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ID-1靶向NF-κB/SHP2/SMAD/Src通路调控乳腺癌MCF-7细胞进展机制研究
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作者 周海丰 刘睿 +5 位作者 赵楠 范玉宏 刘进宇 张义炫 樊建春 张京力 《中国比较医学杂志》 北大核心 2026年第4期63-75,共13页
目的探究分化抑制因子1(ID-1)在乳腺癌中的表达、临床意义及靶向核因子-κB(NF-κB)/含Src同源2结构域的蛋白酪氨酸磷酸酶(SHP2)/SMAD/Src信号通路调控人乳腺癌MCF-7细胞进展的分子机制。方法应用免疫组化检测ID-1在乳腺癌组织和癌旁正... 目的探究分化抑制因子1(ID-1)在乳腺癌中的表达、临床意义及靶向核因子-κB(NF-κB)/含Src同源2结构域的蛋白酪氨酸磷酸酶(SHP2)/SMAD/Src信号通路调控人乳腺癌MCF-7细胞进展的分子机制。方法应用免疫组化检测ID-1在乳腺癌组织和癌旁正常组织中的表达,并分析其临床意义;应用生物信息学分析ID-1与关键蛋白的相关性。在体内实验中,选取45只雌性小鼠构建乳腺癌模型,分为5组各9只,分别为Vivo-control组、Vivo-BMP2组、Vivo-ID-1 mimic+BMP2组、Vivo-BMP2+PHPS1组、Vivo-ID-1 mimic+PHPS1组;剥离5组小鼠肿瘤组织,进行观察称重处理;在体外实验中,将购买的人乳腺癌MCF-7细胞分为7组,分别为NC组、BMP2组、ID-1 mimic+BMP2组、sulfasalazine+BMP2组、ID-1 mimic+sulfasalazine+BMP2组、BMP2+PHPS1组、ID-1 mimic+BMP2+PHPS1组,应用Western blot检测各组蛋白表达情况;划痕实验检测MCF-7细胞的迁移情况;Transwell实验检测MCF-7细胞侵袭情况。结果免疫组化结果显示ID-1在乳腺癌组织中的表达明显高于癌旁正常组织,差异具有统计学意义(P<0.001);ID-1的表达状态与组织学分级、TNM分期、淋巴结转移和远处转移关系密切(P<0.05);生物信息学相关性分析提示,在乳腺癌中,ID-1与BMP2、NF-κB、SMAD1/8、Src均具有一定的相关性(P<0.05);体内实验结果表明,ID-1可以促进乳腺癌的进展,而SHP2被抑制后会减缓乳腺癌的进展(P<0.05,P<0.01);体外实验结果表明,SHP2被抑制后可使得ID-1、NF-κB、磷酸化(p)-SHP2、p-SMAD1/5/8、p-Src蛋白表达明显下降(P<0.05,P<0.01),而NF-κB被抑制后同样使得ID-1、NF-κB、p-SHP2、p-SMAD1/5/8、p-Src蛋白表达降低(P<0.05,P<0.01);划痕实验结果显示,ID-1和BMP2均可促进MCF-7细胞的迁移能力,而SHP2或NF-κB被抑制后可明显降低MCF-7细胞迁移能力(P<0.05,P<0.01);Transwell实验结果显示,ID-1和BMP2均可提高MCF-7细胞侵袭能力,而SHP2或NF-κB被抑制后可明显减缓MCF-7细胞侵袭能力(P<0.05,P<0.01)。结论ID-1可以通过激活NF-κB/SHP2/SMAD/Src信号通路进而促进乳腺癌MCF-7细胞的侵袭和迁移。 展开更多
关键词 ID-1 BMP2 NF-κB/SHP2/SMAD/src信号通路 乳腺癌 机制
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榼藤子体内物质基础及调控SRC介导的小胶质细胞极化对背根神经节慢性压迫大鼠镇痛的药效机制
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作者 李森森 吴含雪 +5 位作者 李元滨 赵丽敏 苏晓慧 熊慧 林娜 王超 《中国中药杂志》 北大核心 2026年第3期811-826,共16页
民族药榼藤子对慢性腰背痛,如腰椎间盘突出症(LDH)等神经病理性疼痛效果良好,但其病理情况下体内物质和镇痛机制不明。该研究建立模拟临床LDH的背根神经节慢性压迫(CCD)模型,采用行为学、安全性评估、体内物质基础分析、网络药理学和分... 民族药榼藤子对慢性腰背痛,如腰椎间盘突出症(LDH)等神经病理性疼痛效果良好,但其病理情况下体内物质和镇痛机制不明。该研究建立模拟临床LDH的背根神经节慢性压迫(CCD)模型,采用行为学、安全性评估、体内物质基础分析、网络药理学和分子生物学等方法探讨榼藤子70%乙醇提取物(KB)镇痛的药效机制。药效学研究表明,KB可剂量依赖性提高CCD大鼠机械痛敏阈值、热辐射痛敏阈值;并可缓解自发痛,改善足印指标;而对正常动物基础痛敏阈值、运动协调功能无明显影响,且无明显副作用。热板实验、甩尾实验、福尔马林实验提示KB发挥镇痛作用的部位于脊髓及以上中枢水平并与抑制中枢神经炎症相关。UHPLC-Q-Orbitrap-HRMS鉴定出马钱子苷、莪术二酮、墨旱莲皂苷V、麝香酮、3-O-β-D-galactopyranosyl-(1→2)-β-D-glucuronopyranosyl-gypsogenin-28-O-β-D-xylopyranosyl(1→4)-[β-D-6-O-acetylglucopyranosyl(1→3)]-α-L-rhamnopy-ranosyl(1→2)-β-D-fucopyranoside、异土木香内酯、N-氧那可汀、獐牙菜苷、三色堇黄苷等9个入脊髓成分;网络分析显示非受体酪氨酸激酶(SRC)、磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B(AKT)1、Kirsten大鼠肉瘤病毒癌基因同源物(KRAS)、RAF原癌基因丝氨酸/苏氨酸蛋白激酶1(RAF1)和细胞外调节蛋白激酶(ERK)等6个药效核心靶标紧密富集于趋化因子信号通路并与入脊髓成分稳定结合。实验进一步采用ELISA、蛋白免疫印迹、免疫荧光、抑制剂、行为学等检测发现,KB的镇痛机制可能与抑制SRC调控的丝裂原活化蛋白激酶(MAPK)和PI3K/AKT信号轴继而抑制脊髓小胶质细胞极化及神经炎症有关,相关研究为KB临床治疗慢性腰背痛及合理用药提供了科学依据。 展开更多
关键词 榼藤子提取物体内物质基础 神经病理性疼痛 腰椎间盘突出症 小胶质细胞极化 神经炎症 src PI3K/AKT信号通路 MAPK信号通路
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漆黄素靶向EGFR/SRC/Bax改善抑郁样损伤的作用及机制
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作者 马昊 武涵涵 +5 位作者 杨锦霞 冯袁辉 马槊乾 赵喜庆 商学良 秦丽娟 《中国药理学通报》 北大核心 2026年第1期164-171,共8页
目的探究漆黄素发挥抗抑郁作用的潜在靶点与分子生物学机制。方法筛选漆黄素与抑郁症相关靶点。CCK-8法确定皮质酮诱导PC12细胞抑郁模型的最佳浓度,以及漆黄素的适宜给药浓度;Western blot分析PC12细胞中表皮生长因子受体(epidermal gro... 目的探究漆黄素发挥抗抑郁作用的潜在靶点与分子生物学机制。方法筛选漆黄素与抑郁症相关靶点。CCK-8法确定皮质酮诱导PC12细胞抑郁模型的最佳浓度,以及漆黄素的适宜给药浓度;Western blot分析PC12细胞中表皮生长因子受体(epidermal growth factor receptor,EGFR)、SRC和Bax蛋白的表达水平;免疫荧光观察EGFR和SRC蛋白的定位与表达。强迫游泳实验、悬尾实验和高架迷宫实验检测小鼠抑郁样行为;HE染色观察小鼠脑组织形态学改变。结果皮质酮可明显上调PC12细胞中EGFR、SRC和Bax蛋白的表达,而漆黄素干预后,这些蛋白的表达水平明显下调。与对照组相比,慢性束缚应激模型组小鼠抑郁样行为明显,而氟西汀组和高、低剂量漆黄素组抑郁样损伤得到修复。结论漆黄素可能通过下调EGFR/SRC/Bax蛋白的表达,减少神经元损伤,改善小鼠的抑郁样行为。 展开更多
关键词 漆黄素 抑郁症 EGFR src 网络药理学 分子动力学模拟
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SRC蛋白激酶在肝癌中作用的研究进展
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作者 张丽婷 斯韬 +1 位作者 黄丽银 陈海辉 《河北医药》 2026年第2期302-307,共6页
原发性肝癌(primary liver cancers, PLC)是全球发病率和病死率最高的恶性肿瘤之一,其发病机制复杂且预后不良。SRC是第一个发现的致癌病毒的转化产物,也是SRC家族激酶(SFK)的原型。SRC激酶在细胞生长、分裂、迁移和存活信号通路中起着... 原发性肝癌(primary liver cancers, PLC)是全球发病率和病死率最高的恶性肿瘤之一,其发病机制复杂且预后不良。SRC是第一个发现的致癌病毒的转化产物,也是SRC家族激酶(SFK)的原型。SRC激酶在细胞生长、分裂、迁移和存活信号通路中起着至关重要的作用。参与多条信号通路如MAPK、PI3K/AKT1、STATs的信号转导,与肝癌等多种肿瘤发生发展密切相关。SRC在肝癌中异常激活,可促进转移、抑制凋亡并增强能量代谢,加速肿瘤恶性进展,且与患者不良临床预后密切相关。此外,SRC还通过调控破骨细胞活性和肿瘤微环境参与癌症诱导的骨痛,促进骨转移。本文系统综述了SRC的结构特征、生物学功能及其相关信号通路,重点阐述了SRC在肝癌发生发展中的分子调控机制,以期为肝癌靶向治疗策略的研发提供新的理论依据。 展开更多
关键词 src蛋白激酶 信号通路 肝癌 研究进展
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Email Classification Using Horse Herd Optimization Algorithm
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作者 N Jaya Lakshmi Sangeetha Viswanadham +2 位作者 Appala Srinuvasu Muttipati B Chakradhar B Kiran Kumar 《Journal of Harbin Institute of Technology(New Series)》 2026年第1期69-80,共12页
