BACKGROUND Due to the dry and cold climate,the obvious temperature difference between day and night,and the low oxygen content of the air in the plateau area,people are prone to upper respiratory tract diseases,and of...BACKGROUND Due to the dry and cold climate,the obvious temperature difference between day and night,and the low oxygen content of the air in the plateau area,people are prone to upper respiratory tract diseases,and often the condition is prolonged,and the patients are prone to anxiety and uneasiness,which may be related to the harshness of the plateau environment,somatic discomfort due to the lack of oxygen,anxiety about the disease,and other factors.AIM To investigate the effects of cognitive behavioral therapy(CBT)on anxiety,sleep disorders,and hypoxia tolerance in patients with high-altitude respiratory diseases.METHODS A total of 2337 patients with high-altitude-related respiratory diseases treated at our hospital between November 2023 and January 2024 were selected as the study subjects.The subjects’pre-high-altitude residential altitude was approximately 1700 meters.They were divided into two groups.Both groups were given symptomatic treatment,and the control group implemented conventional nursing intervention,while the research group simultaneously conducted CBT intervention;assessed the degree of health knowledge of the two groups,and applied the Hamilton Anxiety Scale and the Pittsburgh Sleep Quality Index to assess the anxiety and sleep quality of the patients before and after the intervention,respectively.It also observed the length and efficiency of sleep,and detected the level of serum hypoxia inducible factor-1α,erythropoietin(EPO)and clinical intervention before and after intervention.EPO levels,and investigated satisfaction with the clinical intervention.RESULTS The rate of excellent health knowledge in the intervention group was 93.64%,which was higher than that in the control group(74.23%;P<0.05).Before the intervention,there was no significant difference in Hamilton Anxiety Scale and Pittsburgh Sleep Quality Index scores between the two groups(P>0.05),and after the intervention,the scores of the study group were significantly lower than those of the control group(P<0.05).There was no significant difference in sleep duration and sleep efficiency between the groups before the intervention(P>0.05),and after the intervention,the scores of the study group were significantly larger than those of the control group(P<0.05).There was no significant difference in serum hypoxia inducible factor-1αand EPO between the two groups before intervention(P>0.05),and both research groups were significantly lower than the control group after intervention(P<0.05).According to the questionnaire survey,the intervention satisfaction of the study group was 95.53%,which was higher than that of the control group(80.14%;P<0.05).CONCLUSION The CBT intervention in the treatment of patients with high-altitude-related respiratory diseases helps improve patients'health knowledge,relieve anxiety,improve sleep quality and hypoxia tolerance,and improve nursing satisfaction.展开更多
BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emoti...BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.展开更多
BACKGROUND Substantial clinical evidence supports the efficacy of cognitive behavioral therapy(CBT)for various diseases,particularly in oncology.However,the true impact of CBT interventions on cancer-related fatigue a...BACKGROUND Substantial clinical evidence supports the efficacy of cognitive behavioral therapy(CBT)for various diseases,particularly in oncology.However,the true impact of CBT interventions on cancer-related fatigue and mental health in patients with ovarian cancer remains unknown.AIM To evaluate the effects of CBT on fatigue,anxiety,depression and quality of life in patients with ovarian cancer.METHODS Randomized controlled trials(RCTs)on CBT for patients with ovarian cancer were searched in the PubMed,EMBASE,Web of Science and Cochrane Library databases.According to the preferred reporting items for systematic reviews and meta-analyses statement,we formulated the inclusion and exclusion criteria,strictly screened the literatures,extracted data and performed a meta-analysis.RESULTS Six RCTs with 332 ovarian cancer patients were included.Compared with the control group,cancer fatigue[mean difference(MD)=-0.98,95%confidence interval(CI):-1.47 to-0.50],anxiety[standardized mean difference(SMD)=-0.64,95%CI:-0.91 to-0.36]and depression levels(SMD=-0.41,95%CI:-0.76 to-0.06)of the patients in the experimental group reduced after CBT intervention.Quality of life(MD=1.28,95%CI:0.65 to 1.90)and sleep quality(MD=-0.49,95%CI:-0.66 to-0.33)of the patients improved,and the differences between the groups were statistically significant(P<0.01).The quality evaluation results suggested that the quality of the included RCTs was low.The meta-regression results showed that patient age and nurse guidance affected treatment outcomes,especially anxiety,whereas the specific method of CBT had a non-significant effect.CONCLUSION CBT effectively improves mental status and cancer-related fatigue in patients with ovarian cancer undergoing chemotherapy.Future research should prioritize adequately powered RCTs with standardized outcome measures and longitudinal designs to establish sustained efficacy.展开更多
BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes i...BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.展开更多
Orthodontic osteodilated arch treatment represents a pivotal approach in dental orthodontics to address dental crowding and misalignment.Integrating cognitive behavioral therapy(CBT)into comprehensive nursing interven...Orthodontic osteodilated arch treatment represents a pivotal approach in dental orthodontics to address dental crowding and misalignment.Integrating cognitive behavioral therapy(CBT)into comprehensive nursing interventions(CNI)aims to address these issues holistically.This editorial explores the effectiveness of CBTbased CNI in improving patient outcomes in orthodontic care.Innovations in remote CBT delivery,such as virtual reality,have also shown potential in reducing pain,anxiety,and depression,emphasizing CBT's adaptability in orthodontic settings.The findings underscore the importance of integrating psychological support into orthodontic care to enhance patient adherence,satisfaction,and overall treatment success.The editorial advocates for a holistic approach that combines psychological and physiological care,highlighting the transformative potential of CBT-based interventions in orthodontic treatment.展开更多
BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,eff...BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,effective treatment options,particularly for cognitive dysfunction,remain limited.AIM To evaluate the efficacy of computerized cognitive behavioral therapy(CCBT)with sertraline vs sertraline monotherapy in improving depressive symptoms,cognitive function,and quality of life in schizophrenia and depressive episodes.METHODS In this single-center,randomized controlled trial,68 adults[mean age(SD)=36.5(10.0),57.4%male]with schizophrenia and depressive symptoms were randomly assigned to receive either CCBT with sertraline or sertraline monotherapy during a 4-week hospitalization.The CCBT intervention involved 45-60-minute sessions twice weekly for four weeks.Outcomes included comparisons of depressive symptoms(Calgary depression scale for schizophrenia),cognitive function[MATRICS consensus cognitive battery(MCCB)],and quality of life(36-item short form survey)between the groups.RESULTS The experimental group showed greater improvements in depressive symptoms at 4,8,and 12 weeks compared to the controls,with the most notable difference at 12 weeks[mean difference(MD)=-1.7;P<0.001;Cohen’s d=0.9].Cognitive function improved across all MCCB domains in the experimental group,with higher processing speed scores(MD=4.1;P=0.043;Cohen’s d=0.5)and social cognition scores(MD=4.9;P=0.006;Cohen’s d=0.7)than in the control group.Quality of life,particularly in mental health,was significantly better in the experimental group.CONCLUSION CCBT with sertraline was more effective than sertraline monotherapy for patients with schizophrenia and depressive episodes,supporting its use as an adjunctive therapy.展开更多
BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studi...BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studies on digital cognitive behavioral therapy as a treatment for insomnia.AIM To assess digital cognitive behavioral therapy for insomnia regarding its positive impact on brain function.METHODS Participants were randomly assigned to either a go/no-go group or a dot-probe group.The primary outcome was quality of sleep as assessed by the actigraphy sleep monitoring bracelet,Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and depression anxiety and stress scale(DASS-21).RESULTS Eighty patients were included in the analysis(go/no-go group:n=40;dot-probe group:n=40).We combined the total scale scores of the two groups before and after the intervention in the analysis of covariance.Our study explored whether insomnia symptoms in both groups can be improved by using digital cognitive behavioral therapy instead of trying to compare the two trials;therefore,only one P value is listed.In both groups,we found a short-term time effect on insomnia symptom severity(PSQI:P<0.001,η^(2)=0.336;ISI:P<0.001,η^(2)=0.667;DASS-depression:P<0.001,η^(2)=0.582;DASS-anxiety:P<0.001,η^(2)=0.337;DASS-stress:P<0.001,η^(2)=0.443)and some effect on sleep efficiency(but it was not significant,P=0.585,η^(2)=0.004).CONCLUSION Go/no-go task training of inhibitory function had a short-term positive effect on sleep efficiency,whereas dotprobe task training had a positive short-term effect on emotion regulation.展开更多
BACKGROUND Perinatal anxiety disorder is the main problem affecting mother-infant bonding.Though the impact of perinatal anxiety in primiparous women on the motherinfant relationship is well established,appropriate in...BACKGROUND Perinatal anxiety disorder is the main problem affecting mother-infant bonding.Though the impact of perinatal anxiety in primiparous women on the motherinfant relationship is well established,appropriate interventions need to be explored.AIM To explore the synergistic intervention effect of mindfulness-based stress reduction combined with cognitive behavioral therapy(CBT)on perinatal anxiety disorders and mother-infant bonding in primiparas.METHODS A total of 150 primiparas with perinatal anxiety disorders admitted to the hospital from January 2020 to October 2024 were selected and divided into two groups according to the random number method.The control group(n=75)received CBT,and the observation group(n=75)received mindfulness-based stress reduction combined with CBT.The anxiety and depressive emotions,as well as the mother-infant emotional bonding situation,were compared between the two groups.RESULTS After the intervention,the anxiety and depressive states in the observation group were lower than those in the control group(P<0.05).The mother-infant bonding(sense of pleasure,recognition,understanding,and love)in the observation group was higher than that in the control group,and the role adaptation ability was also higher than in the control group(P<0.05).CONCLUSION Mindfulness-based stress reduction combined with CBT can reduce perinatal anxiety disorders in primiparas,promote mother-infant bonding,and improve their ability to adapt to the mother role.展开更多
BACKGROUND The severe physical and psychological impact of pain on the physical and mental health of women during labor leads to increased risks and complications during childbirth,presenting a major public health con...BACKGROUND The severe physical and psychological impact of pain on the physical and mental health of women during labor leads to increased risks and complications during childbirth,presenting a major public health concern.Some studies have shown that cognitive behavioral therapy(CBT)has a positive effect on maternal psychology during delivery,reducing stress and shortening labor time.Thus,CBT training for mothers and delivery room staff may be beneficial in minimizing complications and adverse effects during natural birth.AIM To investigate the clinical effects of CBT training and psychological care during delivery,and their therapeutic effects on women in labor.METHODS This study used a retrospective analysis and included 140 mothers admitted to the maternity ward between January 2021 and January 2023.The study subjects were randomized into two groups:control(n=70)and observation(n=70).Routine care,CBT training,and psychological care were provided to mothers in both groups.Psychological status scores,delivery time,and satisfaction with care pre-and post-delivery were compared,and the incidence of complications after receiving care was analyzed between the two groups.RESULTS Although the psychological state of both groups improved significantly in the late stages of labor,the psychological state scores of the mothers in the observation group were significantly lower than those of the mothers in the control group(P<0.05).The duration of labor and incidence of complications in the observation group were significantly lower than those in the control group(P<0.05).The mothers in the observation group were significantly more satisfied with nursing care during the course of labor than those in the control group(P<0.05).CONCLUSION CBT training and psychological care for mothers in the midwifery process can effectively improve anxiety and depression,shorten labor duration,reduce postnatal complications,and improve nursing satisfaction and nurse-patient relationships.Its clinical application is effective and has popularization value,providing a new way to protect maternal mental health.展开更多
Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Intern...Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls （N2： P = 0.035; P3a： P = 0.031 P3b： P = 0.043） and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b （P3a： P = 0.045; P3b： P = 0.062）. These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.展开更多
Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synapti...Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.展开更多
BACKGROUND Recently,the efficacy of cognitive behavioral therapy(CBT)-based intervention on health outcomes in patients with coronary heart disease(CHD)has been recognized in randomized controlled trials(RCTs),but no ...BACKGROUND Recently,the efficacy of cognitive behavioral therapy(CBT)-based intervention on health outcomes in patients with coronary heart disease(CHD)has been recognized in randomized controlled trials(RCTs),but no comprehensive systematic review has been conducted.To address this research gap,our study aimed to evaluate whether comprehensive CBT-based interventions positively affect health outcomes in CHD patients.It was hypothesized that CBT-based interventions are effective in:(1)Reducing depression,anxiety,and stress symptoms;(2)Reducing body mass index,blood pressure,and lipid levels;and(3)Improving quality of life,and exercise endurance.AIM To verify the effectiveness of CBT-based interventions on CHD patients through a meta-analysis of previous publications.METHODS Relevant RCTs published in English were obtained by searching electronic databases,including PubMed,Embase,Cochrane Central Register of Controlled Trials,Scopus,and Proquest,with the retrieval time from inception to August 2020.The primary outcomes were psychological factors(depression,anxiety,and stress symptoms),physiological factors(body mass index,blood pressure,blood lipids).The secondary outcomes included quality of life and exercise endurance.We used Review Manager 5.3 to conduct the meta-analysis and used the Physiotherapy Evidence Database tool to evaluate the quality of studies.RESULTS A total of 22 RCTs comprising 4991 patients with CHD were included in the systematic review and meta-analysis.The main analysis revealed that CBT-based intervention can reduce depression symptoms:-2.00[95%confidence interval(CI):-2.83 to-1.16,P<0.001];anxiety symptoms:-2.07(95%CI:-3.39 to-0.75,P=0.002);stress symptoms:-3.33(95%CI:-4.23 to-2.44,P<0.001);body mass index:-0.47(95%CI:-0.81 to-0.13,P=0.006);and improve physical functioning:3.36(95%CI:1.63 to 5.10,P=0.000)and mental functioning:6.91(95%CI:4.10 to 9.73,P<0.001).Moreover,subgroup analysis results showed that CBT-based interventions were more effective for symptoms of depression and anxiety in CHD patients when individual,as opposed to group treatment,and psycho-education,behavioral and cognitive strategies were applied as the core treatment approaches.CONCLUSION CBT-based interventions are effective treatment strategies for CHD patients,significantly improving their symptoms of depression,anxiety and stress,body mass index,and health-related quality of life.展开更多
