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Neutron‑gamma density measurement method using the mass attenuation coefficient function
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作者 Jun‑Yan Chen Qiong Zhang 《Nuclear Science and Techniques》 2026年第1期180-192,共13页
Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging tec... Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging technology.However,NGD measurements are influenced by both neutron and gamma radiations.In the logging environment,variations in the formation composition indicate different elemental compositions,which affect the neutron-gamma reaction cross-sections and gamma generation.Compared to traditional gamma sources such as Cs-137,these changes significantly affect the generation and transport of neutron-induced inelastic gamma rays and hinder accurate measurements.To address this,a novel method is proposed that incorporates the mass attenuation coefficient function to account for the effects of various lithologies and pore contents on gamma-ray attenuation,thereby achieving more accurate density measurements by clarifying the transport processes of inelastic gamma rays with varying energies and spatial distributions in varied logging environments.The proposed method avoids the complex correction of neutron transport and is verified through Monte Carlo simulations for its applicability across various lithologies and pore contents,demonstrating absolute density errors that are less than 0.02 g/cm^(3)in clean formations and indicating good accuracy.This study clarifies the NGD mechanism and provides theoretical guidance for the application of NGD logging methods.Further studies will be conducted on extreme environmental conditions and tool calibration. 展开更多
关键词 Neutron-gamma density Mass attenuation coefficient Monte Carlo simulation
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SDC2表达调控铁死亡参与宫颈癌发生的作用及机制 被引量:2
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作者 姚雪芹 肖雪莲 +2 位作者 罗其英 常德萍 高燕 《安徽医科大学学报》 北大核心 2025年第2期234-239,共6页
目的探究黏结蛋白聚糖2(SDC2)是否可通过调控铁死亡影响宫颈癌细胞增殖、侵袭、迁移及其可能的作用机制。方法培养正常宫颈上皮细胞H8、宫颈鳞状癌细胞C33A,分为H8组与C33A组。培养C33A细胞,分为对照组、低表达SDC2组、低表达SDC2+铁死... 目的探究黏结蛋白聚糖2(SDC2)是否可通过调控铁死亡影响宫颈癌细胞增殖、侵袭、迁移及其可能的作用机制。方法培养正常宫颈上皮细胞H8、宫颈鳞状癌细胞C33A,分为H8组与C33A组。培养C33A细胞,分为对照组、低表达SDC2组、低表达SDC2+铁死亡抑制剂(ferrostation-1)组与低表达SDC2+铁死亡诱导剂(erastin)组。Western blot检测细胞中SDC2、溶质载体家族7成员11(SLC7A11)、谷胱甘肽过氧化酶4(GPX4)蛋白。RT-qPCR检测C33A细胞中SDC2 mRNA水平。ELISA试剂盒检测C33A细胞中活性氧(ROS)、谷胱甘肽(GSH)、亚铁离子(Fe^(2+))水平。平板克隆检测C33A细胞克隆能力。划痕实验检测C33A细胞迁移能力。Transwell实验检测C33A细胞侵袭能力。结果与H8组比较,C33A组细胞中SDC2、SLC7A11、GPX4蛋白及mRNA表达增加(P<0.05)。与对照组比较,低表达SDC2组C33A细胞增殖、迁移及侵袭能力降低(P<0.05),C33A细胞中SLC7A11、GPX4蛋白及mRNA表达减少(P<0.05),GSH水平减少,ROS及Fe^(2+)水平增加(P<0.05)。与低表达SDC2组比较,低表达SDC2+ferrostation-1组SLC7A11、GPX4蛋白及mRNA表达增加(P<0.05),GSH水平增加,ROS及Fe^(2+)水平减少(P<0.05)。与对照组比较,低表达SDC2+erastin组C33A细胞增殖、迁移及侵袭能力降低(P<0.05)。结论SDC2在C33A宫颈癌细胞中表达增加,低表达SDC2可激活SLC7A11/GPX4通路介导的铁死亡,从而降低C33A细胞的增殖、侵袭及迁移能力。 展开更多
关键词 宫颈癌 sdc2 铁死亡 增殖 迁移 侵袭
