BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequen...BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequently influenced by the patient's nutritional status and the quality of nursing care provided.AIM To examine the comprehensive impact of personalized nutritional support and nursing strategies on the postoperative rehabilitation of patients with liver cancer.METHODS In this study,a retrospective comparative analysis was conducted involving 60 post-operative liver cancer patients.The subjects were selected as subjects and divided into two groups based on differing nursing interventions,with each group comprising 30 patients.The control group received standard nutritional support and care,whereas the experimental group received individualized nutritional support and nursing strategies.The study aimed to evaluate the impact of individualized nutrition by comparing the rehabilitation indices,nutritional status,quality of life(QoL),and complication rates between the two groups.RESULTS The results showed that the recovery index of the experimental group was significantly better than that of the control group 2 weeks after surgery,and the average liver function recovery index of the experimental group was 85.significantly higher than that of the control group(73.67±7.19).In terms of nutritional status,the serum albumin level and body weight stabilization rate of the experimental group were also significantly higher than those of the control group,which were 42.33±2.4 g/L and 93.3%,respectively,compared with 36.01±3.85 g/L and 76.7%of the control group.In addition,the average QoL score of the experimental group was 84.66±3.7 points,which was significantly higher than that of the control group(70.92±4.28 points).At the psychological level,the average anxiety score of the experimental group was 1.17±0.29,and the average depression score was 1.47±0.4,which were significantly lower than the 2.26±0.42 and 2.57±0.45 of the control group.This showed that patients in the experimental group were better relieved of anxiety and depression under the individualized nutrition support and nursing strategy.More importantly,the complication rate in the experimental group was only 10%,much lower than the 33.3%in the control group.CONCLUSION Personalized nutritional support and tailored nursing strategies significantly enhance the postoperative rehabilitation of liver cancer patients.Consequently,it is recommended to implement and advocate for these individualized approaches to improve both the recovery outcomes and QoL for these patients.展开更多
An aluminoborate,Na_(2.5)Rb[Al{B_(5)O_(10)}{B_(3)O_(5)}]·0.5NO_(3)·H_(2)O(1),was synthesized under hydrothermal condition,which was built by mixed oxoboron clusters and AlO_(4)tetrahedra.In the structure,the...An aluminoborate,Na_(2.5)Rb[Al{B_(5)O_(10)}{B_(3)O_(5)}]·0.5NO_(3)·H_(2)O(1),was synthesized under hydrothermal condition,which was built by mixed oxoboron clusters and AlO_(4)tetrahedra.In the structure,the[B_(5)O_(10)]^(5-)and[B_(3)O_(7)]^(5-)clusters are alternately connected to form 1D[B_(8)O_(15)]_(n)^(6n-)chains,which are further linked by AlO_(4)units to form a 2D monolayer with 7‑membered ring and 10‑membered ring windows.Two adjacent monolayers with opposite orientations further form a porous‑layered structure with six channels through B—O—Al bonds.Compound 1 was characterized by single crystal X‑ray diffraction,powder X‑ray diffraction(PXRD),IR spectroscopy,UV‑Vis diffuse reflection spectroscopy,and thermogravimetric analysis(TGA),respectively.UV‑Vis diffuse reflectance analysis indicates that compound 1 shows a wide transparency range with a short cutoff edge of 201 nm,suggesting it may have potential application in UV regions.CCDC:2383923.展开更多
Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as...Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as the strongly enhanced synergistic interactions between Pt and Co atoms,the obtained Pt-on-Co/C400 catalysts exhib-ited excellent catalytic activity toward the hydrolysis of ammonia borane with an extremely high turnover frequency(TOF)value of 3022 min^(-1)at 303 K.Durability test indicated that the obtained Pt-on-Co/C400 catalysts possessed high catalytic stability,and there were no changes in the catalyst structures and catalytic activities after 10 cycles.展开更多
Animals can differ in their individual movement behaviors during their daily displacements.Studies of animal movement patterns often disregard the need to understand individual variation in these patterns and the role...Animals can differ in their individual movement behaviors during their daily displacements.Studies of animal movement patterns often disregard the need to understand individual variation in these patterns and the role of this variation in shaping population distributions of movements.To assess the link between individual movements and population distributions,we radio-tracked 13 Fowler's Toads Anaxyrus fowleri in Long Point,Ontario,Canada,after their breeding season.We recorded individual coordinates every 30 min,from the moment they emerged from their burrows around dusk until they burrowed in the morning,and obtained a total of 157 movements.We used the resulting series of step lengths and turning angles in a Hidden Markov Model to estimate movement type as"directed"or"non-directed"We also assigned to each encounter one of 3 space-dependent movement states:"foraging""in transit'or"searching"and found that movement type and state switched within individuals irrespective of time during a single night.We find that switching between movement types varied throughout the night,leading to stochastic within-individual variation in movements,and the distribution of movement distances differed significantly among individuals.Movement states,however,were time-dependent,suggesting displacement routines were similar across individuals.Variation in movement behavior within individuals scales up to result in variation among individuals which,in turn,was found to shape the distribution of the sampled population.Our findings therefore underline the importance of a multi-scale approach in the study of movement.展开更多
Accurate description of noncova-lent interactions in large systems is challenging due to the require-ment of high-level electron corre-lation methods.The generalized energy-based fragmentation(GEBF)approach,in conjunc...Accurate description of noncova-lent interactions in large systems is challenging due to the require-ment of high-level electron corre-lation methods.The generalized energy-based fragmentation(GEBF)approach,in conjunc-tion with the domain-based local pair natural orbital(DLPNO)method,has been applied to assess the average binding energies(ABEs)of large benzene clus-ters,specifically(C6H6)13,at the coupled cluster singles and doubles with perturbative triples correction[CCSD(T)]level and the complete basis set(CBS)limit.Utilizing GEBF-DLPNO-CCSD(T)/CBS ABEs as benchmarks,various DFT functionals were evaluated.It was found that several functionals with empirical dispersion correction,including M06-2X-D3,B3LYP-D3(BJ),and PBE-D3(BJ),provide accurate descriptions of the ABEs for(C6H6)13 clusters.Additionally,the M06-2X-D3 functional was used to calculate the ABEs and relative stabili-ties of(C6H6)n clusters for n=11,12,13,14,and 15 revealing that the(C6H6)13 cluster ex-hibits the highest relative stability.These findings align with experimental evidence suggest-ing that n=13 is one of the magic numbers for benzene clusters(C6H6)n,with n≤30.展开更多
Vocal individuality is essential for social discrimination but has been poorly studied in animals that produce communal signals(duets or choruses).Song overlapping and temporal coordination make the assessment of indi...Vocal individuality is essential for social discrimination but has been poorly studied in animals that produce communal signals(duets or choruses).Song overlapping and temporal coordination make the assessment of individuality in communal signals more complex.In addition,selection may favor the accurate identifcation of pairs over individuals by receivers in year-round territorial species with duetting and long-term pair bonding.Here,we studied pair and individual vocal signatures in the polyphonal duets of rufous horneros Furnarius rufus,a Neotropical bird known for its long-term pair bonds.Hornero partners engage in duets to deter territorial intruders and protect their partnership year-round and can discern duets from neighbors versus strangers.Using a dataset of 471 duets from 43 pairs in 2 populations,we measured fne-scale acoustic features across different duet levels(e.g.,complete duets to non-overlapping syllable parts)and analysis levels(pair or individual).Permuted linear discriminant function analyses classifed pairs and individuals more accurately than expected by chance(means:45%and 47%vs.4 and 2%).Pair identity explained more variance in the multivariate acoustic features of duets than individual or population identities.The initial frequency of the duet showed strong potential for encoding pair identity.The acoustic traits contributing most to individual vocal signatures varied between sexes,which might facilitate the simultaneous assessment of duetters’identities by receivers.Our study indicates that vocal individuality may exist even in species with intricate and innate communal signals and elucidates the mechanisms employed by horneros in their social discrimination ability.展开更多
