MnO 2 was prepared by column method from normal spinel LiMn 2O 4 with purity of 99.38%.The influence of LiMn 2O 4 grain size and acidity of leaching solution on the lithium leaching process was studied.The result...MnO 2 was prepared by column method from normal spinel LiMn 2O 4 with purity of 99.38%.The influence of LiMn 2O 4 grain size and acidity of leaching solution on the lithium leaching process was studied.The results show that the appropriate range of LiMn 2O 4 grain size was 60-160 meshes and the concentration of leaching solution HCl was 0.1 mol·L -1.The adsorption capacity Q of λ-MnO 2 for lithium increased with the increase of pH and changed markedly at pH 6.0-10.0.It was 3.80mmol/g at pH 12.0.The distribution coefficients K d of Li + and Na + were 3.406×10 4 and 2.300 respectively,and the separation coefficient α Li Na was 1.481×10 4 at pH 6.5.As a result,λ-MnO 2 is a high performance ion-sieve material for lithium ion.展开更多
In the Chenggong tunnel of Kunming, aiming at the engineering of shallow buried and strongly expanded surrounding rock, the construction method of three steps plus central columns is introduced. The soil of Chenggong ...In the Chenggong tunnel of Kunming, aiming at the engineering of shallow buried and strongly expanded surrounding rock, the construction method of three steps plus central columns is introduced. The soil of Chenggong Tunnel is tested in laboratory to determine its expansibility. The traditional three-step method and three-step plus center pillar method are compared and analyzed by using MIDAS-GTS. Finally, the deformation of surrounding rock after the construction of three-step plus center pillar method is obtained through on-site monitoring. The results show that: 1) The free expansion rate, montmorillonite content and cation exchange capacity of Chenggong tunnel soil are determined, and the expansive parameters are obtained. 2) Through numerical simulation, it is concluded that under the condition of strong expansive soil and weak surrounding rock, the settlement of vault and two sides caused by the traditional step method are both larger than that of the three steps plus center pillar method. This new improved method can effectively reduce the disturbance to surrounding rock and significantly reduce the settlement of vault;3) The data of vault settlement and displacement of two sides of the tunnel after the construction of the three-step plus center pillar method are obtained by on-site monitoring, and are simulated and analyzed by using MIDAS-GTS software. The relative error value of vault settlement obtained by the two methods is 1%, which indicates that MIDAS-GTS has good simulation effect on the stress state and deformation state of the tunnel, and further indicates that this method is very practical for the case of small convergence of side walls and large vault settlement.展开更多
The Sargent dividing wall column can implement four products separation sequences in one column based on Fully Thermally Coupled Distillation Column. The initial design parameters are required for the design optimizat...The Sargent dividing wall column can implement four products separation sequences in one column based on Fully Thermally Coupled Distillation Column. The initial design parameters are required for the design optimization or dynamic control of the Sargent dividing wall column, and in order to make the rigorous simulation of the Sargent dividing wall column more conducive to convergence, a ten column model for complex Sargent column is established in this paper,and the shortcut design method of this model is proposed. The internal minimum vapor and liquid flow are obtained by the Underwood equations and the mass balance method and the V-min method. The separation for a 4-component shortcut mixture of pentane, hexane, heptane and octane was considered, while the initial values of design parameters and the ratio of vapor-liquid distribution of each column were calculated by using the shortcut design method of a ten column model. And by comparing the shortcut calculations with rigorous simulation results, the practicality and reliability of shortcut calculations were verified. The reason for energy saving was analyzed based on back-mixing. A virtual heat exchanger is proposed to make the Sargent dividing wall column more energy efficient.展开更多
Nicotine and cotinine in hair are good biomarkers for assessing long-term exposure to smoking. However, analytical devices such as GC/MS are associated with high cost and are not widely used. HPLC/UV is used widely in...Nicotine and cotinine in hair are good biomarkers for assessing long-term exposure to smoking. However, analytical devices such as GC/MS are associated with high cost and are not widely used. HPLC/UV is used widely in laboratories, but is unsuitable for measurement of minor constituents, except when using the column-switching method. Thus, we aimed to establish a simple, inexpensive and sensitive method based on HPLC/UV with column switching for measuring nicotine and cotinine in hair. First, we compared the presence and absence of a column selection unit. We then measured amounts of nicotine and cotinine in hair samples collected from the general population, and compared both the corresponding levels and the detection limits with those in previous studies. Finally, initial and running costs of HPLC/UV were compared with other analytical methods. As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 times greater, respectively, than those without the column-switching method. The amount of nicotine and cotinine in hair was significantly correlated to number of cigarettes smoked per day (r = 0.228, p = 0.040). In addition, the HPLC/UV method showed similar sensitivity and detection limit (nicotine, 0.10 ng/mg;cotinine, 0.08 ng/mg) as reported in previous studies. The cost of the HPLC/UV method is lower than that of other analytical methods. We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. The HPLC/UV with a column-switching method will be useful as a first step in screening surveys in order to better understand the effects of smoking exposure.展开更多
