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Neutron‑gamma density measurement method using the mass attenuation coefficient function
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作者 Jun‑Yan Chen Qiong Zhang 《Nuclear Science and Techniques》 2026年第1期180-192,共13页
Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging tec... Although traditional gamma-gamma density(GGD)logging technology is widely utilized,its potential environmental risks have prompted the development of more environmentally friendly neutron-gamma density(NGD)logging technology.However,NGD measurements are influenced by both neutron and gamma radiations.In the logging environment,variations in the formation composition indicate different elemental compositions,which affect the neutron-gamma reaction cross-sections and gamma generation.Compared to traditional gamma sources such as Cs-137,these changes significantly affect the generation and transport of neutron-induced inelastic gamma rays and hinder accurate measurements.To address this,a novel method is proposed that incorporates the mass attenuation coefficient function to account for the effects of various lithologies and pore contents on gamma-ray attenuation,thereby achieving more accurate density measurements by clarifying the transport processes of inelastic gamma rays with varying energies and spatial distributions in varied logging environments.The proposed method avoids the complex correction of neutron transport and is verified through Monte Carlo simulations for its applicability across various lithologies and pore contents,demonstrating absolute density errors that are less than 0.02 g/cm^(3)in clean formations and indicating good accuracy.This study clarifies the NGD mechanism and provides theoretical guidance for the application of NGD logging methods.Further studies will be conducted on extreme environmental conditions and tool calibration. 展开更多
关键词 Neutron-gamma density Mass attenuation coefficient Monte Carlo simulation
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CEA、CYFRA211、NSE,SCC联合检测在肺癌早期诊断中的价值研究
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作者 李艳 张倩 常青 《航空航天医学杂志》 2025年第11期1332-1334,共3页
目的探讨癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)联合检测在肺癌早期诊断中的价值。方法回顾性选择本院2022年05月-2025年03月收治的82例肺癌患者作为肺癌组,另选取同期80名健康... 目的探讨癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)联合检测在肺癌早期诊断中的价值。方法回顾性选择本院2022年05月-2025年03月收治的82例肺癌患者作为肺癌组,另选取同期80名健康体检者作为对照组。对比两组基线资料、实验室指标;采用多因素Logistic模型分析肺癌发生的影响因素;采用ROC曲线分析CEA、CYFRA211、NSE、SCC联合对肺癌发生的预测价值。结果两组基线资料(年龄、性别、体质量、吸烟史)对比无差异(均P>0.05)。肺癌组CEA、CYFRA211、NSE、SCC均高于对照组(P<0.05)。Logistic显示,CEA、CYFRA211、NSE、SCC均为肺癌发生的独立影响因素(P<0.05)。ROC曲线结果显示,CEA、CYFRA211、NSE、SCC联合诊断肺癌发生的敏感度及特异度分别是90.24%、91.25%,AUC达0.921,高于CEA(Z/P=2.452/0.024)、CYFRA211(Z/P=3.667/0.009)、NSE(Z/P=4.037/0.005)、(Z/P=6.578/<0.001)单独诊断。结论CEA、CYFRA211、NSE、SCC在肺癌患者中呈高表达,且四项指标联合检验诊断肺癌效能较高。 展开更多
关键词 肺癌 诊断 CEA CYFRA211 NSE scc
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DSCC剪力墙在弹性基底上的局部屈曲特性