BACKGROUND Poor sleep quality is a common clinical feature in patients with type 2 diabetes mellitus(T2DM),and often negatively related with glycemic control.Cognitive behavioral therapy(CBT)may improve sleep quality ...BACKGROUND Poor sleep quality is a common clinical feature in patients with type 2 diabetes mellitus(T2DM),and often negatively related with glycemic control.Cognitive behavioral therapy(CBT)may improve sleep quality and reduce blood sugar levels in patients with T2DM.However,it is not entirely clear whether CBT delivered by general practitioners is effective for poor sleep quality in T2DM patients in community settings.AIM To test the effect of CBT delivered by general practitioners in improving sleep quality and reducing glycemic levels in patients with T2DM in community.METHODS A cluster randomized controlled trial was conducted from September 2018 to October 2019 in communities of China.Overall 1033 persons with T2DM and poor sleep quality received CBT plus usual care or usual care.Glycosylated hemoglobin A1c(HbAlc)and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were assessed.Repeated measures analysis of variance and generalized linear mixed effects models were used to estimate the intervention effects on hemoglobin A1c and sleep quality.RESULTS The CBT group had 0.64,0.50,and 0.9 lower PSQI scores than the control group at 2 mo,6 mo,and 12 mo,respectively.The CBT group showed 0.17 and 0.43 lower HbAlc values than the control group at 6 mo and 12 mo.The intervention on meanΔHbAlc values was significant at 12 mo(t=3.68,P<0.01)and that meanΔPSQI scores were closely related toΔHbAlc values(t=7.02,P<0.01).Intentionto-treat analysis for primary and secondary outcomes showed identical results with completed samples.No adverse events were reported.CONCLUSION CBT delivered by general practitioners,as an effective and practical method,could reduce glycemic levels and improve sleep quality for patients with T2DM in community.展开更多
BACKGROUND Cancer-related fatigue(CRF)is the most common concomitant symptom in the treatment of colorectal cancer(CRC).Such patients often present with subjective fatigue state accompanied by cognitive dysfunction,wh...BACKGROUND Cancer-related fatigue(CRF)is the most common concomitant symptom in the treatment of colorectal cancer(CRC).Such patients often present with subjective fatigue state accompanied by cognitive dysfunction,which seriously affects the quality of life of patients.AIM To explore the effects of cognitive behavior therapy(CBT)combined with Baduanjin exercise on CRF,cognitive impairment,and quality of life in patients with CRC after chemotherapy,and to provide a theoretical basis and practical reference for rehabilitation of CRC after chemotherapy.METHODS Fifty-five patients with CRC after radical resection and chemotherapy were randomly divided into either an experimental or a control group.The experimental group received the intervention of CBT combined with exercise intervention for 6 mo,and indicators were observed and measured at baseline,3 mo,and 6 mo to evaluate the intervention effect.RESULTS Compared with the baseline values,in the experimental group 3 mo after intervention,cognitive function,quality of life score,and P300 amplitude and latency changes were significantly better(P<0.01).Compared with the control group,at 3 mo,the experimental group had significant differences in CRF,P300 amplitude,and quality of life score(P<0.05),as well as significant differences in P300 latency and cognitive function(P<0.01).Compared with the control group,at 6 mo,CRF,P300 amplitude,P300 latency,cognitive function and quality of life score were further improved in the experimental group,with significant differences(P<0.01).The total score of CRF and the scores of each dimension were negatively correlated with quality of life(P<0.05),while the total score of cognitive impairment and the scores of each dimension were positively correlated with quality of life(P<0.05).CONCLUSION CBT combined with body-building Baduanjin exercise can improve CRF and cognitive impairment in CRC patients after chemotherapy,and improve their quality of life.展开更多
BACKGROUND The efficacy of cognitive behavioral group therapy(CBGT)for cognitive dysfunction and negative symptoms of schizophrenia is established,but more evidence is required.AIM To assess the effectiveness of CBGT ...BACKGROUND The efficacy of cognitive behavioral group therapy(CBGT)for cognitive dysfunction and negative symptoms of schizophrenia is established,but more evidence is required.AIM To assess the effectiveness of CBGT combined with mental health education as a treatment for schizophrenia compared with mental health education alone.METHODS In all,120 schizophrenia out-patients were randomized into CBGT combined with mental health education or single mental health education.The primary outcomes were positive and negative symptoms,cognitive function,excitatory factor,anxiety and depression symptom improvements on the positive and negative syndrome scale score.Secondary outcome measures included social function and drug compliance.RESULTS There were significant differences between CBGT combined with mental health education and single mental health education on measures of positive and negative symptoms,cognitive functions,excitatory factor,anxiety and depression symptoms,and social functions.No other significant difference in outcomes was observed.CONCLUSION CBGT combined with mental health education may be relevant beneficial treatment method in reducing symptoms,cognitive and social functions of patients with schizophrenia.展开更多
BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so on.Patients often feel anger,anxiety,depression,and other negative psychological reactions in the...BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so on.Patients often feel anger,anxiety,depression,and other negative psychological reactions in the process of treatment.AIM To explore the effects of cognitive behavioral therapy on the personality characteristics of cancer patients.METHODS According to the matching design requirements,150 cancer patients were divided into 3 groups based on sex,age,condition,and cultural background.Patients in the control group received conventional treatment.Patients in experimental group 1 received an intervention based on conventional treatment combined with cognitive behavioral therapy.Patients in experimental group 2 received family members'participation in addition to the treatment given in experimental group 1.An Eysenck personality questionnaire was used to investigate all the patients before and after the intervention,and the scores for psychosis,introversion,neuroticism,and concealment degree were analyzed.RESULTS Compared with the control group,for experimental group 1 and experimental group 2 before and after the intervention,the four dimensions of mental quality,neuroticism,introversion and concealment degree all decreased,and the difference was statistically significant(P<0.05).After the intervention,there were no obvious or statistically significant differences(P>0.05)among the control group,experimental group 1,and experimental group 2 for two personality traits,psychoticism and neuroticism,both inside and outside degree and all four dimensions.CONCLUSION Simple cognitive behavioral therapy could not change the personality characteristics of cancer patients quickly,but the patients’personality characteristics were significantly improved after treatment.展开更多
BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore...BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.METHODS Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of this.Before and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different groups.In addition,satisfaction and complications were comparatively analyzed.RESULTS Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance.展开更多
