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Necessary and sufficient condition for modified Nevanlinna-Pick interpolation for closed-loop pole placement
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作者 Bhuvanadas ARUNA Rajagopalan DEVANATHAN 《Control Theory and Technology》 EI CSCD 2017年第1期58-68,共11页
Nevanlinna-Pick interpolation theory has sevaral applications, in particular in robust control. In this paper, we derive necessary and sufficient condition so that a modification of the Nevanlinna-Pick theory can plac... Nevanlinna-Pick interpolation theory has sevaral applications, in particular in robust control. In this paper, we derive necessary and sufficient condition so that a modification of the Nevanlinna-Pick theory can place the closed-loop poles inside a circular region in the left half of the complex plane in addition to the control system design being robust and internally stable. Numerical examples illustrate the theory. 展开更多
关键词 INTERPOLATION pole assignment ROBUSTNESS sensitivity UNCERTAINTY
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不同PD-1单抗治疗POLE基因突变型结直肠癌疗效的比较
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作者 陈盼盼 陈翠珊 +2 位作者 潘庆善 杨曦 周捷 《中国处方药》 2025年第18期6-10,共5页
目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替... 目的明确治疗DNA聚合酶ε催化亚单位(POLE)基因突变型结直肠癌首选的程序性死亡受体-1(PD-1)单抗。方法收集确诊晚期POLE基因突变型结直肠癌患者的临床资料,按使用不同的PD-1单抗分为帕博利珠单抗组(Pem组)、特瑞普利单抗组(Tor组)、替雷利珠单抗组(Tis组)、信迪利单抗组(Sin组)四个组别。按Recist 1.1标准评价药物的疗效。以患者首次接受PD-1单抗治疗为生存时间起点计算无事件生存期(EFS),绘制Kaplan-Meier生存曲线,并用Log-Rank进行检验。对比分析用药前后癌胚抗原(CEA)、糖类抗原19-9(CA19-9)和糖类抗原72-4(CA72-4)等肿瘤标志物的检测结果。统计分析用药过程中各组不良反应的发生率。结果客观缓解率(ORR)高低依次为Pem组(66.67%)、Tor组(53.33%)、Tis组(50.00%)、Sin组(43.75%),各组差异无统计学意义(P>0.05)。EFS依次为Pem组11.45个月、Tis组9.68个月、Tor组9.32个月、Sin组8.85个月。经Log-Rank检验,Pem组累计生存比例显著高于Sin组(P<0.05)。Pem组用药后CA19-9和CA72-4水平显著降低(P<0.05),而Tor组在用药后CA19-9和CA72-4水平显著降低(P<0.05)。各组患者均出现了皮疹、甲状腺功能异常、转氨酶升高、免疫性肺炎、结肠炎、外周神经炎、血细胞减少等免疫相关性不良反应,但发生率差异无统计学意义(P>0.05)。结论对于POLE基因突变型结直肠癌,可首选帕博利珠单抗进行治疗,特瑞普利单抗次选,最后考虑替雷利珠单抗或信迪利单抗。 展开更多
关键词 pole基因 结直肠癌 PD-1单抗
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POLE基因突变型子宫内膜癌的免疫特征分析
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作者 黄育刚 苏小敏 +1 位作者 王莉 汤显斌 《中国免疫学杂志》 北大核心 2025年第4期908-914,共7页
目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCG... 目的:探讨POLE基因突变型子宫内膜癌(EC)的免疫特征。方法:收集2020年12月至2022年10月十堰市太和医院病理科存档的104例EC石蜡包埋组织样本,包括11例POLE突变型和93例POLE野生型。免疫组化检测EC组织中CD4、CD8、PD-L1蛋白表达;结合TCGA数据库分析POLE基因突变型的免疫浸润情况,主要包括CD4、CD8、PD-L1 mRNA的表达及相关预后分析。结果:基于TCGA数据集,与POLE野生型EC相比,POLE突变型的趋化因子家族、免疫细胞表面标志物及溶菌酶等基因的表达差异显著(均P<0.05)。POLE突变型样本中,主要富集的信号途径包括免疫调控、间质上皮转化等(均P<0.01)。相较于POLE野生型,POLE突变型EC样本中CD4^(+)T细胞、CD8^(+)T细胞、M1型巨噬细胞及树突状细胞的丰度高(均P<0.05)。TISIDB平台分析表明,POLE突变状态下,显著驱动了免疫细胞的生物学行为,包括树突状细胞、NK细胞、T细胞等免疫细胞的募集和活化、淋巴细胞归巢等。另外,POLE突变型样本中,多种免疫检查点抑制基因(包括PD-L1、CTLA-4、TIM-3等)显著高表达。临床样本也证实POLE基因突变型与CD8、CD4、PD-L1的高表达显著相关(所有P<0.001)。基于TCGA数据库的预后分析显示,CD8或PD-L1高表达且POLE突变型亚组生存期显著延长,CD8或PD-L1低表达且POLE野生型亚组生存期最短(P<0.01);而CD4亚组差异无统计学意义(P>0.05)。结论:在EC患者中,CD8^(+)T细胞浸润丰度、PD-L1表达情况对POLE突变型的预后或治疗具有重要价值。 展开更多
关键词 子宫内膜癌 pole突变 免疫特征分析 生物信息学分析
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Design and optimization of quadrupole and sextupole magnets for Shenzhen Innovation Light-source Facility storage ring
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作者 Zhu Jiawu Zhang Miao Wang Yong 《强激光与粒子束》 北大核心 2025年第7期83-90,共8页
As an advanced 4^(th) generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude redu... As an advanced 4^(th) generation synchrotron radiation facility,the Shenzhen Innovation Light-source Facility(SILF)storage ring is based on multi-bend achromat(MBA)lattices,enabling one to two orders of magnitude reduction in beam emittance compared to the 3^(rd) generation storage ring.This significantly enhance the radiation brightness and coherence.The multipole magnets of many types for SILF storage ring are under preliminary design,which require high integral field homogeneity.As a result,a dedicated pole tip optimization procedure with high efficiency is developed for quadrupole and sextupole magnets with Opera-2D^(■)python script.The procedure considers also the 3D field effect which makes the optimization more straightforward.In this paper,the design of the quadrupole and sextupole magnets for SILF storage ring is first presented,followed by a detailed description of the implemented pole shape optimization method. 展开更多
