[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold...[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.展开更多
Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment...Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment of the syndrome of cold-dampness obstructing the lung,such as Cangzhu(Rhizoma Atractylo-dis),Chenpi(Pericarpium Gitri Reticulatae),Houpo(Cortex Magnoliae Officinalis),Huoxiang(Herba Agastachis),Caoguo(Fructus Tsaoko),Mahuang(Herba Ephedrae),Qianghuo(Rhizoma et Radix Notoptery-gi),Shengjiang(Rhizoma Zingiberis Recens),Binlang(Semen Arecae)in the Diagnosis and Treatment Pro-gram of COVID-19(Trial Version 6)were taken as research subjects,and the combination of these nine me-dicinals can be called Hanshi Zufei Fang(寒湿阻肺方,HSZFF).The active components and targets of each single Chinese materia medica was screened and obtained through the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database.The target information related to COVID-19 was retrieved through the Gene-Cards disease-related target database.The medicinal prediction targets were mapped to the disease target to ob-tain the intersection targets.The DAVID database was applied to perform gene ontology(GO)enrichment anal-ysis and kyoto encyclopedia of genes and genomes(KEGG)pathway analysis on the targets;GraphPad Prism 5.0 software was applied to plot the biological process(BP)of GO enrichment analysis,cellular component(CC),molecular function(MF)histograms;OmicShare online software was applied to make KEGG advanced bubble chart;Cytoscape software was applied to visualize the interaction with the targets and Chinese materia medica-components-targets results.Results:Totally 56 key active components of 9 Chinese materia medica for cold-dampness obstructing lung syndrome were screened,and 55 targets were obtained.The results of GO and KEGG enrichment analysis showed that the compound prescription mainly regulated the body's immune re-sponse and reduced inflammation by regulating such signaling pathways of inflammatory response and immune regulation as TNF signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,infuenza A signaling pathway,T cell receptor signaling pathway.Conclusion:HSZFF can eliminate infl ammation and inhibit virus by regulating immune inflammatory factors closely related to the occurrence and development of diseases through multi-component and multi-target.展开更多
BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have ...BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.展开更多
目的对基于聚类分析的慢性阻塞性肺疾病患者共病模式相关研究进行范围综述,明确共病模式的种类、特征及其与健康结局的相关性,为今后慢性阻塞性肺疾病患者共病模式研究与自我管理提供参考。方法遵循范围综述的方法,系统检索Cochrane Lib...目的对基于聚类分析的慢性阻塞性肺疾病患者共病模式相关研究进行范围综述,明确共病模式的种类、特征及其与健康结局的相关性,为今后慢性阻塞性肺疾病患者共病模式研究与自我管理提供参考。方法遵循范围综述的方法,系统检索Cochrane Library、PubMed、Web of Science、Embase、CINAHL、中国知网、万方数据库、维普网和中国生物医学文献数据库中关于使用聚类分析方法得出慢性阻塞性肺疾病患者共病模式的研究,检索时限为建库至2025年5月14日。依据纳入、排除标准筛选文献,并提取信息资料。结果共纳入13篇文献,提取出40种共病模式、19个在不同共病模式间存在差异的个体特征及11种与共病模式相关的健康结局(含医疗保健利用和住院费用)。结论慢性阻塞性肺疾病患者存在多种共病模式,不同研究报告的共病模式数量及种类存在差异,未来可构建统一的共病模式命名规范;慢性阻塞性肺疾病患者的个体特征和健康结局在不同共病模式下存在差异,其可为慢性阻塞性肺疾病患者的共病管理提供更为精细、准确的分类依据。展开更多
Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Met...Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Methods:A total of 240 patients with poststroke VD were selected and randomly divided into two groups according to the random number table method,with 120 cases in each group.Both groups received Hua Tan Tong Luo(phlegmresolving and collateral-activating)formula,once daily;the observation group was additionally treated with Yi Shen Tiao Du(kidney-tonifying and Governor Vessel-regulating)acupuncture once daily for 6 consecutive days,followed by 1 d of rest.Both groups were treated for 15 d as one course,for a total of 2 courses.After treatment,the total effective rate was compared.Changes in scores of traditional Chinese medicine(TCM)symptoms,clinical dementia rating(CDR),National Institutes of Health stroke scale(NIHSS),and Chinese version of mini-mental state examination(MMSE),and serum levels of IL-6 and SOD were observed in both groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels in both groups were lower than those before treatment(P<0.05),while MMSE scores and serum SOD levels were higher than those before treatment(P<0.05).After treatment,the observation group showed lower TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels than the control group(P<0.05),and higher MMSE scores and serum SOD levels than the control group(P<0.05).Conclusion:Compared to Hua Tan Tong Luo formula alone,Yi Shen Tiao Du acupuncture combined with Hua Tan Tong Luo formula demonstrates better efficacy in reducing dementia severity,improving cognitive and neurological function,and inhibiting inflammation in patients with poststroke VD.展开更多