Background: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition without a conclusivesubtype dimension. This study will focus on the meta-analysis of the clinical responses of OCD subtypes to co...Background: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition without a conclusivesubtype dimension. This study will focus on the meta-analysis of the clinical responses of OCD subtypes to cognitivebehavioral therapy (CBT), which might clarify this issue. Methods: We performed a systematic search and ameta-analysis for the studies of OCD subtypes and the response to CBT in PubMed, ScienceDirect, Embase, Webof Science, and Scopus databases. The selective criteria were the OCD without significant medical or psychiatricco-morbidities and pre-and post-treatment changes in scores of OCD dimension. In addition, different subtypesof OCD in symptom dimensions, such as symmetry, contamination, unacceptable thoughts, and hoarding, werecompared to find the most significant subtype using the treatment response parameters by CBT. After limitedselection, four studies and 479 OCD subjects were enrolled. The meta-analysis was performed by Review Manager5.4, and only significant results were reported. Results: Among the OCD subtypes, the meta-analysis favors thehoarding subtype with poorer responses to CBT than symmetry, contamination, and unacceptable thoughts.The meta-analysis results were negative mean differences, significant tests for overall effect, and limited heterogeneitiesin the random effects model. In addition, the results were more significant when the hoarding subtypewas compared with non-hoarding subtypes. Conclusion: The hoarding subtype might be the most significantrepresentative subtype of OCD symptom dimension under the impression of unfavorable clinical response toCBT. However, future studies with more treatment parameters will be warranted to confirm this finding.展开更多
BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United States.T...BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United States.The use of CBT for severe mental illness is now more common globally.AIM To investigate the feasibility and acceptability of a culturally adapted,CBT-based,third-wave therapy manual using the Comprehend,Cope,and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare services.METHODS A pilot study was used to assess the feasibility and acceptability of the manualised intervention.Outcome measures were evaluated at baseline,post-intervention and 12 wk-follow up.32 participants with mental health conditions aged 20-53 years were recruited.Assessments were completed at three time points,using Clinical Outcomes in Routine Evaluation(CORE),Hospital Anxiety and Depression Scale(HADS),Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0(WHODAS).The Patient Experience Questionnaire was completed post-treatment.RESULTS Repeated measures of analysis of variance associated with HADS depression,F(2,36)=12.81,P<0.001,partialη^(2)=0.42 and HADS anxiety scores,F(2,26)=9.93,P<0.001,partialη^(2)=0.36;CORE total score and WHODAS both showed significant effect F(1.25,18.72)=14.98,P<0.001,partialη^(2)=0.5.and F(1.29,14.18)=6.73,P<0.001,partialη^(2)=0.38 respectively.CONCLUSION These results indicate the effectiveness and acceptability of the culturally adapted,CBT-based,third-wave therapy manual intervention among minoritized groups with moderate effect sizes.Satisfaction levels and acceptability were highly rated.The viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.展开更多
Background:The mental health challenges faced by police officers due to high-stress work environments necessitate effective interventions.Cognitive-behavioral therapy(CBT)has shown promise in addressing mental health ...Background:The mental health challenges faced by police officers due to high-stress work environments necessitate effective interventions.Cognitive-behavioral therapy(CBT)has shown promise in addressing mental health issues,and this study aims to evaluate the efficacy of smartphone-based cognitive-behavioral therapy(SCBT)in improving mental health outcomes among police officers.This intervention could provide a reference for enhancing mental health literacy and resilience in this population.Methods:A randomized controlled trial(RCT)design was employed,involving 291 police officers who were randomly assigned to either the SCBT intervention group(n=145)or the control group(n=146).Participants completed pre-and post-intervention assessments using the Symptom Checklist-90(SCL-90),which measures multiple psychological symptoms including somatization,obsessive-compulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism.Statistical analyses were conducted to examine group differences in symptom severity and effect sizes.Results:Post-intervention results indicated significant reductions in somatization,obsessivecompulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism,with large effect sizes observed in the intervention group.Notably,the intervention group showed significantly greater improvements compared to the control group,particularly in overall psychological distress as measured by the total SCL-90 score.However,significant reductions in interpersonal sensitivity and paranoid ideation were also observed in the control group,suggesting external factors may have influenced these dimensions.Conclusion:SCBT demonstrated efficacy in reducing psychological distress among police officers,offering a flexible and accessible mental health intervention.However,challenges such as high dropout rates and the complex,dynamic nature of mental health warrant further investigation.Future studies should explore targeted interventions for specific behavioral issues and consider SCBT as a supplementary tool alongside traditional psychotherapy.展开更多
基金Supported by Army Logistics Department Health Bureau Project,No.QJGYXYJZX-012.
文摘BACKGROUND Due to the dry and cold climate,the obvious temperature difference between day and night,and the low oxygen content of the air in the plateau area,people are prone to upper respiratory tract diseases,and often the condition is prolonged,and the patients are prone to anxiety and uneasiness,which may be related to the harshness of the plateau environment,somatic discomfort due to the lack of oxygen,anxiety about the disease,and other factors.AIM To investigate the effects of cognitive behavioral therapy(CBT)on anxiety,sleep disorders,and hypoxia tolerance in patients with high-altitude respiratory diseases.METHODS A total of 2337 patients with high-altitude-related respiratory diseases treated at our hospital between November 2023 and January 2024 were selected as the study subjects.The subjects’pre-high-altitude residential altitude was approximately 1700 meters.They were divided into two groups.Both groups were given symptomatic treatment,and the control group implemented conventional nursing intervention,while the research group simultaneously conducted CBT intervention;assessed the degree of health knowledge of the two groups,and applied the Hamilton Anxiety Scale and the Pittsburgh Sleep Quality Index to assess the anxiety and sleep quality of the patients before and after the intervention,respectively.It also observed the length and efficiency of sleep,and detected the level of serum hypoxia inducible factor-1α,erythropoietin(EPO)and clinical intervention before and after intervention.EPO levels,and investigated satisfaction with the clinical intervention.RESULTS The rate of excellent health knowledge in the intervention group was 93.64%,which was higher than that in the control group(74.23%;P<0.05).Before the intervention,there was no significant difference in Hamilton Anxiety Scale and Pittsburgh Sleep Quality Index scores between the two groups(P>0.05),and after the intervention,the scores of the study group were significantly lower than those of the control group(P<0.05).There was no significant difference in sleep duration and sleep efficiency between the groups before the intervention(P>0.05),and after the intervention,the scores of the study group were significantly larger than those of the control group(P<0.05).There was no significant difference in serum hypoxia inducible factor-1αand EPO between the two groups before intervention(P>0.05),and both research groups were significantly lower than the control group after intervention(P<0.05).According to the questionnaire survey,the intervention satisfaction of the study group was 95.53%,which was higher than that of the control group(80.14%;P<0.05).CONCLUSION The CBT intervention in the treatment of patients with high-altitude-related respiratory diseases helps improve patients'health knowledge,relieve anxiety,improve sleep quality and hypoxia tolerance,and improve nursing satisfaction.