关键词 synchrotron radiation facility quadrupole magnet sextupole magnet pole shape optimization
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信迪利单抗联合贝伐珠单抗转化治疗POLE~(P286R)突变型结直肠癌1例
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作者 杨俊豪 姚光宇 +3 位作者 马晓婷 刘莲 王晰程 巴一 《中国肿瘤临床》 北大核心 2025年第18期971-972,共2页
患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节... 患者男性,44岁。2023年6月开始出现间断性右腹痛,发作时可扪及右侧中下腹凸起肿块,自服“胃药”后未有好转。2024年7月患者于当地医院行腹部增强CT,显示右侧结肠肝区壁有局限性不规则增厚,密度欠均匀,增强呈不均匀明显强化;胰头区结节样软组织密度影,边缘清晰光滑,与胰头分界欠清,增强呈不均匀强化,提示恶性可能。 展开更多
关键词 pole 结直肠癌 免疫治疗 抗血管生成治疗 转化治疗
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Soft sensory-neuromorphic system for closed-loop neuroprostheses
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作者 Jaehyon Kim Sungjun Lee +1 位作者 Jiyong Yoon Donghee Son 《International Journal of Extreme Manufacturing》 2025年第4期2-33,共32页
Prosthetic devices designed to assist individuals with damaged or missing body parts have made significant strides,particularly with advancements in machine intelligence and bioengineering.Initially focused on movemen... Prosthetic devices designed to assist individuals with damaged or missing body parts have made significant strides,particularly with advancements in machine intelligence and bioengineering.Initially focused on movement assistance,the field has shifted towards developing prosthetics that function as seamless extensions of the human body.During this progress,a key challenge remains the reduction of interface artifacts between prosthetic components and biological tissues.Soft electronics offer a promising solution due to their structural flexibility and enhanced tissue adaptability.However,achieving full integration of prosthetics with the human body requires both artificial perception and efficient transmission of physical signals.In this context,synaptic devices have garnered attention as next-generation neuromorphic computing elements because of their low power consumption,ability to enable hardware-based learning,and high compatibility with sensing units.These devices have the potential to create artificial pathways for sensory recognition and motor responses,forming a“sensory-neuromorphic system”that emulates synaptic junctions in biological neurons,thereby connecting with impaired biological tissues.Here,we discuss recent developments in prosthetic components and neuromorphic applications with a focus on sensory perception and sensorimotor actuation.Initially,we explore a prosthetic system with advanced sensory units,mechanical softness,and artificial intelligence,followed by the hardware implementation of memory devices that combine calculation and learning functions.We then highlight the importance and mechanisms of soft-form synaptic devices that are compatible with sensing units.Furthermore,we review an artificial sensory-neuromorphic perception system that replicates various biological senses and facilitates sensorimotor loops from sensory receptors,the spinal cord,and motor neurons.Finally,we propose insights into the future of closed-loop neuroprosthetics through the technical integration of soft electronics,including bio-integrated sensors and synaptic devices,into prosthetic systems. 展开更多
关键词 soft electronics synaptic devices sensory-neuromorphic system closed-loop neuroprosthetics
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Bilateral sleeve fracture of the superior pole of the patella in a healthy adult:A case report
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作者 Wen-Ping He Ci-Meng Ren +5 位作者 Feng Luo Li Chen Wen-Tao Wang Bing-Tao Qiu Xiao-Cao Zhang Hai-TaoChen 《World Journal of Orthopedics》 2025年第11期148-154,共7页