In recent decades,the proliferation of email communication has markedly escalated,resulting in a concomitant surge in spam emails that congest networks and presenting security risks.This study introduces an innovative... In recent decades,the proliferation of email communication has markedly escalated,resulting in a concomitant surge in spam emails that congest networks and presenting security risks.This study introduces an innovative spam detection method utilizing the Horse Herd Optimization Algorithm(HHOA),designed for binary classification within multi⁃objective framework.The method proficiently identifies essential features,minimizing redundancy and improving classification precision.The suggested HHOA attained an impressive accuracy of 97.21%on the Kaggle email dataset,with precision of 94.30%,recall of 90.50%,and F1⁃score of 92.80%.Compared to conventional techniques,such as Support Vector Machine(93.89%accuracy),Random Forest(96.14%accuracy),and K⁃Nearest Neighbours(92.08%accuracy),HHOA exhibited enhanced performance with reduced computing complexity.The suggested method demonstrated enhanced feature selection efficiency,decreasing the number of selected features while maintaining high classification accuracy.The results underscore the efficacy of HHOA in spam identification and indicate its potential for further applications in practical email filtering systems. 展开更多
关键词 email classification optimization technique support vector machine binary classification machine learning
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CANNSkin:A Convolutional Autoencoder Neural Network-Based Model for Skin Cancer Classification
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作者 Abdul Jabbar Siddiqui Saheed Ademola Bello +3 位作者 Muhammad Liman Gambo Abdul Khader Jilani Saudagar Mohamad A.Alawad Amir Hussain 《Computer Modeling in Engineering & Sciences》 2026年第2期1142-1165,共24页
Visual diagnosis of skin cancer is challenging due to subtle inter-class similarities,variations in skin texture,the presence of hair,and inconsistent illumination.Deep learning models have shown promise in assisting ... Visual diagnosis of skin cancer is challenging due to subtle inter-class similarities,variations in skin texture,the presence of hair,and inconsistent illumination.Deep learning models have shown promise in assisting early detection,yet their performance is often limited by the severe class imbalance present in dermoscopic datasets.This paper proposes CANNSkin,a skin cancer classification framework that integrates a convolutional autoencoder with latent-space oversampling to address this imbalance.The autoencoder is trained to reconstruct lesion images,and its latent embeddings are used as features for classification.To enhance minority-class representation,the Synthetic Minority Oversampling Technique(SMOTE)is applied directly to the latent vectors before classifier training.The encoder and classifier are first trained independently and later fine-tuned end-to-end.On the HAM10000 dataset,CANNSkin achieves an accuracy of 93.01%,a macro-F1 of 88.54%,and an ROC–AUC of 98.44%,demonstrating strong robustness across ten test subsets.Evaluation on the more complex ISIC 2019 dataset further confirms the model’s effectiveness,where CANNSkin achieves 94.27%accuracy,93.95%precision,94.09%recall,and 99.02%F1-score,supported by high reconstruction fidelity(PSNR 35.03 dB,SSIM 0.86).These results demonstrate the effectiveness of our proposed latent-space balancing and fine-tuned representation learning as a new benchmark method for robust and accurate skin cancer classification across heterogeneous datasets. 展开更多
关键词 Computational image processing imbalance classification medical image analysis MELANOMA skin cancer classification
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Enhancing multiclass brain tumor classification through automated segmentation-guided deep learning
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作者 Pattaramon Vuttipittayamongkol Phakorn Charoenthiphakorn +2 位作者 Yarida Fuangfoo Pornnapha Na Phirot Thanawat Sanosiang 《Medical Data Mining》 2026年第2期15-33,共19页
Background:Accurate classification of brain tumors from Magnetic Resonance Imaging(MRI)is essential for clinical decision-making but remains challenging due to tumor heterogeneity.Existing approaches often focus solel... Background:Accurate classification of brain tumors from Magnetic Resonance Imaging(MRI)is essential for clinical decision-making but remains challenging due to tumor heterogeneity.Existing approaches often focus solely on classification or treat segmentation and classification as separate tasks,limiting overall performance and interpretability.Methods:This study proposes an end-to-end automated framework that integrates optimized tumor localization with multiclass classification.An optimized segmentation model is first employed to generate tumor masks,which are then overlaid on MRI scans to produce attention-enhanced