Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early v...Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant.展开更多
In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alteration...In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alterations of ocular aberration and crystalline lens biometry during dynamic acoommodative stimuli,we designed an optical coberence tomography with ultra-long penetration depth(UL-OCT)combined with a Shack-Hartmann wavefront sensor(SHWFS).This integrated set up measures human eye's anterior segment as well as mono-chromatie high-order aberrations(HOAs)with 6 um resolution and(1/20)λaccuracy.A total of 10 healthy volunteers without ocular diseases were examined.Upon exposure to accommodative stimuli,the wavefront aberrations became larger.Among the anterior segment biometry,the anterior crystalline lens demonstrated significant curvature during accommodation and was the major cause of high-order aberration.These findings suggest that the front surface of the crys-talline lens can siguificantly affect variation among aberrations,which is a key factor underlying the quality of human vision.展开更多
基金supported by the Jiangsu Province Science Fund for Distinguished Young Scholars(BK20060010)the Frontier Science Research project of the Chinese Academy of Sciences(QYZDBS-SWJSC03)+2 种基金the National Natural Science Foundation of China(61675226)the National Key R&D Program of China(2017YFC0108200,2017YFB0403700)the Jiangsu Province Key R&D Program(BE2018667).
文摘Melanoma,characterized by high mortality,rapid development and accompanied with angio-genesis is the most typical malignant tumor in skin cancer.Hence,the detection of blood vessels is of much significanoe.The early vascular network has small scale.If we remove the tumor early and biopsy it,it will increase the spread of the cancer cells and infection and bleeding.In this case,we presented a new angiography method.A high-resolution OCT system for noninvasive an-giographic imaging of early skin melanoma-Swept Source Optical Coberence Tomography Angiography(SS-OCTA)is proposed.With a high lateral resolution of 10pm in vrivo tomographic angiography,SS-OCTA is used to image and identify the morphology of the early tumor blood vessels.In addition,a control group experiment is conducted to observe the growth of melanoma in the process of rupture,malormation of micro-vessels.The results of the analysis and statistical test(P<0.05)are statistically signifcant.
基金support from the Zhejiang Province Science and Technology Development (Grant No.2013C33170)the Zhejiang Provincial Natural Science Foundation of China (Grant No.Y1110383)the Wenzhou Science and Technology Development (Grant No.Y20100174).
文摘In the human eye,accommodation is essential for functional vision.However,the mechanisms regulating accommodation and the ocular parameters afcting aberrations remain to be ex-plored.In order to measure the alterations of ocular aberration and crystalline lens biometry during dynamic acoommodative stimuli,we designed an optical coberence tomography with ultra-long penetration depth(UL-OCT)combined with a Shack-Hartmann wavefront sensor(SHWFS).This integrated set up measures human eye's anterior segment as well as mono-chromatie high-order aberrations(HOAs)with 6 um resolution and(1/20)λaccuracy.A total of 10 healthy volunteers without ocular diseases were examined.Upon exposure to accommodative stimuli,the wavefront aberrations became larger.Among the anterior segment biometry,the anterior crystalline lens demonstrated significant curvature during accommodation and was the major cause of high-order aberration.These findings suggest that the front surface of the crys-talline lens can siguificantly affect variation among aberrations,which is a key factor underlying the quality of human vision.
