With a focus on the difficulty of quantitatively describing the degree of nonuniformity of temporal and spatial distributions of water resources, quantitative research was carried out on the temporal and spatial distr...With a focus on the difficulty of quantitatively describing the degree of nonuniformity of temporal and spatial distributions of water resources, quantitative research was carried out on the temporal and spatial distribution characteristics of water resources in Guangdong Province from 1956 to 2000 based on a cloud model. The spatial variation of the temporal distribution characteristics and the temporal variation of the spatial distribution characteristics were both analyzed. In addition, the relationships between the numerical characteristics of the cloud model of temporal and spatial distributions of water resources and precipitation were also studied. The results show that, using a cloud model, it is possible to intuitively describe the temporal and spatial distribution characteristics of water resources in cloud images. Water resources in Guangdong Province and their temporal and spatial distribution characteristics are differentiated by their geographic locations. Downstream and coastal areas have a larger amount of water resources with greater uniformity and stronger stability in terms of temporal distribution. Regions with more precipitation possess larger amounts of water resources, and years with more precipitation show greater nonuniformity in the spatial distribution of water resources. The correlation between the nonuniformity of the temporal distribution and local precipitation is small, and no correlation is found between the stability of the nonuniformity of the temporal and spatial distributions of water resources and precipitation. The amount of water resources in Guangdong Province shows an increasing trend from 1956 to 2000, the nonuniformity of the spatial distribution of water resources declines, and the stability of the nonuniformity of the spatial distribution of water resources is enhanced.展开更多
Anti-jamming performance evaluation has recently received significant attention. For Link-16, the anti-jamming performance evaluation and selection of the optimal anti-jamming technologies are urgent problems to be so...Anti-jamming performance evaluation has recently received significant attention. For Link-16, the anti-jamming performance evaluation and selection of the optimal anti-jamming technologies are urgent problems to be solved. A comprehensive evaluation method is proposed, which combines grey relational analysis (GRA) and cloud model, to evaluate the anti-jamming performances of Link-16. Firstly, on the basis of establishing the anti-jamming performance evaluation indicator system of Link-16, the linear combination of analytic hierarchy process(AHP) and entropy weight method (EWM) are used to calculate the combined weight. Secondly, the qualitative and quantitative concept transformation model, i.e., the cloud model, is introduced to evaluate the anti-jamming abilities of Link-16 under each jamming scheme. In addition, GRA calculates the correlation degree between evaluation indicators and the anti-jamming performance of Link-16, and assesses the best anti-jamming technology. Finally, simulation results prove that the proposed evaluation model can achieve the objective of feasible and practical evaluation, which opens up a novel way for the research of anti-jamming performance evaluations of Link-16.展开更多
Well logging technology has accumulated a large amount of historical data through four generations of technological development,which forms the basis of well logging big data and digital assets.However,the value of th...Well logging technology has accumulated a large amount of historical data through four generations of technological development,which forms the basis of well logging big data and digital assets.However,the value of these data has not been well stored,managed and mined.With the development of cloud computing technology,it provides a rare development opportunity for logging big data private cloud.The traditional petrophysical evaluation and interpretation model has encountered great challenges in the face of new evaluation objects.The solution research of logging big data distributed storage,processing and learning functions integrated in logging big data private cloud has not been carried out yet.To establish a distributed logging big-data private cloud platform centered on a unifi ed learning model,which achieves the distributed storage and processing of logging big data and facilitates the learning of novel knowledge patterns via the unifi ed logging learning model integrating physical simulation and data models in a large-scale functional space,thus resolving the geo-engineering evaluation problem of geothermal fi elds.Based on the research idea of“logging big data cloud platform-unifi ed logging learning model-large function space-knowledge learning&discovery-application”,the theoretical foundation of unified learning model,cloud platform architecture,data storage and learning algorithm,arithmetic power allocation and platform monitoring,platform stability,data security,etc.have been carried on analysis.The designed logging big data cloud platform realizes parallel distributed storage and processing of data and learning algorithms.The feasibility of constructing a well logging big data cloud platform based on a unifi ed learning model of physics and data is analyzed in terms of the structure,ecology,management and security of the cloud platform.The case study shows that the logging big data cloud platform has obvious technical advantages over traditional logging evaluation methods in terms of knowledge discovery method,data software and results sharing,accuracy,speed and complexity.展开更多
The cavitating flow in different regimes has the intricate flow structure with multiple time and space scales.The present work develops a multiscale model by coupling the volume of fluid(VOF)method and a discrete bubb...The cavitating flow in different regimes has the intricate flow structure with multiple time and space scales.The present work develops a multiscale model by coupling the volume of fluid(VOF)method and a discrete bubble model(DBM),to simulate the cavitating flow in a convergent-divergent test section.The Schnerr-Sauer cavitation model is used to calculate the mass transfer rate to obtain the macroscale phase structure,and the simplified Rayleigh-Plesset equation is applied to simulate the growing and collapsing of discrete bubbles.An algorithm for bridging between the macroscale cavities and microscale bubbles is also developed to achieve the multiscale simulation.For the flow field,the very large eddy simulation(VLES)approach is applied.Conditions from inception to sheet/cloud cavitation regimes are taken into account and simulations are conducted.Compared with the experimental observations,it is shown that the cavitation inception,bubble clouds formation and glass cavity generation are all well represented,indicating that the proposed VOF-DBM model is a promising approach to accurately and comprehensively reveal the multiscale phase field induced by cavitation.展开更多