BACKGROUND Magnetic resonance imaging(MRI)and endoscopic ultrasonography(EUS)are recommended in combination for screening pancreatic cancer in high-risk individuals.However,in clinical practice,MRI and EUS are increas...BACKGROUND Magnetic resonance imaging(MRI)and endoscopic ultrasonography(EUS)are recommended in combination for screening pancreatic cancer in high-risk individuals.However,in clinical practice,MRI and EUS are increasingly utilized for pancreatic surveillance during routine health examinations.AIM To investigate the feasibility of these imaging modalities for screening in low-risk individuals.METHODS This retrospective study included patients at low risk for pancreatic cancer who underwent MRI or EUS at two health evaluation centers between March 2019 and December 2024.Basic characteristics,laboratory data,and imaging results were collected.RESULTS A total of 3364 low-risk individuals underwent pancreatic screening:1553(46.1%)received MRI,and 1811 underwent EUS.No significant differences were observed in age or sex distribution between the groups.In imaging screening,EUS demonstrated a higher detection rate of abnormal pancreatic lesions(12.8%vs 2.6%;P<0.001).MRI detected more cystic lesions than did EUS(P<0.001).EUS identified smaller nodular lesions compared to MRI(9.2 mm vs 18.0 mm;P=0.044).The MRI group had a higher number of confirmed intraductal papillary mucinous neoplasms(P=0.031),whereas the EUS group identified more suspected branch-duct intraductal papillary mucinous neoplasms(P<0.001).Pancreatic adenocarcinoma was found in three patients(0.08%),with no significant difference in detection rates between EUS and MRI(0.11%vs 0.06%;P=0.656).CONCLUSION In low-risk individuals,MRI and EUS offer comparable effectiveness for pancreatic cancer surveillance.The choice of imaging strategy for health evaluation depends on cost considerations and degree of invasiveness.展开更多
Light hydrocarbons(LHs)are key components of petroleum,and the carbon isotopes composition(δ^(13)C)of individual LHs contains a wealth of geochemical information.Forty-four oil samples from five different basins were...Light hydrocarbons(LHs)are key components of petroleum,and the carbon isotopes composition(δ^(13)C)of individual LHs contains a wealth of geochemical information.Forty-four oil samples from five different basins were analyzed using gas chromatography(GC),gas chromatography-mass spectrometry(GC–MS),and gas chromatography-isotope ratio mass spectrometry(GC-IRMS).Theδ^(13)C values of forty-three LHs were recognized and determined by comparing the GC and GC-IRMS methods.The results revealed significant differences inδ^(13)C distribution characteristics among different LH compounds.Theδ^(13)C variation of individual LHs in iso-paraffins showed the widest range,followed by cycloalkanes and aromatics,whereas theδ^(13)C variation in n-paraffins showed the narrowest range.Theδ^(13)C values of most individual LHs are primarily affected by the source facies and thermal evolution.Among them,c-1,3-dimethylcyclohexane(c-1,3DMCH)is mainly sourced from higher plants but may also form through abiotic mechanisms such as catalysis or cyclization.Theδ^(13)C values of c-1,3DMCH(δ^(13)Cc-1,3DMCH)primarily exhibit parental genetic characteristics,enabling effective distinction of oil from different source facies.Specifically,theδ^(13)Cc-1,3DMCH in marine oils,lacustrine oils,terrigenous oils,and coal-formed oils are<–22‰,from–22‰to−20.2‰,from−20.2‰to−18.4‰,and>−18.4‰,respectively.Moreover,maturity is the primary controlling factor forδ^(13)C values of 3MC7(δ^(13)C3MC7,3MC7:3-methylheptane),while the source facies serve as a secondary influence.The plot ofδ^(13)Cc-1,3DMCH andδ^(13)C3MC7 was introduced to classify source facies.Asδ^(13)Cc-1,3DMCH andδ^(13)C3MC7 increase,the source facies transits from marine to lacustrine,then terrigenous,and finally coal facies.Additionally,increasingδ^(13)C3MC7 indicates a relative increase in maturity.Therefore,theδ^(13)Cc-1,3DMCH vs.δ^(13)C3MC7 plot serves as an effective tool for distinguishing source facies and assessing relative maturity.展开更多
Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of ...Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.展开更多
The theory of human dignity identifies certain inherent human characteristics,elevating humanity as the pinnacle of creation and valuing individuals as carriers of these traits.Under this framework,individuals are cal...The theory of human dignity identifies certain inherent human characteristics,elevating humanity as the pinnacle of creation and valuing individuals as carriers of these traits.Under this framework,individuals are called to actively embody their human essence and participate in political life to serve the community.Overall,this interpretive paradigm of dignity establishes a distinct concept of autonomy and provides methods for its realization,fostering the secularization of politics by emphasizing human value.The doctrine of individual dignity presupposes the intrinsic worth of individuals and defends their autonomy and equal status through the imposition of legal obligations on the state.However,limited by its essentialist and communitarian orientation,the scope of autonomy and equality it provides to individuals remains constrained.By transcending ontology with a value-based approach,the concept of individual dignity creates a unique,open structure that incorporates and reflects on global human rights practices.This adaptability enables it to integrate abstract societies,advance the global human rights agenda,and critique and refine political realities.Consequently,the concept of individual dignity cannot be supplanted by the human dignity theory.展开更多
Objective This study aimed to investigate the prevalence of HIV pretreatment drug resistance(PDR)and the transmission clusters associated with PDR-related mutations in newly diagnosed,treatmentnaive patients between 2...Objective This study aimed to investigate the prevalence of HIV pretreatment drug resistance(PDR)and the transmission clusters associated with PDR-related mutations in newly diagnosed,treatmentnaive patients between 2020 and 2023 in Dehong prefecture,Yunnan province,China.Methods Demographic information and plasma samples were collected from study participants.PDR was assessed using the Stanford HIV Drug Resistance Database.The Tamura-Nei 93 model within HIVTRACE was employed to compute pairwise matches with a genetic distance of 0.015 substitutions per site.Results Among 948 treatment-naive individuals with eligible sequences,36 HIV subtypes were identified,with unique recombinant forms(URFs)being the most prevalent(18.8%,178/948).The overall prevalence of PDR was 12.4%(118/948),and resistance to non-nucleotide reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)was10.7%,1.3%,and 1.6%,respectively.A total of 91 clusters were identified,among which eight showed evidence of PDR strain transmission.The largest PDR-associated cluster consisted of six CRF01_AE drugresistant strains carrying K103N and V179T mutations;five of these individuals had initial CD4^(+)cell counts<200 cells/μL.Conclusion The distribution of HIV subtypes in Dehong is diverse and complex.PDR was moderately prevalent(12.4%)between 2020 and 2023.Evidence of transmission of CRF01_AE strains carrying K103N and V179T mutations was found.Routine surveillance of PDR and the strengthening of control measures are essential to limit the spread of drug-resistance HIV strains.展开更多
Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sect...Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sectional data from seven geographical regions across Chinese mainland.The Changsha version of the Montreal Cognitive Assessment was used to assess cognitive function.A“least absolute shrinkage and selection operator”(LASSO)model,multivariate linear regression analysis,and random forest(RF)model were used.Subgroup analyses were performed to examine the correlation between key TCM constitution types and cognitive function in different population subgroups.Results:A total of 24803 individuals aged 60 and above were included in the study.We selected 18 influential factors using the LASSO model.Higher education,being married,and having insurance were positively correlated with cognitive function in the elderly(all P<0.05).In contrast,poor sleep,vision impairment,hearing impairment,basic activities of daily living disability,instrumental activities of daily living disability,depression,hypertension,coronary heart disease,diabetes,stroke,yang-deficiency constitution(YADC),yin-deficiency constitution(YIDC),qi deficiency constitution(QDC),and blood stasis constitution(BSC)were negatively correlated with cognitive function(all P<0.05).YIDC and BSC affected all dimensions of cognitive function(all P<0.05).YADC mainly affected attention,language,abstraction(verbal analogies),memory,and orientation to time and place dimensions(P<0.001).QDC mainly affected language and abstraction(verbal analogies)dimensions(P<0.05).The negative correlations between BSC,YADC,YIDC,and QDC scores and cognitive function revealed statistically significant dif-ferences across most subgroups.The RF model identified education,BSC,and poor sleep quality as the three most influential factors in our study.Conclusion:BSC,YADC,YIDC,and QDC were associated with cognitive decline in the elderly.Our findings provide new perspectives and significant references for interventions for early-stage cognitive disorders.展开更多
LiNO_(3) is known to significantly enhance the reversibility of lithium metal batteries;however,the modification of solvation structures in various solvents and its further impact on the interface have not been fully ...LiNO_(3) is known to significantly enhance the reversibility of lithium metal batteries;however,the modification of solvation structures in various solvents and its further impact on the interface have not been fully revealed.Herein,we systematically studied the evolution of solvation structures with increasing LiNO_(3) concentration in both carbonate and ether electrolytes.The results from molecular dynamics simulations unveil that the Li^(+)solvation structure is less affected in carbonate electrolytes,while in ether electrolytes,there is a significant decrease of solvent molecules in Li^(+)coordination,and a larger average size of Li^(+)solvation structure emerges as LiNO_(3) concentration increases.Notably,the formation of large ion aggregates with size of several nanometers(nano-clusters),is observed in ether-based electrolytes at conventional Li^(+)concentration(1 M)with higher NO_(3)^(-) ratio,which is further proved by infrared spectroscopy and small-angle X-ray scattering experiments.The nano-clusters with abundant anions are endowed with a narrow energy gap of molecular orbitals,contributing to the formation of an inorganic rich electrode/electrolyte interphase that enhances the reversibility of lithium stripping/plating with Coulombic efficiency up to 99.71%.The discovery of nano-clusters elucidates the underlying mechanism linking ions/solvent aggregation states of electrolytes to interfacial stability in advanced battery systems.展开更多
Objectives:This study aimed to determine the effectiveness of an individual and family selfmanagement(IFSM)education program on triglyceride-glucose(TyG)index,self-management,and diabetes distress among adults with un...Objectives:This study aimed to determine the effectiveness of an individual and family selfmanagement(IFSM)education program on triglyceride-glucose(TyG)index,self-management,and diabetes distress among adults with uncontrolled diabetes mellitus type 2(T2DM).Methods:A multicentre randomized controlled trial was employed.The study included 68 dyads(adults with uncontrolled T2DM and one family member)that were randomly allocated to the intervention(n=34)and control groups(n=34)from March to September 2024.Participants in the intervention group received an 8-week IFSM education program,whereas those in the control group received standard routine care.An automated hematology analyzer XP-100 was used to evaluate triglyceride and fasting blood glucose levels.The Diabetes Distress Scale and Diabetes Self-Management Questionnaire were used to measure diabetes distress and self-management,respectively.Results:A total of 67 participants completed the intervention.The generalized estimating equation demonstrated a significantinteraction between group and time.The IFSM education intervention group had a higher diabetes self-management(β=16.68;95%CI=15.23,18.09;P<0.001),lower diabetes distress(β=-30.74;95%CI=-32.57,-28.90;P<0.001),and lower TyG index(β=-1.97;95%CI=-2.41,-1.53;P<0.001)than the control group.Conclusions:The findingsdocumented the capacity of IFSM education to reduce TyG and diabetes distress,which could potentially escalate diabetes self-management among individuals with T2DM.展开更多
Objective:This study aims to investigate the patterns of symptom occurrence in patients experiencing acute exacerbations of chronic obstructive pulmonary disease(AECOPD).It will explore the composition of symptom clus...Objective:This study aims to investigate the patterns of symptom occurrence in patients experiencing acute exacerbations of chronic obstructive pulmonary disease(AECOPD).It will explore the composition of symptom clusters and analyze the correlation between these clusters and health-related quality of life(HRQoL).Methods:A total of 207 patients with AE-COPD were surveyed from a tertiary grade A hospital.Data collection was conducted using three validated instruments:the Basic Information Questionnaire(BIQ),Disease Symptom Survey Questionnaire(MSAS),and Quality of Life Questionnaire(CAT).Statistical software SPSS 22.0 was used to analyze the correlation between symptom clusters and quality of life.Results:Exploratory factor analysis showed that five major symptom clusters existed in the patients,including the psycho-emotional symptom cluster,the sleep-related symptom cluster,the other side effects symptom cluster,the energy deficiency symptom cluster and the cough-loss of appetite symptom cluster,and the severity of the symptom clusters showed a significant negative correlation with the quality of life of the patients(P<0.05).Conclusion:Strengthening the comprehensive management of symptom clusters in patients with AE-COPD can help to effectively reduce the symptom burden of patients,and then significantly improve their quality of life.展开更多
Two-dimensional(2D)materials loaded with single atoms and clusters are being set at the forefront of catalysis due to their distinctive geometric and electronic features.However,the usually-complicated synthesis proce...Two-dimensional(2D)materials loaded with single atoms and clusters are being set at the forefront of catalysis due to their distinctive geometric and electronic features.However,the usually-complicated synthesis procedures impede in-depth clarification of their catalytic mechanisms.To this end,herein we developed an efficient one-step dimension-reduction carbonization strategy,with which we successfully architected a highly-efficient catalyst for oxygen reduction reaction(ORR),featured with symbiotic cobalt single atoms and clusters decorated in two-dimensional(2D)ultra-thin(3.5 nm thickness)nitrogen-carbon nanosheets.The synergistic effects of the two components afford excellent oxygen reduction activity in alkaline media(E_(1/2)=0.823 V vs.RHE)and thereof a high power density(146.61 mW cm^(-2))in an assembled Zn-air battery.As revealed by theoretical calculations,the cobalt clusters can regulate electrons surrounding those individual atoms and affect the adsorption of intermediate species.As a consequence,the derived active sites of single cobalt atoms lead to a significant improvement of the ORR performance.Thus,our work may fuel interests to delicate architectu re of single atoms and clusters coexisting 2D support toward optimal electrocatalytic performance.展开更多
