and blood oxygen saturation(SPO2)in the study group were significantly different from those in the control group(P<0.05).The complication rate in the study group was lower than that in the control group(P<0.05).Conclusion:Combined spinal-epidural anesthesia for appendicitis surgery can reduce the impact of anesthesia on vital signs,shorten the onset time of anesthesia,and is highly effective and feasible.展开更多
Unstable operating conditions such as surge could cause damage to both aerodynamic performance and structural integrity of a compression system.This paper addresses the critical issue of aerodynamic instability in com...Unstable operating conditions such as surge could cause damage to both aerodynamic performance and structural integrity of a compression system.This paper addresses the critical issue of aerodynamic instability in compressor design,particularly focusing on an axial-centrifugal combined compressor,a widely used yet underexplored configuration.An experimental investigation was conducted on a three-stage axial and one-stage centrifugal compressor(3A1C),using two pipe systems and employing fast-responding transducers to capture the dynamic instability process from choke condition to deep surge.Results reveal that at the design speed,3A1C enters deep surge directly,whereas at off-design speeds,it experiences rotating stall and mild surge across a wide mass flow range.Some special instability features in the combined compressor can be found in the steady state map and dynamic process.The characteristic curve of the first axial stage keeps a positive slope during the whole mass flow range at an off-design speed.The first stage could work stably on the stall characteristic curve because the centrifugal stage has stronger pressurization and plays a dominant role in global aerodynamic instability.Besides,rotating instability occurs at the first rotor tip and disappears as the back pressure increases,which is also rarely seen in a single-axial compressor.This is also related to the strong pressurization of the centrifugal stage.The findings of this paper will contribute to the understanding of aerodynamic instabilities in combined compressors.展开更多
BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE...BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.展开更多
Research on the effects of drug therapy combined with psychological intervention in adolescent patients with depression represents a critical focus in contemporary psychiatric medicine.This study aims to explore the s...Research on the effects of drug therapy combined with psychological intervention in adolescent patients with depression represents a critical focus in contemporary psychiatric medicine.This study aims to explore the synergistic therapeutic approach of integrating pharmacological treatment with psychological interventions,focusing on its positive impacts on symptom alleviation,quality-of-life enhancement,and clinical recovery in adolescent depression.A cohort of 62 adolescents was selected as research participants,with randomized allocation into either monotherapy(drug-only)or combination therapy(drugs+psychological intervention)groups.Key evaluation metrics included anxiety levels,clinical efficacy,and incidence of adverse reactions.展开更多
Purpose:To investigate the clinical effects of improving adolescents’form anxiety after the intervention of visceral massage technique and form training.Methods:A total of 80 adolescent patients with scoliosis abnorm...Purpose:To investigate the clinical effects of improving adolescents’form anxiety after the intervention of visceral massage technique and form training.Methods:A total of 80 adolescent patients with scoliosis abnormalities were selected for this experiment,and they were intervened with form and body training and form and body training+visceral body acupressure techniques,and the anxiety and depression scores,spinal Cobb angle,vertebral body rotation of the parietal vertebrae,and the treatment efficiency were compared between the groups after the clinical interventions.Results:The anxiety and depression scores of patients in the form group were significantly higher than those of the combined group,P<0.05;the improvement of the Cobb angle and vertebral rotation of the parietal vertebrae of patients in the combined group was better than that of the form group,P<0.05;and the total effective rate of the treatment of patients in the form group was significantly lower than that of the combined group,P<0.05.Conclusion:After intervening in adolescents’abnormalities of form,patients were treated with a combination of the internal organs and body acupressure techniques and form training methods,and the results were compared between groups.After the joint intervention of the visceral massage technique and physical training,the patients’scoliosis and other physical problems were positively improved,and the psychological status of the patients was relatively adjusted to ensure their physical and mental health.展开更多
Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a rare hetero-geneous primary malignant liver tumor containing both hepatocellular and cholangiocarcinoma features.The complex presentation of cHCC-CCA tends to b...Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a rare hetero-geneous primary malignant liver tumor containing both hepatocellular and cholangiocarcinoma features.The complex presentation of cHCC-CCA tends to be poorly investigated,and the information derived from traditional diagnostic techniques(histopathology and radiological imaging)is often not optimal.Since cHCC-CCA is usually difficult to diagnose due to complex histopathological features(edge learning)as excessive photos,hence,achieves treatment delays and poor prognosis,the incorporation of advanced artificial intelligence like edge learning is able to improve the patient’s outcome.Using artificial intelligence,particularly deep learning,has recently opened new doorways for the impro-vement of diagnostic accuracy.If artificial intelligence models are deployed on local devices,edge learning exercises this type of learning,which provides real time processing,improved data privacy and reduced bandwidth usage.This narrative review investigates the conceptual formulation of edge learning together with its opportunities for clinical applications in the prediction and classification of cHCC-CCA,the technical solution strategies,the clinical benefits it offers,and associated challenges and future directions.展开更多
[Objectives]This study was conducted to enhance the prevention and control of peste des petits ruminants(PPR)and goatpox(GTP).[Methods]Two experimental sheep farms in Northern Shandong were selected to conduct a compa...[Objectives]This study was conducted to enhance the prevention and control of peste des petits ruminants(PPR)and goatpox(GTP).[Methods]Two experimental sheep farms in Northern Shandong were selected to conduct a comparative experiment between separate vaccinations for PPR and GTP and immunization with a combined live vaccine for both diseases.Antibody levels were measured to assess immunization effect on days 7,14,21 and 28 after vaccination.[Results]The qualified rates of group immune antibodies in both the experimental and control groups exceeded 75%,achieving the goal of preventing both PPR and GTP through a single immunization.[Conclusions]This study provides clinical application references for the prevention of PPR and GTP in the local area.展开更多
Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processe...Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies.Recent advances in gene-editing technologies,including zincfinger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs),CRISPR/Cas9,and base editing,have significantly enhanced the generation of SCID models.These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy,stem cell transplantation,organ transplantation,and infectious diseasemanagement.Thisreviewprovidesa comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.展开更多
Objective:To study the efficacy of biofeedback combined with occupational therapy in stroke patients,including upper arm function,hand function,and self-care ability.Methods:A total of 60 stroke patients who met the i...Objective:To study the efficacy of biofeedback combined with occupational therapy in stroke patients,including upper arm function,hand function,and self-care ability.Methods:A total of 60 stroke patients who met the inclusion and exclusion criteria of this study were divided into a treatment group and a control group,with 30 cases in each group,using a random number table method.The total course of treatment was 4 weeks,with 5 treatments per week.Both groups received routine rehabilitation treatment,while the treatment group was supplemented with biofeedback therapy on the basis of routine rehabilitation.Before treatment and after 4 weeks of treatment,the Hemiplegic Hand Function Assessment Scale,Carroll Upper Extremity Function Assessment Scale,Wolf Motor Function Test(WMFT),and Brunnstrom Scale were used to evaluate patients’hand function,Activities of Daily Living(ADL)ability,and motor function,respectively.Adverse events during treatment were observed.Results:After treatment,the Brunnstrom stages,Carroll upper extremity function scores,and Wolf upper extremity function scores of patients in both groups were significantly improved(p<0.001),and the improvement effect in the treatment group was more significant(p<0.001).Conclusion:Stroke patients receiving basic rehabilitation treatment combined with occupational therapy and biofeedback therapy can better improve their upper arm and hand functions.Meanwhile,the combination of biofeedback therapy and occupational therapy is superior to occupational therapy alone,enhancing the self-care ability of stroke patients.展开更多
基金jointly funded by the National Key Research and Development Projects(No.2017YFE0132000)the National Natural Science Foundation of China(Nos.5211101879,52078251,52108456)the Natural Science Foundation of Jiangsu Province(Nos.BK20211518,BK20210309)
文摘The South China Sea is rich in wind and wave energy resources,and the wind-wave combined power generation device is currently in the concept research and development stage.In recent years,extreme sea conditions such as super typhoons have frequently occurred,which poses a serious challenge to the safety of offshore floating platforms.In view of the lack of safety analysis of wind-wave combined power generation devices in extreme sea conditions at present,this paper takes the OC4-WEC combined with semi-submersible wind turbine(Semi-OC4)and the oscillating buoy wave energy converter as the research object,and establishes a mesoscale WRF-SWANFVCOM(W-S-F)real-time coupling platform based on the model coupling Toolkit(MCT)to analyze the spatial and temporal evolution of wind-wave-current in offshore wind farms during the whole process of super typhoon“Rammasun”transit.Combined with the medium/small scale nested method,the flow field characteristics of OC4-WEC platform are analyzed.The results show that the simulation accuracy of the established W-S-F platform for typhoon track is 42.51%higher than that of the single WRF model.Under the action of typhoon-wave-current,the heave motion amplitude of OC4-WEC platform is reduced by 38.1%,the surge motion amplitude is reduced by 26.7%,and the pitch motion amplitude is reduced by 23.4%.