Background:Knee osteoarthritis(KOA)is a chronic degenerative joint dis-ease that frequently occurs in middle-aged and older individuals.Although celecoxib is a commonly used drug for the treatment of KOA,its efficacy ...Background:Knee osteoarthritis(KOA)is a chronic degenerative joint dis-ease that frequently occurs in middle-aged and older individuals.Although celecoxib is a commonly used drug for the treatment of KOA,its efficacy and safety have limitations.Zushima,a traditional Chinese medicine,is commonly used for treating joint pain and has anti-inflammatory and analgesic proper-ties.This study aims to explore the effect of the Zushima patch combined with celecoxib on pain and inflammatory factor expression in knee osteoarthritis(KOA)patients with cold-dampness obstruction.Methods:A total of 100 patients with KOA of cold-dampness obstruction were randomly divided into a treatment group(n=50)and a control group(n=50).Patients in the control group received oral administration of cele-coxib capsules,whereas the treatment group received the Zushima patch combined with oral administration of celecoxib capsules.Then,the efficacy and safety were compared,together with the traditional Chinese medicine(TCM)syndrome score,pain,and knee joint function.We also determined the concentrations of osteoprotegerin(OPG),insulin-like growth factor(IGF-1),osteocalcin(OC),and inflammatory factors such as interleukin-1β(IL-1β),interleukin-6(IL-6),and C-reactive protein(CRP).Finally,the safety between the two groups was compared.Results:The total effective rate in the treatment group was significantly higher than that in the control group.After treatment,the levels of the TCM syndrome score,pain score,IL-1,IL-6,and CRP in the treatment group showed significant decreases compared with those in the control group,while the scores of OPG,IGF-1,OC,and knee joint function in the treatment group showed significant increases compared with those in the control group.There was no significant difference in adverse events between the two groups.Conclusions:The Zushima patch combined with celecoxib could relieve the pain of KOA with cold-dampness obstruction and improve knee joint function.These effects may be the result of the downregulation of inflammatory factors and the regulation of joint fluid-related indices.展开更多
The mutual relationships of three effective factors, the diameter D/d （d is the diameter of exit） of obstructed plate, exit densimetric Froude number and the distance Hid of the plate from jet orifice for obstructed...The mutual relationships of three effective factors, the diameter D/d （d is the diameter of exit） of obstructed plate, exit densimetric Froude number and the distance Hid of the plate from jet orifice for obstructed buoyant jet in static ambient, are analyzed to explain normal and abnormal rounded flowing （reverberated and bifurcated flowing）. The critical Froude numbers for obstructed buoyant jets with H/d=2, 4, 6, 8 which distinguished normal and abnormal flowing pattern are obtained. Normal rounded flowing is found only for a plate under a special value of H/d. A fitted formula of critical Froude numbers with H/d and D/d is presented to distinguish rounded flowing types. The occurring of reverberated or bifurcated flowing in abnormal rounded flow is analyzed. Based on the results of obstructed buoyant jets with D/d=1, normal rounded flowing occurred only for all conditions and axial dilution behind the plate under different H/D is obtained.展开更多
基金Supported by General Program of the National Natural Science Foundation of China(81973883)Three-Year Action Plan Project for Enhancing Clinical Skills and Clinical Innovation Capabilities of Municipal Hospitals(SHDC2020CR1010A).
文摘[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.