inputs.These inputs are subsequently used to train a convolutional neural network(CNN)classifier.Experiments were conducted on a public dataset comprising 4,237 MRI scans across four categories:normal,glioma,meningioma,and pituitary tumors.Results:Three widely used segmentation models were systematically evaluated,with an optimized U-Net achieving the best performance(accuracy=0.9939,Dice=0.8893).Segmentation-guided classification consistently improved performance across six CNN architectures,with the most notable gains observed in heterogeneous tumor types such as glioma and meningioma.Among the classifiers,EfficientNet-V2 achieved the highest performance,with an accuracy of 0.9835,precision of 0.9858,recall of 0.9804,and F1-score of 0.9828.The framework was further validated on an independent external dataset,demonstrating consistent performance and robustness across diverse MRI sources.Conclusion:The proposed framework demonstrates strong potential for multiclass brain tumor classification by effectively combining segmentation and classification.This segmentation-driven approach not only enhances predictive accuracy but also improves interpretability,making it more suitable for clinical applications. 展开更多
关键词 brain tumor classification MRI segmentation segmentation-guided CNN multiclass classification tumor localization medical imaging
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Multimodal Signal Processing of ECG Signals with Time-Frequency Representations for Arrhythmia Classification
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作者 Yu Zhou Jiawei Tian Kyungtae Kang 《Computer Modeling in Engineering & Sciences》 2026年第2期990-1017,共28页
Arrhythmias are a frequently occurring phenomenon in clinical practice,but how to accurately dis-tinguish subtle rhythm abnormalities remains an ongoing difficulty faced by the entire research community when conductin... Arrhythmias are a frequently occurring phenomenon in clinical practice,but how to accurately dis-tinguish subtle rhythm abnormalities remains an ongoing difficulty faced by the entire research community when conducting ECG-based studies.From a review of existing studies,two main factors appear to contribute to this problem:the uneven distribution of arrhythmia classes and the limited expressiveness of features learned by current models.To overcome these limitations,this study proposes a dual-path multimodal framework,termed DM-EHC(Dual-Path Multimodal ECG Heartbeat Classifier),for ECG-based heartbeat classification.The proposed framework links 1D ECG temporal features with 2D time–frequency features.By setting up the dual paths described above,the model can process more dimensions of feature information.The MIT-BIH arrhythmia database was selected as the baseline dataset for the experiments.Experimental results show that the proposed method outperforms single modalities and performs better for certain specific types of arrhythmias.The model achieved mean precision,recall,and F1 score of 95.14%,92.26%,and 93.65%,respectively.These results indicate that the framework is robust and has potential value in automated arrhythmia classification. 展开更多
关键词 ELECTROCARDIOGRAM arrhythmia classification MULTIMODAL time-frequency representation
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Taxonomic classification of 80 near-Earth asteroids
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作者 Fan Mo Bin Li +9 位作者 HaiBin Zhao Jian Chen Yan Jin MengHui Tang Igor Molotov A.M.Abdelaziz A.Takey S.K.Tealib Ahmed.Shokry JianYang Li 《Earth and Planetary Physics》 2026年第1期196-204,共9页
Near-Earth objects are important not only in studying the early formation of the Solar System,but also because they pose a serious hazard to humanity when they make close approaches to the Earth.Study of their physica... Near-Earth objects are important not only in studying the early formation of the Solar System,but also because they pose a serious hazard to humanity when they make close approaches to the Earth.Study of their physical properties can provide useful information on their origin,evolution,and hazard to human beings.However,it remains challenging to investigate small,newly discovered,near-Earth objects because of our limited observational window.This investigation seeks to determine the visible colors of near-Earth asteroids(NEAs),perform an initial taxonomic classification based on visible colors and analyze possible correlations between the distribution of taxonomic classification and asteroid size or orbital parameters.Observations were performed in the broadband BVRI Johnson−Cousins photometric system,applied to images from the Yaoan High Precision Telescope and the 1.88 m telescope at the Kottamia Astronomical Observatory.We present new photometric observations of 84 