Cloud diurnal variation is crucial for regulating cloud radiative effects and atmospheric dynamics.However,it is often overlooked in the evaluation and development of climate models.Thus,this study aims to investigate...Cloud diurnal variation is crucial for regulating cloud radiative effects and atmospheric dynamics.However,it is often overlooked in the evaluation and development of climate models.Thus,this study aims to investigate the daily mean(CFR)and diurnal variation(CDV)of cloud fraction across high-,middle-,low-level,and total clouds in the FGOALS-f3-L general circulation model.The bias of total CDV is decomposed into the model biases in CFRs and CDVs of clouds at all three levels.Results indicate that the model generally underestimates low-level cloud fraction during the daytime and high-/middle-level cloud fraction at nighttime.The simulation biases of low clouds,especially their CDV biases,dominate the bias of total CDV.Compensation effects exist among the bias decompositions,where the negative contributions of underestimated daytime low-level cloud fraction are partially offset by the opposing contributions from biases in high-/middle-level clouds.Meanwhile,the bias contributions have notable land–ocean differences and region-dependent characteristics,consistent with the model biases in these variables.Additionally,the study estimates the influences of CFR and CDV biases on the bias of shortwave cloud radiative effects.It reveals that the impacts of CDV biases can reach half of those from CFR biases,highlighting the importance of accurate CDV representation in climate models.展开更多
The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic...The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic field has not been previously estimated or incorporated into geomagnetic field models,potentially causing leakage into the core field model.Here,we present a method to account for the circulation-induced magnetic field during geomagnetic field modeling.First,a forward model of the circulation-induced magnetic field is constructed by numerically solving electromagnetic induction equations based on a realistic ocean circulation model.Then,this forward model is subtracted from the observed data.Finally,the core and lithospheric fields,magnetospheric and Earth’s mantle-induced fields,and the ocean tide-induced magnetic field are co-estimated.Applying our method to over 20 years of MSS-1,Swarm,CryoSat-2,and CHAMP satellite magnetic data,we derive a new multisource geomagnetic field model(MGFM).We find that incorporating a forward model of the circulation-induced magnetic field marginally improves the fit to the data.Furthermore,we demonstrate that neglecting the circulation-induced magnetic field in geomagnetic field modeling results in leakage into the core field model.The highlights of the MGFM model include:(i)a good agreement with the widely used CHAOS model series;(ii)the incorporation of magnetic fields induced by both ocean tides and circulation;and(iii)the suppression of leakage of the circulation-induced magnetic field into the core field model.展开更多
Existing reverse-engineering methods struggle to directly generate editable,parametric CAD models from scanned data.To address this limitation,this paper proposes a reverse-modeling approach that reconstructs parametr...Existing reverse-engineering methods struggle to directly generate editable,parametric CAD models from scanned data.To address this limitation,this paper proposes a reverse-modeling approach that reconstructs parametric CAD models from multi-view RGB-D point clouds.Multi-frame point-cloud registration and fusion are first employed to obtain a complete 3-D point cloud of the target object.A region-growing algorithm that jointly exploits color and geometric information segments the cloud,while RANSAC robustly detects and fits basic geometric primitives.These primitives serve as nodes in a graph whose edge features are inferred by a graph neural network to capture spatial constraints.From the detected primitives and their constraints,a high-accuracy,fully editable parametric CAD model is finally exported.Experiments show an average parameter error of 0.3 mm for key dimensions and an overall geometric reconstruction accuracy of 0.35 mm.The work offers an effective technical route toward automated,intelligent 3-D reverse modeling.展开更多
Pronounced climatic differences occur over subtropical South China(SC)and tropical South China Sea(SCS)and understanding the key cloud-radiation characteristics is essential to simulating East Asian climate.This study...Pronounced climatic differences occur over subtropical South China(SC)and tropical South China Sea(SCS)and understanding the key cloud-radiation characteristics is essential to simulating East Asian climate.This study investigated cloud fractions and cloud radiative effects(CREs)over SC and SCS simulated by CMIP6 atmospheric models.Remarkable differences in cloud-radiation characteristics appeared over these two regions.In observations,considerable amounts of low-middle level clouds and cloud radiative cooling effect appeared over SC.In contrast,high clouds prevailed over SCS,where longwave and shortwave CREs offset each other,resulting in a weaker net cloud radiative effect(NCRE).The models underestimated NCRE over SC mainly due to weaker shortwave CRE and less cloud fractions.Conversely,most models overestimated NCRE over SCS because of stronger shortwave CRE and weaker longwave CRE.Regional CREs were closely linked to their dominant cloud fractions.Both observations and simulations showed a negative spatial correlation between total(low)cloud fraction and shortwave CRE over SC,especially in winter,and exhibited a positive correlation between high cloud fraction and longwave CRE over these two regions.Compared with SCS,most models overestimated the spatial correlation between low(high)cloud fraction and SWCRE(LWCRE)over SC,with larger bias ranges among models,indicating the exaggerated cloud radiative cooling(warming)effect caused by low(high)clouds.Moreover,most models struggled to describe regional ascent and its connection with CREs over SC while they can better reproduce these connections over SCS.This study further suggests that reasonable circulation conditions are crucial to simulating well cloud-radiation characteristics over the East Asian regions.展开更多
A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which ca...A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.展开更多
DNAN-based insensitive melt-cast explosives have been widely utilized in insensitive munition in recent years. When constrained DNAN-based melt-cast explosives are ignited under thermal stimulation, the base explosive...DNAN-based insensitive melt-cast explosives have been widely utilized in insensitive munition in recent years. When constrained DNAN-based melt-cast explosives are ignited under thermal stimulation, the base explosive exists in a molten liquid state, where high-temperature gases expand and react in the form of bubble clouds within the liquid explosive;this process is distinctly different from the dynamic crack propagation process observed in the case of solid explosives. In this study, a control model for the reaction evolution of burning-bubble clouds was established to describe the reaction process and quantify the reaction violence of DNAN-based melt-cast explosives, considering the size distribution and activation mechanism of the burning-bubble clouds. The feasibility of the model was verified through experimental results. The results revealed that under geometrically similar conditions, with identical confinement strength and aspect ratio, larger charge structures led to extended initial gas flow and surface burning processes, resulting in greater reaction equivalence and violence at the casing fracture.Under constant charge volume and size, a stronger casing confinement accelerated self-enhanced burning, increasing the internal pressure, reaction degree, and reaction violence. Under a constant casing thickness and radius, higher aspect ratios led to a greater reaction violence at the casing fracture.Moreover, under a constant charge volume and casing thickness, higher aspect ratios resulted in a higher internal pressure, increased reaction degree, and greater reaction violence at the casing fracture. Further,larger ullage volumes extended the reaction evolution time and increased the reaction violence under constant casing dimensions. Through a matching design of the opening threshold of the pressure relief holes and the relief structure area, a stable burning reaction could be maintained until completion,thereby achieving a control of the reaction violence. The proposed model could effectively reflect the effects of the intrinsic burning rate, casing confinement strength, charge size, ullage volume, and pressure relief structure on the reaction evolution process and reaction violence, providing a theoretical method for the thermal safety design and reaction violence evaluation of melt-cast explosives.展开更多
