目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类...目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类风湿关节炎的研究,检索时限至2024年8月。采用Cochrane 5.4手册对纳入的随机对照试验进行质量评价,采用纽卡斯尔-渥太华量表(NOS)对回顾性队列研究进行质量评价。运用R4.1.1软件进行贝叶斯网状Meta分析。结果:最终纳入13篇研究,总样本量891例,共有4种免疫吸附柱。网状Meta分析结果表明,降低C-反应蛋白前3名排序:HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药>A蛋白吸附柱;降低红细胞沉降率前3名排序:白细胞吸附柱>HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节肿胀计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节压痛计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低患者对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>A蛋白吸附柱;降低目测类比评分前3名排序:PH-350型吸附柱+常规西药>A蛋白吸附柱>白细胞吸附柱;降低医师对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>常规西药。结论:基于纳入的13篇文献证据表明,在降低C-反应蛋白方面,HA280型吸附柱联合常规西药作为首选;在降低红细胞沉降率、关节肿胀计数、关节压痛计数方面,白细胞吸附柱作为首选;在降低患者对疾病活动性评分、医师对疾病活动性评分及目测类比评分方面,PH-350型吸附柱联合常规西药作为首选,在临床中可根据患者的具体情况合理选择不同的免疫吸附柱。展开更多
This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and und...This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and underlying mechanisms.The results show that,during the developing winter of EP El Niño,significant SSR reductions occur in southwestern China and the east coast of southern China due to a strong,zonally extended Northwest Pacific anticyclone that transports moisture from the tropical Northwest Pacific and North Indian Ocean,while the northeast of southern China experiences a weak increase in SSR.In contrast,during the developing winter of CP El Niño,SSR decreases in the east of southern China with a significant decrease in the lower basin of the Yangtze River but an increase in the west of southern China with a remarkable increase in eastern Yunnan.The pronounced east-west dipole pattern in SSR anomalies is driven by a meridionally elongated Northwest Pacific anticyclone,which enhances northward moisture transport to the east of southern China while leaving western areas drier.Further research reveals that distinct moisture anomalies during the developing winter of EP and CP events result in divergent SSR distributions across southern China,primarily through modulating the total cloud cover.These findings highlight the critical need to differentiate between El Niño types when predicting medium and long-term variability of radiation in southern China.展开更多
文摘目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类风湿关节炎的研究,检索时限至2024年8月。采用Cochrane 5.4手册对纳入的随机对照试验进行质量评价,采用纽卡斯尔-渥太华量表(NOS)对回顾性队列研究进行质量评价。运用R4.1.1软件进行贝叶斯网状Meta分析。结果:最终纳入13篇研究,总样本量891例,共有4种免疫吸附柱。网状Meta分析结果表明,降低C-反应蛋白前3名排序:HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药>A蛋白吸附柱;降低红细胞沉降率前3名排序:白细胞吸附柱>HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节肿胀计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节压痛计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低患者对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>A蛋白吸附柱;降低目测类比评分前3名排序:PH-350型吸附柱+常规西药>A蛋白吸附柱>白细胞吸附柱;降低医师对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>常规西药。结论:基于纳入的13篇文献证据表明,在降低C-反应蛋白方面,HA280型吸附柱联合常规西药作为首选;在降低红细胞沉降率、关节肿胀计数、关节压痛计数方面,白细胞吸附柱作为首选;在降低患者对疾病活动性评分、医师对疾病活动性评分及目测类比评分方面,PH-350型吸附柱联合常规西药作为首选,在临床中可根据患者的具体情况合理选择不同的免疫吸附柱。
基金funded by a Project from China Southern Power Grid Company Ltd.(Nos.ZBKJXM20232481 and ZBKJXM20232482)。
文摘This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and underlying mechanisms.The results show that,during the developing winter of EP El Niño,significant SSR reductions occur in southwestern China and the east coast of southern China due to a strong,zonally extended Northwest Pacific anticyclone that transports moisture from the tropical Northwest Pacific and North Indian Ocean,while the northeast of southern China experiences a weak increase in SSR.In contrast,during the developing winter of CP El Niño,SSR decreases in the east of southern China with a significant decrease in the lower basin of the Yangtze River but an increase in the west of southern China with a remarkable increase in eastern Yunnan.The pronounced east-west dipole pattern in SSR anomalies is driven by a meridionally elongated Northwest Pacific anticyclone,which enhances northward moisture transport to the east of southern China while leaving western areas drier.Further research reveals that distinct moisture anomalies during the developing winter of EP and CP events result in divergent SSR distributions across southern China,primarily through modulating the total cloud cover.These findings highlight the critical need to differentiate between El Niño types when predicting medium and long-term variability of radiation in southern China.
