Minimally invasive endoscopy offers a high potential for biomedical imaging applications.However,conventional fiberoptic endoscopes require lens systems which are not suitable for real-time 3D imaging.Instead,a diffus...Minimally invasive endoscopy offers a high potential for biomedical imaging applications.However,conventional fiberoptic endoscopes require lens systems which are not suitable for real-time 3D imaging.Instead,a diffuser is utilized for passively encoding incoherent 3D objects into 2D speckle patterns.Neural networks are employed for fast computational image reconstruction beyond the optical memory effect.In this paper,we demonstrate single-shot 3D incoherent fiber imaging with keyhole access at video rate.Applying the diffuser fiber endoscope for fluorescence imaging is promising for in vivo deep brain diagnostics with cellular resolution.展开更多
Endoscopes are indispensable for minimally invasive optical applications in medicine and production engineering.The smallest lensless endoscopes often use digital optics to compensate the intrinsic distortions of ligh...Endoscopes are indispensable for minimally invasive optical applications in medicine and production engineering.The smallest lensless endoscopes often use digital optics to compensate the intrinsic distortions of light propagation of multimode or multicore fibers.However,due to the wavelength dependency of the distortion,the approach is restricted to a narrow spectral range,which prevents multispectral imaging modalities.We employ a spatial light modulator with a high stroke above 2,to generate a hologram which minimizes overall phase distortion for multiple spectral bands.This enables lensless multicore fiber single-shot RGB endoscopy,for the first time in the world.Many applications in advanced manufacturing and biomedicine such as in vivo tissue classification are enabled.展开更多
基金supported by the German Research Foundation(DFG)under grant(CZ 55/48-1).
文摘Minimally invasive endoscopy offers a high potential for biomedical imaging applications.However,conventional fiberoptic endoscopes require lens systems which are not suitable for real-time 3D imaging.Instead,a diffuser is utilized for passively encoding incoherent 3D objects into 2D speckle patterns.Neural networks are employed for fast computational image reconstruction beyond the optical memory effect.In this paper,we demonstrate single-shot 3D incoherent fiber imaging with keyhole access at video rate.Applying the diffuser fiber endoscope for fluorescence imaging is promising for in vivo deep brain diagnostics with cellular resolution.
基金Funding by Deutsche Forschungsgesellschaft(DFG Cz55/47-1)by the German Federation of Industrial Research Associations(AiF 21802 BG)+1 种基金the European Regional Development Fund(ERDF)the Development Bank of Saxony(SAB)is gratefully acknowledged.
文摘Endoscopes are indispensable for minimally invasive optical applications in medicine and production engineering.The smallest lensless endoscopes often use digital optics to compensate the intrinsic distortions of light propagation of multimode or multicore fibers.However,due to the wavelength dependency of the distortion,the approach is restricted to a narrow spectral range,which prevents multispectral imaging modalities.We employ a spatial light modulator with a high stroke above 2,to generate a hologram which minimizes overall phase distortion for multiple spectral bands.This enables lensless multicore fiber single-shot RGB endoscopy,for the first time in the world.Many applications in advanced manufacturing and biomedicine such as in vivo tissue classification are enabled.