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作者 赵钦 张仕祥 周佳 《浙江工业大学学报》 北大核心 2025年第3期272-283,共12页
针对设置拉结件的钢板在弹性基底上的局部稳定问题,首先,根据能量变分原理建立了在轴向压力作用下,考虑弹性基底和拉结件拉力的钢板局部屈曲非线性特征方程及其伽辽金表达式;其次,通过Matlab进行牛顿迭代得到了钢板的屈曲应力和变形模态... 针对设置拉结件的钢板在弹性基底上的局部稳定问题,首先,根据能量变分原理建立了在轴向压力作用下,考虑弹性基底和拉结件拉力的钢板局部屈曲非线性特征方程及其伽辽金表达式;其次,通过Matlab进行牛顿迭代得到了钢板的屈曲应力和变形模态;再次,经过对所得变形曲面的分析,得出了钢板在不同拉结件布置方法下的3种典型屈曲模态;最后,引入板件有效宽度法则,通过瑞利-里兹法推导出了不同模态下组合板的局部失稳临界荷载计算公式,进而得到了组合板在轴向受压状态下纵、横两个方向拉结件最大间距的限制要求。结果表明:当拉结件设置达到4排后非加载边的边界条件对钢板屈曲荷载的影响可以忽略;在拉结件排列密度相同的情况下,当拉结件纵、横向间距之比β为0.6~1.2时,交错排列下的钢板屈曲应力达到最大值,此时板件实际的屈曲系数约为5.8,拉结件正交排列时板件的屈曲系数最大值大致相同,此时其纵、横向间距之比β约为0.6。 展开更多
关键词 双钢板-混凝土组合板 能量法 屈曲系数 拉结件间距 数值模拟
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SCC-3737℃驯化的稳定性及其在常见病毒培养中的应用
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作者 巩金鹏 赵颖 +7 位作者 陈雪兰 蔺凌云 姚嘉赟 穆雪姣 周可欣 王丛旭 沈锦玉 潘晓艺 《水产学报》 北大核心 2025年第3期233-242,共10页
【目的】建立能快速增殖且对鳜源常见病毒敏感的鳜鱼细胞系。【方法】利用已建立的鳜脊髓组织细胞系SCC,采用梯度血清逐步驯化的方式,建立一个连续细胞系SCC-37,分析该连续细胞系的来源、支原体污染、生长特性和冻存后细胞活力,评估其... 【目的】建立能快速增殖且对鳜源常见病毒敏感的鳜鱼细胞系。【方法】利用已建立的鳜脊髓组织细胞系SCC,采用梯度血清逐步驯化的方式,建立一个连续细胞系SCC-37,分析该连续细胞系的来源、支原体污染、生长特性和冻存后细胞活力,评估其对传染性脾肾坏死病毒(ISKNV)、鳜虹彩病毒(SCRaV)和鳜弹状病毒(SCRV)的敏感性。【结果】该细胞系SCC-37已连续培养30代,稳定的生长条件为L-15+10%NBCS、37℃培养;通过鳜28S rRNA基因分析其来源于鳜,支原体检测证实SCC-37无支原体污染;病毒敏感性结果显示,ISKNV、SCRaV和SCRV可在SCC-37中稳定增殖和传代,培养的病毒滴度为103.4~109.6TCID50/mL,电镜观察可见大量病毒颗粒。【结论】新驯化的SCC-37为分离、鉴定和增殖病毒以及疫苗制备提供了重要工具。 展开更多
关键词 鳜脊髓组织细胞系 37℃驯化 生长特性 敏感性
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竹节香附素A通过诱导细胞焦亡对口腔癌SCC25细胞生长的抑制作用 被引量:1
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作者 李一竹 谭婧玉 +1 位作者 黄建华 刘海文 《中成药》 北大核心 2025年第1期278-282,共5页
目的探索竹节香附素A对口腔癌SCC25细胞增殖及焦亡的影响。方法MTT法检测不同浓度及浓度为IC 50时竹节香附素A作用0、3、6、12、24 h后对细胞增殖的影响,细胞克隆形成实验检测细胞集落形成能力,荧光探针DCFH-DA检测细胞内ROS水平,LDH释... 目的探索竹节香附素A对口腔癌SCC25细胞增殖及焦亡的影响。方法MTT法检测不同浓度及浓度为IC 50时竹节香附素A作用0、3、6、12、24 h后对细胞增殖的影响,细胞克隆形成实验检测细胞集落形成能力,荧光探针DCFH-DA检测细胞内ROS水平,LDH释放实验检测细胞上清液中LDH水平,Western blot法检测焦亡相关蛋白NLRP3、ASC、Caspase-1、IL-1β、IL-18、GSDMD表达。结果竹节香附素A可抑制SCC25细胞增殖,且呈浓度和时间依赖性(P<0.01);降低细胞集落形成能力(P<0.01),升高ROS水平和LDH活性(P<0.05,P<0.01),上调NLRP3、ASC、Caspase-1、IL-1β、IL-18、GSDMD蛋白表达(P<0.05);加入NLRP3特异性抑制剂MCC950后,与竹节香附素A组比较,竹节香附素A+MCC950组细胞NLRP3、Caspase-1蛋白表达降低(P<0.05)。结论竹节香附素A通过促进SCC25细胞内ROS的累积诱导细胞焦亡,其机制可能与激活ROS/NLRP3/Caspase-1信号通路有关。 展开更多
关键词 竹节香附素A 口腔癌 scc25细胞 焦亡 ROS/NLRP3/Caspase-1信号通路
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血清CEA、CA125、NSE、SCC、CYFRA21-1水平与肺癌患者肿瘤恶性程度及术后复发的关系分析 被引量:5
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作者 童列杏 李景然 +1 位作者 刘伟 陈闫 《中南医学科学杂志》 2025年第2期341-344,共4页
目的 分析血清肿瘤标志物癌胚抗原[(CEA)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)]水平与肺癌患者肿瘤恶性程度及术后复发的关系。方法 选取本院收治拟行手术治... 目的 分析血清肿瘤标志物癌胚抗原[(CEA)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)]水平与肺癌患者肿瘤恶性程度及术后复发的关系。方法 选取本院收治拟行手术治疗肺癌患者188例为观察组,纳入同期良性肺部疾病患者150例为对照组。比较两组间及观察组不同肿瘤分期以及观察组复发与未复发患者血清肿瘤标志物水平;分析血清肿瘤标志物指标与肺癌患者肿瘤恶性程度的相关性以及对术后复发的预测价值。结果 观察组血清肿瘤标志物水平均高于对照组(P<0.05),且其水平随着T分期进展而升高(P<0.05),与肿瘤恶性程度呈正相关(P<0.05)。随访1年,188例肺癌术后患者中复发69例,复发组患者血清肿瘤标志物水平高于未复发者(P<0.05)。ROC曲线结果显示,血清肿瘤标志物对肺癌患者术后复发的联合预测价值高于各项指标单独预测价值(P<0.05)。结论 肺癌患者血清CEA、CA125、NSE、SCC、CYFRA21-1水平升高与肿瘤恶性程度呈正相关;并具有预测肺癌术后复发的临床价值,且其联合预测价值高于其单独预测价值。 展开更多