基金supported by the National Science Foundation of China(No.82172726)the Youth Project of Science and Technology Department of Shanxi Province(No.202203021212105)the Research Project Supported by the Shanxi Scholarship Council of China(2021-156).
文摘Conventional therapies are primary cancer treatments that directly eliminate or inhibit the growth of tumor cells,reducing the overall tumor burden.Increasing evidence suggests that conventional therapies possess significant immunomodulatory properties in addition to their established direct tumoricidal effects.Emerging immunotherapies have revolutionized the clinical management of various cancer types.Conventional therapy and immunotherapy have demonstrated remarkable clinical efficacy,leading to numerous ongoing clinical investiga-tions exploring their potential synergistic effects.However,trials investigating the combination of conventional therapy and immunotherapy have shown limited synergistic therapeutic efficacy.This unsatisfactory clinical outcome may be attributed to the suboptimal design of the combination approach and the inadequate understanding of the mechanisms and impacts of radiotherapy,chemotherapy,targeted ther-apy regimens(including dosing,timing,and administration route),and surgery on both cancer cells and the host immune system.Here,we comprehensively review preclinical and clinical investigations exploring the therapeutic effects and mechanisms of conventional therapy alone or in combination with immunotherapy.We proposed that optimizing the dosing,timing,and route of administration of conventional therapies can enhance the synergistic efficacy of combination therapies,thus offering significant clinical advantages.
文摘BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.AIM To investigate the analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal hernia.METHODS In this retrospective study,94 patients scheduled for laparoscopic minimally invasive surgery for inguinal hernia,admitted to Yiwu Central Hospital between May 2022 and May 2023,were divided into a control group(inhalation combined general anesthesia)and a treatment group(dexmedetomidine-assisted intrave-nous-inhalation combined general anesthesia).Perioperative indicators,analgesic effect,preoperative and postoperative 24-hours blood pressure(BP)and heart rate(HR),stress indicators,immune function levels,and adverse reactions were com-pared between the two groups.RESULTS Baseline data,including age,hernia location,place of residence,weight,monthly income,education level,and underlying diseases,were not significantly different between the two groups,indicating comparability(P>0.05).No significant difference was found in operation time and anesthesia time between the two groups(P>0.05).However,the treatment group exhibited a shorter postoperative urinary catheter removal time and hospital stay than the control group(P<0.05).Preoperatively,no significant differences were found in the visual analog scale(VAS)scores between the two groups(P>0.05).However,at 12,18,and 24 hours postoper-atively,the treatment group had significantly lower VAS scores than the control group(P<0.05).Although no significant differences in preoperative hemodynamic indicators were found between the two groups(P>0.05),both groups experienced some extent of changes in postoperative HR,diastolic BP(DBP),and systolic BP(SBP).Nevertheless,the treatment group showed smaller changes in HR,DBP,and SBP than the control group(P<0.05).Preoperative immune function indicators showed no significant differences between the two groups(P>0.05).However,postoperatively,the treatment group demonstrated higher levels of CD3+,CD4+,and CD4+/CD8+and lower levels of CD8+than the control group(P<0.05).The rates of adverse reactions were 6.38%and 23.40%in the treatment and control groups,respectively,revealing a significant difference(χ2=5.371,P=0.020).CONCLUSION Dexmedetomidine-assisted intravenous-inhalation combined general anesthesia can promote early recovery of patients undergoing laparoscopic minimally invasive surgery for inguinal hernia.It ensures stable blood flow,improves postoperative analgesic effects,reduces postoperative pain intensity,alleviates stress response,improves immune function,facilitates anesthesia recovery,and enhances safety.
