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Review of satellite disciplined clock system
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作者 单庆晓 杨俊 《Journal of Measurement Science and Instrumentation》 CAS 2012年第1期51-56,共6页
Satellite disciplined clock system(SDCS)composed of satellite timing receiver and local frequency synthesis is widely applied for its high accuracy and low cost.This paper provides a review of SDCS.Key technologies su... Satellite disciplined clock system(SDCS)composed of satellite timing receiver and local frequency synthesis is widely applied for its high accuracy and low cost.This paper provides a review of SDCS.Key technologies such as phase difference measurement,pulse noise process and frequency calibration are surveyed in detail.Disciplined clock model based on PI controller is built and disciplined process is analyzed.The methods of realizing the disciplined clock circuit are classified and summarized.A prototype based on FPGA is proposed.At last development trend of SDCS is discussed. 展开更多
关键词 GPS(global positioning system) Beidou system satellite disciplined clock TIMING frequency calibration
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Epigenetic clocks of female reproductive system aging:Current application and future prospects
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作者 Jie Lin Yang-Yi Chen +3 位作者 Shi-Jie Wang Yang Zhang Hai-Sheng Huang Xiu-Quan Zhang 《World Journal of Obstetrics and Gynecology》 2025年第2期1-8,共8页
A progressive decline in fertility is a well-documented aspect of female aging and is associated with a range of cellular and molecular alterations,including genomic instability and modifications in epigenetic regulat... A progressive decline in fertility is a well-documented aspect of female aging and is associated with a range of cellular and molecular alterations,including genomic instability and modifications in epigenetic regulation.Epigenetic clocks,which estimate biological age based on DNA methylation patterns,have been extensively utilized to evaluate general health status and the risk of various diseases.Despite their broad application,the utility of epigenetic clocks in assessing female reproductive health remains only partially characterized.This minireview consolidates recent advancements in the application of epigenetic clocks to evaluate the functional status of the female reproductive system.The objective is to investigate their potential for quantifying and predicting the biological age of reproductive tissues,thereby establishing a theoretical basis for clinical applications in reproductive medicine.To date,no comprehensive minireview has systematically examined multi-tissue epigenetic clock models in the context of female reproductive aging,positioning this minireview as a novel contribution to the field. 展开更多
关键词 ENDOMETRIUM Epigenetic clock Granulosa cell LEUKOCYTE METHYLATION Ovarian aging Uterine aging
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Steps towards a^(229)Th ionic nuclear clock in a linear ion trap
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作者 Wen-Ting Gan Zi Li +2 位作者 Chen Wang Xia Hua Xin Tong 《Chinese Physics B》 2026年第2期141-155,共15页
Owing to the presence of a low-energy,long-lived nuclear isomeric state,^(229)Th is an ideal candidate for developing the next generation clock—the nuclear clock—holding great promise for both applied and fundamenta... Owing to the presence of a low-energy,long-lived nuclear isomeric state,^(229)Th is an ideal candidate for developing the next generation clock—the nuclear clock—holding great promise for both applied and fundamental physics.The^(229)Th ionic nuclear optical clock has garnered considerable attention,attributed to its high precision with a relative uncertainty of≤1.5×10^(-19)and the potential for common-mode noise cancellation via self-comparison between the nuclear transition and the electronic transition of thorium ions.In this article,we focus on Th^(n+)ions(n=1,2,3)and present a comprehensive review of the current progress in the development of ionic nuclear clocks,covering essential steps such as ion generation,trapping,and cooling.Furthermore,we discuss the realization of a closed-loop clock cycle,addressing key aspects including stable isomer excitation and efficient isomer deexcitation. 展开更多
