Sister chromatid exchange (SCE) frequency,a sensi-tive indicator in mutagenicity testing,and mitoticindex (MI) have been studied to observe genotoxiceffects in epileptic patients on routine combi-nations of anticonvul...Sister chromatid exchange (SCE) frequency,a sensi-tive indicator in mutagenicity testing,and mitoticindex (MI) have been studied to observe genotoxiceffects in epileptic patients on routine combi-nations of anticonvulsant therapy.All patients,展开更多
Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseas...Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.展开更多
Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP ...Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP and the combinatory logic, it has been discussed in Ref. [3] that the basic combinators I, S and K can be defined as展开更多
A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4（3H）-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5（4H,6H）-dione, and 1H-benzo[d]imidaz...A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4（3H）-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5（4H,6H）-dione, and 1H-benzo[d]imidazol-2- amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.展开更多
Objective To observe the effect of different doses of atorvastatin combined with probucol on contrast-induced acute kidney injury(CIAKI) and serum uric acid in elderly patients. Methods Totally 121 cases admitted for ...Objective To observe the effect of different doses of atorvastatin combined with probucol on contrast-induced acute kidney injury(CIAKI) and serum uric acid in elderly patients. Methods Totally 121 cases admitted for coronary angioplasty were randomly divided into展开更多
文摘Sister chromatid exchange (SCE) frequency,a sensi-tive indicator in mutagenicity testing,and mitoticindex (MI) have been studied to observe genotoxiceffects in epileptic patients on routine combi-nations of anticonvulsant therapy.All patients,
基金National Natural Science Foundation of China (Nos.81672327 and 81802319)Program of Shanghai Academic/Technology Research Leader (No.17XD1402600)+1 种基金Program for Outstanding Medical Academic Leader and Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No.20161410)Development Grant for Clinical Trial (No.SHDC12017X06).
文摘Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients, outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.
文摘Ⅰ. INTRODUCTION In Ref. [2] a combinatory-logic foundation has been laid for the functional programming language FP which is shown to be a higher-level combinatory logic. As for the relation between the language FFP and the combinatory logic, it has been discussed in Ref. [3] that the basic combinators I, S and K can be defined as
基金Project supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions （09KJA430003）, Natural Science Foundation of Xuzhou City （XM09B016）, Graduate Foundation of Xuzhou Normal University （09YLB030） and Qing Lan Project （08QLT001）.
文摘A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4（3H）-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5（4H,6H）-dione, and 1H-benzo[d]imidazol-2- amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.
文摘Objective To observe the effect of different doses of atorvastatin combined with probucol on contrast-induced acute kidney injury(CIAKI) and serum uric acid in elderly patients. Methods Totally 121 cases admitted for coronary angioplasty were randomly divided into