In this paper, we prove the local and Supcrlinear convergence theorem of the column-updating method for n>2. This is an oped problem for the convergene theory of the column-updating method given by Martinez in the ...In this paper, we prove the local and Supcrlinear convergence theorem of the column-updating method for n>2. This is an oped problem for the convergene theory of the column-updating method given by Martinez in the Intcrnational Conference of the NATO-ASI (Italy, 1994).展开更多
In order to investigate the calculation methods on crack resistance capacity of connection composed of cross shaped steel encased ultra high strength concrete (CSSEUHSC) columns and steel encased concrete (SEC) beams ...In order to investigate the calculation methods on crack resistance capacity of connection composed of cross shaped steel encased ultra high strength concrete (CSSEUHSC) columns and steel encased concrete (SEC) beams under cycle loads, six interior connection specimens were tested in the laboratory. A discussion on the crack resistance capacity was presented. Calculation methods of crack resistance capacity were deduced based on the experimental case and calculation results were in good agreement with the experimental results. The research results indicated that parameters of connection composed of CSSEUHSC columns and SEC beams with better crack resistance performance may be referred for engineering application.展开更多
The aim of this study is to calculate the critical load of variable inertia columns. The example studied in this paper can be used as a paradigm for other non-uniform columns. The wavelength of equivalent vibratory sy...The aim of this study is to calculate the critical load of variable inertia columns. The example studied in this paper can be used as a paradigm for other non-uniform columns. The wavelength of equivalent vibratory system is used to calculate the critical load of the trigonometrically varied inertia column. In doing so, the equilibrium equation of the column is theoretically studied using the perturbation method. Accuracy of the calculated results is evaluated by comparing the solution with numerical results. Effect of improving the initial guess on the solution accuracy is investigated. Effects of varying parameters of the trigonometrically varied inertia and the uniformly tapered columns on their stability behavior are studied. Finally, using the so-called ＂perfectibility＂ parameter, two design goals, i.e., being lightweight and being strong, are studied for the discussed columns.展开更多
Concrete filled steel tube structures have gained booming development in recent decades, especially in China. Simplified methods have been proposed in design codes, such as the Eurocode 4 (EC4) and the China engineeri...Concrete filled steel tube structures have gained booming development in recent decades, especially in China. Simplified methods have been proposed in design codes, such as the Eurocode 4 (EC4) and the China engineering and construction specification (CECS). In EC4, the confinement effect is reasonably related to slenderness and load eccentricity. The CECS method is much straight forward in that the slenderness ratio and load eccentricity are treated as independent reduction factors. To make use of the advantages of both the CECS and the EC4 methods, the CECS method is modified to consider the confinement effect associated with slenderness and load eccentricity. It is shown that the proposed method can predict well the ultimate load capacity of circular section concrete filled steel tube columns.展开更多
目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类...目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类风湿关节炎的研究,检索时限至2024年8月。采用Cochrane 5.4手册对纳入的随机对照试验进行质量评价,采用纽卡斯尔-渥太华量表(NOS)对回顾性队列研究进行质量评价。运用R4.1.1软件进行贝叶斯网状Meta分析。结果:最终纳入13篇研究,总样本量891例,共有4种免疫吸附柱。网状Meta分析结果表明,降低C-反应蛋白前3名排序:HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药>A蛋白吸附柱;降低红细胞沉降率前3名排序:白细胞吸附柱>HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节肿胀计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节压痛计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低患者对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>A蛋白吸附柱;降低目测类比评分前3名排序:PH-350型吸附柱+常规西药>A蛋白吸附柱>白细胞吸附柱;降低医师对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>常规西药。结论:基于纳入的13篇文献证据表明,在降低C-反应蛋白方面,HA280型吸附柱联合常规西药作为首选;在降低红细胞沉降率、关节肿胀计数、关节压痛计数方面,白细胞吸附柱作为首选;在降低患者对疾病活动性评分、医师对疾病活动性评分及目测类比评分方面,PH-350型吸附柱联合常规西药作为首选,在临床中可根据患者的具体情况合理选择不同的免疫吸附柱。展开更多