关键词 ^(229)Th ionic nuclear clock ion generation ion trapping and cooling closed-loop clock cycle
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Improving BDS-2/3 satellite clock bias prediction using a TCN-Transformer framework with cross-attention mechanism
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作者 Shicheng Xie Xuexiang Yu +3 位作者 Xu Yang Yuchen Han Mingfei Zhu Hao Tan 《Geodesy and Geodynamics》 2026年第2期225-237,共13页
Satellite clock bias(SCB)prediction is essential for enhancing the accuracy and reliability of real-time precise point positioning(RT-PPP)in Global Navigation Satellite Systems(GNSS).To address the nonlinearity,non-st... Satellite clock bias(SCB)prediction is essential for enhancing the accuracy and reliability of real-time precise point positioning(RT-PPP)in Global Navigation Satellite Systems(GNSS).To address the nonlinearity,non-stationarity,and short-term interruptions of SCB data under complex environments,this paper proposes an enhanced SCB prediction model combining Temporal Convolutional Networks(TCN)and Transformers.Experimental results indicate that,in a 24-h prediction task,the proposed model reduces root mean square error(RMSE)and range error(RE)by 95.6%,86.0%,and 61.3%,and93.7%,86.3%,and 58.8%,respectively,compared with LSTM,Transformer,and CNN-BiGRU-Attention models,while improving computational efficiency by 48.6%over the Transformer.Moreover,although the clock bias products generated by the proposed method result in slightly higher static PPP positioning errors than the International GNSS Service(IGS)rapid clock products,the error differences are generally at the millimeter level,demonstrating the feasibility of using predicted clock bias products to replace rapid clock products in the short term.This method addresses the PPP positioning issue during short-term network service interruptions from the perspective of time series prediction and provides potential solutions for engineering applications such as landslide,earthquake,and subsidence monitoring. 展开更多
关键词 Satellite clock bias prediction BDS CEEMDAN TCN-Transformer Cross-attention
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Jumonji C Domain-Containing Protein OsJMJ712 Integrates Epigenetic Regulation and Circadian Clock to Fine-Tune Flowering in Rice
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作者 LI Chao RUAN Chengcheng +4 位作者 HE Yiqin YANG Zhenkun JIANG Zhenyi LI Xiao XU Jianhong 《Rice science》 2026年第2期221-231,I0081-I0085,共16页
The Jumonji C domain-containing(JmjC)histone demethylases(JMJs)are involved in various aspects of plant development and responses to environmental changes.AtJMJs have been extensively studied in Arabidopsis for their ... The Jumonji C domain-containing(JmjC)histone demethylases(JMJs)are involved in various aspects of plant development and responses to environmental changes.AtJMJs have been extensively studied in Arabidopsis for their roles in regulating flowering time,while their functions and molecular mechanisms in regulating flowering time in rice remain underexplored.Here,we demonstrate that the JmjC domain-only group member OsJMJ712 regulates heading date in rice.OsJMJ712 exhibits H3K36me3 demethylase activity at Ehd1 and RFT1 and represses the expression of Ehd1,Hd3a,and RFT1.Furthermore,loss of function of OsJMJ712 disrupts the circadian clock,and OsLHY directly binds to the promoter of OsJMJ712 to suppress its expression.These findings uncover that OsJMJ712 integrates histone demethylation and the circadian clock to fine-tune photoperiodic flowering in rice,providing new insights into the epigenetic control of photoperiodic flowering in crops. 展开更多
关键词 flowering time histone demethylase circadian clock epigenetic modification Oryza sativa
