After the“Ballad Movement”in the early 20th century revealed and systematized the Liang Zhu legend,numerous literary works had created a rich body of classic reinterpretations.This paper argues that Yang Yinshen’s ...After the“Ballad Movement”in the early 20th century revealed and systematized the Liang Zhu legend,numerous literary works had created a rich body of classic reinterpretations.This paper argues that Yang Yinshen’s A Storm stands as the earliest modern literary creation that actively embraced the folk Liang Zhu legend.By situating the ancient story of Zhu Yingtai in a contemporary context,the play replaces the traditional core values of“loyalty and righteousness”with modern themes of pursuing free love,amplifying women’s autonomy.Through a modern tragic love story,it achieves a classic reinterpretation of the classical folk legend.The“revised narrative”in A Storm primarily involves derivative adaptations,incorporating contemporary revisions to characters and themes.Its three-act structure also forms the foundational framework for subsequent reinterpretations of the Liang Zhu legend.The play demonstrates a conscious absorption of the rebellious spirit in folk literature,incorporates dialectal speech,and provides valuable insights into how modern literature can utilize oral traditions.展开更多
Objectives:The PACIFIC trial established the benefit of durvalumab following chemo-radiotherapy for stage III non-small cell lung cancer(NSCLC).However,the concurrent use of radiotherapy(RT)and durvalumab(PACIFIC-2 tr...Objectives:The PACIFIC trial established the benefit of durvalumab following chemo-radiotherapy for stage III non-small cell lung cancer(NSCLC).However,the concurrent use of radiotherapy(RT)and durvalumab(PACIFIC-2 trial)showed no additional advantage.The PD-RAD study was set up to understand the immunological effects of RT on the tumor microenvironment(TME)to aid in optimizing sequencing of combination therapies.Methods:The PD-RAD trial(ClinicalTrials.gov identifier:NCT03258788)aimed to enroll thirty NSCLC patients receiving radical-intent RT.Tumor biopsies and blood samples were collected pre-RT and at week 2 during RT and analyzed using multiplex immunohistochemistry(mIHC)and high-dimensional mass cytometry(CyTOF),respectively.Results:Paired biopsies were collected from only three patients(Pts 1,3&4)and blood from four patients(Pts 1-4)before the study was closed early during the COVID-19 pandemic.Programmed Death-Ligand 1(PD-L1)expression in the TME was raised in Patient 1,who responded well to treatment,and unaltered in two patients with progressive disease.CyTOF analysis revealed elevated circulating classical monocytes,highest in the patient with a good response.Conclusions:This study underscores the challenges of integrating advanced immune monitoring during RT delivery and did not meet its primary endpoint.The hypothesis-generating findings highlight PD-L1+macrophages in the TME and classical monocytes in the blood as potential immune biomarkers of RT response,but larger studies are needed to validate these observations and characterize the immune changes following curative-intent RT in patients with NSCLC.展开更多
Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively util...Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively utilized in dispensing granules,classical prescriptions,and herbal formulas to treat various conditions,including cough,infection,phlegm,nausea,asthma,and inflammation.Despite numerous studies on PR and its classical prescriptions over recent decades,a comprehensive synthesis of available evidence regarding its multifunctional roles and therapeutic potential is lacking.This review aims to address this gap by examining emerging evidence from metabonomics,preclinical studies,and clinical trials,while exploring potential trends and prospects for future research.A systematic literature search was conducted across six electronic databases,including Pub Med,Web of Science,Scopus,Science Direct,Wanfang,and China National Knowledge Infrastructure,to identify relevant articles on PR published until March 2023.PR contains 107 compounds with diverse pharmacological activities,including anti-inflammatory,immune regulatory,anti-viral,anti-cancer,anti-asthma,antitussive and expectorant,antioxidant,anti-obesity,anti-atherosclerosis,antimicrobial,emetic and anti-emetic,anti-convulsant and anti-epileptic,sedative and hypnotic,learning and memory enhancement,and anti-depressant effects.Metabonomic studies suggest that raw PR may exhibit cardiotoxicity and pregnancy toxicity while showing no apparent hepatorenal toxicity.However,limited pharmacokinetic investigations on PR constrain its clinical translation.Furthermore,clinical safety data on PR is scarce,with only four clinical trials assessing its positive effects in pediatric epilepsy,nausea and vomiting,soft tissue injury,and chronic sinus tract.This review aims to enhance understanding of PR and provide valuable information and recommendations for further research and development of herbal medicine.展开更多
Angiomyolipomas(AMLs)represent the most common benign solid renal tumors.The frequency of their detection in the general population is increasing owing to advances in imaging technology.The objective of this review is...Angiomyolipomas(AMLs)represent the most common benign solid renal tumors.The frequency of their detection in the general population is increasing owing to advances in imaging technology.The objective of this review is to discuss computed tomography(CT)and magnetic resonance imaging findings for both typical and atypical renal AMLs,along with their associated complications.AMLs are typically defined as solid triphasic tumors composed of varying amounts of dysmorphic and tortuous blood vessels,smooth muscle components and adipose tissue.In an adult,a classical renal AML appears as a solid,heterogeneous renal cortical mass with macroscopic fat.However,up to 5%of AMLs contain minimal fat and cannot be reliably diagnosed by imaging.Fat-poor AMLs can appear as hyperattenuating masses on unenhanced CT and as hypointense masses on T2WI;other AMLs may be isodense or exhibit cystic components.Hemorrhage is the most common complication,and AMLs with hemorrhage can mimic other tumors,making their diagnosis challenging.Understanding the variable and heterogeneous nature of this neoplasm to correctly classify renal AMLs and to avoid misdiagnosis of other renal lesions is crucial.展开更多
Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment ...A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment effect and interim result.For hypotheses and reversed hypotheses under normal models,we obtain analytical expressions of the ROC curves of the CCP,find optimal ROC curves of the CCP,investigate the superiority of the ROC curves of the CCP,calculate critical values of the False Positive Rate(FPR),True Positive Rate(TPR),and cutoff of the optimal CCP,and give go/no go decisions at the interim of the optimal CCP.In addition,extensive numerical experiments are carried out to exemplify our theoretical results.Finally,a real data example is performed to illustrate the go/no go decisions of the optimal CCP.展开更多
Exploring Greco-Roman and Chinese classics reveals timeless insights for navigating modern crises.THE enduring wisdom of ancient Greece and China–often found in their classics–holds profound potential to address to...Exploring Greco-Roman and Chinese classics reveals timeless insights for navigating modern crises.THE enduring wisdom of ancient Greece and China–often found in their classics–holds profound potential to address today’s pressing global challenges.This vital connection was powerfully underscored at the Second Global Forum on Mutual Learning among Civilizations.展开更多
1 When we immerse ourselves in the pages of a book,we are transported to worlds beyond our own,gaining insights into the human experience and expanding our understanding of ourselves and others.2 Reading can fill our ...1 When we immerse ourselves in the pages of a book,we are transported to worlds beyond our own,gaining insights into the human experience and expanding our understanding of ourselves and others.2 Reading can fill our lives and purify our souls.I enjoy reading and I love life.I enjoy reading Chinese classics such as the Four Great Classical Novels of Chinese literature.I explore the mythical and wonderful stories of demons and monsters in Journey to the West and experience the boldness of martial art heroes in Water Margin.展开更多
AI applications have already-irreversibly-entered the fields of Humanities,Classics,and archaeological research,but are rarely taught in class.This paper attempts to encourage teachers and students of Classical Archae...AI applications have already-irreversibly-entered the fields of Humanities,Classics,and archaeological research,but are rarely taught in class.This paper attempts to encourage teachers and students of Classical Archaeology,Classics,Art History,and related fields,to practically explore,evaluate,and critically discuss pattern recognition(here focusing on Greek vase-painting),without requiring previously acquired coding skills.For this task,I will outline the potential of the open access program“Orange Data Mining”for academic teaching,based on a seminar taught by myself at Heidelberg University in the winter semester of 2024/25.I will introduce four different pattern recognition exercises(“Image Grid,”“Image Clustering,”“Image Classification,”and“Prediction”)that are easily accessible for classicists(please,try this at home!)and report the results and experiences which came out of our seminar.Furthermore,I will evaluate how the“hands-on”use of Orange Data Mining in class enables students to access the current debate on the chances and limitations of AI for research in ancient studies.展开更多
Foshan Liang Garden,as a unique cultural heritage in the Lingnan region,possesses high artistic,scientific,and cultural value.Through field surveys and literature research,this paper sorts out the current problems in ...Foshan Liang Garden,as a unique cultural heritage in the Lingnan region,possesses high artistic,scientific,and cultural value.Through field surveys and literature research,this paper sorts out the current problems in the protection and utilization of Foshan Liang Garden,establishes the basic principles of emphasizing both protection and revitalization and implementing them simultaneously,and summarizes methods for protection and utilization,including expanding funding channels,strengthening dynamic monitoring and scientific protection,exploring cultural connotations,and encouraging multi-stakeholder participation in joint construction.Furthermore,it proposes revitalization strategies such as empowering garden services with digital technology,integrating cultural resources to innovate cultural and creative products,promoting the museumization of idle functional spaces,and using cultural and educational activities for inheritance and dissemination.It is hoped that these measures will help Foshan Liang Garden better integrate into modern life,meet people’s diverse needs,and provide new ideas and methods for the protection and utilization of garden cultural heritage.展开更多