关键词 肺癌 癌胚抗原 糖类抗原125 神经元特异性烯醇化酶 鳞状细胞癌抗原 细胞角质蛋白19片段抗原21-1
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高中信息技术SCCS教学模式分析
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作者 陆红玉 《文理导航》 2025年第26期85-87,共3页
随着我国社会不断发展与进步,教育行业也迎来了新的发展机遇与挑战。教育行业想要在新时代背景下提高自身的教学质量和教学效率,就要注重教学模式的创新。高中阶段作为学生学习的重要阶段,高中学校也应注重全方位的教学优化。通过注重... 随着我国社会不断发展与进步,教育行业也迎来了新的发展机遇与挑战。教育行业想要在新时代背景下提高自身的教学质量和教学效率,就要注重教学模式的创新。高中阶段作为学生学习的重要阶段,高中学校也应注重全方位的教学优化。通过注重信息技术课程的开展,就能有效推动学生的高质量发展,学生可以更好地满足新时代对人才提出的新标准。SCCS教学模式是一种先进的教学模式,能让高中学校的信息技术课程更好地满足实际的教育教学需求。本文阐述了SCCS教学模式和高中信息技术教学存在的问题,并从多方面概括了高中信息技术SCCS教学模式设计策略,希望能够具有一定的参考价值。 展开更多
关键词 高中 信息技术 sccS 教学模式
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Absorption-Reflection-Transmission Power Coefficient Guiding Gradient Distribution of Magnetic MXene in Layered Composites for Electromagnetic Wave Absorption 被引量:3
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作者 Yang Zhou Wen Zhang +7 位作者 Dong Pan Zhaoyang Li Bing Zhou Ming Huang Liwei Mi Chuntai Liu Yuezhan Feng Changyu Shen 《Nano-Micro Letters》 2025年第6期466-481,共16页
The morphological distribution of absorbent in composites is equally important with absorbents for the overall electromagnetic properties,but it is often ignored.Herein,a comprehensive consideration including electrom... The morphological distribution of absorbent in composites is equally important with absorbents for the overall electromagnetic properties,but it is often ignored.Herein,a comprehensive consideration including electromagnetic component regulation,layered arrangement structure,and gradient concentration distribution was used to optimize impedance matching and enhance electromagnetic loss.On the microscale,the incorporation of magnetic Ni nanoparticles into MXene nanosheets(Ni@MXene)endows suitable intrinsic permittivity and permeability.On the macroscale,the layered arrangement of Ni@MXene increases the effective interaction area with electromagnetic waves,inducing multiple reflection/scattering effects.On this basis,according to the analysis of absorption,reflection,and transmission(A-R-T)power coefficients of layered composites,the gradient concentration distribution was constructed to realize the impedance matching at low-concentration surface layer,electromagnetic loss at middle concentration interlayer and microwave reflection at high-concentration bottom layer.Consequently,the layered gradient composite(LG5-10-15)achieves complete absorption coverage of X-band at thickness of 2.00-2.20 mm with RL_(min) of-68.67 dB at 9.85 GHz in 2.05 mm,which is 199.0%,12.6%,and 50.6%higher than non-layered,layered and layered descending gradient composites,respectively.Therefore,this work confirms the importance of layered gradient structure in improving absorption performance and broadens the design of high-performance microwave absorption materials. 展开更多
关键词 Magnetic MXene Layered and gradient structure Power coefficient Electromagnetic wave absorption
