Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the ident...Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the identification of risk factors associated with genetic disorders.Methods:Our study introduces a novel two-tiered analytical framework to raise the precision and reliability of genetic data interpretation.It is initiated by extracting and analyzing salient features from DNA sequences through a CNN-based feature analysis,taking advantage of the power inherent in Convolutional neural networks(CNNs)to attain complex patterns and minute mutations in genetic data.This study embraces an elite collection of machine learning classifiers interweaved through a stern voting mechanism,which synergistically joins the predictions made from multiple classifiers to generate comprehensive and well-balanced interpretations of the genetic data.Results:This state-of-the-art method was further tested by carrying out an empirical analysis on a variants'dataset of DNA sequences taken from patients affected by breast cancer,juxtaposed with a control group composed of healthy people.Thus,the integration of CNNs with a voting-based ensemble of classifiers returned outstanding outcomes,with performance metrics accuracy,precision,recall,and F1-scorereaching the outstanding rate of 0.88,outperforming previous models.Conclusions:This dual accomplishment underlines the transformative potential that integrating deep learning techniques with ensemble machine learning might provide in real added value for further genetic diagnostics and prognostics.These results from this study set a new benchmark in the accuracy of disease diagnosis through DNA sequencing and promise future studies on improved personalized medicine and healthcare approaches with precise genetic information.展开更多
Existing weakly supervised semantic segmentation(WSSS)methods based on image-level labels always rely on class activation maps(CAMs),which measure the relationships between features and classifiers.However,CAMs only f...Existing weakly supervised semantic segmentation(WSSS)methods based on image-level labels always rely on class activation maps(CAMs),which measure the relationships between features and classifiers.However,CAMs only focus on the most discriminative regions of images,resulting in their poor coverage performance.We attribute this to the deficiency in the recognition ability of a single classifier and the negative impacts caused by magnitudes during the CAMs normalisation process.To address the aforementioned issues,we propose to construct selective multiple classifiers(SMC).During the training process,we extract multiple prototypes for each class and store them in the corresponding memory bank.These prototypes are divided into foreground and background prototypes,with the former used to identify foreground objects and the latter aimed at preventing the false activation of background pixels.As for the inference stage,multiple prototypes are adaptively selected from the memory bank for each image as SMC.Subsequently,CAMs are generated by measuring the angle between SMC and features.We enhance the recognition ability of classifiers by adaptively constructing multiple classifiers for each image,while only relying on angle measurement to generate CAMs can alleviate the suppression phenomenon caused by magnitudes.Furthermore,SMC can be integrated into other WSSS approaches to help generate better CAMs.Extensive experiments conducted on standard WSSS benchmarks such as PASCAL VOC 2012 and MS COCO 2014 demonstrate the superiority of our proposed method.展开更多
文摘Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the identification of risk factors associated with genetic disorders.Methods:Our study introduces a novel two-tiered analytical framework to raise the precision and reliability of genetic data interpretation.It is initiated by extracting and analyzing salient features from DNA sequences through a CNN-based feature analysis,taking advantage of the power inherent in Convolutional neural networks(CNNs)to attain complex patterns and minute mutations in genetic data.This study embraces an elite collection of machine learning classifiers interweaved through a stern voting mechanism,which synergistically joins the predictions made from multiple classifiers to generate comprehensive and well-balanced interpretations of the genetic data.Results:This state-of-the-art method was further tested by carrying out an empirical analysis on a variants'dataset of DNA sequences taken from patients affected by breast cancer,juxtaposed with a control group composed of healthy people.Thus,the integration of CNNs with a voting-based ensemble of classifiers returned outstanding outcomes,with performance metrics accuracy,precision,recall,and F1-scorereaching the outstanding rate of 0.88,outperforming previous models.Conclusions:This dual accomplishment underlines the transformative potential that integrating deep learning techniques with ensemble machine learning might provide in real added value for further genetic diagnostics and prognostics.These results from this study set a new benchmark in the accuracy of disease diagnosis through DNA sequencing and promise future studies on improved personalized medicine and healthcare approaches with precise genetic information.
基金supported by the National Natural Science Foundation of China(Grants 62176097,61433007)Fundamental Research Funds for the Central Universities(Grant 2019kfyXKJC024)the 111 Project on Computational Intelligence and Intelligent Control(Grant B18024).
文摘Existing weakly supervised semantic segmentation(WSSS)methods based on image-level labels always rely on class activation maps(CAMs),which measure the relationships between features and classifiers.However,CAMs only focus on the most discriminative regions of images,resulting in their poor coverage performance.We attribute this to the deficiency in the recognition ability of a single classifier and the negative impacts caused by magnitudes during the CAMs normalisation process.To address the aforementioned issues,we propose to construct selective multiple classifiers(SMC).During the training process,we extract multiple prototypes for each class and store them in the corresponding memory bank.These prototypes are divided into foreground and background prototypes,with the former used to identify foreground objects and the latter aimed at preventing the false activation of background pixels.As for the inference stage,multiple prototypes are adaptively selected from the memory bank for each image as SMC.Subsequently,CAMs are generated by measuring the angle between SMC and features.We enhance the recognition ability of classifiers by adaptively constructing multiple classifiers for each image,while only relying on angle measurement to generate CAMs can alleviate the suppression phenomenon caused by magnitudes.Furthermore,SMC can be integrated into other WSSS approaches to help generate better CAMs.Extensive experiments conducted on standard WSSS benchmarks such as PASCAL VOC 2012 and MS COCO 2014 demonstrate the superiority of our proposed method.