基金We thank for the funding support from the National Natural Science Foundation of China(81873285)。
文摘Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment of the syndrome of cold-dampness obstructing the lung,such as Cangzhu(Rhizoma Atractylo-dis),Chenpi(Pericarpium Gitri Reticulatae),Houpo(Cortex Magnoliae Officinalis),Huoxiang(Herba Agastachis),Caoguo(Fructus Tsaoko),Mahuang(Herba Ephedrae),Qianghuo(Rhizoma et Radix Notoptery-gi),Shengjiang(Rhizoma Zingiberis Recens),Binlang(Semen Arecae)in the Diagnosis and Treatment Pro-gram of COVID-19(Trial Version 6)were taken as research subjects,and the combination of these nine me-dicinals can be called Hanshi Zufei Fang(寒湿阻肺方,HSZFF).The active components and targets of each single Chinese materia medica was screened and obtained through the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database.The target information related to COVID-19 was retrieved through the Gene-Cards disease-related target database.The medicinal prediction targets were mapped to the disease target to ob-tain the intersection targets.The DAVID database was applied to perform gene ontology(GO)enrichment anal-ysis and kyoto encyclopedia of genes and genomes(KEGG)pathway analysis on the targets;GraphPad Prism 5.0 software was applied to plot the biological process(BP)of GO enrichment analysis,cellular component(CC),molecular function(MF)histograms;OmicShare online software was applied to make KEGG advanced bubble chart;Cytoscape software was applied to visualize the interaction with the targets and Chinese materia medica-components-targets results.Results:Totally 56 key active components of 9 Chinese materia medica for cold-dampness obstructing lung syndrome were screened,and 55 targets were obtained.The results of GO and KEGG enrichment analysis showed that the compound prescription mainly regulated the body's immune re-sponse and reduced inflammation by regulating such signaling pathways of inflammatory response and immune regulation as TNF signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,infuenza A signaling pathway,T cell receptor signaling pathway.Conclusion:HSZFF can eliminate infl ammation and inhibit virus by regulating immune inflammatory factors closely related to the occurrence and development of diseases through multi-component and multi-target.
文摘BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic procedure.Some oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no research.AIM To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic intervention.METHODS A cross-sectional survey was disseminated among ophthalmologists all over India.The survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up patterns.RESULTS A total of 180 ophthalmologists responded to the survey.Most practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was advised.The most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid surgeries.Sixty-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease patients.CONCLUSION Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular conditions.Many ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract surgery.Eyelid conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.
文摘目的对基于聚类分析的慢性阻塞性肺疾病患者共病模式相关研究进行范围综述,明确共病模式的种类、特征及其与健康结局的相关性,为今后慢性阻塞性肺疾病患者共病模式研究与自我管理提供参考。方法遵循范围综述的方法,系统检索Cochrane Library、PubMed、Web of Science、Embase、CINAHL、中国知网、万方数据库、维普网和中国生物医学文献数据库中关于使用聚类分析方法得出慢性阻塞性肺疾病患者共病模式的研究,检索时限为建库至2025年5月14日。依据纳入、排除标准筛选文献,并提取信息资料。结果共纳入13篇文献,提取出40种共病模式、19个在不同共病模式间存在差异的个体特征及11种与共病模式相关的健康结局(含医疗保健利用和住院费用)。结论慢性阻塞性肺疾病患者存在多种共病模式,不同研究报告的共病模式数量及种类存在差异,未来可构建统一的共病模式命名规范;慢性阻塞性肺疾病患者的个体特征和健康结局在不同共病模式下存在差异,其可为慢性阻塞性肺疾病患者的共病管理提供更为精细、准确的分类依据。
基金supported by the Research Cultivation Project of Beijing Municipal Hospital(北京市属医院科研培育课题,No.PZ2022015).
