Advanced propulsion systems experience critical challenges under extreme service conditions,including aerodynamic loads and thermal loads.Especially,flutter stability is a key bottleneck restricting the design and saf...Advanced propulsion systems experience critical challenges under extreme service conditions,including aerodynamic loads and thermal loads.Especially,flutter stability is a key bottleneck restricting the design and safe op⁃eration of hot structures in advanced propulsion systems employing ceramic matrix composites(CMCs).Compared to traditional nickel-based alloys,CMCs offer superior high-temperature resistance and specific strength,making them ideal for next-generation engine hot structures.The inherent anisotropy,heterogeneity,and complex nonlinear behav⁃ior of CMCs,coupled with extreme operating environments,result in strong multi-physics interactions,including aero-thermo-structural,thermo-mechanical,and damage-aeroelastic coupling.These complexities significantly com⁃plicate vibration stability and flutter analysis.The recent research progresses on these problems are systematically ex⁃amined,focusing on multi-field coupling mechanisms,material constitutive and damage evolution models,multi-scale modeling methods,coupled solution strategies,and the influence of key parameters on flutter characteristics.The current challenges are highlighted,including the complexity of high-temperature nonlinear modeling,the effi⁃ciency of multi-field coupling calculations,and the multi-scale modeling of complex weaving structures.Finally,an outlook on future development directions is presented to provide theoretical support for the design and safety assess⁃ment of hot structures of advanced CMCs.展开更多
In the emerging world of biotech innovation, the fast-to-clinic/market strategy has emerged as a critical “mantra” for biotech, investors, and CDMOs. This approach addresses the escalating costs and complexities of ...In the emerging world of biotech innovation, the fast-to-clinic/market strategy has emerged as a critical “mantra” for biotech, investors, and CDMOs. This approach addresses the escalating costs and complexities of research and development by streamlining the path from concept to clinical trials and, ultimately, to market. The article delves into the intricacies of implementing a fast-to-clinic/market strategy, underlining the empowering role of strategic decision-making in preclinical and commercial stages. The plan advocates for a phase-appropriate approach, where the development decision is tailored to each phase of the product’s lifecycle. This ensures that resources are allocated efficiently, risks are managed effectively, and the product can move through the development pipeline accelerated without compromising quality or regulatory compliance. The article also discusses the role of CDMOs in facilitating rapid product development and the essential factors biotech companies must consider when selecting a partner for outsourcing. These factors include the CDMO’s expertise in navigating regulatory landscapes, technological capabilities, and ability to scale processes efficiently. Moreover, the article stresses the importance of agility and flexibility in the fast-to-clinic/market approach. Biotech companies are encouraged to adopt adaptable strategies that respond to the fast-evolving regulatory and market landscapes.展开更多
The development of science and technology has made it not only possible but very convenient for people living in different parts of the world to communicate with each other, thus bringing forth a new form of communica...The development of science and technology has made it not only possible but very convenient for people living in different parts of the world to communicate with each other, thus bringing forth a new form of communication: computer-mediated communication (CMC). Text-based CMC is one of the most popular forms of CMC in which people send instant messages to others in different settings. Since this mode of interaction combines features of both the written and spoken language (Greenfield & Subrahmanyam, 2003), it's of great interest whether it follows the same sequential rule as the telephone conversation. However, compared to telephone conversations, computer-mediated communication has received much less attention, let alone text-based CMC. The existing body of literature mostly focuses on content analysis and linguistic features but neglects the sequential organization of such interaction (Paolillo, 1999; Greenfield and Subrahmanyam, 2003; Herring, 1999). In light of this, this paper examines the opening moves of instant message exchanges among Chinese adults in an attempt to find out the unique features characterizing the way they open an online chat. The framework that was chosen for data analysis was the sequential model proposed by Schegloff for American telephone openings.展开更多
基金supported by the Na⁃tional Science and Technology Major Project(No.Y2019-Ⅰ⁃0018-0017)the National Natural Science Foundation of China(No.U24A2051)+2 种基金the Natural Science Foundation of Jiangsu Province(No.BK20232037)the Foundation of Key Laboratory of Aero-engine Thermal Environment and Structure,Ministry of Industry and Information Technology(No.CEPE2024002)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KY⁃CX24_0605)。
文摘Advanced propulsion systems experience critical challenges under extreme service conditions,including aerodynamic loads and thermal loads.Especially,flutter stability is a key bottleneck restricting the design and safe op⁃eration of hot structures in advanced propulsion systems employing ceramic matrix composites(CMCs).Compared to traditional nickel-based alloys,CMCs offer superior high-temperature resistance and specific strength,making them ideal for next-generation engine hot structures.The inherent anisotropy,heterogeneity,and complex nonlinear behav⁃ior of CMCs,coupled with extreme operating environments,result in strong multi-physics interactions,including aero-thermo-structural,thermo-mechanical,and damage-aeroelastic coupling.These complexities significantly com⁃plicate vibration stability and flutter analysis.The recent research progresses on these problems are systematically ex⁃amined,focusing on multi-field coupling mechanisms,material constitutive and damage evolution models,multi-scale modeling methods,coupled solution strategies,and the influence of key parameters on flutter characteristics.The current challenges are highlighted,including the complexity of high-temperature nonlinear modeling,the effi⁃ciency of multi-field coupling calculations,and the multi-scale modeling of complex weaving structures.Finally,an outlook on future development directions is presented to provide theoretical support for the design and safety assess⁃ment of hot structures of advanced CMCs.
文摘In the emerging world of biotech innovation, the fast-to-clinic/market strategy has emerged as a critical “mantra” for biotech, investors, and CDMOs. This approach addresses the escalating costs and complexities of research and development by streamlining the path from concept to clinical trials and, ultimately, to market. The article delves into the intricacies of implementing a fast-to-clinic/market strategy, underlining the empowering role of strategic decision-making in preclinical and commercial stages. The plan advocates for a phase-appropriate approach, where the development decision is tailored to each phase of the product’s lifecycle. This ensures that resources are allocated efficiently, risks are managed effectively, and the product can move through the development pipeline accelerated without compromising quality or regulatory compliance. The article also discusses the role of CDMOs in facilitating rapid product development and the essential factors biotech companies must consider when selecting a partner for outsourcing. These factors include the CDMO’s expertise in navigating regulatory landscapes, technological capabilities, and ability to scale processes efficiently. Moreover, the article stresses the importance of agility and flexibility in the fast-to-clinic/market approach. Biotech companies are encouraged to adopt adaptable strategies that respond to the fast-evolving regulatory and market landscapes.
文摘The development of science and technology has made it not only possible but very convenient for people living in different parts of the world to communicate with each other, thus bringing forth a new form of communication: computer-mediated communication (CMC). Text-based CMC is one of the most popular forms of CMC in which people send instant messages to others in different settings. Since this mode of interaction combines features of both the written and spoken language (Greenfield & Subrahmanyam, 2003), it's of great interest whether it follows the same sequential rule as the telephone conversation. However, compared to telephone conversations, computer-mediated communication has received much less attention, let alone text-based CMC. The existing body of literature mostly focuses on content analysis and linguistic features but neglects the sequential organization of such interaction (Paolillo, 1999; Greenfield and Subrahmanyam, 2003; Herring, 1999). In light of this, this paper examines the opening moves of instant message exchanges among Chinese adults in an attempt to find out the unique features characterizing the way they open an online chat. The framework that was chosen for data analysis was the sequential model proposed by Schegloff for American telephone openings.