near-Earth asteroids,and classify 80 of them taxonomically,based on their photometric colors.We find that nearly half(46.3%)of the objects in our sample can be classified as S-complex,26.3%as C-complex,6%as D-complex,and 15.0%as X-complex;the remaining belong to the A-or V-types.Additionally,we identify three P-type NEAs in our sample,according to the Tholen scheme.The fractional abundances of the C/X-complex members with absolute magnitude H≥17.0 were more than twice as large as those with H<17.0.However,the fractions of C-and S-complex members with diameters≤1 km and>1 km are nearly equal,while X-complex members tend to have sub-kilometer diameters.In our sample,the C/D-complex objects are predominant among those with a Jovian Tisserand parameter of T_(J)<3.1.These bodies could have a cometary origin.C-and S-complex members account for a considerable proportion of the asteroids that are potentially hazardous. 展开更多
关键词 near-Earth asteroids optical telescope photometric observation taxonomic classification
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A Novel Unsupervised Structural Attack and Defense for Graph Classification
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作者 Yadong Wang Zhiwei Zhang +2 位作者 Pengpeng Qiao Ye Yuan Guoren Wang 《Computers, Materials & Continua》 2026年第1期1761-1782,共22页
Graph Neural Networks(GNNs)have proven highly effective for graph classification across diverse fields such as social networks,bioinformatics,and finance,due to their capability to learn complex graph structures.Howev... Graph Neural Networks(GNNs)have proven highly effective for graph classification across diverse fields such as social networks,bioinformatics,and finance,due to their capability to learn complex graph structures.However,despite their success,GNNs remain vulnerable to adversarial attacks that can significantly degrade their classification accuracy.Existing adversarial attack strategies primarily rely on label information to guide the attacks,which limits their applicability in scenarios where such information is scarce or unavailable.This paper introduces an innovative unsupervised attack method for graph classification,which operates without relying on label information,thereby enhancing its applicability in a broad range of scenarios.Specifically,our method first leverages a graph contrastive learning loss to learn high-quality graph embeddings by comparing different stochastic augmented views of the graphs.To effectively perturb the graphs,we then introduce an implicit estimator that measures the impact of various modifications on graph structures.The proposed strategy identifies and flips edges with the top-K highest scores,determined by the estimator,to maximize the degradation of the model’s performance.In addition,to defend against such attack,we propose a lightweight regularization-based defense mechanism that is specifically tailored to mitigate the structural perturbations introduced by our attack strategy.It enhances model robustness by enforcing embedding consistency and edge-level smoothness during training.We conduct experiments on six public TU graph classification datasets:NCI1,NCI109,Mutagenicity,ENZYMES,COLLAB,and DBLP_v1,to evaluate the effectiveness of our attack and defense strategies.Under an attack budget of 3,the maximum reduction in model accuracy reaches 6.67%on the Graph Convolutional Network(GCN)and 11.67%on the Graph Attention Network(GAT)across different datasets,indicating that our unsupervised method induces degradation comparable to state-of-the-art supervised attacks.Meanwhile,our defense achieves the highest accuracy recovery of 3.89%(GCN)and 5.00%(GAT),demonstrating improved robustness against structural perturbations. 展开更多
关键词 Graph classification graph neural networks adversarial attack
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Research Review of Deep Learning Algorithms for Agricultural Disease Image Classification
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作者 Shengjiu JIANG Qian WANG 《Plant Diseases and Pests》 2026年第1期30-34,共5页
In the context of rural revitalization and the development of smart agriculture, image classification technology based on deep learning has emerged as a crucial tool for digital monitoring and intelligent prevention a... In the context of rural revitalization and the development of smart agriculture, image classification technology based on deep learning has emerged as a crucial tool for digital monitoring and intelligent prevention and control of agricultural diseases. This paper provides a systematic review of the evolutionary development of algorithms within this field. Addressing challenges such as domain drift and limited global awareness in classical convolutional neural networks (CNNs) applied to complex agricultural