The recently developed elasto-viscoplastic Creep-SCLAY1S model has been used in conjunction with PLAXIS 2D to investigate the effectiveness of vibro-replacement in a creep-prone clay. The Creep-SCLAY1S model accounts ...The recently developed elasto-viscoplastic Creep-SCLAY1S model has been used in conjunction with PLAXIS 2D to investigate the effectiveness of vibro-replacement in a creep-prone clay. The Creep-SCLAY1S model accounts for anisotropy, bonding, and destructuration, and uses the concept of a constant rate of viscoplastic multiplier to calculate creep strain rate. A comparison of settlement improvement factors with and without creep indicates that ‘total’ settlement improvement factors （primary plus creep） are lower than their ‘primary’ counterparts （primary settlement only）. The lowest settlement improvement factors arise for analyses incorporating the effect of bonding and destructuration. Examination of the variations of vertical stress with time and depth has indicated that vertical stress is transferred from the soil to the column as the soil creeps. This results in additional column yielding. In addition, the radial and hoop stresses in the soil are lower for the ‘creep’ case. The reduced radial stresses lead to additional column bulging and hence more settlement, whereas the hoop stress reductions appear to be a secondary effect, caused by additional plastic deformation for the ‘creep’ case.展开更多
A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 ...A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 stationary phase with simple combination of amobile phase containing 750 mL of DI Water, 250 mL of Acetonitrile and 2 mL of Octylamine into suitable container with adjusted pH to 2.50 ± 0.05 with the aid of Ortho phosphoric acid delivered in an isocratic mode and quantification was carried out using UV detection at 240 nm at a flow rate of 1.0 mL·min-1 with an injection volume of 20 μl and ambient column temperature. This method is capable to detect both the drug components of Amlodipine and Benazepril in presence of their degradation products (Amlodipine Imp-A and Benazepril Impurity-C) with a detection level of 0.05%. Amlodipine/Benazepril in their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the samples were analysed. Peak homogeneity data of Amlodipine and Benazeprilis were obtained using PDA detector, in the stressed sample chromatograms, demonstrating the specificity. The method shows excellent linearity over a range of 0.05%-2.0% for Amlodipine, Amlodipine Impurity-A and 0.05%-5.0% for Benazepril and Benazepril Impurity-C. The correlation coefficient for Amlodipine and Benazepril is 1. The relative standard deviation was always less than 2%. The proposed method was found to be suitable and accurate for quantitative determination and the stability study of Amlodipine and Benazepril in pharmaceutical preparations. The developed HPLC method was validated with respect to linearity & range, accuracy, precision and robustness.展开更多
This paper presents a new decomposition method for solving large-scale systems of nonlinear equations. The new method is of superlinear convergence speed and has rather less computa tional complexity than the Newton-t...This paper presents a new decomposition method for solving large-scale systems of nonlinear equations. The new method is of superlinear convergence speed and has rather less computa tional complexity than the Newton-type decomposition method as well as other known numerical methods, Primal numerical experiments show the superiority of the new method to the others.展开更多
The dynamical stability of a homogeneous, simple supported column, subjected to a periodic axial force, is investigated. The viscoelastic material is assumed to obey the Leaderman nonlinear constitutive relation. The ...The dynamical stability of a homogeneous, simple supported column, subjected to a periodic axial force, is investigated. The viscoelastic material is assumed to obey the Leaderman nonlinear constitutive relation. The equation of motion was derived as a nonlinear integro-partial-differential equation, and was simplified into a nonlinear integro-differential equation by the Galerkin method. The averaging method was employed to carry out the stability analysis. Numerical results are presented to compare with the analytical ones. Numerical results also indicate that chaotic motion appears.展开更多
The three-dimensional model of the wave and pile structure was established by using Ansysworkbench software. The bidirectional fluid-structure interaction between the pile and wave was simulated by using Stokes wave t...The three-dimensional model of the wave and pile structure was established by using Ansysworkbench software. The bidirectional fluid-structure interaction between the pile and wave was simulated by using Stokes wave theory and the Volume of Fluid Method. The pressure distribution diagram of the fluid-structure interface and the pile structure were observed and analyzed. The maximum equivalent stress on the pile was studied and its variation range was obtained. Compared with Von Mises yield criterion, it was concluded that the pile was stable under such wave conditions.展开更多
Elastic critical buckling load of a column depends on various parameters,such as boundary conditions,material,and crosssection geometry.The main purpose of this work is to present a new method for investigating the bu...Elastic critical buckling load of a column depends on various parameters,such as boundary conditions,material,and crosssection geometry.The main purpose of this work is to present a new method for investigating the buckling load of tapered columns subjected to axial force.The proposed method is based on modified buckling mode shape of tapered structure and perturbation theory.The mode shape of the damaged structure can be expressed as a linear combination of mode shapes of the intact structure.Variations in length in piecewise form can be positive or negative.The method can be used for single-span and continuous columns.Comparison of results with those of finite element and Timoshenko methods shows the high accuracy and efficiency of the proposed method for detecting buckling load.展开更多