基金financially supported by,the Fundamental Research Funds for the Central Universities(Grant No.2023QN1064)the China Postdoctoral Science Foundation(Grant No.2023M733772)Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2023ZB847)。
文摘Prepulse combined hydraulic fracturing facilitates the development of fracture networks by integrating prepulse hydraulic loading with conventional hydraulic fracturing.The formation mechanisms of fracture networks between hydraulic and pre-existing fractures under different prepulse loading parameters remain unclear.This research investigates the impact of prepulse loading parameters,including the prepulse loading number ratio(C),prepulse loading stress ratio(S),and prepulse loading frequency(f),on the formation of fracture networks between hydraulic and pre-existing fractures,using both experimental and numerical methods.The results suggest that low prepulse loading stress ratios and high prepulse loading number ratios are advantageous loading modes.Multiple hydraulic fractures are generated in the specimen under the advantageous loading modes,facilitating the development of a complex fracture network.Fatigue damage occurs in the specimen at the prepulse loading stage.The high water pressure at the secondary conventional hydraulic fracturing promotes the growth of hydraulic fractures along the damage zones.This allows the hydraulic fractures to propagate deeply and interact with pre-existing fractures.Under advantageous loading conditions,multiple hydraulic fractures can extend to pre-existing fractures,and these hydraulic fractures penetrate or propagate along pre-existing fractures.Especially when the approach angle is large,the damage range in the specimen during the prepulse loading stage increases,resulting in the formation of more hydraulic fractures.
基金Supported by Research Project of Zhejiang Provincial Science and Technology Plan for Traditional Chinese Medicine,No.2024ZL753and Research Project of Zhejiang Provincial Medical and Health Science and Technology Plan,No.2024KY1406.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM),a chronic metabolic disease with a high global incidence,has become a serious public health challenge.China has the largest number of T2DM patients worldwide,imposing a significant economic burden on the healthcare system.T2DM is closely associated with insulin resistance,impaired pancreatic B cell function,and disordered glucose and lipid metabolism,which can lead to various complications,reducing patients'quality of life and increasing the risk of disability and death.Thus,finding effective preventive and intervention measures is crucial.Exercise therapy,a key part of diabetes management,has gained attention in recent years,with many studies indicating its benefits for blood glucose control and other aspects in diabetic patients.AIM To assess the effectiveness of combined resistance and aerobic exercise interventions on blood glucose control and metabolic indicators in patients with T2DM and to explore their application in diabetes management.METHODS Systematic searches were conducted using PubMed,EMBASE,Cochrane Library,and Chinese databases for relevant randomized controlled trials(RCTs).The inclusion criteria were participants aged≥18 years with T2DM and the intervention involved combined resistance and aerobic exercise for≥8 weeks.The primary outcome indicators were fasting blood glucose,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),glycated hemoglobin A1c(HbA1c),and total cholesterol(TC)levels.Data analysis was performed using RevMan software,and the interventional effects were assessed using weighted mean differences or standardized mean differences(SMD).RESULTS Six RCTs meeting the inclusion criteria were included,with a total sample size of 366 participants.The meta-analysis results showed that combined resistance and aerobic exercise significantly improved several metabolic indicators in patients with T2DM.Specific results were as follows:(1)For fasting blood glucose,combined exercise was more effective than aerobic exercise alone[SMD=1.22;95%confidence interval(95%CI):0.70,1.74;P<0.00001];(2)LDL-C levels were significantly reduced by the combined intervention(SMD=1.45;95%CI:1.18-1.72;P<0.00001);(3)The combined intervention significantly increased HDL-C levels(SMD=1.42;95%CI:0.98-1.87;P<0.00001);(4)The combined intervention significantly reduced TG levels(SMD=1.12;95%CI:0.85-1.39;P<0.00001;(5)No statistically significant difference was observed in HbA1c between the combined and the aerobic exercise group(SMD=-0.03;95%CI:-1.09 to 1.04;P<0.00001);and(6)The combined exercise intervention group significantly reduced TC levels(SMD=2.66;95%CI:1.93-3.38;P<0.00001).The subgroup analysis results suggest that the effect of exercise interventions may be influenced by various factors,including the patient's age,baseline blood glucose levels,and exercise intensity.CONCLUSION Combined resistance and aerobic exercise intervention significantly improved fasting blood glucose,LDL-C,HDL-C,TG,and TC levels in patients with T2DM,especially in terms of blood glucose control and cardiovascular risk,demonstrating better outcomes than aerobic exercise alone.