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Progresses on Th-doped materials for solid-state nuclear clock
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作者 Cheng-Chun Zhao Lin Li +5 位作者 Shan-Ming Li Qiao-Rui Gong Pei-Xiong Zhang Yin Hang Long-Sheng Ma Shi-Ning Zhu 《Chinese Physics B》 2026年第2期109-120,共12页
The isomeric transition of thorium-229(^(229)Th),as the only known laser-accessible nuclear transition,offers the possibility for the development of a new generation of optical clocks.Solid-state nuclear optical clock... The isomeric transition of thorium-229(^(229)Th),as the only known laser-accessible nuclear transition,offers the possibility for the development of a new generation of optical clocks.Solid-state nuclear optical clock based on^(229)Th-doped crystals or thin films has attracted much attention due to its potential advantages in high stability,miniaturization,and robustness.This paper reviews the research progress of solid-state nuclear optical clock materials,analyzes the preparation,defects,and properties of the candidate solid material systems for^(229)Th,explores the influence of the local crystal environment on the nuclear transition,focuses on introducing the latest research results of crystal materials such as Th-doped CaF_(2)and LiSrAlF_(6),and looks forward to the future development direction of this field.It could provide a reference for the material selection and optimization of solid-state nuclear optical clocks. 展开更多
关键词 thorium-229 optical clock Th-doped crystal Th-doped film
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DAUNet: Unsupervised Neural Network Based on Dual Attention for Clock Synchronization in Multi-Agent Wireless Ad Hoc Networks
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作者 Haihao He Xianzhou Dong +2 位作者 Shuangshuang Wang Chengzhang Zhu Xiaotong Zhao 《Computers, Materials & Continua》 2026年第1期847-869,共23页
Clock synchronization has important applications in multi-agent collaboration(such as drone light shows,intelligent transportation systems,and game AI),group decision-making,and emergency rescue operations.Synchroniza... Clock synchronization has important applications in multi-agent collaboration(such as drone light shows,intelligent transportation systems,and game AI),group decision-making,and emergency rescue operations.Synchronization method based on pulse-coupled oscillators(PCOs)provides an effective solution for clock synchronization in wireless networks.However,the existing clock synchronization algorithms in multi-agent ad hoc networks are difficult to meet the requirements of high precision and high stability of synchronization clock in group cooperation.Hence,this paper constructs a network model,named DAUNet(unsupervised neural network based on dual attention),to enhance clock synchronization accuracy in multi-agent wireless ad hoc networks.Specifically,we design an unsupervised distributed neural network framework as the backbone,building upon classical PCO-based synchronization methods.This framework resolves issues such as prolonged time synchronization message exchange between nodes,difficulties in centralized node coordination,and challenges in distributed training.Furthermore,we introduce a dual-attention mechanism as the core module of DAUNet.By integrating a Multi-Head Attention module and a Gated Attention module,the model significantly improves information extraction capabilities while reducing computational complexity,effectively mitigating synchronization inaccuracies and instability in multi-agent ad hoc networks.To evaluate the effectiveness of the proposed model,comparative experiments and ablation studies were conducted against classical methods and existing deep learning models.The research results show that,compared with the deep learning networks based on DASA and LSTM,DAUNet can reduce the mean normalized phase difference(NPD)by 1 to 2 orders of magnitude.Compared with the attention models based on additive attention and self-attention mechanisms,the performance of DAUNet has improved by more than ten times.This study demonstrates DAUNet’s potential in advancing multi-agent ad hoc networking technologies. 展开更多