The spatial distribution of discontinuities and the size of rock blocks are the key indicators for rock mass quality evaluation and rockfall risk assessment.Traditional manual measurement is often dangerous or unreach...The spatial distribution of discontinuities and the size of rock blocks are the key indicators for rock mass quality evaluation and rockfall risk assessment.Traditional manual measurement is often dangerous or unreachable at some high-steep rock slopes.In contrast,unmanned aerial vehicle(UAV)photogrammetry is not limited by terrain conditions,and can efficiently collect high-precision three-dimensional(3D)point clouds of rock masses through all-round and multiangle photography for rock mass characterization.In this paper,a new method based on a 3D point cloud is proposed for discontinuity identification and refined rock block modeling.The method is based on four steps:(1)Establish a point cloud spatial topology,and calculate the point cloud normal vector and average point spacing based on several machine learning algorithms;(2)Extract discontinuities using the density-based spatial clustering of applications with noise(DBSCAN)algorithm and fit the discontinuity plane by combining principal component analysis(PCA)with the natural breaks(NB)method;(3)Propose a method of inserting points in the line segment to generate an embedded discontinuity point cloud;and(4)Adopt a Poisson reconstruction method for refined rock block modeling.The proposed method was applied to an outcrop of an ultrahigh steep rock slope and compared with the results of previous studies and manual surveys.The results show that the method can eliminate the influence of discontinuity undulations on the orientation measurement and describe the local concave-convex characteristics on the modeling of rock blocks.The calculation results are accurate and reliable,which can meet the practical requirements of engineering.展开更多
The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud d...The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud data centres and an important concern of research for many researchers.In this paper,we proposed a cuckoo search(CS)-based optimisation technique for the virtual machine(VM)selection and a novel placement algorithm considering the different constraints.The energy consumption model and the simulation model have been implemented for the efficient selection of VM.The proposed model CSOA-VM not only lessens the violations at the service level agreement(SLA)level but also minimises the VM migrations.The proposed model also saves energy and the performance analysis shows that energy consumption obtained is 1.35 kWh,SLA violation is 9.2 and VM migration is about 268.Thus,there is an improvement in energy consumption of about 1.8%and a 2.1%improvement(reduction)in violations of SLA in comparison to existing techniques.展开更多
Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up ...Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up table that contains the optical properties of five hydrometeor types—rain,cloud water,cloud ice,graupel,and snow—for the Advanced Radiative Transfer Modeling System(ARMS)at frequencies below 220 GHz.The discrete dipole approximation(DDA)method is employed to compute the single-scattering properties of solid cloud particles,modeling these particles as aggregated roughened bullet rosettes.The bulk optical properties of the cloud layer are derived by integrating the singlescattering properties with a modified Gamma size distribution,specifically for distributions with 18 effective radii.The bulk phase function is then projected onto a series of generalized spherical functions,applying the delta-M method for truncation.The results indicate that simulations using the newly developed nonspherical scattering look-up table exhibit significant consistency with observations under deep convection conditions.In contrast,assuming spherical solid cloud particles leads to excessive scattering at mid-frequency channels and insufficient scattering at high-frequency channels.This improvement in radiative transfer simulation accuracy for cloudy conditions will better support the assimilation of allsky microwave observations into numerical weather prediction models.·Frozen cloud particles were modeled as aggregates of bullet rosettes and the optical properties at microwave range were computed by DDA.·A complete process and technical details for constructing a look-up table of ARMS are provided.·The ARMS simulations generally show agreement with observations of MWTS and MWHS under typhoon conditions using the new look-up table.展开更多
In the era of AI,especially large models,the importance of open source has become increasingly prominent.First,open source allows innovation to avoid starting from scratch.Through iterative innovation,it promotes tech...In the era of AI,especially large models,the importance of open source has become increasingly prominent.First,open source allows innovation to avoid starting from scratch.Through iterative innovation,it promotes technical exchanges and learning globally.Second,resources required for large model R&D are difficult for a single institution to obtain.The evaluation of general large models also requires the participation of experts from various industries.Third,without open source collaboration,it is difficult to form a unified upper-layer software ecosystem.Therefore,open source has become an important cooperation mechanism to promote the development of AI and large models.There are two cases to illustrate how open source and international standards interact with each other.展开更多
With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare re...With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.展开更多
Many experiments have supported the contact models,such as the GW and MB models,but the majority of previous validations have been performed under light loads,resulting in a linear relationship between normal force an...Many experiments have supported the contact models,such as the GW and MB models,but the majority of previous validations have been performed under light loads,resulting in a linear relationship between normal force and contact area.However,the real contact area fraction should never equal one;there must be a limit smaller than the apparent area,implying that the real contact area cannot increase linearly indefinitely.In this paper,the real contact area between two polymethylmethacrylate(PMMA)blocks under heavy load is measured using the total reflection method,and the contact area is analyzed using the image processing method.The results show that the real contact area increases with normal load linearly in light loads but non-linearly in heavy loads;the number of contact spots increases with load linearly in light loads but also non-linearly in heavy loads,synchronous with the change in the real contact area.The GW,MB,and Zhao,Maietta,and Chang(ZMC)models were used to predict the experiment results,but none of them predicted the non-linear stage.A revised GW model based on the bulk deformation hypothesis performs better in predicting the non-linear stage.The study’s findings can be applied to PMMA or other similar materials,and they can serve as a useful reference for future research on the contact mechanisms of other materials.展开更多