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Study on the variation of the permeability coefficient of soil-rock mixtures in fault zones under different stress states 被引量:1
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作者 Wenhui Tan Shuang Liang +1 位作者 Xuewen Ma Pengfei Wang 《Deep Underground Science and Engineering》 2025年第2期210-221,共12页
As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted ... As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted structure coupled with the overlying water.As the mining proceeds deeper,the risk of water inrush increases.The mine's maximum water yield reaches 15000 m3/day,which is attributable to water channels present in fault zones.Predominantly composed of soil–rock mixtures(SRM),these fault zones'seepage characteristics significantly impact water inrush risk.Consequently,investigating the seepage characteristics of SRM is of paramount importance.However,the existing literature mostly concentrates on a single stress state.Therefore,this study examined the characteristics of the permeability coefficient under three distinct stress states:osmotic,osmotic–uniaxial,and osmotic–triaxial pressure.The SRM samples utilized in this study were extracted from in situ fault zones and then reshaped in the laboratory.In addition,the micromechanical properties of the SRM samples were analyzed using computed tomography scanning.The findings reveal that the permeability coefficient is the highest under osmotic pressure and lowest under osmotic–triaxial pressure.The sensitivity coefficient shows a higher value when the rock block percentage ranges between 30%and 40%,but it falls below 1.0 when this percentage exceeds 50%under no confining pressure.Notably,rock block percentages of 40%and 60%represent the two peak points of the sensitivity coefficient under osmotic–triaxial pressure.However,SRM samples with a 40%rock block percentage consistently show the lowest permeability coefficient under all stress states.This study establishes that a power function can model the relationship between the permeability coefficient and osmotic pressure,while its relationship with axial pressure can be described using an exponential function.These insights are invaluable for developing water inrush prevention and control strategies in mining environments. 展开更多
关键词 permeability coefficient rock block percentage sensitivity analysis soil-rock mixture stress state
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Numerical Methods for Boundary Value Problems in Variable Coefficient Ordinary Differential Equations 被引量:1
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作者 ZHAO Ting-ting CAI Wei-yun 《Chinese Quarterly Journal of Mathematics》 2025年第3期295-303,共9页