关键词 clock synchronization deep learning dual attention mechanism pulse-coupled oscillator
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Experimental setup of NTSC SrII optical lattice clock
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作者 Feng Guo Jia-An Li +2 位作者 Yan-Yan Liu Xiao-Tong Lu Hong Chang 《Chinese Physics B》 2026年第2期202-209,共8页
We report the SrII optical lattice clock at the National Time Service Center(NTSC).In this system,a blackbody radiation shield with movable lattice mitigates blackbody radiation shifts through active temperature contr... We report the SrII optical lattice clock at the National Time Service Center(NTSC).In this system,a blackbody radiation shield with movable lattice mitigates blackbody radiation shifts through active temperature control.A shallow optical lattice with minimal tunneling minimizes AC Stark shifts.Phase-locked counter-propagating lattice beams and conductive vacuum viewports further reduce systematic uncertainties and a novel initial-state preparation method simplifies the system.Clock transition spectra achieve a linewidth of 2.5 Hz with a 400 ms clock pulse,and self-comparison stability reaches 5.1×10^(-16)at 1 s.These advancements give this clock the potential to be a critical platform for realizing outstanding systematic uncertainties in the future. 展开更多
关键词 optical lattice optical clock STRONTIUM
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Predicting BDS-3's short-term clock bias using the RIME-WNN model
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作者 Xu Wang Chang Wang 《Geodesy and Geodynamics》 2026年第2期238-248,共11页
Aiming at the problems that the clock bias prediction model of the Wavelet Neural Network(WNN)is greatly affected by the selection of network parameters,and the Particle Swarm Optimization Wavelet Neural Network is pr... Aiming at the problems that the clock bias prediction model of the Wavelet Neural Network(WNN)is greatly affected by the selection of network parameters,and the Particle Swarm Optimization Wavelet Neural Network is prone to fall into local optima and has insufficient convergence efficiency in clock bias prediction,a short-term clock bias prediction model for BDS-3 based on the Rime Optimization Algorithm(RIME)-optimized Wavelet Neural Network is proposed.Firstly,the specific steps of the WNN model based on the RIME optimization algorithm in clock bias prediction are elaborated in detail.Then,the stability characteristics and training efficiency of the RIME optimization algorithm during the optimization stage are analyzed to determine the population size that suits the characteristics of clock bias data.Finally,using the BDS-3 clock bias data provided by the Wuhan University Data Center,shortterm clock bias prediction experiments with durations of 1 h,3 h,and 6 h are carried out.The experimental results show that in the 6h prediction,the average prediction accuracy of the RIME-WNN model is better than 0.1 ns,which is 93.92%,88.35%,and 48.11%higher than that of the Quadratic Polynomial model,the Grey Model(GM(1,1)),and the PSO-WNN model,respectively.In addition,when the RIMEWNN model predicts different types of Beidou satellites,the maximum difference in the Root Mean Square Error(RMSE)is relatively smaller,which fully demonstrates that the model has a wide and good accuracy adaptability when predicting various types of Beidou satellites. 展开更多
关键词 Satellite clock bias Wavelet neural network Rime optimization algorithm Prediction
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Towards a^(229)Th nuclear clock:Understanding nucleus–electron–environment interactions
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作者 Yan-Ling Xu Hong-Yuan Zheng +3 位作者 Xi-Chen Yu Yong-Hui Zhang Ting-Yun Shi Li-Yan Tang 《Chinese Physics B》 2026年第2期121-140,共20页