文摘Objective:To observe the efficacy of acupuncture combined with traditional Chinese herbs in the treatment of poststroke vascular dementia(VD)and the effects on serum interleukin(IL)-6 and superoxide dismutase(SOD).Methods:A total of 240 patients with poststroke VD were selected and randomly divided into two groups according to the random number table method,with 120 cases in each group.Both groups received Hua Tan Tong Luo(phlegmresolving and collateral-activating)formula,once daily;the observation group was additionally treated with Yi Shen Tiao Du(kidney-tonifying and Governor Vessel-regulating)acupuncture once daily for 6 consecutive days,followed by 1 d of rest.Both groups were treated for 15 d as one course,for a total of 2 courses.After treatment,the total effective rate was compared.Changes in scores of traditional Chinese medicine(TCM)symptoms,clinical dementia rating(CDR),National Institutes of Health stroke scale(NIHSS),and Chinese version of mini-mental state examination(MMSE),and serum levels of IL-6 and SOD were observed in both groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels in both groups were lower than those before treatment(P<0.05),while MMSE scores and serum SOD levels were higher than those before treatment(P<0.05).After treatment,the observation group showed lower TCM symptom,CDR,and NIHSS scores,and serum IL-6 levels than the control group(P<0.05),and higher MMSE scores and serum SOD levels than the control group(P<0.05).Conclusion:Compared to Hua Tan Tong Luo formula alone,Yi Shen Tiao Du acupuncture combined with Hua Tan Tong Luo formula demonstrates better efficacy in reducing dementia severity,improving cognitive and neurological function,and inhibiting inflammation in patients with poststroke VD.
基金New Medical Emergency Requirement Demonstration,Grant/Award Number:LB2023B010100。
文摘Background:Knee osteoarthritis(KOA)is a chronic degenerative joint dis-ease that frequently occurs in middle-aged and older individuals.Although celecoxib is a commonly used drug for the treatment of KOA,its efficacy and safety have limitations.Zushima,a traditional Chinese medicine,is commonly used for treating joint pain and has anti-inflammatory and analgesic proper-ties.This study aims to explore the effect of the Zushima patch combined with celecoxib on pain and inflammatory factor expression in knee osteoarthritis(KOA)patients with cold-dampness obstruction.Methods:A total of 100 patients with KOA of cold-dampness obstruction were randomly divided into a treatment group(n=50)and a control group(n=50).Patients in the control group received oral administration of cele-coxib capsules,whereas the treatment group received the Zushima patch combined with oral administration of celecoxib capsules.Then,the efficacy and safety were compared,together with the traditional Chinese medicine(TCM)syndrome score,pain,and knee joint function.We also determined the concentrations of osteoprotegerin(OPG),insulin-like growth factor(IGF-1),osteocalcin(OC),and inflammatory factors such as interleukin-1β(IL-1β),interleukin-6(IL-6),and C-reactive protein(CRP).Finally,the safety between the two groups was compared.Results:The total effective rate in the treatment group was significantly higher than that in the control group.After treatment,the levels of the TCM syndrome score,pain score,IL-1,IL-6,and CRP in the treatment group showed significant decreases compared with those in the control group,while the scores of OPG,IGF-1,OC,and knee joint function in the treatment group showed significant increases compared with those in the control group.There was no significant difference in adverse events between the two groups.Conclusions:The Zushima patch combined with celecoxib could relieve the pain of KOA with cold-dampness obstruction and improve knee joint function.These effects may be the result of the downregulation of inflammatory factors and the regulation of joint fluid-related indices.
基金Project supported by the National Natural Science Foundation of China (No.50479038)
文摘The mutual relationships of three effective factors, the diameter D/d （d is the diameter of exit） of obstructed plate, exit densimetric Froude number and the distance Hid of the plate from jet orifice for obstructed buoyant jet in static ambient, are analyzed to explain normal and abnormal rounded flowing （reverberated and bifurcated flowing）. The critical Froude numbers for obstructed buoyant jets with H/d=2, 4, 6, 8 which distinguished normal and abnormal flowing pattern are obtained. Normal rounded flowing is found only for a plate under a special value of H/d. A fitted formula of critical Froude numbers with H/d and D/d is presented to distinguish rounded flowing types. The occurring of reverberated or bifurcated flowing in abnormal rounded flow is analyzed. Based on the results of obstructed buoyant jets with D/d=1, normal rounded flowing occurred only for all conditions and axial dilution behind the plate under different H/D is obtained.