Accurate cloud classification plays a crucial role in aviation safety,climate monitoring,and localized weather forecasting.Current research has been focusing on machine learning techniques,particularly deep learning b...Accurate cloud classification plays a crucial role in aviation safety,climate monitoring,and localized weather forecasting.Current research has been focusing on machine learning techniques,particularly deep learning based model,for the types identification.However,traditional approaches such as convolutional neural networks(CNNs)encounter difficulties in capturing global contextual information.In addition,they are computationally expensive,which restricts their usability in resource-limited environments.To tackle these issues,we present the Cloud Vision Transformer(CloudViT),a lightweight model that integrates CNNs with Transformers.The integration enables an effective balance between local and global feature extraction.To be specific,CloudViT comprises two innovative modules:Feature Extraction(E_Module)and Downsampling(D_Module).These modules are able to significantly reduce the number of model parameters and computational complexity while maintaining translation invariance and enhancing contextual comprehension.Overall,the CloudViT includes 0.93×10^(6)parameters,which decreases more than ten times compared to the SOTA(State-of-the-Art)model CloudNet.Comprehensive evaluations conducted on the HBMCD and SWIMCAT datasets showcase the outstanding performance of CloudViT.It achieves classification accuracies of 98.45%and 100%,respectively.Moreover,the efficiency and scalability of CloudViT make it an ideal candidate for deployment inmobile cloud observation systems,enabling real-time cloud image classification.The proposed hybrid architecture of CloudViT offers a promising approach for advancing ground-based cloud image classification.It holds significant potential for both optimizing performance and facilitating practical deployment scenarios.展开更多
The complex geometrical features of mechanical components significantly influence contact interactions and system dynamics.However,directly modeling contact forces on surfaces with intricate geometries presents consid...The complex geometrical features of mechanical components significantly influence contact interactions and system dynamics.However,directly modeling contact forces on surfaces with intricate geometries presents considerable challenges.This study focuses on the helically twisted wire rope-sheave contact and proposes a contact force model that incorporates complex geometric features through a parameter identification approach.The model's impact on contact forces and system dynamics is thoroughly investigated.Leveraging a point contact model and an elliptic integral approximation,a loss function is formulated using the finite element(FE)contact model results as the reference data.Geometric parameters are subsequently determined by optimizing this loss function via a genetic algorithm(GA).The findings reveal that the contact stiffness increases with the wire rope pitch length,the radius of principal curvature,and the elliptic eccentricity of the contact zone.The proposed contact force model is integrated into a rigid-flexible coupled dynamics model,developed by the absolute node coordinate formulation,to examine the effects of contact geometry on system dynamics.The results demonstrate that the variations in wire rope geometry alter the contact stiffness,which in turn affects dynamic rope tension through frictional energy dissipation.The enhanced model's predictions exhibit superior alignment with the experimental data,thereby validating the methodology.This approach provides new insights for deducing the contact geometry from kinetic parameters and monitoring the performance degradation of mechanical components.展开更多
Background:In view of the ever-increasing representation of Staphylococcus spp.strains resistant to various antibiotics,the development of in vivo models for evaluation of novel antimicrobials is of utmost importance....Background:In view of the ever-increasing representation of Staphylococcus spp.strains resistant to various antibiotics,the development of in vivo models for evaluation of novel antimicrobials is of utmost importance.Methods:In this article,we describe the development of a fully immunocompetent porcine model of extensive skin and soft tissue damage suitable for testing topical anti-microbial agents that matches the real clinical situation.The model was developed in three consecutive stages with protocols for each stage amended based on the results of the previous one.Results:In the final model,10 excisions of the skin and underlying soft tissue were created in each pig under general anesthesia,with additional incisions to the fascia performed at the base of the defects and immediately inoculated with Staphylococcus aureus suspension.One pig was not inoculated and used as the negative control.Subsequently,the bandages were changed on Days 4,8,11,and 15.At these time points,a filter paper imprint technique(FPIT)was made from each wound for semi-quantitative microbiological evaluation.Tissue samples from the base of the wound together with the adjacent intact tissue of three randomly selected defects of each pig were taken for microbiological,histopathological,and molecular-biological examination.The infection with the inoculated S.aureus strains was sufficient during the whole experiment as confirmed by both FPIT and from tissue samples.The dynamics of the inflammatory markers and clinical signs of infection are also described.Conclusions:A successfully developed porcine model is suitable for in vivo testing of novel short-acting topical antimicrobial agents.展开更多
Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was ...Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.展开更多
基金supported by the National Science and Technology Major Project of Water Pollution Control and Treatment(Grants No.2014ZX07405002,2012ZX07506007,2012ZX07506006,and 2012ZX07506002)the Natural Science Foundation of the Anhui Higher Education Institutions of China(Grant No.KJ2016A868)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘With a focus on the difficulty of quantitatively describing the degree of nonuniformity of temporal and spatial distributions of water resources, quantitative research was carried out on the temporal and spatial distribution characteristics of water resources in Guangdong Province from 1956 to 2000 based on a cloud model. The spatial variation of the temporal distribution characteristics and the temporal variation of the spatial distribution characteristics were both analyzed. In addition, the relationships between the numerical characteristics of the cloud model of temporal and spatial distributions of water resources and precipitation were also studied. The results show that, using a cloud model, it is possible to intuitively describe the temporal and spatial distribution characteristics of water resources in cloud images. Water resources in Guangdong Province and their temporal and spatial distribution characteristics are differentiated by their geographic locations. Downstream and coastal areas have a larger amount of water resources with greater uniformity and stronger stability in terms of temporal distribution. Regions with more precipitation possess larger amounts of water resources, and years with more precipitation show greater nonuniformity in the spatial distribution of water resources. The correlation between the nonuniformity of the temporal distribution and local precipitation is small, and no correlation is found between the stability of the nonuniformity of the temporal and spatial distributions of water resources and precipitation. The amount of water resources in Guangdong Province shows an increasing trend from 1956 to 2000, the nonuniformity of the spatial distribution of water resources declines, and the stability of the nonuniformity of the spatial distribution of water resources is enhanced.