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医务工作者结直肠癌筛查问卷与粪便SDC2基因甲基化联合筛查对结肠镜依从性的影响分析 被引量:2
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作者 陆美吉 程伟 +5 位作者 郭晓晨 杨怀中 戴宁 纪峰 顾知恩 杨宇飞 《中国医药科学》 2025年第2期142-145,共4页
目的研究结直肠癌高危人群筛查问卷与硫酸类肝素蛋白多糖(SDC2)基因甲基化检测联合筛查对医务工作者结肠镜依从性的影响及其相关因素。方法2021年1月至2022年12月以中国中医科学院西苑医院医务工作者作为研究对象,收集结直肠癌高危人群... 目的研究结直肠癌高危人群筛查问卷与硫酸类肝素蛋白多糖(SDC2)基因甲基化检测联合筛查对医务工作者结肠镜依从性的影响及其相关因素。方法2021年1月至2022年12月以中国中医科学院西苑医院医务工作者作为研究对象,收集结直肠癌高危人群筛查问卷和SDC2基因甲基化试剂盒结果,评定高危人群并提醒进行肠镜检查,分析肠镜依从性以及影响因素。结果本研究共纳入771人并全部完成结直肠癌高危人群筛查问卷,其中604人接受SDC2基因甲基化检测,联合筛查后高危人群中肠镜依从性为22.91%,经多因素分析后,联合筛查高危人群中肠镜依从性与SDC2基因甲基化检测高危有关(OR=174.167,P<0.001)。结论联合筛查肠镜依从性较低,医务工作者对于结直肠癌筛查缺乏重视,单独使用SDC2基因甲基化检测能有效提高肠镜依从性。 展开更多
关键词 结直肠癌 筛查 医务工作者 sdc2基因甲基化 结肠镜依从性
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Septin9、SDC2基因甲基化和CEA及FOBT联合检测在结直肠癌筛查中的临床应用价值 被引量:3
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作者 邹超世 刘燕萍 +6 位作者 王东旭 谢钰玲 李明强 梁宗超 陈伊 苏志乐 刘康海 《标记免疫分析与临床》 2025年第3期537-543,共7页
目的探讨血浆Septin9、粪便硫酸类肝素蛋白多糖2(syndecan-2,SDC2)基因甲基化、血清癌胚抗原(CEA)和粪便隐血测试(FOBT)联合检测在结直肠癌筛查中的临床价值。方法收集2022年10月至2024年1月间收治的101例结直癌患者作为结直肠癌组,选... 目的探讨血浆Septin9、粪便硫酸类肝素蛋白多糖2(syndecan-2,SDC2)基因甲基化、血清癌胚抗原(CEA)和粪便隐血测试(FOBT)联合检测在结直肠癌筛查中的临床价值。方法收集2022年10月至2024年1月间收治的101例结直癌患者作为结直肠癌组,选取同期参加体检健康人员40例作为对照组,检测CEA水平、FOBT、Septin9和SDC2基因甲基化。比较两组CEA、FOBT单项检测、两项联合(Septin9和SDC2基因甲基化)、3项联合(FOBT、Septin9和SDC2基因甲基化)及4项联合检测阳性情况,比较结直肠癌患者不同病理特征,不同TNM分期CEA、FOBT单项检测、两项联合及4项联合检测阳性情况。将FOBT、CEA、SDC2和Septin9纳入Logistic回归分析,并构建Logistic回归模型,通过受试者工作曲线(ROC)评估CEA、FOBT、Septin9和SDC2基因甲基化各单项及两项联合,3项联合和4项联合对结直肠癌的诊断价值。结果两组CEA水平比较,结直肠癌组高于健康对照组(P<0.01)。结直肠癌组CEA、FOBT、两项联合,3项联合及4项联合检测阳性率分别为49.5%、67.3%、86.1%、93.1%、92.1%,高于健康对照组的5.0%、10.0%、5.0%、12.5%、17.5%,差异均有统计学意义(P<0.01)。结直肠癌组中SDC2基因甲基化、FOBT单项检测阳性率分别高于CEA检测阳性率。两项联合检测I-IV期结直肠癌患者阳性率分别为78.6%、79.4%、91.2%、94.7%,均显著高于CEA(P<0.01)。Logistic单因素回归分析显示FOBT、CEA、SDC2和Septin9是结直肠癌发生的影响因素,多因素回归分析得出结直肠癌预测模型为P=1/[1+exp(2.013-2.089×FOBT-2.771×Septin9-4.035×SDC2)]。ROC曲线分析两项联合、3项联合、4项联合检测灵敏度和曲线下面积(AUC)分别为86.1%和0.931、93.1%和0.946、92.1%和0.957,均高于各单项检测(P<0.01)。结直肠癌组中,3项联合诊断结直肠癌相比于两项联合,灵敏度、特异性和AUC差异无统计学意义(P>0.05)。结论SDC2和Septin9联合检测对结直肠癌的早期筛查和诊断具有一定的临床价值,基于FOBT、SDC2和Septin93项联合的预测模型可一定程度上优化临床决策。 展开更多
关键词 结直肠癌 甲基化 Septin9 sdc2 联合检测
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粪便SDC2基因甲基化检测对贵州地区结直肠癌的早筛价值 被引量:1
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作者 晏芳 吴世敏 +2 位作者 杨赟翰 袁文强 崔德军 《贵州医药》 2025年第2期181-184,188,共5页
目的观察贵州地区粪便黏结蛋白聚糖2(SDC2)基因甲基化检测在结直肠癌及癌前病变诊断的临床价值。方法选取2023年4月至2024年7月期间在贵州省人民医院消化内科门诊及住院就诊的患者1980例进行研究,收集所有患者的粪便样本进行粪便SDC2基... 目的观察贵州地区粪便黏结蛋白聚糖2(SDC2)基因甲基化检测在结直肠癌及癌前病变诊断的临床价值。方法选取2023年4月至2024年7月期间在贵州省人民医院消化内科门诊及住院就诊的患者1980例进行研究,收集所有患者的粪便样本进行粪便SDC2基因甲基化检测(mSDC2),对检查结果为阳性者建议接受肠镜检查,对肠镜异常者建议接受进一步治疗。观察mSDC2初筛的阳性预测值(PPV)、肠镜依从率、肠道病变检出率;同时探讨mSDC2的CT值与肠道病变之间的关系。结果mSDC2阳性共1980例患者,年龄19~99岁,检测结果中207例患者mSDC2结果为阳性,PPV为10.45%(207/1980),PPV在男性和女性中无统计学意义(P>0.05)。207例mSDC2阳性受试者中109例接受结直肠镜检查(肠镜依从性52.66%),其中男62例(肠镜依从性52.54%);女47例(肠镜依从性52.81%,其中产妇1例),比较男性和女性的肠镜依从性无显著差异(P>0.05)。通过肠镜检查发现肠道病变共77例,mSDC2对肠癌的PPV为16.51%;对肠道病变的PPV为70.64%,各年龄段行肠镜检查的比例存在显著差异(P<0.05)。mSDC2CT值≤38为阳性结果。CT值在肠道肿瘤与肠道其他病变的mSDC2存在显著差异(P<0.05)。结论粪便SDC2基因甲基化检测作为一种新颖的、非侵入性的结直肠癌早诊早筛技术,具有较高的临床诊断价值,为贵州地区患者的肠癌风险分层与结直肠癌早诊早筛提供了有效工具。 展开更多