Recent advances in atomic optical clocks based on electronic transitions have achieved frequency uncertainties at the10^(-19)level,enabling wide applications in testing variations of physical constants,exploring dark ... Recent advances in atomic optical clocks based on electronic transitions have achieved frequency uncertainties at the10^(-19)level,enabling wide applications in testing variations of physical constants,exploring dark matter signatures,and enhancing precision metrology for position,navigation,and timing systems.To pursue higher-precision optical clocks,the development of nuclear optical clocks has emerged,with the^(229)Th system distinguished by its unique low-lying isomeric state at~8.4 eV and a natural linewidth of approximately 100μHz,promising uncertainties below 10^(-19).The intrinsic insensitivity of nuclear transitions to external perturbations and their subatomic-scale spatial confinement provide significant advantages over electronic transitions in mitigating environmental shifts.Recent experimental breakthroughs include the excitation of the nuclear clock transition in solid-state^(229)Th-doped crystals with spectral resolution at the k Hz level.However,critical challenges persist,particularly in implementing effective laser excitation schemes(e.g.,via the electronic bridge mechanism)and closed-loop quantum control in trapped ion systems.Addressing these requires comprehensive understanding of complex many-body interactions in^(229)Th,encompassing electronic structure,nuclear deformation,hyperfine and field shift,and solid-state environmental coupling.This review synthesizes recent advancements in(i)the characterization of nuclear and atomic structures of the^(229)Th nuclear clock,and(ii)precise evaluation and mitigation of external perturbations affecting the clock transitions.The analysis provides a solid theoretical and experimental foundation for optimizing^(229)Th-based nuclear clock performance. 展开更多
关键词 ^(229)Th nuclear clock electronic bridge external field effects
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近日节律基因Clock调控小鼠肠道菌群及肠道结构影响NAFLD的发生发展
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作者 陈晓惠 任欣欣 +4 位作者 雷艳 李敏倩 王芳 王蓓 杨淑红 《兰州大学学报(自然科学版)》 北大核心 2025年第1期109-117,共9页
构建肝-肠轴部位敲低Clock基因的C57BL/6小鼠,通过西方饮食喂养建立非酒精性脂肪肝疾病(NAFLD)型,检测Clock基因对肝脏和肠道组织的影响,通过16S rDNA测序分析小鼠肠道微生物组学变化.结果显示,敲低Clock基因会加剧小鼠NAFLD症状,表现... 构建肝-肠轴部位敲低Clock基因的C57BL/6小鼠,通过西方饮食喂养建立非酒精性脂肪肝疾病(NAFLD)型,检测Clock基因对肝脏和肠道组织的影响,通过16S rDNA测序分析小鼠肠道微生物组学变化.结果显示,敲低Clock基因会加剧小鼠NAFLD症状,表现为肝脏脂肪沉积增多和纤维化明显;改变肠道组织结构,表现为肠道绒毛高度降低,杯状细胞数目减少,且肠道紧密连接蛋白质TJP1和OCCLUDIN表达水平下调.Clock基因会改变小鼠肠道微生物组成,可能通过影响NAFLD小鼠肠道组织结构及肠道菌群参与NAFLD的发生发展. 展开更多
关键词 非酒精性脂肪肝疾病 clock基因 肠道菌群 肠道紧密连接
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Integrated, reliable laser system for an ^(87)Rb cold atom fountain clock 被引量:2
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作者 张镇 项静峰 +7 位作者 徐斌 冯盼 孙广伟 孟一鸣 邓思敏达 任伟 万金银 吕德胜 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第1期68-73,共6页
We designed, assembled, and tested a reliable laser system for ^(87)Rb cold atom fountain clocks. The laser system is divided into four modules according to function, which are convenient for installing, adjusting, ma... We designed, assembled, and tested a reliable laser system for ^(87)Rb cold atom fountain clocks. The laser system is divided into four modules according to function, which are convenient for installing, adjusting, maintaining, and replacing of the modules. In each functional module, all optical components are fixed on a baseplate with glue and screws, ensuring the system's structural stability. Mechanical stability was verified in a 6.11g RMS randomvibration test, where the change in output power before and after vibration was less than 5%. Thermal stability was realized by optimizing of the structure and appropriate selection of component materials of the modules through thermal simulation. In the laser splitting and output module, the change in laser power was less than 20% for each fiber in thermal cycles from 5℃ to 43℃. Finally,the functionality of the laser system was verified for a rubidium fountain clock. 展开更多