基金Heilongjiang Provincial Natural Science Foundation of China (LH2021F009)。
文摘Anti-jamming performance evaluation has recently received significant attention. For Link-16, the anti-jamming performance evaluation and selection of the optimal anti-jamming technologies are urgent problems to be solved. A comprehensive evaluation method is proposed, which combines grey relational analysis (GRA) and cloud model, to evaluate the anti-jamming performances of Link-16. Firstly, on the basis of establishing the anti-jamming performance evaluation indicator system of Link-16, the linear combination of analytic hierarchy process(AHP) and entropy weight method (EWM) are used to calculate the combined weight. Secondly, the qualitative and quantitative concept transformation model, i.e., the cloud model, is introduced to evaluate the anti-jamming abilities of Link-16 under each jamming scheme. In addition, GRA calculates the correlation degree between evaluation indicators and the anti-jamming performance of Link-16, and assesses the best anti-jamming technology. Finally, simulation results prove that the proposed evaluation model can achieve the objective of feasible and practical evaluation, which opens up a novel way for the research of anti-jamming performance evaluations of Link-16.
基金supported By Grant (PLN2022-14) of State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Southwest Petroleum University)。
文摘Well logging technology has accumulated a large amount of historical data through four generations of technological development,which forms the basis of well logging big data and digital assets.However,the value of these data has not been well stored,managed and mined.With the development of cloud computing technology,it provides a rare development opportunity for logging big data private cloud.The traditional petrophysical evaluation and interpretation model has encountered great challenges in the face of new evaluation objects.The solution research of logging big data distributed storage,processing and learning functions integrated in logging big data private cloud has not been carried out yet.To establish a distributed logging big-data private cloud platform centered on a unifi ed learning model,which achieves the distributed storage and processing of logging big data and facilitates the learning of novel knowledge patterns via the unifi ed logging learning model integrating physical simulation and data models in a large-scale functional space,thus resolving the geo-engineering evaluation problem of geothermal fi elds.Based on the research idea of“logging big data cloud platform-unifi ed logging learning model-large function space-knowledge learning&discovery-application”,the theoretical foundation of unified learning model,cloud platform architecture,data storage and learning algorithm,arithmetic power allocation and platform monitoring,platform stability,data security,etc.have been carried on analysis.The designed logging big data cloud platform realizes parallel distributed storage and processing of data and learning algorithms.The feasibility of constructing a well logging big data cloud platform based on a unifi ed learning model of physics and data is analyzed in terms of the structure,ecology,management and security of the cloud platform.The case study shows that the logging big data cloud platform has obvious technical advantages over traditional logging evaluation methods in terms of knowledge discovery method,data software and results sharing,accuracy,speed and complexity.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.52006197 and 51676174)the Natural Science Foundation of Jiangsu Province(Grant No.BK20180505)+1 种基金the National Science Foundation of Zhejiang Province(Grant Nos.LQ21E060012 and LR20E090001)the Key Research and Development Program of Zhejiang Province(Grant No.2020C01027)。
文摘The cavitating flow in different regimes has the intricate flow structure with multiple time and space scales.The present work develops a multiscale model by coupling the volume of fluid(VOF)method and a discrete bubble model(DBM),to simulate the cavitating flow in a convergent-divergent test section.The Schnerr-Sauer cavitation model is used to calculate the mass transfer rate to obtain the macroscale phase structure,and the simplified Rayleigh-Plesset equation is applied to simulate the growing and collapsing of discrete bubbles.An algorithm for bridging between the macroscale cavities and microscale bubbles is also developed to achieve the multiscale simulation.For the flow field,the very large eddy simulation(VLES)approach is applied.Conditions from inception to sheet/cloud cavitation regimes are taken into account and simulations are conducted.Compared with the experimental observations,it is shown that the cavitation inception,bubble clouds formation and glass cavity generation are all well represented,indicating that the proposed VOF-DBM model is a promising approach to accurately and comprehensively reveal the multiscale phase field induced by cavitation.
基金supported by the National Natural Science Foundation of China[grant number 42275074].
文摘Cloud diurnal variation is crucial for regulating cloud radiative effects and atmospheric dynamics.However,it is often overlooked in the evaluation and development of climate models.Thus,this study aims to investigate the daily mean(CFR)and diurnal variation(CDV)of cloud fraction across high-,middle-,low-level,and total clouds in the FGOALS-f3-L general circulation model.The bias of total CDV is decomposed into the model biases in CFRs and CDVs of clouds at all three levels.Results indicate that the model generally underestimates low-level cloud fraction during the daytime and high-/middle-level cloud fraction at nighttime.The simulation biases of low clouds,especially their CDV biases,dominate the bias of total CDV.Compensation effects exist among the bias decompositions,where the negative contributions of underestimated daytime low-level cloud fraction are partially offset by the opposing contributions from biases in high-/middle-level clouds.Meanwhile,the bias contributions have notable land–ocean differences and region-dependent characteristics,consistent with the model biases in these variables.Additionally,the study estimates the influences of CFR and CDV biases on the bias of shortwave cloud radiative effects.It reveals that the impacts of CDV biases can reach half of those from CFR biases,highlighting the importance of accurate CDV representation in climate models.
基金supported by the National Natural Science Foundation of China(42250101,42250102)the Macao Foundation.
文摘The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic field has not been previously estimated or incorporated into geomagnetic field models,potentially causing leakage into the core field model.Here,we present a method to account for the circulation-induced magnetic field during geomagnetic field modeling.First,a forward model of the circulation-induced magnetic field is constructed by numerically solving electromagnetic induction equations based on a realistic ocean circulation model.Then,this forward model is subtracted from the observed data.Finally,the core and lithospheric fields,magnetospheric and Earth’s mantle-induced fields,and the ocean tide-induced magnetic field are co-estimated.Applying our method to over 20 years of MSS-1,Swarm,CryoSat-2,and CHAMP satellite magnetic data,we derive a new multisource geomagnetic field model(MGFM).We find that incorporating a forward model of the circulation-induced magnetic field marginally improves the fit to the data.Furthermore,we demonstrate that neglecting the circulation-induced magnetic field in geomagnetic field modeling results in leakage into the core field model.The highlights of the MGFM model include:(i)a good agreement with the widely used CHAOS model series;(ii)the incorporation of magnetic fields induced by both ocean tides and circulation;and(iii)the suppression of leakage of the circulation-induced magnetic field into the core field model.