BACKGROUND Sleeve fracture of the patella is an unusual fracture,almost unique to children.The majority of sleeve fractures involve the inferior patellar pole.However,sleeve fractures of the superior pole of the patel... BACKGROUND Sleeve fracture of the patella is an unusual fracture,almost unique to children.The majority of sleeve fractures involve the inferior patellar pole.However,sleeve fractures of the superior pole of the patella are extremely rare in adults.CASE SUMMARY An 18-year-old male patient fell while running in the morning.The patient had tenderness to palpation at the superior pole of the patella,with a palpable gap over the upper part of the patella in both knees.We applied two 4.5-mm suture anchors with the Krackow stitch to repair the sleeve fracture,augmented by autogenous gracilis through performing the figure-of-eight technique.The patient regained approximately the full range of motion of the knee joint without any quadriceps weakness and a normal gait 6 weeks after surgery.CONCLUSION Sleeve fractures of the superior pole of the patella are extremely rare in adults,especially bilateral sleeve fractures.Suture anchors,augmented by autogenous gracilis,provided secure fixation and achieved excellent results in this rare injury. 展开更多
关键词 Sleeve fracture Patella Superior pole Adult Suture anchors Case report
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Design and Implementation of Closed-Loop Control of Vector Force in Static Push-the-bit Rotary Steering System
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作者 Liang Yao Kang Hong-bo +4 位作者 Liu Yue Chen wen Sun Yan Ma Li Zhao Yan-Wei 《Applied Geophysics》 2025年第3期796-803,896,共9页
Rotary steering systems(RSSs)have been increasingly used to develop horizontal wells.A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve changes in the p... Rotary steering systems(RSSs)have been increasingly used to develop horizontal wells.A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve changes in the pushing force acting on the wellbore in different sizes and directions within a circular range,ultimately allowing the wellbore trajectory to be drilled in a predetermined direction.By analyzing its mathematical principles and the actual characteristics of the instrument,a vector force closed-loop control method,including steering and holding modes,was designed.The adjustment criteria for the three hydraulic modules are determined to achieve rapid adjustment of the vector force.The theoretical feasibility of the developed method was verified by comparing its results with the on-site application data of an imported rotary guidance system. 展开更多
关键词 Static push-the-bit hydraulic modules closed-loop control vector force working mode
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Simultaneous second and third harmonics generation in periodically poled lithium niobate:Coupling and competition
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作者 Junming Liu Liqiang Liu +1 位作者 Lihong Hong Zhiyuan Li 《Chinese Physics B》 2025年第8期591-599,共9页
Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bu... Conventional approaches for obtaining the second and third harmonics typically employ several nonlinear crystals to generate them,which is restricted in application due to the complexity of the optical path and the bulkiness of the device.In this work,we present a comprehensive theoretical and numerical investigation of the simultaneous generation and competition between the second harmonic waves(SHW)and the third harmonic waves(THW)in a single nonlinear crystal.Through analyzing both small-signal and large-signal regimes,we reveal the complex coupling mechanisms between SHW and THW generation processes.Using periodically poled lithium niobate as an example,we demonstrate that the relative conversion efficiencies between SHW and THW can be freely adjusted by controlling the input fundamental wave power.This work provides new insights for designing efficient frequency converters capable of generating both SHW and THW outputs with controllable intensity ratios. 展开更多
关键词 second harmonic generation third harmonic generation quasi-phase matching periodically poled lithium niobate
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Visualization of domain structure in periodically poled lithium niobate using radially polarized light
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作者 Yang Han Hongfei Zhang +3 位作者 Fei Chen Chen Yang Yue Wang Kebin Shi 《Advanced Photonics Nexus》 2025年第4期113-118,共6页