文摘BACKGROUND Approximately 30%of patients with head and neck cancer experience adverse effects caused by anxiety and depression.Considering the high prevalence,implementing customized interventions to ease adverse emotional states is imperative.AIM To evaluate the efficacy of cognitive behavioral therapy(CBT)-based psychological interventions in improving the psychological well-being and quality of life(QoL)of patients with laryngeal carcinoma.METHODS This study enrolled 120 patients admitted from February 2022 to February 2024.The control group,comprising 50 participants,received standard supportive psychological care,while the research group,consisting 70 participants,underwent CBT-based interventions.Several clinical outcomes were systematically assessed that included postoperative recovery metrics(duration of tracheostomy and nasogastric tube dependence and length of hospitalization),psychological status(Self-Rating Anxiety Scale and Self-Rating Depression Scale),nutritional markers(serum albumin and hemoglobin levels),sleep quality(Self-Rating Scale of Sleep and Athens Insomnia Scale),and QoL(Functional Assessment of Cancer Therapy-Head and Neck).RESULTS The results demonstrated that the research group experienced superior outcomes,with significantly reduced durations of tracheostomy and nasogastric tube dependence,as well as shorter hospital stays,compared with the control group.Additionally,the research group exhibited markedly lower post-intervention Self-Rating Anxiety Scale,Self-Rating Depression Scale,Self-Rating Scale of Sleep,and Athens Insomnia Scale scores,along with minimal but higher change in serum albumin and hemoglobin levels compared with the control group.All five domains of Functional Assessment of Cancer Therapy-Head and Neck showed notable improvements in the research group,exceeding those observed in the control group.CONCLUSION CBT-based psychological support positively affects the mental well-being and QoL of patients with laryngeal carcinoma,highlighting its potential for broader clinical application.
基金Supported by the National Natural Science Foundation of China,No.81860716Natural Science Foundation of Gansu Province,No.22JR11RA237Fundamental Research Funds for the Central Universities of Northwest Minzu University,No.31920230067.
文摘BACKGROUND Substantial clinical evidence supports the efficacy of cognitive behavioral therapy(CBT)for various diseases,particularly in oncology.However,the true impact of CBT interventions on cancer-related fatigue and mental health in patients with ovarian cancer remains unknown.AIM To evaluate the effects of CBT on fatigue,anxiety,depression and quality of life in patients with ovarian cancer.METHODS Randomized controlled trials(RCTs)on CBT for patients with ovarian cancer were searched in the PubMed,EMBASE,Web of Science and Cochrane Library databases.According to the preferred reporting items for systematic reviews and meta-analyses statement,we formulated the inclusion and exclusion criteria,strictly screened the literatures,extracted data and performed a meta-analysis.RESULTS Six RCTs with 332 ovarian cancer patients were included.Compared with the control group,cancer fatigue[mean difference(MD)=-0.98,95%confidence interval(CI):-1.47 to-0.50],anxiety[standardized mean difference(SMD)=-0.64,95%CI:-0.91 to-0.36]and depression levels(SMD=-0.41,95%CI:-0.76 to-0.06)of the patients in the experimental group reduced after CBT intervention.Quality of life(MD=1.28,95%CI:0.65 to 1.90)and sleep quality(MD=-0.49,95%CI:-0.66 to-0.33)of the patients improved,and the differences between the groups were statistically significant(P<0.01).The quality evaluation results suggested that the quality of the included RCTs was low.The meta-regression results showed that patient age and nurse guidance affected treatment outcomes,especially anxiety,whereas the specific method of CBT had a non-significant effect.CONCLUSION CBT effectively improves mental status and cancer-related fatigue in patients with ovarian cancer undergoing chemotherapy.Future research should prioritize adequately powered RCTs with standardized outcome measures and longitudinal designs to establish sustained efficacy.
基金Supported by the Pharmaceutical Science and Technology Project of Zhejiang Province,No.2023RC266the Natural Science Foundation of Ningbo,No.202003N4266.
文摘BACKGROUND Group cognitive behavioral therapy(GCBT)is increasingly being used to treat obsessive-compulsive disorder(OCD)because of its high efficiency,economy,and interaction among group members.However,the changes in network functional connectivity(FC)in patients with OCD with GCBT remain unclear.AIM To investigate inter-and intra-network resting-state FC(rs-FC)abnormalities before and after GCBT in unmedicated patients with OCD and validate the efficacy of GCBT.METHODS Overall,33 individuals with OCD and 26 healthy controls underwent resting-state functional magnetic resonance imaging.The patients were rescanned 12 weeks after GCBT.Four cognition-related networks-default mode network(DMN),dorsal attention network(DAN),salience network(SAN),and frontoparietal network(FPN)-were selected to examine FC abnormalities within and between OCD networks before and after GCBT.Neuropsychological assessments including memory,executive function,speech,attention,and visuospatial ability were reassessed following GCBT.Pearson’s correlations were used to analyze the relationship between aberrant FC in cognition-related networks and altered neuropsychological assessments in patients.RESULTS Rs-FC within the DMN and DAN decreased significantly.Additionally,rs-FC between the DMN-DAN,DMNFPN,DMN-SAN,and DAN-SAN also decreased.Significant improvements were observed in cognitive functions,such as memory,executive function,attention,and visuospatial ability.Furthermore,reduced rs-FC within the DMN correlated with visuospatial ability and executive function;DAN positively correlated with Shape Trails Test(STT)-A test elapsed time;DMN-DAN negatively correlated with Rey-Osterrieth Complex Figure(Rey-O)mimicry time and the three elapsed times of the tower of Hanoi;DMN-SAN negatively correlated with Rey-O imitation time and positively correlated with STT-A test elapsed time;and DMN-FPN negatively correlated with Auditory Word Learning Test N1 and N4 scores.CONCLUSION Decreased rs-FC within the DMN and DAN,which correlated with executive function post-treatment,has potential as a neuroimaging marker to predict treatment response to GCBT in patients with OCD.
基金Basic Science Research Program Through the National Research Foundation of Korea Funded by the Ministry of Education,No.NRF-RS-2023-00237287 and No.NRF-2021S1A5A8062526Local Government-University Cooperation-Based Regional Innovation Projects,No.2021RIS-003.
文摘Orthodontic osteodilated arch treatment represents a pivotal approach in dental orthodontics to address dental crowding and misalignment.Integrating cognitive behavioral therapy(CBT)into comprehensive nursing interventions(CNI)aims to address these issues holistically.This editorial explores the effectiveness of CBTbased CNI in improving patient outcomes in orthodontic care.Innovations in remote CBT delivery,such as virtual reality,have also shown potential in reducing pain,anxiety,and depression,emphasizing CBT's adaptability in orthodontic settings.The findings underscore the importance of integrating psychological support into orthodontic care to enhance patient adherence,satisfaction,and overall treatment success.The editorial advocates for a holistic approach that combines psychological and physiological care,highlighting the transformative potential of CBT-based interventions in orthodontic treatment.
基金Supported by Fuzhou Science and Technology Plan Project,No.2023-S-028.