A large number of column-bracing systems were modeled and analyzed by second-order analysis using finite element program ANSYS,in which the random combination of the initial imperfections between columns and horizonta...A large number of column-bracing systems were modeled and analyzed by second-order analysis using finite element program ANSYS,in which the random combination of the initial imperfections between columns and horizontal braces was well considered by Monte Carlo Method.According to the analysis results,four kinds of instability modes of column-bracing systems were found,the probability density function of the mid-height horizontal bracing forces was established based on probability statistics,and the design bracing forces were also obtained.The results indicated that the above design bracing forces are smaller than that proposed by the "Code for design of steel structures"(GB50017-2003) when the top axial compressions on the braced columns are equal,and much smaller than the latter when the top axial compressions on the braced columns are unequal.The results also indicated that the random combination of the initial imperfections between columns and horizontal braces leads to the randomness of the mid-height horizontal bracing forces in compression or in tension,so that the design bracing forces can be reduced.展开更多
In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutr...In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, neutral and oxidative conditions. Mild degradation was observed in basic conditions. The drug is relatively stable in the solid-state. Successful separation of drug from degradation products formed under stress conditions was achieved on a Kromasil C18 column (250 mm × 4.6 mm, 5.0 μ particle size) using methanol: THF: acetate buffer (68:12:20 v/v) pH adjusted to 6.0 with acetic acid as mobile phase, flow rate was 1.0 mL●min–1 and column was maintained at 45°C. Quantification and linearity was achieved at 307 nm over the concentration range of 0.5 - 160 μg●mL–1 for tenatoprazole. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness.展开更多
A numerical investigation of thin-walled complex section steel columns with intermediate stiffeners was performed using finite element analysis. An accurate and reliable finite element model was developed and verified...A numerical investigation of thin-walled complex section steel columns with intermediate stiffeners was performed using finite element analysis. An accurate and reliable finite element model was developed and verified against test results. Veri-fication indicates that the model could predict the ultimate strengths and failure modes of the tested columns with reasonable accuracy. Therefore,the developed model was used for the parametric study. In addition,the effect of geometric imperfection on column ultimate strength and the effect of boundary conditions on the elastic distortional buckling of complex section columns were investigated. An equation for the elastic distortional buckling load of fixed-ended columns having different column lengths was proposed. The elastic distortional buckling load obtained from the proposed equation was used in the direct strength method to calculate the column ultimate strength. Generally,it is shown that the proposed design equation conservatively predicted the ultimate strengths of complex section columns with different column lengths.展开更多
This work aims at comparing surface tension models in VOF(Volume of Fluid) modeling and investigating the effects of gas distributor and gas velocity. Hydrodynamics of a continuous chain of bubbles inside a bubble col...This work aims at comparing surface tension models in VOF(Volume of Fluid) modeling and investigating the effects of gas distributor and gas velocity. Hydrodynamics of a continuous chain of bubbles inside a bubble column reactor was simulated. The grid independence study was first conducted and a grid size of 1.0 mm was adopted in order to minimize the computing time without compromising the accuracy of the results. The predictions were validated by comparing the experimental studies reported in the literature. It was found that all surface tension models can describe the bubble rise and bubble plume in a column with slight deviations.展开更多
基金theNationalNaturalScienceFoundationofChi na (No .5 9972 0 2 7)theNaturalScienceFoundationofHubeiProvince (No .2 0 0 2AB0 74) )
文摘MnO 2 was prepared by column method from normal spinel LiMn 2O 4 with purity of 99.38%.The influence of LiMn 2O 4 grain size and acidity of leaching solution on the lithium leaching process was studied.The results show that the appropriate range of LiMn 2O 4 grain size was 60-160 meshes and the concentration of leaching solution HCl was 0.1 mol·L -1.The adsorption capacity Q of λ-MnO 2 for lithium increased with the increase of pH and changed markedly at pH 6.0-10.0.It was 3.80mmol/g at pH 12.0.The distribution coefficients K d of Li + and Na + were 3.406×10 4 and 2.300 respectively,and the separation coefficient α Li Na was 1.481×10 4 at pH 6.5.As a result,λ-MnO 2 is a high performance ion-sieve material for lithium ion.