基金the National Natural Science Foundation of China(No.52075264)。
文摘With the continuous escalation of modern war,soldiers need to transport more combat materials to the combat area.The limited load-bearing capacity of soldiers seriously restricts their carrying capacity and mobility.It is urgent to develop a power-assisted exoskeleton robot suitable for individual combat.In the past,most power-assisted exoskeleton robots were driven by motors.This driving method has an excellent power-assisted effect,but the endurance is often insufficient.In view of this shortcoming,this study designed an ankle exoskeleton robot based on an active-passive combined drive through simulation analysis of human motion.It used OpenSim software to simulate and verify that the addition of spring could achieve a good effect.At the same time,according to the gait characteristics of the human body,the gait planning of an exoskeleton robot was carried out.Afterwards,theoretical analysis explained that the cooperation among spring,motor and wearer could be realized in this gait.Finally,the assisting ability and driving coordination of the active-passive combination driven ankle exoskeleton robot were verified through experiments.
基金supported by the National Natural Science Foundation of China(Nos.52293442,52300249,and 52388101)the Scientific Research Project of China Three Gorges Corporation(No.201903139).
文摘Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.
基金support by the National Natural Science Foundation of China(Nos.52104266,52074206,52374278)Key Research and Development Project of Shaanxi Province,China(No.2023GXLH-054).
文摘The effects of combined microwave and hydrogen peroxide(H_(2)O_(2))oxidation on the flotation separation of molybdenite and chalcopyrite,as well as the underlying mechanism were investigated via microflotation,zeta potential,contact angle,X-ray photoelectron spectroscopy(XPS),scanning electron microscopy(SEM)and atomic force microscopy(AFM)analyses.The microflotation experiments showed that the effective inhibition of chalcopyrite can be obtained through combined oxidation pretreatments with low microwave power and H_(2)O_(2)consumption.The zeta potential,contact angle and XPS analyses indicated that the surface hydrophobicity of molybdenite changed minimally after different treatments,whereas significant amounts of hydrophilic oxidation species were formed on the surface of chalcopyrite,thus decreasing its surface hydrophobicity and floatability.Moreover,the SEM and AFM analyses indicated that more uniform oxidative products were formed on the chalcopyrite surface,further significantly increasing the surface roughness.
基金supported by the National Key Research and Development Program of China(No.2020YFC1808204)the National Natural Science Foundation of China(Nos.22206001 and U22A20406)the Scientific Research Foundation of Education Department of Anhui Province of China(No.KJ2021A0074).
文摘Nanoplastics are emerging contaminants that may co-exist with organochlorine pesticides and adversely affect invertebrates in the environment.However,the impact of environmental aging on the combined toxicity of nanoplastics and organochlorine pesticides remains unclear.This study investigated the effects of aging on the combined toxicity of polystyrene nanoplastics(PS NPs)and chlordane against Caenorhabditis elegans.The results showed that photo-aging altered the physicochemical properties of PS NPs and promoted the combined toxicity of PS NPs and chlordane to nematodes by reducing survival rate,body length and enhancing germline apoptosis.Additionally,combined exposure of nematodes to aged PS NPs and chlordane significantly increased reactive oxygen species production and intestinal permeability,suggesting that aging enhances combined toxicity through oxidative stress and intestinal damage.Moreover,aging increased chlordane contents in nematodes without promoting PS NPs accumulation,potentially leading to increased combined toxicity of PS NPs and chlordane.Notably,aging significantly increased the accumulation of PS NPs in the posterior intestine of the nematode during co-exposure,which may be responsible for the most sensitive and highest degree of change in germline apoptosis.These observations emphasize the significance of accounting for environmental aging as well as the accumulation and distribution of nanoplastics in organisms when assessing the combined effects of nanoplastics and coexisting pollutants.
基金The authors thank the National Natural Science Foundation of China(Grant No.U20B6003)for their financial support to carry out this research.