关键词 粪便 sdc2基因甲基化检测 贵州 结直肠癌 早筛
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粪便中SDC2基因甲基化检测在结直肠病变诊断中的应用
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作者 张九存 杨云 +7 位作者 葛志明 赵红波 王梦媛 李燕 张淼 陈蕊 陈金珠 史振滏 《宁夏医科大学学报》 2025年第9期951-955,共5页
目的 探讨粪便硫酸类肝素蛋白多糖2(SDC2)配合结肠镜下活检在结直肠癌诊断应用中的价值。方法 以500名健康体检及肠道疾病就诊者为研究对象,观察不同检测方法对结直肠癌病变的诊断效能比较。结果 粪便样本中SDC2基因甲基化阳性率为10.20... 目的 探讨粪便硫酸类肝素蛋白多糖2(SDC2)配合结肠镜下活检在结直肠癌诊断应用中的价值。方法 以500名健康体检及肠道疾病就诊者为研究对象,观察不同检测方法对结直肠癌病变的诊断效能比较。结果 粪便样本中SDC2基因甲基化阳性率为10.20%(51/500),粪便中SDC2基因甲基化阳性组患者中的敏感度比血清肿瘤标记物检测高(P均<0.05),且结肠镜下活检与粪便SDC2基因甲基化检测具有较强的一致性(Kappa=0.615,P<0.05)。粪便SDC2基因甲基化检测的诊断效能较为显著(Z=7.545,P<0.05)。结论 粪便SDC2基因甲基化在结直肠疾病无创筛检中有一定价值。 展开更多
关键词 sdc2基因甲基化 血清肿瘤标志物 结肠镜
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Septin9基因甲基化和SDC2基因甲基化联合检测辅助诊断结直肠癌 被引量:2
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作者 黄仁 施卫忠 +2 位作者 卢仁泉 郭林 王砚春 《检验医学》 2025年第6期519-524,共6页
目的探讨血浆Septin9基因甲基化和粪便SDC2基因甲基化联合检测在结直肠癌(CRC)诊断中的临床应用价值。方法选取2023年11月—2024年1月复旦大学附属肿瘤医院CRC患者110例[CRC组,包括早期(TNM分期Ⅰ~Ⅱ期)患者48例(早期CRC组)、晚期(TNM... 目的探讨血浆Septin9基因甲基化和粪便SDC2基因甲基化联合检测在结直肠癌(CRC)诊断中的临床应用价值。方法选取2023年11月—2024年1月复旦大学附属肿瘤医院CRC患者110例[CRC组,包括早期(TNM分期Ⅰ~Ⅱ期)患者48例(早期CRC组)、晚期(TNM分期Ⅲ~Ⅳ期)患者62例(晚期CRC组)]、结直肠良性肿瘤患者21例(疾病对照组)、健康体检者37名(正常对照组)。检测所有研究对象血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)水平和粪便SDC2基因甲基化、血浆Septin9基因甲基化水平。采用一致性检验分析血浆Septin9基因甲基化与粪便SDC2基因甲基化检测结果的一致性。采用受试者工作特征(ROC)曲线评价各项指标联合检测诊断CRC的效能。结果与正常对照组比较,疾病对照组和CRC组SDC2基因甲基化阳性率均显著升高(P<0.01);CRC组Septin9基因甲基化阳性率显著升高(P<0.001),且早期CRC组、晚期CRC组SDC2基因甲基化和Septin9基因甲基化阳性率均显著升高(P<0.001)。疾病对照组与正常对照组之间Septin9基因甲基化阳性率差异无统计学意义(P>0.05)。除正常对照组(Kappa=0.358,P=0.026)外,其他各组SDC2基因甲基化与Septin9基因甲基化均无一致性(P>0.05)。SDC2基因+Septin9基因+CA19-9联合检测模型诊断CRC的曲线下面积(AUC)为0.958,最佳临界值为0.571,敏感性为95.5%,特异性为90.3%;诊断早期CRC的AUC为0.940,最佳临界值为0.700,敏感性为91.7%,特异性为90.3%。结论Septin9基因甲基化、SDC2基因甲基化与传统肿瘤标志物CA19-9联合检测有助于提高CRC的诊断效能。 展开更多
关键词 Septin9基因 sdc2基因 甲基化 结直肠癌
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人粪便SDC2甲基化检测在结直肠癌早期筛查中的应用 被引量:2
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作者 黎娜 徐烨 +2 位作者 施倩斐 袁航 吴雯 《临床医药实践》 2025年第2期83-87,共5页
目的:探讨人粪便SDC2甲基化在结直肠癌(CRC)早期筛查中的临床价值。方法:选择2022年8月-2023年12月接受治疗的CRC患者60例(CRC组)以及同期健康体检人群60例(健康组)。使用荧光定量聚合酶链式反应(PCR)技术分析粪便SDC2甲基化水平,并使... 目的:探讨人粪便SDC2甲基化在结直肠癌(CRC)早期筛查中的临床价值。方法:选择2022年8月-2023年12月接受治疗的CRC患者60例(CRC组)以及同期健康体检人群60例(健康组)。使用荧光定量聚合酶链式反应(PCR)技术分析粪便SDC2甲基化水平,并使用化学发光法检测血清肿瘤标志物癌胚抗原(CEA)和糖类抗原19-9(CA19-9)浓度,分析粪便SDC2甲基化和血清肿瘤标志物对CRC的诊断价值。通过受试者工作特征(ROC)曲线评估不同检测指标对CRC诊断的曲线下面积(AUC)。结果:CRC组粪便SDC2甲基化水平高于健康组(P<0.05)。组间比较表明,CRC组的SDC2甲基化、CEA和CA19-9阳性检出率均显著高于健康组(P<0.05)。CRC组中,SDC2甲基化、CEA和CA19-9的阳性检出率分别为81.7%,43.3%和40.0%,表明SDC2甲基化检测的真阳性率高于血清肿瘤标志物。ROC曲线分析表明,粪便SDC2甲基化检测的AUC值为0.8968,高于CEA/CA19-9联合检测的AUC值0.8297。其中,SDC2/CEA/CA19-9联合检测的AUC值最高,为0.9347。SDC2甲基化、CEA和CA19-9及SDC2/CEA/CA19-9联合检测的灵敏度分别为83.3%,71.7%,50.0%和88.3%,特异性分别为83.3%,85.0%,85.0%和88.3%,表明联合诊断模型灵敏度和特异性最高。结论:粪便SDC2甲基化检测对CRC具有较高的灵敏度和特异性,但是SDC2/CEA/CA19-9联合诊断模型对早期CRC具有更好的筛查效果。 展开更多