文摘In the Chenggong tunnel of Kunming, aiming at the engineering of shallow buried and strongly expanded surrounding rock, the construction method of three steps plus central columns is introduced. The soil of Chenggong Tunnel is tested in laboratory to determine its expansibility. The traditional three-step method and three-step plus center pillar method are compared and analyzed by using MIDAS-GTS. Finally, the deformation of surrounding rock after the construction of three-step plus center pillar method is obtained through on-site monitoring. The results show that: 1) The free expansion rate, montmorillonite content and cation exchange capacity of Chenggong tunnel soil are determined, and the expansive parameters are obtained. 2) Through numerical simulation, it is concluded that under the condition of strong expansive soil and weak surrounding rock, the settlement of vault and two sides caused by the traditional step method are both larger than that of the three steps plus center pillar method. This new improved method can effectively reduce the disturbance to surrounding rock and significantly reduce the settlement of vault;3) The data of vault settlement and displacement of two sides of the tunnel after the construction of the three-step plus center pillar method are obtained by on-site monitoring, and are simulated and analyzed by using MIDAS-GTS software. The relative error value of vault settlement obtained by the two methods is 1%, which indicates that MIDAS-GTS has good simulation effect on the stress state and deformation state of the tunnel, and further indicates that this method is very practical for the case of small convergence of side walls and large vault settlement.
基金supported by the High-level Talents Program of Hebei Province (A 2017002032)
文摘The Sargent dividing wall column can implement four products separation sequences in one column based on Fully Thermally Coupled Distillation Column. The initial design parameters are required for the design optimization or dynamic control of the Sargent dividing wall column, and in order to make the rigorous simulation of the Sargent dividing wall column more conducive to convergence, a ten column model for complex Sargent column is established in this paper,and the shortcut design method of this model is proposed. The internal minimum vapor and liquid flow are obtained by the Underwood equations and the mass balance method and the V-min method. The separation for a 4-component shortcut mixture of pentane, hexane, heptane and octane was considered, while the initial values of design parameters and the ratio of vapor-liquid distribution of each column were calculated by using the shortcut design method of a ten column model. And by comparing the shortcut calculations with rigorous simulation results, the practicality and reliability of shortcut calculations were verified. The reason for energy saving was analyzed based on back-mixing. A virtual heat exchanger is proposed to make the Sargent dividing wall column more energy efficient.
文摘Nicotine and cotinine in hair are good biomarkers for assessing long-term exposure to smoking. However, analytical devices such as GC/MS are associated with high cost and are not widely used. HPLC/UV is used widely in laboratories, but is unsuitable for measurement of minor constituents, except when using the column-switching method. Thus, we aimed to establish a simple, inexpensive and sensitive method based on HPLC/UV with column switching for measuring nicotine and cotinine in hair. First, we compared the presence and absence of a column selection unit. We then measured amounts of nicotine and cotinine in hair samples collected from the general population, and compared both the corresponding levels and the detection limits with those in previous studies. Finally, initial and running costs of HPLC/UV were compared with other analytical methods. As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 times greater, respectively, than those without the column-switching method. The amount of nicotine and cotinine in hair was significantly correlated to number of cigarettes smoked per day (r = 0.228, p = 0.040). In addition, the HPLC/UV method showed similar sensitivity and detection limit (nicotine, 0.10 ng/mg;cotinine, 0.08 ng/mg) as reported in previous studies. The cost of the HPLC/UV method is lower than that of other analytical methods. We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. The HPLC/UV with a column-switching method will be useful as a first step in screening surveys in order to better understand the effects of smoking exposure.