文摘Existing reverse-engineering methods struggle to directly generate editable,parametric CAD models from scanned data.To address this limitation,this paper proposes a reverse-modeling approach that reconstructs parametric CAD models from multi-view RGB-D point clouds.Multi-frame point-cloud registration and fusion are first employed to obtain a complete 3-D point cloud of the target object.A region-growing algorithm that jointly exploits color and geometric information segments the cloud,while RANSAC robustly detects and fits basic geometric primitives.These primitives serve as nodes in a graph whose edge features are inferred by a graph neural network to capture spatial constraints.From the detected primitives and their constraints,a high-accuracy,fully editable parametric CAD model is finally exported.Experiments show an average parameter error of 0.3 mm for key dimensions and an overall geometric reconstruction accuracy of 0.35 mm.The work offers an effective technical route toward automated,intelligent 3-D reverse modeling.
基金Guangdong Major Project of Basic and Applied Basic Research(2020B0301030004)National Natural Science Foundation of China(72293604,42275026)Open Grants of the State Key Laboratory of Severe Weather(2023LASW-B09)。
文摘Pronounced climatic differences occur over subtropical South China(SC)and tropical South China Sea(SCS)and understanding the key cloud-radiation characteristics is essential to simulating East Asian climate.This study investigated cloud fractions and cloud radiative effects(CREs)over SC and SCS simulated by CMIP6 atmospheric models.Remarkable differences in cloud-radiation characteristics appeared over these two regions.In observations,considerable amounts of low-middle level clouds and cloud radiative cooling effect appeared over SC.In contrast,high clouds prevailed over SCS,where longwave and shortwave CREs offset each other,resulting in a weaker net cloud radiative effect(NCRE).The models underestimated NCRE over SC mainly due to weaker shortwave CRE and less cloud fractions.Conversely,most models overestimated NCRE over SCS because of stronger shortwave CRE and weaker longwave CRE.Regional CREs were closely linked to their dominant cloud fractions.Both observations and simulations showed a negative spatial correlation between total(low)cloud fraction and shortwave CRE over SC,especially in winter,and exhibited a positive correlation between high cloud fraction and longwave CRE over these two regions.Compared with SCS,most models overestimated the spatial correlation between low(high)cloud fraction and SWCRE(LWCRE)over SC,with larger bias ranges among models,indicating the exaggerated cloud radiative cooling(warming)effect caused by low(high)clouds.Moreover,most models struggled to describe regional ascent and its connection with CREs over SC while they can better reproduce these connections over SCS.This study further suggests that reasonable circulation conditions are crucial to simulating well cloud-radiation characteristics over the East Asian regions.
基金supported in part by financial support from the National Key R&D Program of China(No.2023YFB3407003)the National Natural Science Foundation of China(No.52375378).
文摘A new analytical model for geometric size and forming force prediction in incremental flanging(IF)is presented in this work.The complex deformation characteristics of IF are considered in the modeling process,which can accurately describe the strain and stress states in IF.Based on strain analysis,the model can predict the material thickness distribution and neck height after IF.By considering contact area,strain characteristics,material thickness changes,and friction,the model can predict specific moments and corresponding values of maximum axial forming force and maximum horizontal forming force during IF.In addition,an IF experiment involving different tool diameters,flanging diameters,and opening hole diameters is conducted.On the basis of the experimental strain paths,the strain characteristics of different deformation zones are studied,and the stable strain ratio is quantitatively described through two dimensionless parameters:relative tool diameter and relative hole diameter.Then,the changing of material thickness and forming force in IF,and the variation of minimum material thickness,neck height,maximum axial forming force,and maximum horizontal forming force with flanging parameters are studied,and the reliability of the analytical model is verified in this process.Finally,the influence of the horizontal forming force on the tool design and the fluctuation of the forming force are explained.
基金supported by the National Natural Science Foundation of China (Grant No. 12002044)。
文摘DNAN-based insensitive melt-cast explosives have been widely utilized in insensitive munition in recent years. When constrained DNAN-based melt-cast explosives are ignited under thermal stimulation, the base explosive exists in a molten liquid state, where high-temperature gases expand and react in the form of bubble clouds within the liquid explosive;this process is distinctly different from the dynamic crack propagation process observed in the case of solid explosives. In this study, a control model for the reaction evolution of burning-bubble clouds was established to describe the reaction process and quantify the reaction violence of DNAN-based melt-cast explosives, considering the size distribution and activation mechanism of the burning-bubble clouds. The feasibility of the model was verified through experimental results. The results revealed that under geometrically similar conditions, with identical confinement strength and aspect ratio, larger charge structures led to extended initial gas flow and surface burning processes, resulting in greater reaction equivalence and violence at the casing fracture.Under constant charge volume and size, a stronger casing confinement accelerated self-enhanced burning, increasing the internal pressure, reaction degree, and reaction violence. Under a constant casing thickness and radius, higher aspect ratios led to a greater reaction violence at the casing fracture.Moreover, under a constant charge volume and casing thickness, higher aspect ratios resulted in a higher internal pressure, increased reaction degree, and greater reaction violence at the casing fracture. Further,larger ullage volumes extended the reaction evolution time and increased the reaction violence under constant casing dimensions. Through a matching design of the opening threshold of the pressure relief holes and the relief structure area, a stable burning reaction could be maintained until completion,thereby achieving a control of the reaction violence. The proposed model could effectively reflect the effects of the intrinsic burning rate, casing confinement strength, charge size, ullage volume, and pressure relief structure on the reaction evolution process and reaction violence, providing a theoretical method for the thermal safety design and reaction violence evaluation of melt-cast explosives.