In order to solve the problem of the variable coefficient ordinary differen-tial equation on the bounded domain,the Lagrange interpolation method is used to approximate the exact solution of the equation,and the error... In order to solve the problem of the variable coefficient ordinary differen-tial equation on the bounded domain,the Lagrange interpolation method is used to approximate the exact solution of the equation,and the error between the numerical solution and the exact solution is obtained,and then compared with the error formed by the difference method,it is concluded that the Lagrange interpolation method is more effective in solving the variable coefficient ordinary differential equation. 展开更多
关键词 Variable coefficient ordinary differential equations Lagrange interpolation Difference methods
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Role of disturbance coefficient in monitoring and treatment of cerebral edema in patients with cerebral hemorrhage 被引量:1
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作者 Wen-Wen Gao Xiao-Bing Jiang +9 位作者 Peng Chen Liang Zhang Lei Yang Zhi-Hai Yuan Yao Wei Xiao-Qiang Li Xiao-Lu Tang Feng-Lu Wang Hao Wu Hai-Kang Zhao 《World Journal of Clinical Cases》 2025年第14期16-24,共9页
BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral... BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment. 展开更多
关键词 Noninvasive cerebral edema monitor Disturbance coefficient HYPERTENSION Cerebral hemorrhage Cerebral edema MANNITOL
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Role of variation coefficient of stone density in determining success of shock wave lithotripsy in urinary calculi 被引量:1
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作者 Nadeem Iqbal Aisha Hasan +2 位作者 Sajid Iqbal Sadaf Noureen Saeed Akhter 《World Journal of Nephrology》 2025年第1期110-118,共9页
BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free r... BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free rates.AIM To assess the role of VCSD in determining success of SWL in urinary calculi.METHODS Charts review was utilized for collection of data variables.The patients were subjected to SWL,using an electromagnetic lithotripter.Mean stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)images.Role of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically significant.RESULTS There were a total of 407 patients included in the analysis.The mean age of the subjects in this study was 38.89±14.61 years.In total,165 out of the 407 patients could not achieve stone free status.The successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes. 展开更多
关键词 Computed tomography Shock wave lithotripsy Stone heterogeneity Variation coefficient of stone density Kidney stones
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肺鳞癌患者新辅助免疫治疗联合化疗前后血清CEA、CA-125、SCC表达变化及其临床意义
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作者 刘东海 《实用癌症杂志》 2025年第10期1606-1610,共5页