文摘BACKGROUND Schizophrenia is commonly associated with comorbid depression,which exacerbates cognitive impairments and negatively impacts quality of life.Despite the high prevalence and burden of these comorbidities,effective treatment options,particularly for cognitive dysfunction,remain limited.AIM To evaluate the efficacy of computerized cognitive behavioral therapy(CCBT)with sertraline vs sertraline monotherapy in improving depressive symptoms,cognitive function,and quality of life in schizophrenia and depressive episodes.METHODS In this single-center,randomized controlled trial,68 adults[mean age(SD)=36.5(10.0),57.4%male]with schizophrenia and depressive symptoms were randomly assigned to receive either CCBT with sertraline or sertraline monotherapy during a 4-week hospitalization.The CCBT intervention involved 45-60-minute sessions twice weekly for four weeks.Outcomes included comparisons of depressive symptoms(Calgary depression scale for schizophrenia),cognitive function[MATRICS consensus cognitive battery(MCCB)],and quality of life(36-item short form survey)between the groups.RESULTS The experimental group showed greater improvements in depressive symptoms at 4,8,and 12 weeks compared to the controls,with the most notable difference at 12 weeks[mean difference(MD)=-1.7;P<0.001;Cohen’s d=0.9].Cognitive function improved across all MCCB domains in the experimental group,with higher processing speed scores(MD=4.1;P=0.043;Cohen’s d=0.5)and social cognition scores(MD=4.9;P=0.006;Cohen’s d=0.7)than in the control group.Quality of life,particularly in mental health,was significantly better in the experimental group.CONCLUSION CCBT with sertraline was more effective than sertraline monotherapy for patients with schizophrenia and depressive episodes,supporting its use as an adjunctive therapy.
基金Supported by the Shanghai Pujiang Program,No.2020PJC115Social Science Incubation Fund of Naval Medical University,No.2022SK027+1 种基金Scientific Research Program of Provincial Department of Education,No.Q20224105Research on the High-quality Development of Sports Talents in Hubei Province’s Universities Under the Background of Integration of Sports and Education,No.2022GA059.
文摘BACKGROUND As a substitute for traditional drug therapy,digital cognitive-behavioral therapy positively impacts the regulation of brain function,which can improve insomnia.However,there is currently a paucity of studies on digital cognitive behavioral therapy as a treatment for insomnia.AIM To assess digital cognitive behavioral therapy for insomnia regarding its positive impact on brain function.METHODS Participants were randomly assigned to either a go/no-go group or a dot-probe group.The primary outcome was quality of sleep as assessed by the actigraphy sleep monitoring bracelet,Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),and depression anxiety and stress scale(DASS-21).RESULTS Eighty patients were included in the analysis(go/no-go group:n=40;dot-probe group:n=40).We combined the total scale scores of the two groups before and after the intervention in the analysis of covariance.Our study explored whether insomnia symptoms in both groups can be improved by using digital cognitive behavioral therapy instead of trying to compare the two trials;therefore,only one P value is listed.In both groups,we found a short-term time effect on insomnia symptom severity(PSQI:P<0.001,η^(2)=0.336;ISI:P<0.001,η^(2)=0.667;DASS-depression:P<0.001,η^(2)=0.582;DASS-anxiety:P<0.001,η^(2)=0.337;DASS-stress:P<0.001,η^(2)=0.443)and some effect on sleep efficiency(but it was not significant,P=0.585,η^(2)=0.004).CONCLUSION Go/no-go task training of inhibitory function had a short-term positive effect on sleep efficiency,whereas dotprobe task training had a positive short-term effect on emotion regulation.
文摘BACKGROUND Perinatal anxiety disorder is the main problem affecting mother-infant bonding.Though the impact of perinatal anxiety in primiparous women on the motherinfant relationship is well established,appropriate interventions need to be explored.AIM To explore the synergistic intervention effect of mindfulness-based stress reduction combined with cognitive behavioral therapy(CBT)on perinatal anxiety disorders and mother-infant bonding in primiparas.METHODS A total of 150 primiparas with perinatal anxiety disorders admitted to the hospital from January 2020 to October 2024 were selected and divided into two groups according to the random number method.The control group(n=75)received CBT,and the observation group(n=75)received mindfulness-based stress reduction combined with CBT.The anxiety and depressive emotions,as well as the mother-infant emotional bonding situation,were compared between the two groups.RESULTS After the intervention,the anxiety and depressive states in the observation group were lower than those in the control group(P<0.05).The mother-infant bonding(sense of pleasure,recognition,understanding,and love)in the observation group was higher than that in the control group,and the role adaptation ability was also higher than in the control group(P<0.05).CONCLUSION Mindfulness-based stress reduction combined with CBT can reduce perinatal anxiety disorders in primiparas,promote mother-infant bonding,and improve their ability to adapt to the mother role.
基金The study was reviewed and approved by the Institutional Review Board of Dushu Lake Hospital Affiliated to Soochow University.
文摘BACKGROUND The severe physical and psychological impact of pain on the physical and mental health of women during labor leads to increased risks and complications during childbirth,presenting a major public health concern.Some studies have shown that cognitive behavioral therapy(CBT)has a positive effect on maternal psychology during delivery,reducing stress and shortening labor time.Thus,CBT training for mothers and delivery room staff may be beneficial in minimizing complications and adverse effects during natural birth.AIM To investigate the clinical effects of CBT training and psychological care during delivery,and their therapeutic effects on women in labor.METHODS This study used a retrospective analysis and included 140 mothers admitted to the maternity ward between January 2021 and January 2023.The study subjects were randomized into two groups:control(n=70)and observation(n=70).Routine care,CBT training,and psychological care were provided to mothers in both groups.Psychological status scores,delivery time,and satisfaction with care pre-and post-delivery were compared,and the incidence of complications after receiving care was analyzed between the two groups.RESULTS Although the psychological state of both groups improved significantly in the late stages of labor,the psychological state scores of the mothers in the observation group were significantly lower than those of the mothers in the control group(P<0.05).The duration of labor and incidence of complications in the observation group were significantly lower than those in the control group(P<0.05).The mothers in the observation group were significantly more satisfied with nursing care during the course of labor than those in the control group(P<0.05).CONCLUSION CBT training and psychological care for mothers in the midwifery process can effectively improve anxiety and depression,shorten labor duration,reduce postnatal complications,and improve nursing satisfaction and nurse-patient relationships.Its clinical application is effective and has popularization value,providing a new way to protect maternal mental health.
基金the Shanxi Soft Science Research Program, No. 2008041061-03
文摘Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls （N2： P = 0.035; P3a： P = 0.031 P3b： P = 0.043） and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b （P3a： P = 0.045; P3b： P = 0.062）. These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.
文摘Synapsins are a family of phosphoproteins specifically associated with the cytoplasmic surface of the synaptic vesicle membrane, appearing to regulate neurotransmitter release, the formation and maintenance of synaptic contacts. They could induce the change of the synaptic plasticity to regulate various adaptation reactions, and change the cognitive behaviors. So we presume that if some cognitive behavior are damaged, synapsins would be changed as well. This gives us a new recognition of better diagnosis and therapy of cognitive disorder desease.