文摘China boasts abundant heavy oil resources,which is vital for its energy security.However,its heavy oil typically exhibits high viscosity,which severely hinders its flow and extraction.Enhancing heavy oil flowability is vital for its effective exploitation.This study independently developed a visualization experimental system and explored the mechanisms through which combined thermal flooding(a combination of heat,chemical agents and gas)enhances heavy oil flowability.Results indicate that combined thermal flooding,that is,synergistically integrating heat,chemical agents,and gas,can effectively enhance the recovery of heavy oil by improving its flowability.Its working mechanisms were explored from the aspects of thermal effects,emulsification,precursor film,profile control capacity,and CO_(2) solution and extraction effects.The emulsification was observed using a confocal laser scanning fluorescence microscope(CLSFM).Findings reveal that steam flooding can boost crude oil flowability by augmenting temperature,while a chemical system tends to produce low-viscosity oil-in-water emul-sions,thus further aiding the flow of crude oil.During CO_(2) flooding,the solvent initially reduced crude oil viscosity and formed foamy oil,followed by the pronounced component separation of the produced fluids in the later stage.This demonstrates the effectiveness of CO_(2) in viscosity reduction and component extraction.Additionally,the results of interfacial tension experiments indicate that surfactants can reduce the heavy oil's interfacial tension,fostering the formation of nano-scale precursor films.They can also thicken these films and diminish their spreading resistance,thus accelerating residual oil removal and promoting heavy oil production.This study further elaborated the mechanisms behind the combined thermal flooding's efficiency in enhancing heavy oil recovery,offering a theoretical foundation for its broader application.
基金financially supported by the Shandong Provincial Natural Science Foundation(Grant No.ZR2023QE063)。
文摘This paper presents a numerical investigation of nonlinear sloshing in a prismatic tank.A three-dimensional,twophase flow model based on Cartesian grid is developed to simulate the phenomenon.The model solves incompressible Navier-Stokes equations,utilizing the fractional step method for velocity-pressure decoupling.The finite difference method discretizes spatial derivatives,with specific schemes implemented to enhance model robustness.Model validation involves simulating benchmark cases,and comparing wave profiles and pressure results with published experimental data and numerical findings.The model demonstrates robustness and accuracy in simulating violent sloshing.The validated model examines sloshing in a partially filled prismatic tank under combined surge and roll excitations.The study employs eight frequencies encompassing the natural frequencies of tank roll and surge motions.Roll motion excitation is fixed at 2°,while surge motion considers three excitation amplitudes(0.0 m,0.01 m,and 0.02m).Analysis reveals the effects of surge amplitude and excitation frequency on wave patterns,amplitudes,and pressure peaks.Results indicate the presence of multi-component waves,including transverse,diagonal,and longitudinal waves.Furthermore,the findings demonstrate a reduction in the natural frequency for surge motion through pressure peak analysis.
文摘Objective:To analyze the effects of combined spinal-epidural anesthesia and epidural anesthesia in patients undergoing appendicitis surgery.Methods:Seventy-eight patients who underwent surgical treatment for appendicitis from February 2022 to February 2025 were selected as samples and randomly divided into two groups.The study group received combined spinal-epidural anesthesia,while the control group received epidural anesthesia.Anesthesia indicators,vital signs,and complication indicators were compared between the two groups.Results:The onset time of anesthesia in the study group was shorter than that in the control group,the visual analog scale(VAS)score was lower than that in the control group,and the highest plane of anesthesia block was lower than that in the control group(P<0.05).At 15 minutes after anesthesia induction and at the end of surgery,the heart rate(HR),mean arterial pressure(MAP),and blood oxygen saturation(SPO2)in the study group were significantly different from those in the control group(P<0.05).The complication rate in the study group was lower than that in the control group(P<0.05).Conclusion:Combined spinal-epidural anesthesia for appendicitis surgery can reduce the impact of anesthesia on vital signs,shorten the onset time of anesthesia,and is highly effective and feasible.
基金supported by the National Science and Technology Major Project of China(Nos.2017-II-0004-0016 and J2019-I-0011-0011).