关键词 结直肠癌 sdc2甲基化 生物标志物 早期检测
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老年骨质疏松患者SDC4、TNC表达水平与骨代谢标志物、骨折的关系 被引量:1
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作者 向奎 《临床研究》 2025年第1期79-83,共5页
目的探究老年骨质疏松性患者血清多配体蛋白聚糖-4(SDC4)、肌腱蛋白C(TNC)表达水平与骨代谢标志物、骨折的关系。方法选取2021年3月至2023年3月于安阳市第三人民医院就诊的80例老年骨质疏松性患者为研究对象作为观察组,另选同一个时间... 目的探究老年骨质疏松性患者血清多配体蛋白聚糖-4(SDC4)、肌腱蛋白C(TNC)表达水平与骨代谢标志物、骨折的关系。方法选取2021年3月至2023年3月于安阳市第三人民医院就诊的80例老年骨质疏松性患者为研究对象作为观察组,另选同一个时间段本院实施健康体检的72例老年人为此次试验的正常对照组,依据所纳入的老年骨质疏松患者有无骨折分为骨折组(n=32)和非骨折组(n=48)。收集全部研究对象的一般资料,检测血清SDC4、TNC表达水平与I型前胶原氨基端原肽(PINP)、I型胶原C末端肽(CTX)、骨钙素(BGP)等骨代谢标志物水平,采用Pearson分析血清SDC4、TNC表达水平与骨代谢标志物的相关性,采用Logistic回归分析血清SDC4、TNC表达水平与骨折之间的关系。结果观察组的SDC4、TNC、CTX水平均高于对照组,差异有统计学意义(P<0.05),而PINP、BGP水平明显低于对照组,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,血清SDC4、TNC表达水平与PINP、BGP呈负相关(P<0.05),血清SDC4、TNC表达水平与CTX呈正相关(P<0.05)。骨折组的血清SDC4、TNC表达水平明显高于非骨折组,差异有统计学意义(P<0.05)。多因素Logistic回归结果显示,血清SDC4(OR:1.475;95%CI:1.179~1.845)、TNC(OR:1.544;95%CI:1.143~2.086)表达水平均是老年骨质疏松性患者发生骨折的危险因素(P<0.05),血清SDC4、TNC表达水平越高的老年骨质疏松性患者骨折的发生风险越大。由受试者工作曲线(ROC)曲线分析可得,血清SDC4、TNC表达水平预测老年骨质疏松性患者发生骨折的曲线下面积(AUC)分别为0.856、0.830,灵敏度分别为84.42%、78.18%,特异度分别为79.23%、75.06%;两个指标联合预测的AUC为0.959,灵敏度为96.90%,特异度为85.45%。结论老年骨质疏松病人血清里面的SDC4、TNC表达水平均升高,其在老年骨质疏松病人骨折预测方面存在一定的价值。 展开更多
关键词 老年骨质疏松 sdc4 TNC 骨代谢标志物 骨折
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Absorption-Reflection-Transmission Power Coefficient Guiding Gradient Distribution of Magnetic MXene in Layered Composites for Electromagnetic Wave Absorption 被引量:3
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作者 Yang Zhou Wen Zhang +7 位作者 Dong Pan Zhaoyang Li Bing Zhou Ming Huang Liwei Mi Chuntai Liu Yuezhan Feng Changyu Shen 《Nano-Micro Letters》 2025年第6期466-481,共16页
The morphological distribution of absorbent in composites is equally important with absorbents for the overall electromagnetic properties,but it is often ignored.Herein,a comprehensive consideration including electrom... The morphological distribution of absorbent in composites is equally important with absorbents for the overall electromagnetic properties,but it is often ignored.Herein,a comprehensive consideration including electromagnetic component regulation,layered arrangement structure,and gradient concentration distribution was used to optimize impedance matching and enhance electromagnetic loss.On the microscale,the incorporation of magnetic Ni nanoparticles into MXene nanosheets(Ni@MXene)endows suitable intrinsic permittivity and permeability.On the macroscale,the layered arrangement of Ni@MXene increases the effective interaction area with electromagnetic waves,inducing multiple reflection/scattering effects.On this basis,according to the analysis of absorption,reflection,and transmission(A-R-T)power coefficients of layered composites,the gradient concentration distribution was constructed to realize the impedance matching at low-concentration surface layer,electromagnetic loss at middle concentration interlayer and microwave reflection