文摘BACKGROUND Recently,the efficacy of cognitive behavioral therapy(CBT)-based intervention on health outcomes in patients with coronary heart disease(CHD)has been recognized in randomized controlled trials(RCTs),but no comprehensive systematic review has been conducted.To address this research gap,our study aimed to evaluate whether comprehensive CBT-based interventions positively affect health outcomes in CHD patients.It was hypothesized that CBT-based interventions are effective in:(1)Reducing depression,anxiety,and stress symptoms;(2)Reducing body mass index,blood pressure,and lipid levels;and(3)Improving quality of life,and exercise endurance.AIM To verify the effectiveness of CBT-based interventions on CHD patients through a meta-analysis of previous publications.METHODS Relevant RCTs published in English were obtained by searching electronic databases,including PubMed,Embase,Cochrane Central Register of Controlled Trials,Scopus,and Proquest,with the retrieval time from inception to August 2020.The primary outcomes were psychological factors(depression,anxiety,and stress symptoms),physiological factors(body mass index,blood pressure,blood lipids).The secondary outcomes included quality of life and exercise endurance.We used Review Manager 5.3 to conduct the meta-analysis and used the Physiotherapy Evidence Database tool to evaluate the quality of studies.RESULTS A total of 22 RCTs comprising 4991 patients with CHD were included in the systematic review and meta-analysis.The main analysis revealed that CBT-based intervention can reduce depression symptoms:-2.00[95%confidence interval(CI):-2.83 to-1.16,P<0.001];anxiety symptoms:-2.07(95%CI:-3.39 to-0.75,P=0.002);stress symptoms:-3.33(95%CI:-4.23 to-2.44,P<0.001);body mass index:-0.47(95%CI:-0.81 to-0.13,P=0.006);and improve physical functioning:3.36(95%CI:1.63 to 5.10,P=0.000)and mental functioning:6.91(95%CI:4.10 to 9.73,P<0.001).Moreover,subgroup analysis results showed that CBT-based interventions were more effective for symptoms of depression and anxiety in CHD patients when individual,as opposed to group treatment,and psycho-education,behavioral and cognitive strategies were applied as the core treatment approaches.CONCLUSION CBT-based interventions are effective treatment strategies for CHD patients,significantly improving their symptoms of depression,anxiety and stress,body mass index,and health-related quality of life.
基金The Preventive Medicine Research Projects of Jiangsu Province Health Department,No.Y2015010 and No.Y2018016The Science and Technology projects of Xuzhou city,No.KC15SM046the Youth Medical Talent Project of“Ke Jiao Qiang Wei Projects”in Jiangsu Province,No.QNRC2016375.
文摘BACKGROUND Poor sleep quality is a common clinical feature in patients with type 2 diabetes mellitus(T2DM),and often negatively related with glycemic control.Cognitive behavioral therapy(CBT)may improve sleep quality and reduce blood sugar levels in patients with T2DM.However,it is not entirely clear whether CBT delivered by general practitioners is effective for poor sleep quality in T2DM patients in community settings.AIM To test the effect of CBT delivered by general practitioners in improving sleep quality and reducing glycemic levels in patients with T2DM in community.METHODS A cluster randomized controlled trial was conducted from September 2018 to October 2019 in communities of China.Overall 1033 persons with T2DM and poor sleep quality received CBT plus usual care or usual care.Glycosylated hemoglobin A1c(HbAlc)and sleep quality[Pittsburgh Sleep Quality Index(PSQI)]were assessed.Repeated measures analysis of variance and generalized linear mixed effects models were used to estimate the intervention effects on hemoglobin A1c and sleep quality.RESULTS The CBT group had 0.64,0.50,and 0.9 lower PSQI scores than the control group at 2 mo,6 mo,and 12 mo,respectively.The CBT group showed 0.17 and 0.43 lower HbAlc values than the control group at 6 mo and 12 mo.The intervention on meanΔHbAlc values was significant at 12 mo(t=3.68,P<0.01)and that meanΔPSQI scores were closely related toΔHbAlc values(t=7.02,P<0.01).Intentionto-treat analysis for primary and secondary outcomes showed identical results with completed samples.No adverse events were reported.CONCLUSION CBT delivered by general practitioners,as an effective and practical method,could reduce glycemic levels and improve sleep quality for patients with T2DM in community.
基金The Scientific Research Funds Project of Liaoning Education Department,No.LJC2019ST02.
文摘BACKGROUND Cancer-related fatigue(CRF)is the most common concomitant symptom in the treatment of colorectal cancer(CRC).Such patients often present with subjective fatigue state accompanied by cognitive dysfunction,which seriously affects the quality of life of patients.AIM To explore the effects of cognitive behavior therapy(CBT)combined with Baduanjin exercise on CRF,cognitive impairment,and quality of life in patients with CRC after chemotherapy,and to provide a theoretical basis and practical reference for rehabilitation of CRC after chemotherapy.METHODS Fifty-five patients with CRC after radical resection and chemotherapy were randomly divided into either an experimental or a control group.The experimental group received the intervention of CBT combined with exercise intervention for 6 mo,and indicators were observed and measured at baseline,3 mo,and 6 mo to evaluate the intervention effect.RESULTS Compared with the baseline values,in the experimental group 3 mo after intervention,cognitive function,quality of life score,and P300 amplitude and latency changes were significantly better(P<0.01).Compared with the control group,at 3 mo,the experimental group had significant differences in CRF,P300 amplitude,and quality of life score(P<0.05),as well as significant differences in P300 latency and cognitive function(P<0.01).Compared with the control group,at 6 mo,CRF,P300 amplitude,P300 latency,cognitive function and quality of life score were further improved in the experimental group,with significant differences(P<0.01).The total score of CRF and the scores of each dimension were negatively correlated with quality of life(P<0.05),while the total score of cognitive impairment and the scores of each dimension were positively correlated with quality of life(P<0.05).CONCLUSION CBT combined with body-building Baduanjin exercise can improve CRF and cognitive impairment in CRC patients after chemotherapy,and improve their quality of life.
基金Supported by Science and Technology Innovation Bureau,Longhua District,Shenzhen,Guangdong Province,China,No.2020202.
文摘BACKGROUND The efficacy of cognitive behavioral group therapy(CBGT)for cognitive dysfunction and negative symptoms of schizophrenia is established,but more evidence is required.AIM To assess the effectiveness of CBGT combined with mental health education as a treatment for schizophrenia compared with mental health education alone.METHODS In all,120 schizophrenia out-patients were randomized into CBGT combined with mental health education or single mental health education.The primary outcomes were positive and negative symptoms,cognitive function,excitatory factor,anxiety and depression symptom improvements on the positive and negative syndrome scale score.Secondary outcome measures included social function and drug compliance.RESULTS There were significant differences between CBGT combined with mental health education and single mental health education on measures of positive and negative symptoms,cognitive functions,excitatory factor,anxiety and depression symptoms,and social functions.No other significant difference in outcomes was observed.CONCLUSION CBGT combined with mental health education may be relevant beneficial treatment method in reducing symptoms,cognitive and social functions of patients with schizophrenia.