关键词 cold atoms laser system atomic fountain clock RELIABILITY
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基于BMAL1:CLOCK复合体探讨小檗碱调控肝糖酵解、糖氧化和糖异生改善能量代谢的体外降糖作用机制 被引量:1
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作者 徐中华 延李科 +4 位作者 刘伟华 崔灿 肖汉月 李慧平 涂珺 《中国中药杂志》 北大核心 2025年第15期4293-4303,共11页
基于脑和肌肉芳香烃受体核转位样蛋白1(BMAL1):昼夜自发输出周期蛋白kaput(CLOCK)复合体探讨小檗碱多途径调控糖代谢改善能量代谢的体外降糖作用机制。采用地塞米松诱导肝胰岛素抵抗(IR)HepG2细胞模型,0.5、1、5、10、20μmol·L^(... 基于脑和肌肉芳香烃受体核转位样蛋白1(BMAL1):昼夜自发输出周期蛋白kaput(CLOCK)复合体探讨小檗碱多途径调控糖代谢改善能量代谢的体外降糖作用机制。采用地塞米松诱导肝胰岛素抵抗(IR)HepG2细胞模型,0.5、1、5、10、20μmol·L^(-1)小檗碱给药15、18、21、24、30、36 h,葡萄糖氧化酶法检测细胞外液葡萄糖含量的时-量效应;确定小檗碱最佳给药剂量和最佳给药时间用于后续研究;葡萄糖氧化酶法和化学发光法分别检测细胞肝糖输出量和细胞三磷酸腺苷(ATP)相对含量;荧光探针检测Ca^(2+)、活性氧(ROS)、线粒体结构及膜电位;紫外比色法检测肝型丙酮酸激酶(L-PK)和磷酸烯醇式丙酮酸羧激酶(PEPCK);蛋白免疫印迹法检测丙酮酸脱氢酶E1亚基α1(PDHA1)、磷酸果糖激酶肝型(PFKL)、叉头盒子蛋白O1(FoxO1)、过氧化物酶体增殖物激活受体γ共激活因子1α(PGC1α)、葡萄糖-6-磷酸酶(G6Pase)、胰高血糖素(glucagon)、磷酸化核因子红细胞2相关因子2(p-Nrf2)(Ser40)、血红素加氧酶1(HO-1)、NAD(P)H醌氧化还原酶1(NQO1)、成纤维细胞生长因子21(FGF21)、解偶联蛋白(UCP)1、UCP2。免疫荧光双染法结合小分子抑制剂CLK8检测BMAL1:CLOCK复合体;蛋白免疫印迹法检测CLK8组PDHA1、PFKL、FoxO1、PGC1α、G6Pase、glucagon、Nrf2、HO-1、NQO1、FGF21、UCP1、UCP2蛋白。结果显示,小檗碱可下调IR-HepG2细胞外液葡萄糖含量,呈时间-剂量依赖性;抑制肝糖输出;降低胞内Ca^(2+)和ROS,改善线粒体结构及膜电位,促进ATP生成;上调限速酶PFKL、L-PK和PDHA1,促进糖酵解和有氧氧化;下调PGC1α、FoxO1、G6Pase、PEPCK和glucagon,抑制肝糖异生;上调p-Nrf2(Ser40)、HO-1和NQO1,增强抗氧化能力;上调FGF21、UCP1和UCP2,促进能量代谢。同时,小檗碱可增加BMAL1、CLOCK和核内BMAL1:CLOCK复合体,加入CLK8后可减少核内BMAL1:CLOCK复合体;与20μmol·L^(-1)小檗碱组相比,加入CLK8后可降低PDHA1、PFKL、Nrf2、HO-1、NQO1、FGF21、UCP1、UCP2,增加FoxO1、PGC1α、G6Pase、glucagon。鉴于BMAL1:CLOCK复合体抑制IR-HepG2细胞糖异生,促进糖酵解和糖有氧氧化途径,改善线粒体内还原环境,保护线粒体结构功能,增加ATP能量存储和促进热量消耗,揭示小檗碱介导BMAL1:CLOCK复合体协调调控肝IR细胞改善能量代谢的体外降糖作用机制。 展开更多
关键词 胰岛素抵抗 糖代谢 能量代谢 BMAL1:clock复合体 小檗碱
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Miniaturized optical system for atomic fountain clock 被引量:1
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作者 吕德胜 屈求智 +4 位作者 汪斌 赵剑波 李唐 刘亮 王育竹 《Chinese Physics B》 SCIE EI CAS CSCD 2011年第6期197-201,共5页
Using modularized components, we have built a miniaturized optical system for 87Rb atomic fountain clock that is fitted on an 80 cm × 60 cm optical breadboard. Compared with the conventional optical setup on the ... Using modularized components, we have built a miniaturized optical system for 87Rb atomic fountain clock that is fitted on an 80 cm × 60 cm optical breadboard. Compared with the conventional optical setup on the table, our system is more compact, more robust and miniaturized. Taking advantage of this system, laser beams are transmitted through eight optical fibre patch cords from the optical breadboard to an ultra high vacuum system. This optical setup has operated for five months in our fountain system and required no alignment. 展开更多
关键词 atomic clock laser cooling
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Clock synchronization design and evaluation for trigger-less data acquisition system 被引量:2
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作者 SHANG Linfeng SONG Kezhu CAO Ping 《Nuclear Science and Techniques》 SCIE CAS CSCD 2012年第6期361-368,共8页
For modern particle physics experiments,trigger-less data acquisition(DAQ) system has been put into practice because of the need of reaction multiplicity and trigger flexibility.In such new DAQ systems,global synchron... For modern particle physics experiments,trigger-less data acquisition(DAQ) system has been put into practice because of the need of reaction multiplicity and trigger flexibility.In such new DAQ systems,global synchronized clock plays an important role because it affects the granularity of time slice and precision of reference clock.In this paper,a novel synchronized clock distribution method is proposed.With the help of modulation technique,master clock module distributes system clock to each slave module.To synchronize slave clocks,the propagation delay is adjusted and the clock phase is aligned by an FPGA chip automatically.Furthermore,an ADCbased method is proposed to evaluate the performance of multi-module clock synchronization simultaneously.The experiments of a prototype system show that slave clocks can be synchronized less than 100 ps over 150 m range.The proposed method is simple and flexible,and it can be used in trigger-less DAQ system and other applications of clock distribution preciously. 展开更多