Due to its broken out-of-plane symmetry,z-cut periodically poled lithium niobate(PPLN)has exhibited ultrahigh second-order optical nonlinearity.Precise quantification of the domain structure of z-cut PPLN plays a crit... Due to its broken out-of-plane symmetry,z-cut periodically poled lithium niobate(PPLN)has exhibited ultrahigh second-order optical nonlinearity.Precise quantification of the domain structure of z-cut PPLN plays a critical role during poling fabrication.To enhance the imaging detection efficiency of the domain structure in z-cut PPLN,we have developed a second-harmonic generation microscope system specifically designed to produce a longitudinal electric field in foci for the imaging domain inversion.We demonstrated that imaging using a longitudinal electric field can achieve a contrast ratio enhancement by a factor of 1.77,showing high imaging efficiency and making the proposed method suitable for in situ monitoring of the z-cut PPLN poling process. 展开更多
关键词 domain structure periodically poled lithium niobate radially polarized light longitudinal electric field
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Fishing Ship Trajectory Tracking Control Based on the Closed-Loop Gain Shaping Algorithm Under Rough Sea
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作者 SONG Chun-yu GUO Te-er SUI Jiang-hua 《China Ocean Engineering》 2025年第2期365-372,共8页
This paper proposes a separated trajectory tracking controller for fishing ships at sea state level 6 to solve the trajectory tracking problem of a fishing ship in a 6-level sea state,and to adapt to different working... This paper proposes a separated trajectory tracking controller for fishing ships at sea state level 6 to solve the trajectory tracking problem of a fishing ship in a 6-level sea state,and to adapt to different working environments and safety requirements.The nonlinear feedback method is used to improve the closed-loop gain shaping algorithm.By introducing the sine function,the problem of excessive control energy of the system can be effectively solved.Moreover,an integral separation design is used to solve the influence of the integral term in conventional PID controllers on the transient performance of the system.In this paper,a common 32.98 m large fiberglass reinforced plastic(FRP)trawler is adopted for simulation research at the winds scale of Beaufort No.7.The results show that the track error is smaller than 3.5 m.The method is safe,feasible,concise and effective and has popularization value in the direction of fishing ship trajectory tracking control.This method can be used to improve the level of informatization and intelligence of fishing ships. 展开更多
关键词 trajectory tracking control nonlinear feedback control fishing ship closed-loop gain shaping algorithm rough sea
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Advancing Railway Infrastructure Monitoring:A Case Study on Railway Pole Detection
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作者 Yuxin Yan Huirui Wang +2 位作者 Jingyi Wen Zerong Lan Liang Wang 《Computers, Materials & Continua》 2025年第5期3059-3073,共15页
The development of artificial intelligence(AI)technologies creates a great chance for the iteration of railway monitoring.This paper proposes a comprehensive method for railway utility pole detection.The framework of ... The development of artificial intelligence(AI)technologies creates a great chance for the iteration of railway monitoring.This paper proposes a comprehensive method for railway utility pole detection.The framework of this paper on railway systems consists of two parts:point cloud preprocessing and railway utility pole detection.Thismethod overcomes the challenges of dynamic environment adaptability,reliance on lighting conditions,sensitivity to weather and environmental conditions,and visual occlusion issues present in 2D images and videos,which utilize mobile LiDAR(Laser Radar)acquisition devices to obtain point cloud data.Due to factors such as acquisition equipment and environmental conditions,there is a significant amount of noise interference in the point cloud data,affecting subsequent detection tasks.We designed a Dual-Region Adaptive Point Cloud Preprocessing method,which divides the railway point cloud data into track and non-track regions.The track region undergoes projection dimensionality reduction,with the projected results being unique and subsequently subjected to 2D density clustering,greatly reducing data computation volume.The non-track region undergoes PCA-based dimensionality reduction and clustering operations to achieve preprocessing of large-scale point cloud scenes.Finally,the preprocessed results are used for training,achieving higher accuracy in utility pole detection and data communication.Experimental results show that our proposed preprocessing method not only improves efficiency but also enhances detection accuracy. 展开更多