基金Supported by Science and Technology Foundation of the Guizhou Health Department,No.GZWKJ2011-1-026National Natural Science Foundation of China,No.81760548.
文摘BACKGROUND The main treatment methods for cancer include surgery,radiotherapy,chemotherapy,targeted drug therapy and so on.Patients often feel anger,anxiety,depression,and other negative psychological reactions in the process of treatment.AIM To explore the effects of cognitive behavioral therapy on the personality characteristics of cancer patients.METHODS According to the matching design requirements,150 cancer patients were divided into 3 groups based on sex,age,condition,and cultural background.Patients in the control group received conventional treatment.Patients in experimental group 1 received an intervention based on conventional treatment combined with cognitive behavioral therapy.Patients in experimental group 2 received family members'participation in addition to the treatment given in experimental group 1.An Eysenck personality questionnaire was used to investigate all the patients before and after the intervention,and the scores for psychosis,introversion,neuroticism,and concealment degree were analyzed.RESULTS Compared with the control group,for experimental group 1 and experimental group 2 before and after the intervention,the four dimensions of mental quality,neuroticism,introversion and concealment degree all decreased,and the difference was statistically significant(P<0.05).After the intervention,there were no obvious or statistically significant differences(P>0.05)among the control group,experimental group 1,and experimental group 2 for two personality traits,psychoticism and neuroticism,both inside and outside degree and all four dimensions.CONCLUSION Simple cognitive behavioral therapy could not change the personality characteristics of cancer patients quickly,but the patients’personality characteristics were significantly improved after treatment.
基金The research was reviewed and approved by the Review Committee of Hospital of Chengdu University of Traditional Chinese Medicine(Approval No.NSH-23-319).
文摘BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.METHODS Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of this.Before and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different groups.In addition,satisfaction and complications were comparatively analyzed.RESULTS Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance.
基金National Natural Science Foundation of China(No.82171542)Beijing Municipal Administration of Hospitals Incubating Program(code:PX2020075)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(code:XMLX202129).
文摘Background: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition without a conclusivesubtype dimension. This study will focus on the meta-analysis of the clinical responses of OCD subtypes to cognitivebehavioral therapy (CBT), which might clarify this issue. Methods: We performed a systematic search and ameta-analysis for the studies of OCD subtypes and the response to CBT in PubMed, ScienceDirect, Embase, Webof Science, and Scopus databases. The selective criteria were the OCD without significant medical or psychiatricco-morbidities and pre-and post-treatment changes in scores of OCD dimension. In addition, different subtypesof OCD in symptom dimensions, such as symmetry, contamination, unacceptable thoughts, and hoarding, werecompared to find the most significant subtype using the treatment response parameters by CBT. After limitedselection, four studies and 479 OCD subjects were enrolled. The meta-analysis was performed by Review Manager5.4, and only significant results were reported. Results: Among the OCD subtypes, the meta-analysis favors thehoarding subtype with poorer responses to CBT than symmetry, contamination, and unacceptable thoughts.The meta-analysis results were negative mean differences, significant tests for overall effect, and limited heterogeneitiesin the random effects model. In addition, the results were more significant when the hoarding subtypewas compared with non-hoarding subtypes. Conclusion: The hoarding subtype might be the most significantrepresentative subtype of OCD symptom dimension under the impression of unfavorable clinical response toCBT. However, future studies with more treatment parameters will be warranted to confirm this finding.
文摘BACKGROUND Recommendations for psychotherapy have evolved over the years,with cognitive behavioral therapy(CBT)taking precedence since its inception within clinical guidelines in the United Kingdom and United States.The use of CBT for severe mental illness is now more common globally.AIM To investigate the feasibility and acceptability of a culturally adapted,CBT-based,third-wave therapy manual using the Comprehend,Cope,and Connect approach with individuals from a diverse population presenting to primary and secondary healthcare services.METHODS A pilot study was used to assess the feasibility and acceptability of the manualised intervention.Outcome measures were evaluated at baseline,post-intervention and 12 wk-follow up.32 participants with mental health conditions aged 20-53 years were recruited.Assessments were completed at three time points,using Clinical Outcomes in Routine Evaluation(CORE),Hospital Anxiety and Depression Scale(HADS),Bradford Somatic Inventory and World Health Organization Disability Assessment Schedule 2.0(WHODAS).The Patient Experience Questionnaire was completed post-treatment.RESULTS Repeated measures of analysis of variance associated with HADS depression,F(2,36)=12.81,P<0.001,partialη^(2)=0.42 and HADS anxiety scores,F(2,26)=9.93,P<0.001,partialη^(2)=0.36;CORE total score and WHODAS both showed significant effect F(1.25,18.72)=14.98,P<0.001,partialη^(2)=0.5.and F(1.29,14.18)=6.73,P<0.001,partialη^(2)=0.38 respectively.CONCLUSION These results indicate the effectiveness and acceptability of the culturally adapted,CBT-based,third-wave therapy manual intervention among minoritized groups with moderate effect sizes.Satisfaction levels and acceptability were highly rated.The viability and cost-effectiveness of this approach should be explored further to support universal implementation across healthcare systems.
基金supported by the Shaanxi Police Officers’Vocational College Scientific Research Project(grant number YJKY202310).
文摘Background:The mental health challenges faced by police officers due to high-stress work environments necessitate effective interventions.Cognitive-behavioral therapy(CBT)has shown promise in addressing mental health issues,and this study aims to evaluate the efficacy of smartphone-based cognitive-behavioral therapy(SCBT)in improving mental health outcomes among police officers.This intervention could provide a reference for enhancing mental health literacy and resilience in this population.Methods:A randomized controlled trial(RCT)design was employed,involving 291 police officers who were randomly assigned to either the SCBT intervention group(n=145)or the control group(n=146).Participants completed pre-and post-intervention assessments using the Symptom Checklist-90(SCL-90),which measures multiple psychological symptoms including somatization,obsessive-compulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism.Statistical analyses were conducted to examine group differences in symptom severity and effect sizes.Results:Post-intervention results indicated significant reductions in somatization,obsessivecompulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism,with large effect sizes observed in the intervention group.Notably,the intervention group showed significantly greater improvements compared to the control group,particularly in overall psychological distress as measured by the total SCL-90 score.However,significant reductions in interpersonal sensitivity and paranoid ideation were also observed in the control group,suggesting external factors may have influenced these dimensions.Conclusion:SCBT demonstrated efficacy in reducing psychological distress among police officers,offering a flexible and accessible mental health intervention.However,challenges such as high dropout rates and the complex,dynamic nature of mental health warrant further investigation.Future studies should explore targeted interventions for specific behavioral issues and consider SCBT as a supplementary tool alongside traditional psychotherapy.