基金supported by the National Natural Science Foundation of China(Grant Nos.41941017 and 42177139)Graduate Innovation Fund of Jilin University(Grant No.2024CX099)。
文摘The spatial distribution of discontinuities and the size of rock blocks are the key indicators for rock mass quality evaluation and rockfall risk assessment.Traditional manual measurement is often dangerous or unreachable at some high-steep rock slopes.In contrast,unmanned aerial vehicle(UAV)photogrammetry is not limited by terrain conditions,and can efficiently collect high-precision three-dimensional(3D)point clouds of rock masses through all-round and multiangle photography for rock mass characterization.In this paper,a new method based on a 3D point cloud is proposed for discontinuity identification and refined rock block modeling.The method is based on four steps:(1)Establish a point cloud spatial topology,and calculate the point cloud normal vector and average point spacing based on several machine learning algorithms;(2)Extract discontinuities using the density-based spatial clustering of applications with noise(DBSCAN)algorithm and fit the discontinuity plane by combining principal component analysis(PCA)with the natural breaks(NB)method;(3)Propose a method of inserting points in the line segment to generate an embedded discontinuity point cloud;and(4)Adopt a Poisson reconstruction method for refined rock block modeling.The proposed method was applied to an outcrop of an ultrahigh steep rock slope and compared with the results of previous studies and manual surveys.The results show that the method can eliminate the influence of discontinuity undulations on the orientation measurement and describe the local concave-convex characteristics on the modeling of rock blocks.The calculation results are accurate and reliable,which can meet the practical requirements of engineering.
文摘The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud data centres and an important concern of research for many researchers.In this paper,we proposed a cuckoo search(CS)-based optimisation technique for the virtual machine(VM)selection and a novel placement algorithm considering the different constraints.The energy consumption model and the simulation model have been implemented for the efficient selection of VM.The proposed model CSOA-VM not only lessens the violations at the service level agreement(SLA)level but also minimises the VM migrations.The proposed model also saves energy and the performance analysis shows that energy consumption obtained is 1.35 kWh,SLA violation is 9.2 and VM migration is about 268.Thus,there is an improvement in energy consumption of about 1.8%and a 2.1%improvement(reduction)in violations of SLA in comparison to existing techniques.
基金supported by the National Key Research and Development Program of China(Grant No.2021YFB3900400)the National Natural Science Foundation of China(Grant Nos.U2142212 and 42361074)。
文摘Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up table that contains the optical properties of five hydrometeor types—rain,cloud water,cloud ice,graupel,and snow—for the Advanced Radiative Transfer Modeling System(ARMS)at frequencies below 220 GHz.The discrete dipole approximation(DDA)method is employed to compute the single-scattering properties of solid cloud particles,modeling these particles as aggregated roughened bullet rosettes.The bulk optical properties of the cloud layer are derived by integrating the singlescattering properties with a modified Gamma size distribution,specifically for distributions with 18 effective radii.The bulk phase function is then projected onto a series of generalized spherical functions,applying the delta-M method for truncation.The results indicate that simulations using the newly developed nonspherical scattering look-up table exhibit significant consistency with observations under deep convection conditions.In contrast,assuming spherical solid cloud particles leads to excessive scattering at mid-frequency channels and insufficient scattering at high-frequency channels.This improvement in radiative transfer simulation accuracy for cloudy conditions will better support the assimilation of allsky microwave observations into numerical weather prediction models.·Frozen cloud particles were modeled as aggregates of bullet rosettes and the optical properties at microwave range were computed by DDA.·A complete process and technical details for constructing a look-up table of ARMS are provided.·The ARMS simulations generally show agreement with observations of MWTS and MWHS under typhoon conditions using the new look-up table.
文摘In the era of AI,especially large models,the importance of open source has become increasingly prominent.First,open source allows innovation to avoid starting from scratch.Through iterative innovation,it promotes technical exchanges and learning globally.Second,resources required for large model R&D are difficult for a single institution to obtain.The evaluation of general large models also requires the participation of experts from various industries.Third,without open source collaboration,it is difficult to form a unified upper-layer software ecosystem.Therefore,open source has become an important cooperation mechanism to promote the development of AI and large models.There are two cases to illustrate how open source and international standards interact with each other.
文摘With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.
基金Supported by National Natural Science Foundation of China(Grant No.11872033)Beijing Municipal Natural Science Foundation(Grant No.3172017)。
文摘Many experiments have supported the contact models,such as the GW and MB models,but the majority of previous validations have been performed under light loads,resulting in a linear relationship between normal force and contact area.However,the real contact area fraction should never equal one;there must be a limit smaller than the apparent area,implying that the real contact area cannot increase linearly indefinitely.In this paper,the real contact area between two polymethylmethacrylate(PMMA)blocks under heavy load is measured using the total reflection method,and the contact area is analyzed using the image processing method.The results show that the real contact area increases with normal load linearly in light loads but non-linearly in heavy loads;the number of contact spots increases with load linearly in light loads but also non-linearly in heavy loads,synchronous with the change in the real contact area.The GW,MB,and Zhao,Maietta,and Chang(ZMC)models were used to predict the experiment results,but none of them predicted the non-linear stage.A revised GW model based on the bulk deformation hypothesis performs better in predicting the non-linear stage.The study’s findings can be applied to PMMA or other similar materials,and they can serve as a useful reference for future research on the contact mechanisms of other materials.
基金funded by Innovation and Development Special Project of China Meteorological Administration(CXFZ2022J038,CXFZ2024J035)Sichuan Science and Technology Program(No.2023YFQ0072)+1 种基金Key Laboratory of Smart Earth(No.KF2023YB03-07)Automatic Software Generation and Intelligent Service Key Laboratory of Sichuan Province(CUIT-SAG202210).