关键词 Railway pole detection point cloud data mobile LiDAR dual-region adaptive method PCA-based dimensionality reduction
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Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis
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作者 Yan-Fei Feng Hui-Kun Zhou +8 位作者 Bo-Bin Hu Hang Wang Heng-Kai Liang Lu Wei Qing-Mei Li Tu-Mei Su Qian-Bing Yin Ming-Hua Su Jian-Ning Jiang 《World Journal of Hepatology》 2025年第7期221-232,共12页
BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging e... BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients. 展开更多
关键词 Extra spindle pole bodies-like 1 p53 antibody Hepatocellular carcinoma Hepatitis B virus Diagnostic biomarker Case-control study
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Fast and Accurate Prediction of Electromagnetic and Temperature Fields for SPMSM Equipped with Unequally Thick Magnetic Poles
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作者 Feng Liu Xiuhe Wang +1 位作者 Lingling Sun Hongye Wei 《CES Transactions on Electrical Machines and Systems》 2025年第2期199-211,共13页
With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher ... With the continuous upgrading of traditional manufacturing industries and the rapid rise of emerging technology fields,the performance requirements for the permanent magnet synchronous motors(PMSMs)have become higher and higher.The importance of fast and accurate electromagnetic thermal coupling analysis of such motors becomes more and more prominent.In view of this,the surfacemounted PMSM(SPMSM)equipped with unequally thick magnetic poles is taken as the main object and its electromagnetic thermal coupling analytical model(ETc AM)is investigated.First,the electromagnetic analytical model(EAM)is studied based on the modified subdomain method.It realizes the fast calculation of key electromagnetic characteristics.Subsequently,the 3D thermal analytical model(TAM)is developed by combining the EAM,the lumped parameter thermal network method(LPTNM),and the partial differential equation of heat flux.It realizes the fast calculation of key thermal characteristics in 3D space.Further,the information transfer channel between EAM and TAM is built with reference to the intrinsic connection between electromagnetic field and temperature field.Thereby,the novel ETcAM is proposed to realize the fast and accurate prediction of electromagnetic and temperature fields.Besides,ETcAM has a lot to commend it.One is that it well accounts for the complex structure,saturation,and heat exchange behavior.Second,it saves a lot of computer resources.It offers boundless possibilities for initial design,scheme evaluation,and optimization of motors.Finally,the validity,accuracy,and practicality of this study are verified by simulation and experiment. 展开更多
关键词 Electromagnetic field and temperature field Electromagnetic thermal coupling analytical model(ETcAM) Fast and accurate prediction SPMSM Unequally thick magnetic poles
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POLE/POLD1突变对结直肠癌预后及免疫治疗影响的生物信息学分析
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作者 赵龙 杨长江 +1 位作者 叶颖江 申占龙 《肿瘤学杂志》 CAS 2024年第6期439-448,共10页
[目的]利用生物信息学方法对结直肠癌(colorectal cancer,CRC)中的DNA聚合酶ε(POLE)和DNA聚合酶δ1(POLD1)的突变情况进行分析,并探索两者对CRC预后及免疫治疗的影响。[方法]基于TCGA数据库的数据集,利用c BioPortal工具对所有癌症中的... [目的]利用生物信息学方法对结直肠癌(colorectal cancer,CRC)中的DNA聚合酶ε(POLE)和DNA聚合酶δ1(POLD1)的突变情况进行分析,并探索两者对CRC预后及免疫治疗的影响。[方法]基于TCGA数据库的数据集,利用c BioPortal工具对所有癌症中的POLE/POLD1的改变及其预后进行分析,利用MSIsensor、MANTIS两种评分系统对POLE/POLD1野生型和突变型的CRC患者微卫星不稳定性进行评价,并利用TIMER数据库分析CRC的免疫细胞浸润以及免疫检查点表达与POLE/POLD1突变之间相关性。[结果]在CRC中POLE/POLD1基因的改变频率为6%,且均以错义突变为主。在泛癌中POLE的突变后患者无进展生存期(P<0.001)、无病生存期(P<0.001)及疾病特异性生存期(P=0.017 8)均显著延长。POLE/POLD1突变型CRC患者的微卫星不稳定性占比相比较于野生型患者显著提高(P<0.001),且免疫检查点相关基因CD274、HAVCR2、PDCD1、CTLA4、LAG3、TIGIT和PDCD1LG2的表达均显著上升。CRC中POLE和POLD1基因表达均与肿瘤突变负荷显著相关。此外,CRC中POLE/POLD1突变还与CD8^(+)T细胞、中性粒细胞、树突状细胞等免疫细胞的浸润相关。[结论]POLE/POLD1基因的改变在CRC中较为常见,在泛癌中POLD1突变与患者预后相关。POLE/POLD1基因突变后可能造成微卫星不稳定性增高、免疫检查点的表达上调和免疫细胞浸润程度增加,其可能成为免疫治疗的新靶点。 展开更多