目的 探讨肺鳞癌患者新辅助免疫治疗联合化疗前后血清癌胚抗原(CEA)、癌抗原125(CA-125)、鳞状上皮细胞癌抗原(SCC)水平的变化及其临床意义。方法 选取80例接受新辅助免疫治疗联合化疗的肺鳞癌患者血清样本,单中心、回顾性队列分析CEA、... 目的 探讨肺鳞癌患者新辅助免疫治疗联合化疗前后血清癌胚抗原(CEA)、癌抗原125(CA-125)、鳞状上皮细胞癌抗原(SCC)水平的变化及其临床意义。方法 选取80例接受新辅助免疫治疗联合化疗的肺鳞癌患者血清样本,单中心、回顾性队列分析CEA、CA-125、SCC水平表达,以治疗周期结束后疾病是否进展为标准分析CEA、CA-125、SCC预测新辅助免疫化疗疗效,绘制受试者操作特性曲线(ROC)。结果 治疗后疾病进展29例归为疾病进展组,余51例(63.75%)归为未进展组,2组间肿瘤分期具有统计差异(P<0.05)。治疗前后疾病进展组和未进展组CEA、SCC、CA-125水平均存在统计差异(P<0.05),但2组治疗前后各指标变化率比较无差异(P>0.05)。多因素逻辑回归分析结果表明治疗前血清CEA、SCC、CA-125表达水平与治疗后疾病进展具有相关性(P<0.05),利用治疗前血清CEA、SCC、CA-125表达绘制ROC曲线,CEA检测ROC曲线下面积(AUC)为0.897,截断值为4.89 ng/ml;SCC检测AUC为0.920,截断值为2.35 ng/ml;CA-125检测AUC为0.761,截断值为29.33 U/ml;联合检测AUC为0.997。结论 血清CEA、CA-125、SCC水平对肺鳞癌患者新辅助免疫治疗疗效有一定评估作用。 展开更多
关键词 NSCLC 肺鳞癌 新辅助免疫化疗 CEA CA-125 scc
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Prediction of joint roughness coefficient via hybrid machine learning model combined with principal components analysis 被引量:1
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作者 Shijie Xie Hang Lin +2 位作者 Tianxing Ma Kang Peng Zhen Sun 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第4期2291-2306,共16页
Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC... Joint roughness coefficient(JRC)is the most commonly used parameter for quantifying surface roughness of rock discontinuities in practice.The system composed of multiple roughness statistical parameters to measure JRC is a nonlinear system with a lot of overlapping information.In this paper,a dataset of eight roughness statistical parameters covering 112 digital joints is established.Then,the principal component analysis method is introduced to extract the significant information,which solves the information overlap problem of roughness characterization.Based on the two principal components of extracted features,the white shark optimizer algorithm was introduced to optimize the extreme gradient boosting model,and a new machine learning(ML)prediction model was established.The prediction accuracy of the new model and the other 17 models was measured using statistical metrics.The results show that the prediction result of the new model is more consistent with the real JRC value,with higher recognition accuracy and generalization ability. 展开更多
关键词 Rock discontinuities Joint roughness coefficient(JRC) Roughness characterization Principal components analysis(PCA) Machine learning
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血清AFP、CA125、CA19-9、SCC、NSE、CYFRA21-1联合检测在肺癌诊断中的应用价值
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作者 孟盈君 苌哲宗 +1 位作者 杜帅格 王耀飞 《实用癌症杂志》 2025年第8期1295-1299,共5页
目的探讨血清AFP、CA125、CA19-9、SCC、NSE、CYFRA21-1联合检测在肺癌诊断中的应用价值。方法选取108例肺癌患者作为肺癌组,同期选取60例肺部良性病变者作为良性组、30例健康体检者作为对照组,采用全自动电化学发光免疫分析仪检测血清... 目的探讨血清AFP、CA125、CA19-9、SCC、NSE、CYFRA21-1联合检测在肺癌诊断中的应用价值。方法选取108例肺癌患者作为肺癌组,同期选取60例肺部良性病变者作为良性组、30例健康体检者作为对照组,采用全自动电化学发光免疫分析仪检测血清AFP、CA125、CA19-9、SCC、NSE、CYFRA21-1水平,统计不同组别、不同临床分期、不同淋巴结转移患者血清肿瘤标志物水平。ROC曲线分析血清SCC、NSE、CYFRA21-1单独以及联合检测诊断肺癌的价值。结果3组SCC、NSE、CYFRA21-1水平比较,差异有统计学意义(P<0.05),其中肺癌组SCC、NSE、CYFRA21-1水平均显著高于对照组和良性组;3组AFP、CA125、CA19-9比较,差异无统计学意义(P>0.05)。3组SCC、NSE、CYFRA21-1阳性表达率比较,差异有统计学意义(P<0.05),其中肺癌组SCC、NSE、CYFRA21-1阳性表达率均显著高于对照组和良性组;3组AFP、CA125、CA19-9阳性表达率比较,差异无统计学意义(P>0.05)。Ⅲ~Ⅳ期血清SCC、NSE、CYFRA21-1水平高于Ⅰ~Ⅱ期(P<0.05);不同分期患者血清AFP、CA125、CA19-9比较,差异无统计学意义(P>0.05)。有淋巴结转移患者血清SCC、NSE、CYFRA21-1水平高于无淋巴结转移患者(P<0.05);不同淋巴结转移患者血清AFP、CA125、CA19-9比较,差异无统计学意义(P>0.05)。ROC曲线显示,血清SCC、NSE、CYFRA21-1水平联合诊断肺癌的AUC为0.867,灵敏度为0.833,特异度为0.822,95%CI为0.809~0.925,P<0.001。结论血清SCC、NSE、CYFRA21-1联合检测在肺癌的诊断中具有较高的敏感性和特异性,能够有效区分肺癌患者与良性肺部病变患者及健康对照者,有助于早期发现肺癌。 展开更多