We investigated the ionization and dissociation processes of ammonia clusters ranging from dimer to pentamer induced by 800-nm femtosecond laser fields.Time-of-flight(TOF)mass spectra of the ammonia clusters were reco...We investigated the ionization and dissociation processes of ammonia clusters ranging from dimer to pentamer induced by 800-nm femtosecond laser fields.Time-of-flight(TOF)mass spectra of the ammonia clusters were recorded over a range of laser intensities from 2.1×10^(12)W/cm^(2) to 5.6×10^(12)W/cm^(2).The protonated ion signals dominate the spectra,which is consistent with the stability of the geometric structures.The ionization and dissociation channels of ammonia clusters are discussed.The competition and switching among observed dissociation channels are revealed by analyzing the variations in the relative ionic yields of specific protonated and unprotonated clusters under different laser intensities.These results indicate that the ionization of the neutral multiple-ammonia units,produced through the dissociation of cluster ions,may start to contribute,as well as the additional processes to consume protonated ions and/or produce unprotonated ions induced by the femtosecond laser fields when the laser intensity is above^4×10^(12)W/cm^(2).These findings provide deeper insights into the ionization and dissociation dynamics in multi-photon ionization experiments involving ammonia clusters.展开更多
Surface-supported clusters forming by aggregation of excessive adatoms could be the main defects of 2D materials after chemical vapor deposition.They will significantly impact the electronic/magnetic properties.Moreov...Surface-supported clusters forming by aggregation of excessive adatoms could be the main defects of 2D materials after chemical vapor deposition.They will significantly impact the electronic/magnetic properties.Moreover,surface supported atoms are also widely explored for high active and selecting catalysts.Severe deformation,even dipping into the surface,of these clusters can be expected because of the very active edge of clusters and strong interaction between supported clusters and surfaces.However,most models of these clusters are supposed to simply float on the top of the surface because ab initio simulations cannot afford the complex reconstructions.Here,we develop an accurate graph neural network machine learning potential(MLP)from ab initio data by active learning architecture through fine-tuning pre-trained models,and then employ the MLP into Monte Carlo to explore the structural evolutions of Mo and S clusters(1-8 atoms)on perfect and various defective MoS2 monolayers.Interestingly,Mo clusters can always sink and embed themselves into MoS2 layers.In contrast,S clusters float on perfect surfaces.On the defective surface,a few S atoms will fill the vacancy and rest S clusters float on the top.Such significant structural reconstructions should be carefully taken into account.展开更多
Atrial fibrillation(AF)is a growing global health burden,with a prevalence of over 52.55 million cases.Rising disability-adjusted life-years,increasing age,and disparities in care have contributed to the worsening sev...Atrial fibrillation(AF)is a growing global health burden,with a prevalence of over 52.55 million cases.Rising disability-adjusted life-years,increasing age,and disparities in care have contributed to the worsening severity and mortality of AF.Modifiable risk factors,such as hypertension,obesity,and diabetes mellitus,are associated with alterations in gut microbiota,making the gut-heart axis a potential therapeutic target.Gut dysbiosis influences AF pathogenesis through inflam-mation,metabolic disruption,and autonomic dysfunction.Key mechanisms include gut barrier dysfunction,short-chain fatty acid(SCFA)depletion,lipopoly-saccharides(LPS)-induced inflammation,and ferroptosis-mediated atrial remodeling.Trimethylamine N-oxide,bile acids,and tryptophan metabolites contribute to arrhythmogenic remodeling.Emerging evidence suggests that dietary interventions,including prebiotics and probiotics,as well as gut surveillance,may help mitigate AF progression.Clinical implications of gut modulation in AF include person-alized dietary strategies,microbiome assessment through metagenomic sequencing,and targeted interventions such as SCFA-based therapies and ferroptosis inhibition.Metabolite surveillance,including LPS and indoxyl sulfate monitoring,may influence the effectiveness of anticoagulant and antiarrhythmic therapy.Despite growing mechanistic evidence linking gut dysbiosis to AF,clinical applications remain unexplored.This review summarizes the current understanding of the gut microbiome's role in AF.展开更多
Dispersing metals from nanoparticles to clusters is often achieved using ligand protection methods,which exhibit unique properties such as suppressing structure-sensitive side reactions.However,this method is limited ...Dispersing metals from nanoparticles to clusters is often achieved using ligand protection methods,which exhibit unique properties such as suppressing structure-sensitive side reactions.However,this method is limited by the use of different metal precursor salts corresponding to different ligands.An alternative approach,the ion exchange(IE)method,can overcome this limitation to some extent.Nevertheless,there is still an urgent need to address the stabilization of metals(especially precious metals)by using IE method.Here,we reported a Pt cluster catalyst prepared mainly by anchoring Pt atoms via O located near the framework Zn in zincosilicate zeolites and riveted by zeolite surface rings after reduction(reduced Pt/Zn-3-IE).The catalyst can achieve an initial propane conversion of 26%in a pure propane atmosphere at 550℃and shows little deactivation even after 7.5 d of operation.Moreover,the alteration of catalyst by the introduction of framework Zn was also highlighted and interpreted.展开更多
文摘BACKGROUND Hepatocellular carcinoma ranks among the most prevalent malignant neoplasms.Surgical intervention constitutes a critical therapeutic approach for this condition.Nonetheless,postoperative recovery is frequently influenced by the patient's nutritional status and the quality of nursing care provided.AIM To examine the comprehensive impact of personalized nutritional support and nursing strategies on the postoperative rehabilitation of patients with liver cancer.METHODS In this study,a retrospective comparative analysis was conducted involving 60 post-operative liver cancer patients.The subjects were selected as subjects and divided into two groups based on differing nursing interventions,with each group comprising 30 patients.The control group received standard nutritional support and care,whereas the experimental group received individualized nutritional support and nursing strategies.The study aimed to evaluate the impact of individualized nutrition by comparing the rehabilitation indices,nutritional status,quality of life(QoL),and complication rates between the two groups.RESULTS The results showed that the recovery index of the experimental group was significantly better than that of the control group 2 weeks after surgery,and the average liver function recovery index of the experimental group was 85.significantly higher than that of the control group(73.67±7.19).In terms of nutritional status,the serum albumin level and body weight stabilization rate of the experimental group were also significantly higher than those of the control group,which were 42.33±2.4 g/L and 93.3%,respectively,compared with 36.01±3.85 g/L and 76.7%of the control group.In addition,the average QoL score of the experimental group was 84.66±3.7 points,which was significantly higher than that of the control group(70.92±4.28 points).At the psychological level,the average anxiety score of the experimental group was 1.17±0.29,and the average depression score was 1.47±0.4,which were significantly lower than the 2.26±0.42 and 2.57±0.45 of the control group.This showed that patients in the experimental group were better relieved of anxiety and depression under the individualized nutrition support and nursing strategy.More importantly,the complication rate in the experimental group was only 10%,much lower than the 33.3%in the control group.CONCLUSION Personalized nutritional support and tailored nursing strategies significantly enhance the postoperative rehabilitation of liver cancer patients.Consequently,it is recommended to implement and advocate for these individualized approaches to improve both the recovery outcomes and QoL for these patients.