关键词 pole突变 POLD1突变 结直肠肿瘤 生物信息学 免疫治疗
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具有POLE致病性突变子宫内膜癌的临床病理及分子特征分析 被引量:2
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作者 蔡宇梦 周杨 +4 位作者 汪昊 庞钧译 吴焕文 师晓华 梁智勇 《诊断病理学杂志》 2024年第4期282-286,322,共6页
目的探讨具有POLE致病性突变子宫内膜癌(EC)的临床病理及分子特征。方法选取179例EC患者,根据POLE基因突变、错配修复(MMR)蛋白表达及p53表达/TP53突变进行分子分型,分析POLE mut型EC的临床病理及分子特征。结果POLE mut20例,MMRd 48例,... 目的探讨具有POLE致病性突变子宫内膜癌(EC)的临床病理及分子特征。方法选取179例EC患者,根据POLE基因突变、错配修复(MMR)蛋白表达及p53表达/TP53突变进行分子分型,分析POLE mut型EC的临床病理及分子特征。结果POLE mut20例,MMRd 48例,NSMP 90例,p53 abn 21例。POLE mut EC多为FIGOⅠ期(17/20),中-低分化子宫内膜样癌(EEC)(13/20)、局限于内膜/浅肌层(17/20)、肿瘤浸润性淋巴细胞(TILs)显著(17/20)、无/局灶(LVSI)(18/20)、无淋巴结转移(19/20)。4个亚组间临床病理特征的差异均有统计学意义(P<0.05)。POLE mut型预后最好,具有多重分类特征的病例预后更接近POLE mut型。结论POLE mut EC提示着较高的组织学分级,较早的临床分期及较好的预后;POLE mut可继发dMMR/MSI-H表型及p53/TP53异常,应归类为POLE mut型。 展开更多
关键词 子宫内膜癌 分子分型 pole 错配修复缺陷 TP53
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Planar matrices and arrays of Feynman diagrams:poles for higher k
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作者 Alfredo Guevara Yong Zhang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2024年第4期1-13,共13页
Planar arrays of tree diagrams were introduced as a generalization of Feynman diagrams that enable the computation of biadjoint amplitudes m_(n)(^(k))for k>2.In this follow-up work,we investigate the poles of m_(n)... Planar arrays of tree diagrams were introduced as a generalization of Feynman diagrams that enable the computation of biadjoint amplitudes m_(n)(^(k))for k>2.In this follow-up work,we investigate the poles of m_(n)(^(k))from the perspective of such arrays.For general k,we characterize the underlying polytope as a Flag Complex and propose a computation of the amplitude-based solely on the knowledge of the poles,whose number is drastically less than the number of the full arrays.As an example,we first provide all the poles for the cases(k,n)=(3,7),(3,8),(3,9),(3,10),(4,8)and(4,9)in terms of their planar arrays of degenerate Feynman diagrams.We then implement simple compatibility criteria together with an addition operation between arrays and recover the full collections/arrays for such cases.Along the way,we implement hard and soft kinematical limits,which provide a map between the poles in kinematic space and their combinatoric arrays.We use the operation to give a proof of a previously conjectured combinatorial duality for arrays in(k,n)and(n-k,n).We also outline the relation to boundary maps of the hypersimplex Δ_(k,n) and rays in the tropical Grassmannian Tr(k,n). 展开更多
关键词 Feynman diagrams biadjoint amplitudes poleS
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The interannual periodicity of precipitation and its links to the large-scale circulations over the Third Pole
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作者 LIANG Liqiao LIU Qiang LI Jiuyi 《Journal of Geographical Sciences》 SCIE CSCD 2024年第8期1457-1471,共15页
To understand the spatio-temporal variability of precipitation(P)in the Third Pole region(centered on the Tibetan Plateau-TP),it is necessary to quantify the interannual periodicity of P and its relationship with larg... To understand the spatio-temporal variability of precipitation(P)in the Third Pole region(centered on the Tibetan Plateau-TP),it is necessary to quantify the interannual periodicity of P and its relationship with large-scale circulations.In this study,Morlet wavelet transform was used to detect significant(p<0.05)periodic characteristics in P data from meteorological stations in four climate domains in the Third Pole,and to reveal the major large-scale circulations that triggered the variability of periodic P,in addition to bringing large amounts of water vapour.The wavelet transform results were as follows.(1)Significant quasiperiodicity varied from 2 to 11 years.The high-frequency variability mode(2 to 6 years quasi-periods)was universal,and the low-frequency variability mode(7 to 11 years quasi-periods)was rare,occurring mainly in the westerlies and Indian monsoon domains.(2)The majority of periods were base periods(53%),followed by two-base periods.Almost all stations in the Third Pole(95%)showed one or two periods.