environments, the paper focuses on the latest advancements in vision transformers (ViT) and their hybrid architectures to enhance cross-domain robustness and fine-grained recognition capabilities. In response to the challenges posed by scarce long-tail data and limited edge computing power in real-world scenarios, the paper explores solutions related to few-shot learning and ultra-lightweight network deployment. Finally, a forward-looking analysis is presented on the application paradigms of multimodal feature fusion, vision-based large models, and explainable artificial intelligence (AI) within smart plant protection. This analysis aims to offer theoretical insights for the development of efficient and transparent intelligent diagnostic systems for agricultural diseases, thereby supporting the advancement of digital agriculture and the construction of a robust agricultural nation. 展开更多
关键词 Agricultural disease image classification algorithm Deep learning Research Review
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A Dynamic Masking-Based Multi-Learning Framework for Sparse Classification
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作者 Woo Hyun Park Dong Ryeol Shin 《Computers, Materials & Continua》 2026年第3期1365-1380,共16页
With the recent increase in data volume and diversity,traditional text representation techniques are struggling to capture context,particularly in environments with sparse data.To address these challenges,this study p... With the recent increase in data volume and diversity,traditional text representation techniques are struggling to capture context,particularly in environments with sparse data.To address these challenges,this study proposes a new model,the Masked Joint Representation Model(MJRM).MJRM approximates the original hypothesis by leveraging multiple elements in a limited context.It dynamically adapts to changes in characteristics based on data distribution through three main components.First,masking-based representation learning,termed selective dynamic masking,integrates topic modeling and sentiment clustering to generate and train multiple instances across different data subsets,whose predictions are then aggregated with optimized weights.This design alleviates sparsity,suppresses noise,and preserves contextual structures.Second,regularization-based improvements are applied.Third,techniques for addressing sparse data are used to perform final inference.As a result,MJRM improves performance by up to 4%compared to existing AI techniques.In our experiments,we analyzed the contribution of each factor,demonstrating that masking,dynamic learning,and aggregating multiple instances complement each other to improve performance.This demonstrates that a masking-based multi-learning strategy is effective for context-aware sparse text classification,and can be useful even in challenging situations such as data shortage or data distribution variations.We expect that the approach can be extended to diverse fields such as sentiment analysis,spam filtering,and domain-specific document classification. 展开更多
关键词 Text classification dynamic learning contextual features data sparsity masking-based representation
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Graph Attention Networks for Skin Lesion Classification with CNN-Driven Node Features
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作者 Ghadah Naif Alwakid Samabia Tehsin +3 位作者 Mamoona Humayun Asad Farooq Ibrahim Alrashdi Amjad Alsirhani 《Computers, Materials & Continua》 2026年第1期1964-1984,共21页
Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and ... Skin diseases affect millions worldwide.Early detection is key to preventing disfigurement,lifelong disability,or death.Dermoscopic images acquired in primary-care settings show high intra-class visual similarity and severe class imbalance,and occasional imaging artifacts can create ambiguity for state-of-the-art convolutional neural networks(CNNs).We frame skin lesion recognition as graph-based reasoning and,to ensure fair evaluation and avoid data leakage,adopt a strict lesion-level partitioning strategy.Each image is first over-segmented using SLIC(Simple Linear Iterative Clustering)to produce perceptually homogeneous superpixels.These superpixels form the nodes of a region-adjacency graph whose edges encode spatial continuity.Node attributes are 1280-dimensional embeddings extracted with a lightweight yet expressive EfficientNet-B0 backbone,providing strong representational power at modest computational cost.The resulting graphs are processed by a five-layer Graph Attention Network(GAT)that learns to weight inter-node relationships dynamically and aggregates multi-hop context before classifying lesions into seven classes with a log-softmax output.Extensive experiments on the DermaMNIST benchmark show the proposed pipeline achieves 88.35%accuracy and 98.04%AUC,outperforming contemporary CNNs,AutoML approaches,and alternative graph neural networks.An ablation study indicates EfficientNet-B0 produces superior node descriptors compared with ResNet-18 and DenseNet,and that roughly five GAT layers strike a good balance between being too shallow and over-deep while avoiding oversmoothing.The method requires no data augmentation or external metadata,making it a drop-in upgrade for clinical computer-aided diagnosis systems. 展开更多