文摘An aluminoborate,Na_(2.5)Rb[Al{B_(5)O_(10)}{B_(3)O_(5)}]·0.5NO_(3)·H_(2)O(1),was synthesized under hydrothermal condition,which was built by mixed oxoboron clusters and AlO_(4)tetrahedra.In the structure,the[B_(5)O_(10)]^(5-)and[B_(3)O_(7)]^(5-)clusters are alternately connected to form 1D[B_(8)O_(15)]_(n)^(6n-)chains,which are further linked by AlO_(4)units to form a 2D monolayer with 7‑membered ring and 10‑membered ring windows.Two adjacent monolayers with opposite orientations further form a porous‑layered structure with six channels through B—O—Al bonds.Compound 1 was characterized by single crystal X‑ray diffraction,powder X‑ray diffraction(PXRD),IR spectroscopy,UV‑Vis diffuse reflection spectroscopy,and thermogravimetric analysis(TGA),respectively.UV‑Vis diffuse reflectance analysis indicates that compound 1 shows a wide transparency range with a short cutoff edge of 201 nm,suggesting it may have potential application in UV regions.CCDC:2383923.
文摘Ultrafine,highly dispersed Pt clusters were immobilized onto the Co nanoparticle surfaces by one-step pyrolysis of the precursor Pt(Ⅱ)-encapsulating Co-MOF-74.Owing to the small size effects of Pt clusters as well as the strongly enhanced synergistic interactions between Pt and Co atoms,the obtained Pt-on-Co/C400 catalysts exhib-ited excellent catalytic activity toward the hydrolysis of ammonia borane with an extremely high turnover frequency(TOF)value of 3022 min^(-1)at 303 K.Durability test indicated that the obtained Pt-on-Co/C400 catalysts possessed high catalytic stability,and there were no changes in the catalyst structures and catalytic activities after 10 cycles.
基金funded by grants from the Fonds de Recherche du Quebec-Nature et Technologies(FRQNT)to NJthe Ontario Ministry of Natural Resources and Forestrythe Ontario Ministry of Environment,Conservation and Parks,and the Natural Sciences and Engineering Research Council(NSERC)of Canada to DMG.
文摘Animals can differ in their individual movement behaviors during their daily displacements.Studies of animal movement patterns often disregard the need to understand individual variation in these patterns and the role of this variation in shaping population distributions of movements.To assess the link between individual movements and population distributions,we radio-tracked 13 Fowler's Toads Anaxyrus fowleri in Long Point,Ontario,Canada,after their breeding season.We recorded individual coordinates every 30 min,from the moment they emerged from their burrows around dusk until they burrowed in the morning,and obtained a total of 157 movements.We used the resulting series of step lengths and turning angles in a Hidden Markov Model to estimate movement type as"directed"or"non-directed"We also assigned to each encounter one of 3 space-dependent movement states:"foraging""in transit'or"searching"and found that movement type and state switched within individuals irrespective of time during a single night.We find that switching between movement types varied throughout the night,leading to stochastic within-individual variation in movements,and the distribution of movement distances differed significantly among individuals.Movement states,however,were time-dependent,suggesting displacement routines were similar across individuals.Variation in movement behavior within individuals scales up to result in variation among individuals which,in turn,was found to shape the distribution of the sampled population.Our findings therefore underline the importance of a multi-scale approach in the study of movement.
基金supported by the National Key R&D Program of China(No.2023YFB3712504)the National Natural Science Foundation of China(Nos.22273038,22073043,and 22033004)。
文摘Accurate description of noncova-lent interactions in large systems is challenging due to the require-ment of high-level electron corre-lation methods.The generalized energy-based fragmentation(GEBF)approach,in conjunc-tion with the domain-based local pair natural orbital(DLPNO)method,has been applied to assess the average binding energies(ABEs)of large benzene clus-ters,specifically(C6H6)13,at the coupled cluster singles and doubles with perturbative triples correction[CCSD(T)]level and the complete basis set(CBS)limit.Utilizing GEBF-DLPNO-CCSD(T)/CBS ABEs as benchmarks,various DFT functionals were evaluated.It was found that several functionals with empirical dispersion correction,including M06-2X-D3,B3LYP-D3(BJ),and PBE-D3(BJ),provide accurate descriptions of the ABEs for(C6H6)13 clusters.Additionally,the M06-2X-D3 functional was used to calculate the ABEs and relative stabili-ties of(C6H6)n clusters for n=11,12,13,14,and 15 revealing that the(C6H6)13 cluster ex-hibits the highest relative stability.These findings align with experimental evidence suggest-ing that n=13 is one of the magic numbers for benzene clusters(C6H6)n,with n≤30.
基金P.D.and P.S.A.received Ph.D.scholarships from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)(Finance Code 001)P.D.received a Postdoctoral fellowship from CAPES(grant number:88887.469218/2019-00)+4 种基金R.H.M.received a fellowship from Conselho Nacional de Desenvolvimento Científco e Tecnológico(CNPq)for the duration of the study.Funding was also provided by Animal Behavior Society[ABS Student Research Grant to P.S.A.]Association of Field Ornithologists[E.Alexander Bergstrom Memorial Research Award to P.S.A.]American Ornithological Society[Postdoctoral Research Award to P.D.]the logistic and fnancial support provided by Programa de Pós-Graduação em Ecologia from Universidade de Brasília in association with Programa de Excelência Acadêmica PROEX/CAPES(1789/2015)the fnancial support provided by CNPq(471945/2013-7).
