Sleep disturbances are common in synucleinopathies such as Parkinson’s disease(PD)and dementia with Lewy bodies(DLB)suggesting a central role in their pathophysiology and progression.Isolated REM sleep behavior disor...Sleep disturbances are common in synucleinopathies such as Parkinson’s disease(PD)and dementia with Lewy bodies(DLB)suggesting a central role in their pathophysiology and progression.Isolated REM sleep behavior disorder(iRBD),a parasomnia,frequently precedes PD and DLB and is now regarded as a prodromal synucleinopathy[1].The biological clock,regulated by clock genes and secretion of the hormone melatonin,coordinates various systems including sleep,metabolism,immune and endocrine function[2].Dysregulation of melatonin levels and clock gene expression rhythms has been reported in iRBD and PD[3,4],with mixed findings,and has not yet been studied in DLB.There is a need for clinical and biological markers that predict the risk of phenoconversion in patients with iRBD,and their trajectory towards either DLB or PD.展开更多
基金supported by a National Health and Medical Research Council Emerging Leadership Fellowship(2008565)the US Department of Defense Congressionally Directed Medical Research Program Early Investigator Grant(PD220061)+1 种基金supported by a National Health and Medical Research Council Leadership Fellowship(1195830)has received research funding from the Michael J.Fox Foundation and the Australian Research Council,as well as consulting for Pharmaxis Ltd.
文摘Sleep disturbances are common in synucleinopathies such as Parkinson’s disease(PD)and dementia with Lewy bodies(DLB)suggesting a central role in their pathophysiology and progression.Isolated REM sleep behavior disorder(iRBD),a parasomnia,frequently precedes PD and DLB and is now regarded as a prodromal synucleinopathy[1].The biological clock,regulated by clock genes and secretion of the hormone melatonin,coordinates various systems including sleep,metabolism,immune and endocrine function[2].Dysregulation of melatonin levels and clock gene expression rhythms has been reported in iRBD and PD[3,4],with mixed findings,and has not yet been studied in DLB.There is a need for clinical and biological markers that predict the risk of phenoconversion in patients with iRBD,and their trajectory towards either DLB or PD.