关键词 数据采集系统 同步时钟 同步触发 评估 粒子物理实验 设计 时钟分配 参考时钟
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Heuristics Scheduling Algorithm on the Links Scheduling of Satellite-Ground Clock Synchronization and Ephemeris Uploading in COMPASS System
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作者 张忠山 闫俊刚 +1 位作者 谭跃进 王沛 《Journal of Donghua University(English Edition)》 EI CAS 2016年第3期462-466,共5页
The execution process of satellite-ground clock synchronization and ephemeris uploading in the system is analyzed,as well as their characterized operation and their relationship.Based on the analysis of the scheduling... The execution process of satellite-ground clock synchronization and ephemeris uploading in the system is analyzed,as well as their characterized operation and their relationship.Based on the analysis of the scheduling goal and constraint character,a heuristics rule-based multi-stage link scheduling algorithm was put forward.The algorithm distinguishes the on-off-frontier satellites from the others and schedules them by turns.The paper presented the main flow as well as the detailed design of the rule.Finally based on the current COMPASS global system,some typical resources and constraints are selected to generate an instance.Then the comparison analysis between the heuristics scheduling algorithm and three other traditional scheduling strategies are carried out.The result shows the validity and reasonability of the multi-stage strategy. 展开更多
关键词 heuristics algorithm COMPASS system CROSSLINKS satelliteground clock synchronization and ephemeris uploading SCHEDULING
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A combined magnetic field stabilization system for improving the stability of 40Ca^(+) optical clock
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作者 曾孟彦 马子晓 +6 位作者 胡如明 张宝林 郝艳梅 张华青 黄垚 管桦 高克林 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第11期226-231,共6页
Future applications of portable40Ca^(+)optical clocks require reliable magnetic field stabilization to improve frequency stability, which can be achieved by implementing an active and passive magnetic field noise supp... Future applications of portable40Ca^(+)optical clocks require reliable magnetic field stabilization to improve frequency stability, which can be achieved by implementing an active and passive magnetic field noise suppression system. On the one hand, we have optimized the magnetic shielding performance of the portable optical clock by reducing its apertures and optimizing its geometry;on the other hand, we have introduced an active magnetic field noise suppression system to further suppress the magnetic field noise experienced by the ions. These efforts reduced the ambient magnetic field noise by about 10000 times, significantly reduced the linewidth of the clock transition spectrum, improved the stability of the portable40Ca+optical clock, and created the conditions for using portable optical clocks in non-laboratory magnetic field environments. This active magnetic field suppression scheme has the advantages of simple installation and wide applicability. 展开更多
关键词 40Ca^(+)optical clock magnetic field compensation frequency stability
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Maximum Likelihood Estimation of Clock Synchronization Error in OFDM System
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作者 崔小准 胡光锐 陈豪 《Journal of Donghua University(English Edition)》 EI CAS 2004年第4期1-3,共3页