文摘Vocal individuality is essential for social discrimination but has been poorly studied in animals that produce communal signals(duets or choruses).Song overlapping and temporal coordination make the assessment of individuality in communal signals more complex.In addition,selection may favor the accurate identifcation of pairs over individuals by receivers in year-round territorial species with duetting and long-term pair bonding.Here,we studied pair and individual vocal signatures in the polyphonal duets of rufous horneros Furnarius rufus,a Neotropical bird known for its long-term pair bonds.Hornero partners engage in duets to deter territorial intruders and protect their partnership year-round and can discern duets from neighbors versus strangers.Using a dataset of 471 duets from 43 pairs in 2 populations,we measured fne-scale acoustic features across different duet levels(e.g.,complete duets to non-overlapping syllable parts)and analysis levels(pair or individual).Permuted linear discriminant function analyses classifed pairs and individuals more accurately than expected by chance(means:45%and 47%vs.4 and 2%).Pair identity explained more variance in the multivariate acoustic features of duets than individual or population identities.The initial frequency of the duet showed strong potential for encoding pair identity.The acoustic traits contributing most to individual vocal signatures varied between sexes,which might facilitate the simultaneous assessment of duetters’identities by receivers.Our study indicates that vocal individuality may exist even in species with intricate and innate communal signals and elucidates the mechanisms employed by horneros in their social discrimination ability.
文摘BACKGROUND Magnetic resonance imaging(MRI)and endoscopic ultrasonography(EUS)are recommended in combination for screening pancreatic cancer in high-risk individuals.However,in clinical practice,MRI and EUS are increasingly utilized for pancreatic surveillance during routine health examinations.AIM To investigate the feasibility of these imaging modalities for screening in low-risk individuals.METHODS This retrospective study included patients at low risk for pancreatic cancer who underwent MRI or EUS at two health evaluation centers between March 2019 and December 2024.Basic characteristics,laboratory data,and imaging results were collected.RESULTS A total of 3364 low-risk individuals underwent pancreatic screening:1553(46.1%)received MRI,and 1811 underwent EUS.No significant differences were observed in age or sex distribution between the groups.In imaging screening,EUS demonstrated a higher detection rate of abnormal pancreatic lesions(12.8%vs 2.6%;P<0.001).MRI detected more cystic lesions than did EUS(P<0.001).EUS identified smaller nodular lesions compared to MRI(9.2 mm vs 18.0 mm;P=0.044).The MRI group had a higher number of confirmed intraductal papillary mucinous neoplasms(P=0.031),whereas the EUS group identified more suspected branch-duct intraductal papillary mucinous neoplasms(P<0.001).Pancreatic adenocarcinoma was found in three patients(0.08%),with no significant difference in detection rates between EUS and MRI(0.11%vs 0.06%;P=0.656).CONCLUSION In low-risk individuals,MRI and EUS offer comparable effectiveness for pancreatic cancer surveillance.The choice of imaging strategy for health evaluation depends on cost considerations and degree of invasiveness.
基金funded by the National Natural Science Foundation of China(Grant No.42173054).
文摘Light hydrocarbons(LHs)are key components of petroleum,and the carbon isotopes composition(δ^(13)C)of individual LHs contains a wealth of geochemical information.Forty-four oil samples from five different basins were analyzed using gas chromatography(GC),gas chromatography-mass spectrometry(GC–MS),and gas chromatography-isotope ratio mass spectrometry(GC-IRMS).Theδ^(13)C values of forty-three LHs were recognized and determined by comparing the GC and GC-IRMS methods.The results revealed significant differences inδ^(13)C distribution characteristics among different LH compounds.Theδ^(13)C variation of individual LHs in iso-paraffins showed the widest range,followed by cycloalkanes and aromatics,whereas theδ^(13)C variation in n-paraffins showed the narrowest range.Theδ^(13)C values of most individual LHs are primarily affected by the source facies and thermal evolution.Among them,c-1,3-dimethylcyclohexane(c-1,3DMCH)is mainly sourced from higher plants but may also form through abiotic mechanisms such as catalysis or cyclization.Theδ^(13)C values of c-1,3DMCH(δ^(13)Cc-1,3DMCH)primarily exhibit parental genetic characteristics,enabling effective distinction of oil from different source facies.Specifically,theδ^(13)Cc-1,3DMCH in marine oils,lacustrine oils,terrigenous oils,and coal-formed oils are<–22‰,from–22‰to−20.2‰,from−20.2‰to−18.4‰,and>−18.4‰,respectively.Moreover,maturity is the primary controlling factor forδ^(13)C values of 3MC7(δ^(13)C3MC7,3MC7:3-methylheptane),while the source facies serve as a secondary influence.The plot ofδ^(13)Cc-1,3DMCH andδ^(13)C3MC7 was introduced to classify source facies.Asδ^(13)Cc-1,3DMCH andδ^(13)C3MC7 increase,the source facies transits from marine to lacustrine,then terrigenous,and finally coal facies.Additionally,increasingδ^(13)C3MC7 indicates a relative increase in maturity.Therefore,theδ^(13)Cc-1,3DMCH vs.δ^(13)C3MC7 plot serves as an effective tool for distinguishing source facies and assessing relative maturity.
基金The Trùndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trùndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public HealthThe coordination of European Prospective Investigation into Cancer and Nutrition - Spain study (EPIC) is financially supported by the International Agency for Research on Cancer (IARC)+7 种基金by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC)supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc 1a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)funded by The Netherlands Organisation for Health Research and DevelopmentZon Mw (Grant No.: 531-00141-3)Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBFidentification codes 01 ZZ96030, 01 ZZ0103, and 01 ZZ0701)support from the Swedish Research Council (2018-02527 and 2019-00193)financed by the Helmholtz Zentrum München - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.
文摘Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.
基金This is a phased research outcome of a Key Project of the National Social Science Fund of China,entitled“Research on Improving the Legal Governance System to Guarantee Social Equity and Justice”(Project Number 20AZD028).
文摘The theory of human dignity identifies certain inherent human characteristics,elevating humanity as the pinnacle of creation and valuing individuals as carriers of these traits.Under this framework,individuals are called to actively embody their human essence and participate in political life to serve the community.Overall,this interpretive paradigm of dignity establishes a distinct concept of autonomy and provides methods for its realization,fostering the secularization of politics by emphasizing human value.The doctrine of individual dignity presupposes the intrinsic worth of individuals and defends their autonomy and equal status through the imposition of legal obligations on the state.However,limited by its essentialist and communitarian orientation,the scope of autonomy and equality it provides to individuals remains constrained.By transcending ontology with a value-based approach,the concept of individual dignity creates a unique,open structure that incorporates and reflects on global human rights practices.This adaptability enables it to integrate abstract societies,advance the global human rights agenda,and critique and refine political realities.Consequently,the concept of individual dignity cannot be supplanted by the human dignity theory.