文摘Unstable operating conditions such as surge could cause damage to both aerodynamic performance and structural integrity of a compression system.This paper addresses the critical issue of aerodynamic instability in compressor design,particularly focusing on an axial-centrifugal combined compressor,a widely used yet underexplored configuration.An experimental investigation was conducted on a three-stage axial and one-stage centrifugal compressor(3A1C),using two pipe systems and employing fast-responding transducers to capture the dynamic instability process from choke condition to deep surge.Results reveal that at the design speed,3A1C enters deep surge directly,whereas at off-design speeds,it experiences rotating stall and mild surge across a wide mass flow range.Some special instability features in the combined compressor can be found in the steady state map and dynamic process.The characteristic curve of the first axial stage keeps a positive slope during the whole mass flow range at an off-design speed.The first stage could work stably on the stall characteristic curve because the centrifugal stage has stronger pressurization and plays a dominant role in global aerodynamic instability.Besides,rotating instability occurs at the first rotor tip and disappears as the back pressure increases,which is also rarely seen in a single-axial compressor.This is also related to the strong pressurization of the centrifugal stage.The findings of this paper will contribute to the understanding of aerodynamic instabilities in combined compressors.
基金Supported by the National Natural Science Foundation of China,No.82360111Xinjiang Science and Technology Department-Leading Talents in Technological Innovation-High-Level Leading Talents,No.2022TSYCLJ0034+1 种基金State Key Laboratory for The Cause and Control of High Incidence in Central Asia Jointly Constructed by The Ministry and The Province,No.SKL-HIDCA-2023-2 and No.SKLHIDCA-2024-22Xinjiang Uygur Autonomous Region Graduate Innovation Program,No.XJ2024G153.
文摘BACKGROUND Alveolar and cystic echinococcoses are lethal zoonotic diseases caused by Echinococcus multilocularis and Echinococcus granulosus infections,leading to alveolar echinococcosis(AE)or cystic echinococcosis(CE),respectively.No study has hitherto reported effective treatment approaches for AE or CE with concurrent hepatorenal involvement.AIM To investigate the feasibility and efficacy of simultaneous combined surgery(SCS)as a comprehensive treatment approach for patients with hepatorenal echinococcosis.METHODS Clinical datasets of hepatorenal AE(n=10)and CE(n=11)patients were retrospectively collected and systematically analyzed.The SCS approach was introduced,and surgical outcomes,complications,and prognoses were documented in detail.RESULTS The SCS approach incorporated hybridized techniques,including partial hepatectomy,partial or total nephrectomy,ex vivo liver resection and autotransplantation,and total or subtotal cystectomy with endocystectomy.Radical SCS was achieved in 100%of AE patients and 63.6%of CE patients.All surgeries were completed without intraoperative complications.The short-term complication rate was 28.6%(Clavien-Dindo classification:AE-1 IIIb,3 IIIa;CE-2 II),while the long-term complication rate was 4.8%(Clavien-Dindo classification:AE-1 IIIb).Patients were followed up for a median of 37 months(AE:6-81 months;CE:34-123 months),with no reported deaths or disease relapses.CONCLUSION CS appears to be a feasible and effective treatment method for patients with hepatorenal involvement of AE or CE.It fulfills the management criteria for advanced AE or CE cases,aiming to maximize patient benefits.
文摘Research on the effects of drug therapy combined with psychological intervention in adolescent patients with depression represents a critical focus in contemporary psychiatric medicine.This study aims to explore the synergistic therapeutic approach of integrating pharmacological treatment with psychological interventions,focusing on its positive impacts on symptom alleviation,quality-of-life enhancement,and clinical recovery in adolescent depression.A cohort of 62 adolescents was selected as research participants,with randomized allocation into either monotherapy(drug-only)or combination therapy(drugs+psychological intervention)groups.Key evaluation metrics included anxiety levels,clinical efficacy,and incidence of adverse reactions.
文摘Purpose:To investigate the clinical effects of improving adolescents’form anxiety after the intervention of visceral massage technique and form training.Methods:A total of 80 adolescent patients with scoliosis abnormalities were selected for this experiment,and they were intervened with form and body training and form and body training+visceral body acupressure techniques,and the anxiety and depression scores,spinal Cobb angle,vertebral body rotation of the parietal vertebrae,and the treatment efficiency were compared between the groups after the clinical interventions.Results:The anxiety and depression scores of patients in the form group were significantly higher than those of the combined group,P<0.05;the improvement of the Cobb angle and vertebral rotation of the parietal vertebrae of patients in the combined group was better than that of the form group,P<0.05;and the total effective rate of the treatment of patients in the form group was significantly lower than that of the combined group,P<0.05.Conclusion:After intervening in adolescents’abnormalities of form,patients were treated with a combination of the internal organs and body acupressure techniques and form training methods,and the results were compared between groups.After the joint intervention of the visceral massage technique and physical training,the patients’scoliosis and other physical problems were positively improved,and the psychological status of the patients was relatively adjusted to ensure their physical and mental health.