The performance degradation of an orthogonal frequency division multiplexing (OFDM) systems due to clock synchronization error is analyzed and a pilot-aided maximum likelihood (ML) estimating method is proposed to cor... The performance degradation of an orthogonal frequency division multiplexing (OFDM) systems due to clock synchronization error is analyzed and a pilot-aided maximum likelihood (ML) estimating method is proposed to correct it. The proposed algorithm enables clock synchronization error estimation from a pilot whose duration is only two symbol periods. The study shows that this method is simple and exact. The clock synchronization error can be corrected almost entirely. 展开更多
关键词 Orthogonal frequency-division multiplexing clock synchronization error maximum likelihood estimator
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棘胸蛙Clock基因克隆及其转录表达分析
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作者 袁鸿 汪小冬 +4 位作者 魏秀英 王加品 陈以芳 姚红艳 陈敦学 《广西师范大学学报(自然科学版)》 北大核心 2025年第3期201-212,共12页
生物钟在生物体内出现昼夜周期性震荡,影响着生物的生长发育。棘胸蛙Quasipaa spinosa作为一种重要的两栖类动物,蝌蚪期主要在白天活动,而变态后则主要在夜间活动,出现相反的昼夜节律特征。目前关于棘胸蛙Clock基因的昼夜变化特征尚不... 生物钟在生物体内出现昼夜周期性震荡,影响着生物的生长发育。棘胸蛙Quasipaa spinosa作为一种重要的两栖类动物,蝌蚪期主要在白天活动,而变态后则主要在夜间活动,出现相反的昼夜节律特征。目前关于棘胸蛙Clock基因的昼夜变化特征尚不清楚。因此,本研究克隆棘胸蛙的Clock基因,发现其蛋白序列含有1个HLH结构域、2个PAS结构域和1个PAC结构域,且这些结构域在不同物种中高度保守。进化分析表明,鱼类Clock基因可以分为2个不同的组:Clock A组和Clock B组,两栖类Clock基因不分亚型地聚在一起,其中棘胸蛙与高山倭蛙Clock基因紧密聚在一起。为了探索节律基因在棘胸蛙体内的转录特征,选择5个关键节律基因(Clock、Bmal1、Per2、Cry1和RoRα)研究它们不同发育阶段和不同组织中的表达谱。结果显示:Clock基因在所有组织和所有发育阶段中均存在本底表达,且在变态阶段的表达水平最高。节律表达谱显示Clock和Bmal1基因的表达较为一致,均在夜间观察到表达峰值,Per2和Cry1都在一天开始的时候出现表达高峰。但Per2和Cry1的表达模式具有组织特异性,Cry1基因在T4阶段的肌肉、脑、肝和心脏组织中呈现另一个短暂的表达峰,这可能与夜间褪黑素水平的增加或实验动物的行为模式有关。实验结果有助于深刻理解两栖类动物错综复杂的昼夜节律系统。 展开更多
关键词 棘胸蛙 clock基因 昼夜节律 进化 表达谱 协同作用
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Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells
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作者 CHANG Xiaoyu ZHANG Hanwen +5 位作者 CAO Hongting HOU Ling MENG Xin TAO Hong LUO Yan LI Guanghua 《南方医科大学学报》 北大核心 2025年第7期1353-1362,共10页
Objective To investigate the structural changes of rat thoracic aorta and changes in expression levels of Bmal1 and cyclins in thoracic aorta endothelial cells following heat stress.Methods Twenty male SD rats were ra... Objective To investigate the structural changes of rat thoracic aorta and changes in expression levels of Bmal1 and cyclins in thoracic aorta endothelial cells following heat stress.Methods Twenty male SD rats were randomized equally into control group and heat stress group.After exposure to 32℃for 2 weeks in the latter group,the rats were examined for histopathological changes and Bmal1 expression in the thoracic aorta using HE staining and immunohistochemistry.In the cell experiments,cultured rat thoracic aortic endothelial cells(RTAECs)were incubated at 40℃for 12 h with or without prior transfection with a Bmal1-specific small interfering RNA(si-Bmal1)or a negative sequence.In both rat thoracic aorta and RTAECs,the expressions of Bmal1,the cell cycle proteins CDK1,CDK4,CDK6,and cyclin B1,and apoptosis-related proteins Bax and Bcl-2 were detected using Western blotting.TUNEL staining was used to detect cell apoptosis in rat thoracic aorta,and the changes in cell cycle distribution and apoptosis in RTAECs were analyzed with flow cytometry.Results Compared with the control rats,the rats exposed to heat stress showed significantly increased blood pressures and lowered heart rate with elastic fiber disruption and increased expressions of Bmal1,cyclin B1 and CDK1 in the thoracic aorta(P<0.05).In cultured RTAECs,heat stress caused significant increase of Bmal1,cyclin B1 and CDK1 protein expression levels,which were obviously lowered in cells with prior si-Bmal1 transfection.Bmal1 knockdown also inhibited heat stress-induced increase of apoptosis in RTAECs as evidenced by decreased expression of Bax and increased expression of Bcl-2.Conclusion Heat stress upregulates Bmal1 expression and causes alterations in expressions of cyclins to trigger apoptosis of rat thoracic aorta endothelial cells,which can be partly alleviated by suppressing Bmal1 expression. 展开更多
关键词 heat stress circadian clock genes BMAL1 thoracic aortic endothelial cells CYCLINS APOPTOSIS
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