文摘In this paper, we prove the local and Supcrlinear convergence theorem of the column-updating method for n>2. This is an oped problem for the convergene theory of the column-updating method given by Martinez in the Intcrnational Conference of the NATO-ASI (Italy, 1994).
基金supported by National Natural Science Foundation of China (Nos. 51168034, 50878037)China Postdoctoral Science Foundation (No. 20100471445)Open Foundation of State Key Laboratory of Coastal and Offshore Engineering(No. LP1015)
文摘In order to investigate the calculation methods on crack resistance capacity of connection composed of cross shaped steel encased ultra high strength concrete (CSSEUHSC) columns and steel encased concrete (SEC) beams under cycle loads, six interior connection specimens were tested in the laboratory. A discussion on the crack resistance capacity was presented. Calculation methods of crack resistance capacity were deduced based on the experimental case and calculation results were in good agreement with the experimental results. The research results indicated that parameters of connection composed of CSSEUHSC columns and SEC beams with better crack resistance performance may be referred for engineering application.
文摘The aim of this study is to calculate the critical load of variable inertia columns. The example studied in this paper can be used as a paradigm for other non-uniform columns. The wavelength of equivalent vibratory system is used to calculate the critical load of the trigonometrically varied inertia column. In doing so, the equilibrium equation of the column is theoretically studied using the perturbation method. Accuracy of the calculated results is evaluated by comparing the solution with numerical results. Effect of improving the initial guess on the solution accuracy is investigated. Effects of varying parameters of the trigonometrically varied inertia and the uniformly tapered columns on their stability behavior are studied. Finally, using the so-called ＂perfectibility＂ parameter, two design goals, i.e., being lightweight and being strong, are studied for the discussed columns.
文摘Concrete filled steel tube structures have gained booming development in recent decades, especially in China. Simplified methods have been proposed in design codes, such as the Eurocode 4 (EC4) and the China engineering and construction specification (CECS). In EC4, the confinement effect is reasonably related to slenderness and load eccentricity. The CECS method is much straight forward in that the slenderness ratio and load eccentricity are treated as independent reduction factors. To make use of the advantages of both the CECS and the EC4 methods, the CECS method is modified to consider the confinement effect associated with slenderness and load eccentricity. It is shown that the proposed method can predict well the ultimate load capacity of circular section concrete filled steel tube columns.
文摘目的:运用网状Meta分析评估不同免疫吸附柱治疗类风湿关节炎的有效性与安全性,为临床诊治提供循证依据。方法:计算机检索维普、万方、中国知网、PubMed、CBM、CochraneLibrary、Web of Science等数据库,检索公开发表的免疫吸附柱治疗类风湿关节炎的研究,检索时限至2024年8月。采用Cochrane 5.4手册对纳入的随机对照试验进行质量评价,采用纽卡斯尔-渥太华量表(NOS)对回顾性队列研究进行质量评价。运用R4.1.1软件进行贝叶斯网状Meta分析。结果:最终纳入13篇研究,总样本量891例,共有4种免疫吸附柱。网状Meta分析结果表明,降低C-反应蛋白前3名排序:HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药>A蛋白吸附柱;降低红细胞沉降率前3名排序:白细胞吸附柱>HA280型吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节肿胀计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低关节压痛计数前3名排序:白细胞吸附柱>A蛋白吸附柱+常规西药>PH-350型吸附柱+常规西药;降低患者对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>A蛋白吸附柱;降低目测类比评分前3名排序:PH-350型吸附柱+常规西药>A蛋白吸附柱>白细胞吸附柱;降低医师对疾病活动性评分前3名排序:PH-350型吸附柱+常规西药>白细胞吸附柱>常规西药。结论:基于纳入的13篇文献证据表明,在降低C-反应蛋白方面,HA280型吸附柱联合常规西药作为首选;在降低红细胞沉降率、关节肿胀计数、关节压痛计数方面,白细胞吸附柱作为首选;在降低患者对疾病活动性评分、医师对疾病活动性评分及目测类比评分方面,PH-350型吸附柱联合常规西药作为首选,在临床中可根据患者的具体情况合理选择不同的免疫吸附柱。
基金the funding provided by the Irish Research Council(IRC) for the research into stone column behaviour in creep-prone soilspart of CREEP(Creep of Geomaterials,PIAP-GA-2011-286397) project supported by the European Community through the programme Marie Curie Industry-Academia Partnerships and Pathways(IAPP) under the 7th Framework ProgrammeThe support from the BIG(Better Interaction in Geotechnics) project from the Swedish Transport Administration