at high-concentration bottom layer.Consequently,the layered gradient composite(LG5-10-15)achieves complete absorption coverage of X-band at thickness of 2.00-2.20 mm with RL_(min) of-68.67 dB at 9.85 GHz in 2.05 mm,which is 199.0%,12.6%,and 50.6%higher than non-layered,layered and layered descending gradient composites,respectively.Therefore,this work confirms the importance of layered gradient structure in improving absorption performance and broadens the design of high-performance microwave absorption materials. 展开更多
关键词 Magnetic MXene Layered and gradient structure Power coefficient Electromagnetic wave absorption
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结直肠癌早期筛查中SDC2基因甲基化检测的研究进展
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作者 葛子萌 刘春雷 +3 位作者 秦晓润 姚佳奇 宋懿 何玉 《临床医学进展》 2025年第5期2764-2768,共5页
结直肠癌(colorectal cancer, CRC)是全球范围内高发的恶性肿瘤之一,早期筛查是降低其发病率和死亡率的关键。近年来,基于表观遗传学的生物标志物研究为CRC筛查提供了新方向,其中SDC2 (Syndecan-2)基因甲基化检测因其高敏感性和特异性... 结直肠癌(colorectal cancer, CRC)是全球范围内高发的恶性肿瘤之一,早期筛查是降低其发病率和死亡率的关键。近年来,基于表观遗传学的生物标志物研究为CRC筛查提供了新方向,其中SDC2 (Syndecan-2)基因甲基化检测因其高敏感性和特异性备受关注。现有研究表明,SDC2甲基化在CRC早期病变(如腺瘤和癌前息肉)中已呈现异常,且可通过非侵入性粪便DNA检测实现高效筛查,然而标准化检测流程的建立和成本效益的优化仍需进一步探索。本文综述了SDC2基因在CRC发生中的甲基化机制、检测技术的优化及其临床应用进展。未来,SDC2甲基化检测有望成为CRC早期筛查的重要工具。Colorectal cancer (CRC) is one of the highly prevalent malignant tumors worldwide, and early screening is the key to reducing its morbidity and mortality. In recent years, epigenetic-based biomarker studies have provided a new direction for CRC screening, among which the SDC2 (Syndecan-2) gene methylation assay has attracted much attention due to its high sensitivity and specificity. Existing studies have shown that SDC2 methylation has been aberrant in early CRC lesions (e.g., adenomas and precancerous polyps) and can be efficiently screened by non-invasive fecal DNA testing. Still, the establishment of a standardized testing process and the optimization of cost-effectiveness need to be further explored. This article reviews the methylation mechanism of the SDC2 gene in CRC development, the optimization of detection technology, and its clinical application progress. In the future, SDC2 methylation detection is expected to become an essential tool for early screening of CRC. 展开更多
关键词 结直肠癌 sdc2基因 甲基化 早期筛查 粪便DNA检测
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血浆ctDNA Septin9、SDC2基因甲基化在结直肠癌无创筛查中的应用
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作者 刘泳心 尹卫国 +3 位作者 王攀 禤淑霞 潘秀锋 林金端 《分子诊断与治疗杂志》 2025年第11期2256-2259,共4页
目的 比较血浆ctDNA中Septin9基因甲基化(mSEPT9)、SDC2基因的甲基化(mSDC2)检测在结直肠癌(CRC)筛查中的应用,并与传统生物标志物癌胚抗原(CEA)、糖类抗原199(CA199)、粪便隐血试验(FOBT)比较,评估这些指标单独应用与联合应用在CRC无... 目的 比较血浆ctDNA中Septin9基因甲基化(mSEPT9)、SDC2基因的甲基化(mSDC2)检测在结直肠癌(CRC)筛查中的应用,并与传统生物标志物癌胚抗原(CEA)、糖类抗原199(CA199)、粪便隐血试验(FOBT)比较,评估这些指标单独应用与联合应用在CRC无创筛查中的临床应用价值。方法 收集2021年4月至2023年10月清远市人民医院诊治的260例结直肠癌病变患者及同期48例健康体检者的临床资料,用McNemar检验分析血浆mSEPT9和mSDC2检测效能的一致性,并与传统CRC生物标志物比较,评估各指标单独及联合应用的诊断效能。结果 mSEPT9和mSDC2的阳性率分别为25.3%和16.6%,差异有统计学意义(χ^(2)=7.148,P<0.05),两种方法的Kappa值为0.564,其检测结果具有中等一致性;两者的阳性率与CRC所在解剖位置无关,差异无统计学意义(P>0.05),mSDC2对于左半结肠癌的阳性率高于mSEPT9,差异有统计学意义(χ^(2)=0.174,P<0.05),mSEPT9对于右半结肠和直肠的阳性率优于mSDC2,差异有统计学意义(χ^(2)=4.819、4.935,P<0.05)。mSEPT9与CRC肿瘤生长类型有关,mSEPT9在胶样型(100%)的阳性率最高,其次是浸润型(50%),差异具有统计学意义(χ^(2)=10.227,P<0.05)。FOBT的阳性率在CRC的不同临床分期均较高,CEA和CA199阳性率在癌前病变组较高,5项联合检测的阳性率最高,其中Septin9基因与SDC2基因联合检测的阳性率均高于单基因检测。结论 血浆ctDNA mSEPT9与FOBT联合检测能够提高CRC的灵敏度和特异性,为CRC早期筛查和诊断提供重要的临床价值。 展开更多