基金supported by the National Key Research and Development Program of China(2022YFC2305201)National Natural Science Foundation of China(71874168)。
文摘Objective This study aimed to investigate the prevalence of HIV pretreatment drug resistance(PDR)and the transmission clusters associated with PDR-related mutations in newly diagnosed,treatmentnaive patients between 2020 and 2023 in Dehong prefecture,Yunnan province,China.Methods Demographic information and plasma samples were collected from study participants.PDR was assessed using the Stanford HIV Drug Resistance Database.The Tamura-Nei 93 model within HIVTRACE was employed to compute pairwise matches with a genetic distance of 0.015 substitutions per site.Results Among 948 treatment-naive individuals with eligible sequences,36 HIV subtypes were identified,with unique recombinant forms(URFs)being the most prevalent(18.8%,178/948).The overall prevalence of PDR was 12.4%(118/948),and resistance to non-nucleotide reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)was10.7%,1.3%,and 1.6%,respectively.A total of 91 clusters were identified,among which eight showed evidence of PDR strain transmission.The largest PDR-associated cluster consisted of six CRF01_AE drugresistant strains carrying K103N and V179T mutations;five of these individuals had initial CD4^(+)cell counts<200 cells/μL.Conclusion The distribution of HIV subtypes in Dehong is diverse and complex.PDR was moderately prevalent(12.4%)between 2020 and 2023.Evidence of transmission of CRF01_AE strains carrying K103N and V179T mutations was found.Routine surveillance of PDR and the strengthening of control measures are essential to limit the spread of drug-resistance HIV strains.
基金supported by the National Key R&D Program of China(2020YFC2003102).
文摘Objective:To identify key factors influencing cognitive function in the elderly,including traditional Chinese medicine(TCM)constitutional classification,and to rank their relative importance.Methods:We used cross-sectional data from seven geographical regions across Chinese mainland.The Changsha version of the Montreal Cognitive Assessment was used to assess cognitive function.A“least absolute shrinkage and selection operator”(LASSO)model,multivariate linear regression analysis,and random forest(RF)model were used.Subgroup analyses were performed to examine the correlation between key TCM constitution types and cognitive function in different population subgroups.Results:A total of 24803 individuals aged 60 and above were included in the study.We selected 18 influential factors using the LASSO model.Higher education,being married,and having insurance were positively correlated with cognitive function in the elderly(all P<0.05).In contrast,poor sleep,vision impairment,hearing impairment,basic activities of daily living disability,instrumental activities of daily living disability,depression,hypertension,coronary heart disease,diabetes,stroke,yang-deficiency constitution(YADC),yin-deficiency constitution(YIDC),qi deficiency constitution(QDC),and blood stasis constitution(BSC)were negatively correlated with cognitive function(all P<0.05).YIDC and BSC affected all dimensions of cognitive function(all P<0.05).YADC mainly affected attention,language,abstraction(verbal analogies),memory,and orientation to time and place dimensions(P<0.001).QDC mainly affected language and abstraction(verbal analogies)dimensions(P<0.05).The negative correlations between BSC,YADC,YIDC,and QDC scores and cognitive function revealed statistically significant dif-ferences across most subgroups.The RF model identified education,BSC,and poor sleep quality as the three most influential factors in our study.Conclusion:BSC,YADC,YIDC,and QDC were associated with cognitive decline in the elderly.Our findings provide new perspectives and significant references for interventions for early-stage cognitive disorders.
基金supported by the National Natural Science Foundation of China(No.22372083,52201259)the National Key R&D Program of China(2021YFB2500300)+2 种基金the Fundamental Research Funds for the Central Universities:Nankai University(63241607)the Natural Science Foundation of Tianjin(No.22JCZDJC00380)the Young Elite Scientist Sponsorship Program by CAST.
文摘LiNO_(3) is known to significantly enhance the reversibility of lithium metal batteries;however,the modification of solvation structures in various solvents and its further impact on the interface have not been fully revealed.Herein,we systematically studied the evolution of solvation structures with increasing LiNO_(3) concentration in both carbonate and ether electrolytes.The results from molecular dynamics simulations unveil that the Li^(+)solvation structure is less affected in carbonate electrolytes,while in ether electrolytes,there is a significant decrease of solvent molecules in Li^(+)coordination,and a larger average size of Li^(+)solvation structure emerges as LiNO_(3) concentration increases.Notably,the formation of large ion aggregates with size of several nanometers(nano-clusters),is observed in ether-based electrolytes at conventional Li^(+)concentration(1 M)with higher NO_(3)^(-) ratio,which is further proved by infrared spectroscopy and small-angle X-ray scattering experiments.The nano-clusters with abundant anions are endowed with a narrow energy gap of molecular orbitals,contributing to the formation of an inorganic rich electrode/electrolyte interphase that enhances the reversibility of lithium stripping/plating with Coulombic efficiency up to 99.71%.The discovery of nano-clusters elucidates the underlying mechanism linking ions/solvent aggregation states of electrolytes to interfacial stability in advanced battery systems.
基金supported by a Second Century Fund Chulalongkorn University-postdoctoral fellow。
文摘Objectives:This study aimed to determine the effectiveness of an individual and family selfmanagement(IFSM)education program on triglyceride-glucose(TyG)index,self-management,and diabetes distress among adults with uncontrolled diabetes mellitus type 2(T2DM).Methods:A multicentre randomized controlled trial was employed.The study included 68 dyads(adults with uncontrolled T2DM and one family member)that were randomly allocated to the intervention(n=34)and control groups(n=34)from March to September 2024.Participants in the intervention group received an 8-week IFSM education program,whereas those in the control group received standard routine care.An automated hematology analyzer XP-100 was used to evaluate triglyceride and fasting blood glucose levels.The Diabetes Distress Scale and Diabetes Self-Management Questionnaire were used to measure diabetes distress and self-management,respectively.Results:A total of 67 participants completed the intervention.The generalized estimating equation demonstrated a significantinteraction between group and time.The IFSM education intervention group had a higher diabetes self-management(β=16.68;95%CI=15.23,18.09;P<0.001),lower diabetes distress(β=-30.74;95%CI=-32.57,-28.90;P<0.001),and lower TyG index(β=-1.97;95%CI=-2.41,-1.53;P<0.001)than the control group.Conclusions:The findingsdocumented the capacity of IFSM education to reduce TyG and diabetes distress,which could potentially escalate diabetes self-management among individuals with T2DM.