文摘The recently developed elasto-viscoplastic Creep-SCLAY1S model has been used in conjunction with PLAXIS 2D to investigate the effectiveness of vibro-replacement in a creep-prone clay. The Creep-SCLAY1S model accounts for anisotropy, bonding, and destructuration, and uses the concept of a constant rate of viscoplastic multiplier to calculate creep strain rate. A comparison of settlement improvement factors with and without creep indicates that ‘total’ settlement improvement factors （primary plus creep） are lower than their ‘primary’ counterparts （primary settlement only）. The lowest settlement improvement factors arise for analyses incorporating the effect of bonding and destructuration. Examination of the variations of vertical stress with time and depth has indicated that vertical stress is transferred from the soil to the column as the soil creeps. This results in additional column yielding. In addition, the radial and hoop stresses in the soil are lower for the ‘creep’ case. The reduced radial stresses lead to additional column bulging and hence more settlement, whereas the hoop stress reductions appear to be a secondary effect, caused by additional plastic deformation for the ‘creep’ case.
文摘A stability indicating LC method was developed for the simultaneous determination of Amlodipine and Benazepril capsules in pharmaceutical dosage form. Efficient chromatographic separation was achieved on Symmetry C18 stationary phase with simple combination of amobile phase containing 750 mL of DI Water, 250 mL of Acetonitrile and 2 mL of Octylamine into suitable container with adjusted pH to 2.50 ± 0.05 with the aid of Ortho phosphoric acid delivered in an isocratic mode and quantification was carried out using UV detection at 240 nm at a flow rate of 1.0 mL·min-1 with an injection volume of 20 μl and ambient column temperature. This method is capable to detect both the drug components of Amlodipine and Benazepril in presence of their degradation products (Amlodipine Imp-A and Benazepril Impurity-C) with a detection level of 0.05%. Amlodipine/Benazepril in their combination drug product were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the samples were analysed. Peak homogeneity data of Amlodipine and Benazeprilis were obtained using PDA detector, in the stressed sample chromatograms, demonstrating the specificity. The method shows excellent linearity over a range of 0.05%-2.0% for Amlodipine, Amlodipine Impurity-A and 0.05%-5.0% for Benazepril and Benazepril Impurity-C. The correlation coefficient for Amlodipine and Benazepril is 1. The relative standard deviation was always less than 2%. The proposed method was found to be suitable and accurate for quantitative determination and the stability study of Amlodipine and Benazepril in pharmaceutical preparations. The developed HPLC method was validated with respect to linearity & range, accuracy, precision and robustness.
文摘This paper presents a new decomposition method for solving large-scale systems of nonlinear equations. The new method is of superlinear convergence speed and has rather less computa tional complexity than the Newton-type decomposition method as well as other known numerical methods, Primal numerical experiments show the superiority of the new method to the others.
文摘The dynamical stability of a homogeneous, simple supported column, subjected to a periodic axial force, is investigated. The viscoelastic material is assumed to obey the Leaderman nonlinear constitutive relation. The equation of motion was derived as a nonlinear integro-partial-differential equation, and was simplified into a nonlinear integro-differential equation by the Galerkin method. The averaging method was employed to carry out the stability analysis. Numerical results are presented to compare with the analytical ones. Numerical results also indicate that chaotic motion appears.
文摘The three-dimensional model of the wave and pile structure was established by using Ansysworkbench software. The bidirectional fluid-structure interaction between the pile and wave was simulated by using Stokes wave theory and the Volume of Fluid Method. The pressure distribution diagram of the fluid-structure interface and the pile structure were observed and analyzed. The maximum equivalent stress on the pile was studied and its variation range was obtained. Compared with Von Mises yield criterion, it was concluded that the pile was stable under such wave conditions.