关键词 结直肠癌 Septin9基因 sdc2基因 早期筛查 癌胚抗原 糖类抗原199
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Study on the variation of the permeability coefficient of soil-rock mixtures in fault zones under different stress states 被引量:1
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作者 Wenhui Tan Shuang Liang +1 位作者 Xuewen Ma Pengfei Wang 《Deep Underground Science and Engineering》 2025年第2期210-221,共12页
As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted ... As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted structure coupled with the overlying water.As the mining proceeds deeper,the risk of water inrush increases.The mine's maximum water yield reaches 15000 m3/day,which is attributable to water channels present in fault zones.Predominantly composed of soil–rock mixtures(SRM),these fault zones'seepage characteristics significantly impact water inrush risk.Consequently,investigating the seepage characteristics of SRM is of paramount importance.However,the existing literature mostly concentrates on a single stress state.Therefore,this study examined the characteristics of the permeability coefficient under three distinct stress states:osmotic,osmotic–uniaxial,and osmotic–triaxial pressure.The SRM samples utilized in this study were extracted from in situ fault zones and then reshaped in the laboratory.In addition,the micromechanical properties of the SRM samples were analyzed using computed tomography scanning.The findings reveal that the permeability coefficient is the highest under osmotic pressure and lowest under osmotic–triaxial pressure.The sensitivity coefficient shows a higher value when the rock block percentage ranges between 30%and 40%,but it falls below 1.0 when this percentage exceeds 50%under no confining pressure.Notably,rock block percentages of 40%and 60%represent the two peak points of the sensitivity coefficient under osmotic–triaxial pressure.However,SRM samples with a 40%rock block percentage consistently show the lowest permeability coefficient under all stress states.This study establishes that a power function can model the relationship between the permeability coefficient and osmotic pressure,while its relationship with axial pressure can be described using an exponential function.These insights are invaluable for developing water inrush prevention and control strategies in mining environments. 展开更多
关键词 permeability coefficient rock block percentage sensitivity analysis soil-rock mixture stress state
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Numerical Methods for Boundary Value Problems in Variable Coefficient Ordinary Differential Equations 被引量:1
