1.Introduction Since the publication of our original study comparing large language models(LLMs)in scientific computing and scientific machine learning tasks,Anthropic has released Claude 4.0[1],a major upgrade in its...1.Introduction Since the publication of our original study comparing large language models(LLMs)in scientific computing and scientific machine learning tasks,Anthropic has released Claude 4.0[1],a major upgrade in its Claude family of LLMs.Claude 4.0 is designed to introduce substantial improvements in reasoning,coding,and mathematical capabilities.展开更多
患者，男，60岁。以行走不稳4 d 伴右眼睑下垂15 h 于2013年6月20日入院。既往有高血压病史1年，未服药，入院查体：BP 150／100 mm Hg。意识清楚，理解力、计算力、记忆力正常，双侧瞳孔正大等圆，光反射存在，右眼睑下垂，眼球呈外展...患者，男，60岁。以行走不稳4 d 伴右眼睑下垂15 h 于2013年6月20日入院。既往有高血压病史1年，未服药，入院查体：BP 150／100 mm Hg。意识清楚，理解力、计算力、记忆力正常，双侧瞳孔正大等圆，光反射存在，右眼睑下垂，眼球呈外展位，内收及向上和向下不能，四肢肌力5级，肌张力正常。左侧肢体指鼻试验和跟膝胫试验笨拙，Romberg 征（＋），向左偏斜，左下肢 Chadock 征阳性。实验室检查血常规、血生化未见异常，心电图正常，胸部 X 线片见主动脉弓突出，心脏向左扩大，头颅 CT 示左侧颞顶部片状低密度影，核磁 MR 发现右侧中脑可疑长 T1信号，诊断急性脑梗死，高血压3级，给予依达拉奉等治疗10 d 后症状及体征部分缓解出院。2013年7月9日复查，再次行头颅 MR 检查（见图1、2），发现右侧中脑有异常信号，诊断：（1）脑干梗死，（2） Claude 综合征。继续按脑梗死治疗，1个月后随访，行走自如，眼睑下垂部分恢复，复视消失， Romberg 征（-），共济运动正常，病理征未引出，临床治愈出院。讨论Claude 综合征于1912年由法国学者 Claude 首先描述，认为是中脑损害的结果，病变位于中脑背侧部大脑导水管附近，累及了同侧动眼神经、小脑上脚和红核［1］。 Claude 综合征临床较少见，表现为病侧动眼神经麻痹而对侧肢体共济失调，多由肿瘤或炎性反应引起，也有部分病例由血管病变造成。国内仅见个例报告［2］。国外学者报道该综合征也少见大样本患者，多数为个案病例［3］。 Seo 等［1］分析了6例经 MR 证实的Claude 综合征患者，提出病灶位于小脑上脚红核内侧以下，同侧动眼神经麻痹和对侧肢体共济失调为核心表现，脑梗死是最常见的原因。本例患者复查头颅 MR 结果见右侧大脑导水管旁有一异常信号病灶，解剖定位于小脑上脚，结合临床体征及影像学检查，本例患者完全符合 Claude 综合征的表现，最终确诊。展开更多
This essay analyzes the two Christians, who are Reverend Master Dimmesdale in Nathaniel Hawthorne's The Scarlet Letter and Vicar General Claude Frollo in Victor Hugo's Notre Dame de Paris. These two men have m...This essay analyzes the two Christians, who are Reverend Master Dimmesdale in Nathaniel Hawthorne's The Scarlet Letter and Vicar General Claude Frollo in Victor Hugo's Notre Dame de Paris. These two men have many similarities and differences. This essay posits their personalities and life experiences to discuss similarities and differences.展开更多
In 2014 I have ended my“decade mirabilis”in the European Parliament,after the European Enlargement in 2004,when ten countries entered to the European Parliament.I had a pleasure to work on several industrial and tec...In 2014 I have ended my“decade mirabilis”in the European Parliament,after the European Enlargement in 2004,when ten countries entered to the European Parliament.I had a pleasure to work on several industrial and technological and research related legislations.The transitions due to the changed legislation show that the most difficult element of the transition is always twofold:To be aware of the changed legislation is difficult,but the cultural shift is a real challenge.展开更多
文摘1.Introduction Since the publication of our original study comparing large language models(LLMs)in scientific computing and scientific machine learning tasks,Anthropic has released Claude 4.0[1],a major upgrade in its Claude family of LLMs.Claude 4.0 is designed to introduce substantial improvements in reasoning,coding,and mathematical capabilities.
文摘患者，男，60岁。以行走不稳4 d 伴右眼睑下垂15 h 于2013年6月20日入院。既往有高血压病史1年，未服药，入院查体：BP 150／100 mm Hg。意识清楚，理解力、计算力、记忆力正常，双侧瞳孔正大等圆，光反射存在，右眼睑下垂，眼球呈外展位，内收及向上和向下不能，四肢肌力5级，肌张力正常。左侧肢体指鼻试验和跟膝胫试验笨拙，Romberg 征（＋），向左偏斜，左下肢 Chadock 征阳性。实验室检查血常规、血生化未见异常，心电图正常，胸部 X 线片见主动脉弓突出，心脏向左扩大，头颅 CT 示左侧颞顶部片状低密度影，核磁 MR 发现右侧中脑可疑长 T1信号，诊断急性脑梗死，高血压3级，给予依达拉奉等治疗10 d 后症状及体征部分缓解出院。2013年7月9日复查，再次行头颅 MR 检查（见图1、2），发现右侧中脑有异常信号，诊断：（1）脑干梗死，（2） Claude 综合征。继续按脑梗死治疗，1个月后随访，行走自如，眼睑下垂部分恢复，复视消失， Romberg 征（-），共济运动正常，病理征未引出，临床治愈出院。讨论Claude 综合征于1912年由法国学者 Claude 首先描述，认为是中脑损害的结果，病变位于中脑背侧部大脑导水管附近，累及了同侧动眼神经、小脑上脚和红核［1］。 Claude 综合征临床较少见，表现为病侧动眼神经麻痹而对侧肢体共济失调，多由肿瘤或炎性反应引起，也有部分病例由血管病变造成。国内仅见个例报告［2］。国外学者报道该综合征也少见大样本患者，多数为个案病例［3］。 Seo 等［1］分析了6例经 MR 证实的Claude 综合征患者，提出病灶位于小脑上脚红核内侧以下，同侧动眼神经麻痹和对侧肢体共济失调为核心表现，脑梗死是最常见的原因。本例患者复查头颅 MR 结果见右侧大脑导水管旁有一异常信号病灶，解剖定位于小脑上脚，结合临床体征及影像学检查，本例患者完全符合 Claude 综合征的表现，最终确诊。
文摘This essay analyzes the two Christians, who are Reverend Master Dimmesdale in Nathaniel Hawthorne's The Scarlet Letter and Vicar General Claude Frollo in Victor Hugo's Notre Dame de Paris. These two men have many similarities and differences. This essay posits their personalities and life experiences to discuss similarities and differences.
文摘In 2014 I have ended my“decade mirabilis”in the European Parliament,after the European Enlargement in 2004,when ten countries entered to the European Parliament.I had a pleasure to work on several industrial and technological and research related legislations.The transitions due to the changed legislation show that the most difficult element of the transition is always twofold:To be aware of the changed legislation is difficult,but the cultural shift is a real challenge.