文摘Elastic critical buckling load of a column depends on various parameters,such as boundary conditions,material,and crosssection geometry.The main purpose of this work is to present a new method for investigating the buckling load of tapered columns subjected to axial force.The proposed method is based on modified buckling mode shape of tapered structure and perturbation theory.The mode shape of the damaged structure can be expressed as a linear combination of mode shapes of the intact structure.Variations in length in piecewise form can be positive or negative.The method can be used for single-span and continuous columns.Comparison of results with those of finite element and Timoshenko methods shows the high accuracy and efficiency of the proposed method for detecting buckling load.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51008055)the China Postdoctoral Science Foundation(Grant No.20100471124)+1 种基金the Fundamental Research Funds for the Central Universities(Grant No.DL09BB09)the Heilongjiang Province Postdoctoral Sicence Foundation
文摘A large number of column-bracing systems were modeled and analyzed by second-order analysis using finite element program ANSYS,in which the random combination of the initial imperfections between columns and horizontal braces was well considered by Monte Carlo Method.According to the analysis results,four kinds of instability modes of column-bracing systems were found,the probability density function of the mid-height horizontal bracing forces was established based on probability statistics,and the design bracing forces were also obtained.The results indicated that the above design bracing forces are smaller than that proposed by the "Code for design of steel structures"(GB50017-2003) when the top axial compressions on the braced columns are equal,and much smaller than the latter when the top axial compressions on the braced columns are unequal.The results also indicated that the random combination of the initial imperfections between columns and horizontal braces leads to the randomness of the mid-height horizontal bracing forces in compression or in tension,so that the design bracing forces can be reduced.
文摘In the present study, comprehensive stress testing of tenatoprazole was carried out according to ICH guide-line Q1A (R2). Tenatoprazole was subjected to stress conditions of hydrolysis, oxidation, photolysis and neutral decomposition. Extensive degradation was found to occur in acidic, neutral and oxidative conditions. Mild degradation was observed in basic conditions. The drug is relatively stable in the solid-state. Successful separation of drug from degradation products formed under stress conditions was achieved on a Kromasil C18 column (250 mm × 4.6 mm, 5.0 μ particle size) using methanol: THF: acetate buffer (68:12:20 v/v) pH adjusted to 6.0 with acetic acid as mobile phase, flow rate was 1.0 mL●min–1 and column was maintained at 45°C. Quantification and linearity was achieved at 307 nm over the concentration range of 0.5 - 160 μg●mL–1 for tenatoprazole. The method was validated for specificity, linearity, accuracy, precision, LOD, LOQ and robustness.
基金Project supported by the Department of Education of Zhejiang Province (No.Y200804537)the Zhejiang University Zijin Project,and the Zhejiang College of Construction (No.200914), China
文摘A numerical investigation of thin-walled complex section steel columns with intermediate stiffeners was performed using finite element analysis. An accurate and reliable finite element model was developed and verified against test results. Veri-fication indicates that the model could predict the ultimate strengths and failure modes of the tested columns with reasonable accuracy. Therefore,the developed model was used for the parametric study. In addition,the effect of geometric imperfection on column ultimate strength and the effect of boundary conditions on the elastic distortional buckling of complex section columns were investigated. An equation for the elastic distortional buckling load of fixed-ended columns having different column lengths was proposed. The elastic distortional buckling load obtained from the proposed equation was used in the direct strength method to calculate the column ultimate strength. Generally,it is shown that the proposed design equation conservatively predicted the ultimate strengths of complex section columns with different column lengths.
基金Supported by the National Ministry of Science and Technology of China(2017YFB0602401)the National Natural Science Foundation of China(21776173,91834303,U1862201,21625603)the Program of Shanghai Subject Chief Scientists(18XD1402000).
文摘This work aims at comparing surface tension models in VOF(Volume of Fluid) modeling and investigating the effects of gas distributor and gas velocity. Hydrodynamics of a continuous chain of bubbles inside a bubble column reactor was simulated. The grid independence study was first conducted and a grid size of 1.0 mm was adopted in order to minimize the computing time without compromising the accuracy of the results. The predictions were validated by comparing the experimental studies reported in the literature. It was found that all surface tension models can describe the bubble rise and bubble plume in a column with slight deviations.