关键词 肺癌 AFP CA125 CA19-9 scc NSE CYFRA21-1 诊断
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A Programming Method for Mean Behavior of Fourier Coefficients of Modular Forms on Sparse Sequences
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作者 HU Yuanrui YAO Weili 《数学进展》 北大核心 2025年第4期709-724,共16页
Let f be a primitive holomorphic cusp form with even integral weight k≥2 for the full modular groupΓ=SL(2,Z)andλ_(sym^(j)f)(n)be the n-th coefficient of Dirichlet series of j-th symmetric L-function L(s,sym^(j)f)at... Let f be a primitive holomorphic cusp form with even integral weight k≥2 for the full modular groupΓ=SL(2,Z)andλ_(sym^(j)f)(n)be the n-th coefficient of Dirichlet series of j-th symmetric L-function L(s,sym^(j)f)attached to f.In this paper,we study the mean value distribution over a specific sparse sequence of positive integers of the following sum∑(a^(2)+b^(2)+c^(2)+d^(2)≤x(a,b,c,d)∈Z^(4))λ_(sym^(j))^(i)f(a^(2)+b^(2)+c^(2)+d^(2))where j≥2 is a given positive integer,i=2,3,4 andαis sufficiently large.We utilize Python programming to design algorithms for higher power conditions,combining Perron's formula,latest results of representations of natural integers as sums of squares,as well as analytic properties and subconvexity and convexity bounds of automorphic L-functions,to ensure the accuracy and verifiability of asymptotic formulas.The conclusion we obtained improves previous results and extends them to a more general settings. 展开更多
关键词 automorphic L-function holomorphic cusp form Fourier coefficient
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钢纤维自密实混凝土(SFRSCC)工作性和力学性能研究进展
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作者 郑昊 张国辉 +2 位作者 孙俊崇 顾德锦 顾艳霜 《混凝土与水泥制品》 2025年第11期57-61,共5页
介绍了钢纤维自密实混凝土(Steel fiber reinforced self-compacting concrete,SFRSCC)的工作性(坍落扩展度、扩展时间、J环扩展度)和力学性能(抗压、抗拉和弯曲性能)研究进展,重点分析了SF掺量对SFRSCC性能的影响规律,揭示了SF的作用机... 介绍了钢纤维自密实混凝土(Steel fiber reinforced self-compacting concrete,SFRSCC)的工作性(坍落扩展度、扩展时间、J环扩展度)和力学性能(抗压、抗拉和弯曲性能)研究进展,重点分析了SF掺量对SFRSCC性能的影响规律,揭示了SF的作用机理,并对SFRSCC的未来研究方向进行了展望。 展开更多
关键词 钢纤维(SF) 自密实混凝土(scc) 工作性 力学性能 作用机理
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An Improved Repetitive-Control System Using a Complex-Coefficient Filter 被引量:1
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作者 Qicheng Mei Jinhua She +1 位作者 Fei Long Yanjun Shen 《IEEE/CAA Journal of Automatica Sinica》 2025年第1期282-284,共3页
Dear Editor,This letter presents an improved repetitive controller(IRC) that uses a complex-coefficient filter to enhance the tracking performance of a system for periodic signals. Compared with the low-pass filter us... Dear Editor,This letter presents an improved repetitive controller(IRC) that uses a complex-coefficient filter to enhance the tracking performance of a system for periodic signals. Compared with the low-pass filter used in the conventional repetitive controller(CRC), the complex-coefficient filter causes less change in the phase and amplitude of a signal at the frequencies of the periodic signal, especially at the fundamental frequency, when the two filters have the same cutofffrequency. 展开更多