(3)Periodicity was widely detected in the majority of years(84%).(4)The power spectra of P in the four domains were dominated by statistically significant high-frequency oscillations(ie.,with short periodicity).(5)Large-scale circulations directly and indirectly influenced the periodic P variability in the different domains.The mode of P variability in the different domains was influenced by interactions between large-scale circulation features and not only by the dominant circulation and its control of water vapour transport.The results of this study will contribute to better understanding of the causal mechanisms associated with P variability,which is important for hydrological science and waterresourcemanagement. 展开更多
关键词 PRECIPITATION interannual periodicity Morlet wavelet large-scale circulations Third pole
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Bioinspired Closed-loop CPG-based Control of a Robotic Manta for Autonomous Swimming
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作者 Yiwei Hao Yonghui Cao +5 位作者 Yingzhuo Cao Xiong Mo Qiaogao Huang Lei Gong Guang Pan Yong Cao 《Journal of Bionic Engineering》 SCIE EI CSCD 2024年第1期177-191,共15页
Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral reefs.It is still difficult for a robotic fish ... Fish in nature exhibit a variety of swimming modes such as forward swimming,backward swimming,turning,pitching,etc.,enabling them to swim in complex scenes such as coral reefs.It is still difficult for a robotic fish to swim autonomously in a confined area as a real fish.Here,we develop an untethered robotic manta as an experimental platform,which consists of two flexible pectoral fins and a tail fin,with three infrared sensors installed on the front,left,and right sides of the head to sense the surrounding obstacles.To generate multiple swimming modes of the robotic manta and online switching of different modes,we design a closed-loop Central Pattern Generator(CPG)controller based on distance information and use a combination of phase difference and amplitude of the CPG model to achieve stable and rapid adjustment of yaw angle.To verify the autonomous swimming ability of the robotic manta in complex scenes,we design an experimental scenario with a concave obstacle.The experimental results show that the robotic manta can achieve forward swimming,backward swimming,in situ turning within the concave obstacle,and finally exit from the area safely while relying on the perception of external obstacles,which can provide insight into the autonomous exploration of complex scenes by the biomimetic robotic fish.Finally,the swimming ability of the robotic manta is verified by field tests. 展开更多
关键词 Biomimetic robotic manta Central Pattern Generator closed-loop control Backward swimming
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A chaotic hierarchical encryption/watermark embedding scheme for multi-medical images based on row-column confusion and closed-loop bi-directional diffusion
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作者 张哲祎 牟俊 +1 位作者 Santo Banerjee 曹颖鸿 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期228-237,共10页
Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is desi... Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is designed,and a multiimage encryption(MIE)algorithm with row and column confusion and closed-loop bi-directional diffusion is adopted in the paper.While ensuring secure communication of medical image information,people with different security levels have different levels of decryption keys,and differentiated visual effects can be obtained by using the strong sensitivity of chaotic keys.The highest security level can obtain decrypted images without watermarks,and at the same time,patient information and copyright attribution can be verified by obtaining watermark images.The experimental results show that the scheme is sufficiently secure as an MIE scheme with visualized differences and the encryption and decryption efficiency is significantly improved compared to other works. 展开更多
关键词 chaotic hierarchical encryption multi-medical image encryption differentiated visual effects row-column confusion closed-loop bi-directional diffusion transform domain watermark embedding
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