文摘Accurate cloud classification plays a crucial role in aviation safety,climate monitoring,and localized weather forecasting.Current research has been focusing on machine learning techniques,particularly deep learning based model,for the types identification.However,traditional approaches such as convolutional neural networks(CNNs)encounter difficulties in capturing global contextual information.In addition,they are computationally expensive,which restricts their usability in resource-limited environments.To tackle these issues,we present the Cloud Vision Transformer(CloudViT),a lightweight model that integrates CNNs with Transformers.The integration enables an effective balance between local and global feature extraction.To be specific,CloudViT comprises two innovative modules:Feature Extraction(E_Module)and Downsampling(D_Module).These modules are able to significantly reduce the number of model parameters and computational complexity while maintaining translation invariance and enhancing contextual comprehension.Overall,the CloudViT includes 0.93×10^(6)parameters,which decreases more than ten times compared to the SOTA(State-of-the-Art)model CloudNet.Comprehensive evaluations conducted on the HBMCD and SWIMCAT datasets showcase the outstanding performance of CloudViT.It achieves classification accuracies of 98.45%and 100%,respectively.Moreover,the efficiency and scalability of CloudViT make it an ideal candidate for deployment inmobile cloud observation systems,enabling real-time cloud image classification.The proposed hybrid architecture of CloudViT offers a promising approach for advancing ground-based cloud image classification.It holds significant potential for both optimizing performance and facilitating practical deployment scenarios.
基金supported by the National Key Research and Development Program of China(No.2023YFC3010400)。
文摘The complex geometrical features of mechanical components significantly influence contact interactions and system dynamics.However,directly modeling contact forces on surfaces with intricate geometries presents considerable challenges.This study focuses on the helically twisted wire rope-sheave contact and proposes a contact force model that incorporates complex geometric features through a parameter identification approach.The model's impact on contact forces and system dynamics is thoroughly investigated.Leveraging a point contact model and an elliptic integral approximation,a loss function is formulated using the finite element(FE)contact model results as the reference data.Geometric parameters are subsequently determined by optimizing this loss function via a genetic algorithm(GA).The findings reveal that the contact stiffness increases with the wire rope pitch length,the radius of principal curvature,and the elliptic eccentricity of the contact zone.The proposed contact force model is integrated into a rigid-flexible coupled dynamics model,developed by the absolute node coordinate formulation,to examine the effects of contact geometry on system dynamics.The results demonstrate that the variations in wire rope geometry alter the contact stiffness,which in turn affects dynamic rope tension through frictional energy dissipation.The enhanced model's predictions exhibit superior alignment with the experimental data,thereby validating the methodology.This approach provides new insights for deducing the contact geometry from kinetic parameters and monitoring the performance degradation of mechanical components.
基金Supported by the Ministry of Health of the Czech Republic,Grant/Award Number:NU22-05-00475 and NV19-05-00214。
文摘Background:In view of the ever-increasing representation of Staphylococcus spp.strains resistant to various antibiotics,the development of in vivo models for evaluation of novel antimicrobials is of utmost importance.Methods:In this article,we describe the development of a fully immunocompetent porcine model of extensive skin and soft tissue damage suitable for testing topical anti-microbial agents that matches the real clinical situation.The model was developed in three consecutive stages with protocols for each stage amended based on the results of the previous one.Results:In the final model,10 excisions of the skin and underlying soft tissue were created in each pig under general anesthesia,with additional incisions to the fascia performed at the base of the defects and immediately inoculated with Staphylococcus aureus suspension.One pig was not inoculated and used as the negative control.Subsequently,the bandages were changed on Days 4,8,11,and 15.At these time points,a filter paper imprint technique(FPIT)was made from each wound for semi-quantitative microbiological evaluation.Tissue samples from the base of the wound together with the adjacent intact tissue of three randomly selected defects of each pig were taken for microbiological,histopathological,and molecular-biological examination.The infection with the inoculated S.aureus strains was sufficient during the whole experiment as confirmed by both FPIT and from tissue samples.The dynamics of the inflammatory markers and clinical signs of infection are also described.Conclusions:A successfully developed porcine model is suitable for in vivo testing of novel short-acting topical antimicrobial agents.
基金Supported by the National Natural Science Foundation of China(42302141).
文摘Taking the second member of the Xujiahe Formation of the Upper Triassic in the Xinchang structural belt as an example,based on data such as logging,production,seismic interpretation and test,a systematic analysis was conducted on the structural characteristics and evolution,reservoir diagenesis and densification processes,and types and stages of faults/fractures,and revealing the multi-stage and multi-factor dynamic coupled enrichment mechanisms of tight gas reservoirs.(1)In the early Yanshan period,the paleo-structural traps were formed with low-medium maturity hydrocarbons accumulating in structural highs driven by buoyancy since reservoirs were not fully densified in this stage,demonstrating paleo-structure control on traps and early hydrocarbon accumulation.(2)In the middle-late Yanshan period,the source rocks became mature to generate and expel a large quantity of hydrocarbons.Grain size and type of sandstone controlled the time of reservoir densification,which restricted the scale of hydrocarbon charging,allowing for only a small-scale migration through sand bodies near the fault/fracture or less-densified matrix reservoirs.(3)During the Himalayan period,the source rocks reached overmaturity,and the residual oil cracking gas was efficiently transported along the late-stage faults/fractures.Wells with high production capacity were mainly located in Type I and II fault/fracture zones comprising the late-stage north-south trending fourth-order faults and the late-stage fractures.The productivity of the wells was controlled by the transformation of the late-stage faults/fractures.(4)The Xinchang structural belt underwent three stages of tectonic evolution,two stages of reservoir formation,and three stages of fault/fractures development.Hydrocarbons mainly accumulated in the paleo-structure highs.After reservoir densification and late fault/fracture adjustment,a complex gas-water distribution pattern was formed.Thus,it is summarized as the model of“near-source and low-abundance hydrocarbon charging in the early stage,and differential enrichment of natural gas under the joint control of fault-fold-fracture complex,high-quality reservoirs and structural highs in the late stage”.Faults/fractures with well-coupled fault-fold-fracture-pore are favorable exploration targets with high exploration effectiveness.