文摘Objective:This study aims to investigate the patterns of symptom occurrence in patients experiencing acute exacerbations of chronic obstructive pulmonary disease(AECOPD).It will explore the composition of symptom clusters and analyze the correlation between these clusters and health-related quality of life(HRQoL).Methods:A total of 207 patients with AE-COPD were surveyed from a tertiary grade A hospital.Data collection was conducted using three validated instruments:the Basic Information Questionnaire(BIQ),Disease Symptom Survey Questionnaire(MSAS),and Quality of Life Questionnaire(CAT).Statistical software SPSS 22.0 was used to analyze the correlation between symptom clusters and quality of life.Results:Exploratory factor analysis showed that five major symptom clusters existed in the patients,including the psycho-emotional symptom cluster,the sleep-related symptom cluster,the other side effects symptom cluster,the energy deficiency symptom cluster and the cough-loss of appetite symptom cluster,and the severity of the symptom clusters showed a significant negative correlation with the quality of life of the patients(P<0.05).Conclusion:Strengthening the comprehensive management of symptom clusters in patients with AE-COPD can help to effectively reduce the symptom burden of patients,and then significantly improve their quality of life.
基金supported by the National Natural Science Foundation of China(51872115 and 12234018)Beijing Synchrotron Radiation Facility(BSRF)4B9A.
文摘Two-dimensional(2D)materials loaded with single atoms and clusters are being set at the forefront of catalysis due to their distinctive geometric and electronic features.However,the usually-complicated synthesis procedures impede in-depth clarification of their catalytic mechanisms.To this end,herein we developed an efficient one-step dimension-reduction carbonization strategy,with which we successfully architected a highly-efficient catalyst for oxygen reduction reaction(ORR),featured with symbiotic cobalt single atoms and clusters decorated in two-dimensional(2D)ultra-thin(3.5 nm thickness)nitrogen-carbon nanosheets.The synergistic effects of the two components afford excellent oxygen reduction activity in alkaline media(E_(1/2)=0.823 V vs.RHE)and thereof a high power density(146.61 mW cm^(-2))in an assembled Zn-air battery.As revealed by theoretical calculations,the cobalt clusters can regulate electrons surrounding those individual atoms and affect the adsorption of intermediate species.As a consequence,the derived active sites of single cobalt atoms lead to a significant improvement of the ORR performance.Thus,our work may fuel interests to delicate architectu re of single atoms and clusters coexisting 2D support toward optimal electrocatalytic performance.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.92261201,12134005,12334011)。
文摘We investigated the ionization and dissociation processes of ammonia clusters ranging from dimer to pentamer induced by 800-nm femtosecond laser fields.Time-of-flight(TOF)mass spectra of the ammonia clusters were recorded over a range of laser intensities from 2.1×10^(12)W/cm^(2) to 5.6×10^(12)W/cm^(2).The protonated ion signals dominate the spectra,which is consistent with the stability of the geometric structures.The ionization and dissociation channels of ammonia clusters are discussed.The competition and switching among observed dissociation channels are revealed by analyzing the variations in the relative ionic yields of specific protonated and unprotonated clusters under different laser intensities.These results indicate that the ionization of the neutral multiple-ammonia units,produced through the dissociation of cluster ions,may start to contribute,as well as the additional processes to consume protonated ions and/or produce unprotonated ions induced by the femtosecond laser fields when the laser intensity is above^4×10^(12)W/cm^(2).These findings provide deeper insights into the ionization and dissociation dynamics in multi-photon ionization experiments involving ammonia clusters.
基金supported by the National Natural Science Foundation of China(Grant No.12374253,12074053,12004064)J.G.thanks the Foreign talents project(G2022127004L),The authors also acknowledge computer support from the Shanghai Supercomputer Center,the DUT Supercomputing Center,and the Tianhe supercomputer of Tianjin Center.
文摘Surface-supported clusters forming by aggregation of excessive adatoms could be the main defects of 2D materials after chemical vapor deposition.They will significantly impact the electronic/magnetic properties.Moreover,surface supported atoms are also widely explored for high active and selecting catalysts.Severe deformation,even dipping into the surface,of these clusters can be expected because of the very active edge of clusters and strong interaction between supported clusters and surfaces.However,most models of these clusters are supposed to simply float on the top of the surface because ab initio simulations cannot afford the complex reconstructions.Here,we develop an accurate graph neural network machine learning potential(MLP)from ab initio data by active learning architecture through fine-tuning pre-trained models,and then employ the MLP into Monte Carlo to explore the structural evolutions of Mo and S clusters(1-8 atoms)on perfect and various defective MoS2 monolayers.Interestingly,Mo clusters can always sink and embed themselves into MoS2 layers.In contrast,S clusters float on perfect surfaces.On the defective surface,a few S atoms will fill the vacancy and rest S clusters float on the top.Such significant structural reconstructions should be carefully taken into account.
文摘Atrial fibrillation(AF)is a growing global health burden,with a prevalence of over 52.55 million cases.Rising disability-adjusted life-years,increasing age,and disparities in care have contributed to the worsening severity and mortality of AF.Modifiable risk factors,such as hypertension,obesity,and diabetes mellitus,are associated with alterations in gut microbiota,making the gut-heart axis a potential therapeutic target.Gut dysbiosis influences AF pathogenesis through inflam-mation,metabolic disruption,and autonomic dysfunction.Key mechanisms include gut barrier dysfunction,short-chain fatty acid(SCFA)depletion,lipopoly-saccharides(LPS)-induced inflammation,and ferroptosis-mediated atrial remodeling.Trimethylamine N-oxide,bile acids,and tryptophan metabolites contribute to arrhythmogenic remodeling.Emerging evidence suggests that dietary interventions,including prebiotics and probiotics,as well as gut surveillance,may help mitigate AF progression.Clinical implications of gut modulation in AF include person-alized dietary strategies,microbiome assessment through metagenomic sequencing,and targeted interventions such as SCFA-based therapies and ferroptosis inhibition.Metabolite surveillance,including LPS and indoxyl sulfate monitoring,may influence the effectiveness of anticoagulant and antiarrhythmic therapy.Despite growing mechanistic evidence linking gut dysbiosis to AF,clinical applications remain unexplored.This review summarizes the current understanding of the gut microbiome's role in AF.
文摘Dispersing metals from nanoparticles to clusters is often achieved using ligand protection methods,which exhibit unique properties such as suppressing structure-sensitive side reactions.However,this method is limited by the use of different metal precursor salts corresponding to different ligands.An alternative approach,the ion exchange(IE)method,can overcome this limitation to some extent.Nevertheless,there is still an urgent need to address the stabilization of metals(especially precious metals)by using IE method.Here,we reported a Pt cluster catalyst prepared mainly by anchoring Pt atoms via O located near the framework Zn in zincosilicate zeolites and riveted by zeolite surface rings after reduction(reduced Pt/Zn-3-IE).The catalyst can achieve an initial propane conversion of 26%in a pure propane atmosphere at 550℃and shows little deactivation even after 7.5 d of operation.Moreover,the alteration of catalyst by the introduction of framework Zn was also highlighted and interpreted.