关键词 Graph neural network image classification DermaMNIST dataset graph representation
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Classification of Job Offers into Job Positions Using O*NET and BERT Language Models
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作者 Lino Gonzalez-Garcia Miguel-Angel Sicilia Elena García-Barriocanal 《Computers, Materials & Continua》 2026年第2期2133-2147,共15页
Classifying job offers into occupational categories is a fundamental task in human resource information systems,as it improves and streamlines indexing,search,and matching between openings and job seekers.Comprehensiv... Classifying job offers into occupational categories is a fundamental task in human resource information systems,as it improves and streamlines indexing,search,and matching between openings and job seekers.Comprehensive occupational databases such as O∗NET or ESCO provide detailed taxonomies of interrelated positions that can be leveraged to align the textual content of postings with occupational categories,thereby facilitating standardization,cross-system interoperability,and access to metadata for each occupation(e.g.,tasks,knowledge,skills,and abilities).In this work,we explore the effectiveness of fine-tuning existing language models(LMs)to classify job offers with occupational descriptors from O∗NET.This enables a more precise assessment of candidate suitability by identifying the specific knowledge and skills required for each position,and helps automate recruitment processes by mitigating human bias and subjectivity in candidate selection.We evaluate three representative BERT-like models:BERT,RoBERTa,and DeBERTa.BERT serves as the baseline encoder-only architecture;RoBERTa incorporates advances in pretraining objectives and data scale;and DeBERTa introduces architectural improvements through disentangled attention mechanisms.The best performance was achieved with the DeBERTa model,although the other models also produced strong results,and no statistically significant differences were observed acrossmodels.We also find that these models typically reach optimal performance after only a few training epochs,and that training with smaller,balanced datasets is effective.Consequently,comparable results can be obtained with models that require fewer computational resources and less training time,facilitating deployment and practical use. 展开更多
关键词 Occupational databases job offer classification language models O∗NET BERT RoBERTa DeBERTa
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A Real Time YOLO Based Container Grapple Slot Detection and Classification System
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作者 Chen-Chiung Hsieh Chun-An Chen Wei-Hsin Huang 《Computers, Materials & Continua》 2026年第3期305-329,共25页
Container transportation is pivotal in global trade due to its efficiency,safety,and cost-effectiveness.However,structural defects—particularly in grapple slots—can result in cargo damage,financial loss,and elevated... Container transportation is pivotal in global trade due to its efficiency,safety,and cost-effectiveness.However,structural defects—particularly in grapple slots—can result in cargo damage,financial loss,and elevated safety risks,including container drops during lifting operations.Timely and accurate inspection before and after transit is therefore essential.Traditional inspection methods rely heavily on manual observation of internal and external surfaces,which are time-consuming,resource-intensive,and prone to subjective errors.Container roofs pose additional challenges due to limited visibility,while grapple slots are especially vulnerable to wear from frequent use.This study proposes a two-stage automated detection framework targeting defects in container roof grapple slots.In the first stage,YOLOv7 is employed to localize grapple slot regions with high precision.In the second stage,ResNet50 classifies the extracted slots as either intact or defective.The results from both stages are integrated into a human-machine interface for real-time visualization and user verification.Experimental evaluations demonstrate that YOLOv7 achieves a 99%detection rate at 100 frames per second(FPS),while ResNet50 attains 87%classification accuracy at 34 FPS.Compared to some state of the arts,the proposed system offers significant speed,reliability,and usability improvements,enabling efficient defect identification and visual reconfirmation via the interface. 展开更多