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作者 ZHAO Ting-ting CAI Wei-yun 《Chinese Quarterly Journal of Mathematics》 2025年第3期295-303,共9页
In order to solve the problem of the variable coefficient ordinary differen-tial equation on the bounded domain,the Lagrange interpolation method is used to approximate the exact solution of the equation,and the error... In order to solve the problem of the variable coefficient ordinary differen-tial equation on the bounded domain,the Lagrange interpolation method is used to approximate the exact solution of the equation,and the error between the numerical solution and the exact solution is obtained,and then compared with the error formed by the difference method,it is concluded that the Lagrange interpolation method is more effective in solving the variable coefficient ordinary differential equation. 展开更多
关键词 Variable coefficient ordinary differential equations Lagrange interpolation Difference methods
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Role of disturbance coefficient in monitoring and treatment of cerebral edema in patients with cerebral hemorrhage 被引量:1
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作者 Wen-Wen Gao Xiao-Bing Jiang +9 位作者 Peng Chen Liang Zhang Lei Yang Zhi-Hai Yuan Yao Wei Xiao-Qiang Li Xiao-Lu Tang Feng-Lu Wang Hao Wu Hai-Kang Zhao 《World Journal of Clinical Cases》 2025年第14期16-24,共9页
BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral... BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment. 展开更多
关键词 Noninvasive cerebral edema monitor Disturbance coefficient HYPERTENSION Cerebral hemorrhage Cerebral edema MANNITOL
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基于SDC-IC准则的T管氦冷偏滤器单元结构优化分析
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作者 胡华枫 王晓涛 +2 位作者 周晓剑 彭慧 栗再新 《核安全》 2025年第2期70-78,共9页
偏滤器是聚变堆中承受高热负荷的主要部件之一,被用于处理等离子体排出时的高热负荷,因此,偏滤器的设计对于聚变装置的稳定运行至关重要。在T管氦冷偏滤器单元结构中,钨被用于钨瓦结构以承受大量的热负荷,氦气作为冷却剂带走钨瓦表面的... 偏滤器是聚变堆中承受高热负荷的主要部件之一,被用于处理等离子体排出时的高热负荷,因此,偏滤器的设计对于聚变装置的稳定运行至关重要。在T管氦冷偏滤器单元结构中,钨被用于钨瓦结构以承受大量的热负荷,氦气作为冷却剂带走钨瓦表面的热量。为确保偏滤器在高热运行工况下的稳定性,本文基于SDC-IC准则对优化前后偏滤器单元的机械性能开展了分析对比评估。分析结果表明,优化后的T管氦冷偏滤器单元结构性能更好,其结果为未来偏滤器的热—结构分析工作提供参考。 展开更多
关键词 T管偏滤器单元 sdc-IC准则 热—机械性能分析 结构优化
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血清SDC-1、MCP-1和毛细血管渗漏指数与脓毒症并发急性呼吸窘迫综合征关系研究
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作者 陈东升 李宝山 李学柱 《陕西医学杂志》 2025年第8期1061-1065,共5页
目的:探讨血清多配体蛋白聚糖-1(SDC-1)、单核细胞趋化蛋白-1(MCP-1)和毛细血管渗漏指数与脓毒症并发急性呼吸窘迫综合征(ARDS)的关系。方法:选取脓毒症患者118例,根据是否并发ARDS将患者分为ARDS组(46例)和非ARDS组(72例)。比较两组患... 目的:探讨血清多配体蛋白聚糖-1(SDC-1)、单核细胞趋化蛋白-1(MCP-1)和毛细血管渗漏指数与脓毒症并发急性呼吸窘迫综合征(ARDS)的关系。方法:选取脓毒症患者118例,根据是否并发ARDS将患者分为ARDS组(46例)和非ARDS组(72例)。比较两组患者血清SDC-1、MCP-1水平和毛细血管渗漏指数。采用多因素Logistic回归分析脓毒症患者并发ARDS的影响因素。血清SDC-1、MCP-1、毛细血管渗漏指数对脓毒症患者并发ARDS的预测价值通过绘制受试者工作特征(ROC)曲线进行分析。结果:两组血清SDC-1、MCP-1水平、毛细血管渗漏指数比较,非ARDS组低于ARDS组(均P<0.05)。ARDS组低氧合指数低于非ARDS组,急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)、序贯器官衰竭评估(SOFA)高于非ARDS组(均P<0.05)。脓毒症患者并发ARDS的独立影响因素包括氧合指数、APACHEⅡ评分、SOFA评分、毛细血管渗漏指数、血清SDC-1及MCP-1(均P<0.05)。血清SDC-1、MCP-1、毛细血管渗漏指数单独及联合预测脓毒症患者并发ARDS的曲线下面积(AUC)分别为0.833、0.818、0.708、0.932,且联合预测价值最高(均P<0.05)。结论:血清SDC-1、MCP-1和毛细血管渗漏指数与脓毒症患者并发ARDS有关,且三者联合对脓毒症并发ARDS具有一定预测价值。 展开更多