文摘Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a rare hetero-geneous primary malignant liver tumor containing both hepatocellular and cholangiocarcinoma features.The complex presentation of cHCC-CCA tends to be poorly investigated,and the information derived from traditional diagnostic techniques(histopathology and radiological imaging)is often not optimal.Since cHCC-CCA is usually difficult to diagnose due to complex histopathological features(edge learning)as excessive photos,hence,achieves treatment delays and poor prognosis,the incorporation of advanced artificial intelligence like edge learning is able to improve the patient’s outcome.Using artificial intelligence,particularly deep learning,has recently opened new doorways for the impro-vement of diagnostic accuracy.If artificial intelligence models are deployed on local devices,edge learning exercises this type of learning,which provides real time processing,improved data privacy and reduced bandwidth usage.This narrative review investigates the conceptual formulation of edge learning together with its opportunities for clinical applications in the prediction and classification of cHCC-CCA,the technical solution strategies,the clinical benefits it offers,and associated challenges and future directions.
基金Supported by Shandong Provincial Sheep Industry Technology System Position Expert Project(SDAIT-10-06)Binzhou Municipal Science and Technology Innovation Policy Guidance Plan Project for the Agricultural Social Service Field(2023SHFZ004).
文摘[Objectives]This study was conducted to enhance the prevention and control of peste des petits ruminants(PPR)and goatpox(GTP).[Methods]Two experimental sheep farms in Northern Shandong were selected to conduct a comparative experiment between separate vaccinations for PPR and GTP and immunization with a combined live vaccine for both diseases.Antibody levels were measured to assess immunization effect on days 7,14,21 and 28 after vaccination.[Results]The qualified rates of group immune antibodies in both the experimental and control groups exceeded 75%,achieving the goal of preventing both PPR and GTP through a single immunization.[Conclusions]This study provides clinical application references for the prevention of PPR and GTP in the local area.
基金supported by the Postdoctoral Fellowship Program of CPSF (GZC20231064)China Postdoctoral Science Foundation (2024M761345)+3 种基金Guangzhou Basic and Applied Basic Research Foundation (2024A04J6615)Scientific Research Project of Southern Medical University Stomatological Hospital (PY2023004)National Key Research and Development Program of China (2021YFA0805300)National Natural Science Foundation of China (82171244,32470564)。
文摘Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death.Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies.Recent advances in gene-editing technologies,including zincfinger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs),CRISPR/Cas9,and base editing,have significantly enhanced the generation of SCID models.These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy,stem cell transplantation,organ transplantation,and infectious diseasemanagement.Thisreviewprovidesa comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.
文摘Objective:To study the efficacy of biofeedback combined with occupational therapy in stroke patients,including upper arm function,hand function,and self-care ability.Methods:A total of 60 stroke patients who met the inclusion and exclusion criteria of this study were divided into a treatment group and a control group,with 30 cases in each group,using a random number table method.The total course of treatment was 4 weeks,with 5 treatments per week.Both groups received routine rehabilitation treatment,while the treatment group was supplemented with biofeedback therapy on the basis of routine rehabilitation.Before treatment and after 4 weeks of treatment,the Hemiplegic Hand Function Assessment Scale,Carroll Upper Extremity Function Assessment Scale,Wolf Motor Function Test(WMFT),and Brunnstrom Scale were used to evaluate patients’hand function,Activities of Daily Living(ADL)ability,and motor function,respectively.Adverse events during treatment were observed.Results:After treatment,the Brunnstrom stages,Carroll upper extremity function scores,and Wolf upper extremity function scores of patients in both groups were significantly improved(p<0.001),and the improvement effect in the treatment group was more significant(p<0.001).Conclusion:Stroke patients receiving basic rehabilitation treatment combined with occupational therapy and biofeedback therapy can better improve their upper arm and hand functions.Meanwhile,the combination of biofeedback therapy and occupational therapy is superior to occupational therapy alone,enhancing the self-care ability of stroke patients.