关键词 Container grapple slot detection defect classification deep learning TWO-STAGE YOLO
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Federated Dynamic Aggregation Selection Strategy-Based Multi-Receptive Field Fusion Classification Framework for Point Cloud Classification
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作者 Yuchao Hou Biaobiao Bai +3 位作者 Shuai Zhao Yue Wang Jie Wang Zijian Li 《Computers, Materials & Continua》 2026年第2期1889-1918,共30页
Recently,large-scale deep learning models have been increasingly adopted for point cloud classification.However,thesemethods typically require collecting extensive datasets frommultiple clients,which may lead to priva... Recently,large-scale deep learning models have been increasingly adopted for point cloud classification.However,thesemethods typically require collecting extensive datasets frommultiple clients,which may lead to privacy leaks.Federated learning provides an effective solution to data leakage by eliminating the need for data transmission,relying instead on the exchange of model parameters.However,the uneven distribution of client data can still affect the model’s ability to generalize effectively.To address these challenges,we propose a new framework for point cloud classification called Federated Dynamic Aggregation Selection Strategy-based Multi-Receptive Field Fusion Classification Framework(FDASS-MRFCF).Specifically,we tackle these challenges with two key innovations:(1)During the client local training phase,we propose a Multi-Receptive Field Fusion Classification Model(MRFCM),which captures local and global structures in point cloud data through dynamic convolution and multi-scale feature fusion,enhancing the robustness of point cloud classification.(2)In the server aggregation phase,we introduce a Federated Dynamic Aggregation Selection Strategy(FDASS),which employs a hybrid strategy to average client model parameters,skip aggregation,or reallocate local models to different clients,thereby balancing global consistency and local diversity.We evaluate our framework using the ModelNet40 and ShapeNetPart benchmarks,demonstrating its effectiveness.The proposed method is expected to significantly advance the field of point cloud classification in a secure environment. 展开更多
关键词 Point cloud classification federated learning multi-receptive field fusion dynamic aggregation
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Multi-Task Disaster Tweet Classification Using Hybrid TF-IDF and Graph Convolutional Networks
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作者 Basudev Nath Deepak Sahoo +4 位作者 Sudhansu Shekhar Patra Hassan Alkhiri Subrata Chowdhury Sheraz Aslam Kainat Mustafa 《Computers, Materials & Continua》 2026年第5期2077-2099,共23页
Accurate,up to date,and quick information related to any disaster supports disaster management team/authorities to perform quick,easy,and cost-effective response to enhance rescue operations to alleviate the possible ... Accurate,up to date,and quick information related to any disaster supports disaster management team/authorities to perform quick,easy,and cost-effective response to enhance rescue operations to alleviate the possible loss of lives,financial risks,and properties.Due to damaged infrastructure in disaster-affected areas,social media is the only way to share/exchange real time information.Therefore,‘X’(formerly Twitter)has become a major platform for disseminating real-time information during disaster events or emergencies,i.e.,floods and earthquake.Rapid identification of actionable content is critical for effective humanitarian response;however,the brief and noisy nature of tweets makes automated classification challenging.To tackle this problem,this study proposes a hybrid classification framework that integrates term frequency–inverse document frequency(TF-IDF)features with graph convolutional networks(GCNs)to enhance disaster-related tweet analysis.The proposed model performs three classification tasks:identifying disaster-related tweets(achieving 94.47%accuracy),categorizing disaster types(earthquake,flood,and non-disaster)with 91.78%accuracy,and detecting aid requests such as food,donations,and medical assistance(94.64%accuracy).By combining the statistical strengths of TF-IDF with the relational learning capabilities of GCNs,the model attains high accuracy while maintaining computational efficiency and interpretability.The results demonstrate the framework’s strong potential for real-time disaster response,offering valuable insights to support emergency management systems and humanitarian decision-making. 展开更多