关键词 脓毒症 急性呼吸窘迫综合征 多配体蛋白聚糖-1 单核细胞趋化蛋白-1 毛细血管渗漏指数 预测价值
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Role of variation coefficient of stone density in determining success of shock wave lithotripsy in urinary calculi 被引量:1
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作者 Nadeem Iqbal Aisha Hasan +2 位作者 Sajid Iqbal Sadaf Noureen Saeed Akhter 《World Journal of Nephrology》 2025年第1期110-118,共9页
BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free r... BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes. 展开更多
关键词 Computed tomography Shock wave lithotripsy Stone heterogeneity Variation coefficient of stone density Kidney stones
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Prediction of joint roughness coefficient via hybrid machine learning model combined with principal components analysis 被引量:1
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作者 Shijie Xie Hang Lin +2 位作者 Tianxing Ma Kang Peng Zhen Sun 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第4期2291-2306,共16页
Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC... Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability. 展开更多
关键词 Rock discontinuities Joint roughness coefficient(JRC) Roughness characterization Principal components analysis(PCA) Machine learning
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A Programming Method for Mean Behavior of Fourier Coefficients of Modular Forms on Sparse Sequences
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作者 HU Yuanrui YAO Weili 《数学进展》 北大核心 2025年第4期709-724,共16页
Let f be a primitive holomorphic cusp form with even integral weight k≥2 for the full modular groupΓ=SL(2,Z)andλ_(sym^(j)f)(n)be the n-th coefficient of Dirichlet series of j-th symmetric L-function L(s,sym^(j)f)at... Let f be a primitive holomorphic cusp form with even integral weight k≥2 for the full modular groupΓ=SL(2,Z)andλ_(sym^(j)f)(n)be the n-th coefficient of Dirichlet series of j-th symmetric L-function L(s,sym^(j)f)attached to f.In this paper,we study the mean value distribution over a specific sparse sequence of positive integers of the following sum∑(a^(2)+b^(2)+c^(2)+d^(2)≤x(a,b,c,d)∈Z^(4))λ_(sym^(j))^(i)f(a^(2)+b^(2)+c^(2)+d^(2))where j≥2 is a given positive integer,i=2,3,4 andαis sufficiently large.We utilize Python programming to design algorithms for higher power conditions,combining Perron's formula,latest results of representations of natural integers as sums of squares,as well as analytic properties and subconvexity and convexity bounds of automorphic L-functions,to ensure the accuracy and verifiability of asymptotic formulas.The conclusion we obtained improves previous results and extends them to a more general settings. 展开更多
关键词 automorphic L-function holomorphic cusp form Fourier coefficient
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