关键词 improved repetitive controller irc periodic signals repetitive control system complex coefficient filter tracking performance conventional repetitive controller crc periodic signal enhance tracking performance
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AAVC-I通过ERK1/2/MAPK信号通路抑制人口腔鳞状细胞癌SCC4、Cal27细胞增殖迁移的作用研究
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作者 韦玲杰 张明宇 +4 位作者 陶志豪 王梦雨 燕静静 王心怡 柴琳 《中国临床药理学与治疗学》 北大核心 2025年第11期1516-1523,共8页
目的:探究皖南尖吻蝮蛇毒抑瘤组分I(AAVC-I)能否抑制人口腔鳞状细胞癌SCC4、Cal27细胞的增殖迁移及其是否通过ERK1/2/MAPK信号通路抑制其增殖迁移。方法:将不同浓度的AAVCI(0、2.5、5、10、20、40μg/mL)作用于人口腔鳞状细胞癌SCC4、Ca... 目的:探究皖南尖吻蝮蛇毒抑瘤组分I(AAVC-I)能否抑制人口腔鳞状细胞癌SCC4、Cal27细胞的增殖迁移及其是否通过ERK1/2/MAPK信号通路抑制其增殖迁移。方法:将不同浓度的AAVCI(0、2.5、5、10、20、40μg/mL)作用于人口腔鳞状细胞癌SCC4、Cal27细胞24 h后,通过CCK-8、EDU-488实验检测细胞增殖能力,通过流式细胞术检测细胞凋亡情况,通过Transwell实验检测细胞侵袭能力,通过划痕实验检测细胞迁移能力,通过Western blot实验检测MAPK信号通路中相关蛋白的表达情况。结果:不同浓度的AAVC-I(0、2.5、5、10、20、40μg/mL)作用于人口腔鳞状细胞癌SCC4、Cal27细胞24 h后,实验组与正常对照组相比较,其结果显示,随着AAVC-I浓度的增高,人口腔鳞状细胞癌SCC4、Cal27细胞的增殖、侵袭迁移能力逐渐减弱,凋亡百分率逐渐增高,MAPK信号通路中的MEK1、ERK1/2的表达量无明显变化,而磷酸化的MEK1和磷酸化的ERK1/2随着药物浓度增高,其表达水平下调。结论:AAVC-I可抑制人口腔鳞状细胞癌SCC4、Cal27细胞的增殖、侵袭迁移,其抑制细胞增殖、侵袭迁移的机制可能与ERK1/2/MAPK信号通路密切相关。 展开更多
关键词 AAVC-I scc4、Cal27细胞 侵袭迁移 ERK1/2/MAPK信号通路
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Growth Parameters and Condition Coefficient of Three Species from Bas-Kouilou (Congo Brazzaville): Chrysichthys auratus, Geoffroy, 1809, Liza falcipinnis, Valenciennes, 1836 and Pellonula vorax, Gunther, 1868
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作者 Marcellin Mikia Anthelme Tsoumou +1 位作者 Durelle Brith Caëlle Olabi-Obath Isabelle Mady-Goma Dirat 《Open Journal of Ecology》 2025年第1期100-114,共15页
The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of... The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of Chrysichthys auratus varies between 43.57 and 210 mm, for an average of 96.70 ± 28.63 mm;the weight varies between 2.92 and 140.83 mg, an average of 73.03 ± 21.62 mg. The condition coefficient is equal to 4.42 ± 1.52. Liza falcipinnis has a standard length which varies between 59.9 mm and 158.08 mm for an average of 88.15 ± 29.74 mm;its weight varies between 4.77 and 76.21 mg, an average of 18.61 ± 11.82 mg. The condition coefficient is equal to 2.47 ± 1.57. Pellonula vorax has a standard length which varies between 60.33 mm and 117.72 mm;for an average of 80.48 ± 17.75 mm;the weight varies between 3.61 and 25.17 mg, an average of 9.03 ± 3.61 mg. The condition coefficient is equal to 2.17 ± 0.57. These three species have a minor allometric growth. 展开更多
关键词 Kouilou River Chrysichthys auratus Liza falcipinnis Pellonula vorax Growth Parameters Condition coefficient
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