关键词 Natural language processing tweet classification graph neural networks deep learning
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Adversarial robustness evaluation based on classification confidence-based confusion matrix
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作者 YAO Xuemei SUN Jianbin +1 位作者 LI Zituo YANG Kewei 《Journal of Systems Engineering and Electronics》 2026年第1期184-196,共13页
Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces ... Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces a visual evaluation index named confidence centroid skewing quadrilateral,which is based on a classification confidence-based confusion matrix,offering a quantitative and visual comparison of the adversarial robustness among different classification algorithms,and enhances intuitiveness and interpretability of attack impacts.We first conduct a validity test and sensitive analysis of the method.Then,prove its effectiveness through the experiments of five classification algorithms including artificial neural network(ANN),logistic regression(LR),support vector machine(SVM),convolutional neural network(CNN)and transformer against three adversarial attacks such as fast gradient sign method(FGSM),DeepFool,and projected gradient descent(PGD)attack. 展开更多
关键词 adversarial robustness evaluation visual evaluation classification confidence-based confusion matrix centroid SKEWING
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Key Technologies for AI-Driven Network Traffic Classification Workflow and Data Distribution Shift
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作者 Zhao Jianchao Geng Zhaosen +1 位作者 Li Zeyi Wang Pan 《ZTE Communications》 2026年第1期34-44,共11页
With the evolution of next-generation network technologies,the complexity of network management has significantly increased,and the means of network attacks are diversified,bringing new challenges to network traffic c... With the evolution of next-generation network technologies,the complexity of network management has significantly increased,and the means of network attacks are diversified,bringing new challenges to network traffic classification.This paper presents a general AIdriven network traffic classification workflow and elaborates on a traffic data and feature engineering framework.Most importantly,it analyzes the concept and causes of data distribution shifts in ne twork traffic,proposing detection methods and countermeasures.Experimental results on real traffic collected at different time intervals show that application evolution can induce data distribution shifts,which in turn lead to a noticeable degradation in traffic classification performance.Comparative drift detection experiments further confirm that such shifts are more evident over long-term intervals,while short-term traffic remains relatively stable.These findings demonstrate the necessity of incorporating drift-aware mechanisms into AI-driven network traffic classification systems. 展开更多
关键词 traffic classification traffic identification deep learning data distribution shift concept shifting
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Effective Token Masking Augmentation Using Term-Document Frequency for Language Model-Based Legal Case Classification
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作者 Ye-Chan Park Mohd Asyraf Zulkifley +1 位作者 Bong-Soo Sohn Jaesung Lee 《Computers, Materials & Continua》 2026年第4期928-945,共18页
Legal case classification involves the categorization of legal documents into predefined categories,which facilitates legal information retrieval and case management.However,real-world legal datasets often suffer from... Legal case classification involves the categorization of legal documents into predefined categories,which facilitates legal information retrieval and case management.However,real-world legal datasets often suffer from class imbalances due to the uneven distribution of case types across legal domains.This leads to biased model performance,in the form of high accuracy for overrepresented categories and underperformance for minority classes.To address this issue,in this study,we propose a data augmentation method that masks unimportant terms within a document selectively while preserving key terms fromthe perspective of the legal domain.This approach enhances data diversity and improves the generalization capability of conventional models.Our experiments demonstrate consistent improvements achieved by the proposed augmentation strategy in terms of accuracy and F1 score across all models,validating the effectiveness of the proposed method in legal case classification. 展开更多
关键词 Legal case classification class imbalance data augmentation token masking legal NLP
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