Explorations into new electrolytes have highlighted the critical impact of solvation structure on battery performance,Classical molecular dynamics(CMD)using semi-empirical force fields has become an essential tool for...Explorations into new electrolytes have highlighted the critical impact of solvation structure on battery performance,Classical molecular dynamics(CMD)using semi-empirical force fields has become an essential tool for simulating solvation structures.However,mainstream force fields often lack accuracy in describing strong ion-solvent interactions,causing disparities between CMD simulations and experimental observations.Although some empirical methods have been employed in some of the studies to address this issue,their effectiveness has been limited.Our CMD research,supported by quantum chemical calculations and experimental data,reveals that the solvation structure is influenced not only by the charge model but also by the polarization description.Previous empirical approaches that focused solely on adjusting ion-solvent interaction strengths overlooked the importance of polarization effects.Building on this insight,we propose integrating the Drude polarization model into mainstream force fields and verify its feasibility in carbonate,ether,and nitrile electrolytes.Our experimental results demonstrate that this approach significantly enhances the accuracy of CMD-simulated solvation structures.This work is expected to provide a more reliable CMD method for electrolyte design,shielding researchers from the pitfalls of erroneous simulation outcomes.展开更多
This paper concerns the Cauchy problem of 3D compressible micropolar fluids in the whole space R^(3). For regular initial data with m0E0 is suitable small, where m0 and E0 represent the upper bound of initial density ...This paper concerns the Cauchy problem of 3D compressible micropolar fluids in the whole space R^(3). For regular initial data with m0E0 is suitable small, where m0 and E0 represent the upper bound of initial density and initial energy, we prove that if ρ0 ∈ Lγ ∩ H3 with γ ∈ (1, 6), then the problem possesses a unique global classical solution on R^(3) × [0, T] with any T ∈ (0, ∞). It’s worth noting that both the vacuum states and possible random largeness of initial energy are allowed.展开更多
The article examines the diverse musical environments for older adults on the West Coast of North America,ranging from descriptions of regional variations in senior community living presented in a variety of sources,i...The article examines the diverse musical environments for older adults on the West Coast of North America,ranging from descriptions of regional variations in senior community living presented in a variety of sources,including fiction,and the place of music in institutional settings to various musical activities designed for older adults.Given that people living on the West Coast have diverse ethno-religious backgrounds,may or may not be sensitive to the music that surrounded them in their formative years at the local and national levels,and have different habits regarding listening to the radio or attending various musical events,additional aspects were taken into account,such as 1980s and 1990s music styles;ethnic musical heritage relevant to the West Coast population;classical,popular,and religious music on the radio;and affordable symphony orchestra programs.The article provides an overview that opens avenues for further exploration of its sub-topics.展开更多
Compilation ofSagya Classics Editor-in-chief of this book is Sagya Palden Donyu,a researcher at the High-level Tibetan Buddhism College of China and the Director of the Sagya Culture Research Office.This volume system...Compilation ofSagya Classics Editor-in-chief of this book is Sagya Palden Donyu,a researcher at the High-level Tibetan Buddhism College of China and the Director of the Sagya Culture Research Office.This volume systematically compiles the academic achievements of the Sagya Dharma Kings.The contents in elude a wide range of topics,including religious philosophy.展开更多
Grass constitutes a vital poetic imagery in classical Chinese poetry,embodying multifaceted symbolic connotations ranging from the tenacity of life to sentiments of separation and nostalgic longing.The translation of ...Grass constitutes a vital poetic imagery in classical Chinese poetry,embodying multifaceted symbolic connotations ranging from the tenacity of life to sentiments of separation and nostalgic longing.The translation of this botanical motif necessitates not merely lexical equivalence,but more importantly,the transmission of its profound cultural resonance and aesthetic essence.This study posits that effective rendition of grass imagery should adopt an integrative approach synthesizing the objectives of cultural translation with the intrinsic aesthetic characteristics of classical poetry.Through systematic analysis of the cultural semiotics embedded in grass symbolism,the research investigates practical translation techniques at lexical,syntactic,and stylistic dimensions.The findings aim to contribute to the theoretical framework of cultural image translation in Chinese poetic tradition while providing methodological references for cross-cultural interpretation of classical verse.By bridging cultural semiotics with translation praxis,this investigation seeks to advance the intercultural communication of Chinese poetic heritage through nuanced treatment of its botanical symbolism.展开更多
This concise paper,delivered at a conference,addresses a broad topic with the goal of providing a condensed and inevitably subjective perspective.Initially,it outlines the primary characteristics that distinguish coin...This concise paper,delivered at a conference,addresses a broad topic with the goal of providing a condensed and inevitably subjective perspective.Initially,it outlines the primary characteristics that distinguish coins from other historical sources.Subsequently,it provides a succinct overview of numismatics,categorized into seven phases:1.Pre-1550(coins as reflections of vice and virtue);2.From circa 1550 to circa 1620(coins as testimony of authentic history);3.From circa 1650 to circa 1730(the heyday of the“Republic of Medals”);4.From circa 1730 to circa 1840(the decline of the“Republic of Medals”and the emergence of scientific practices by Viennese Jesuits);5.From circa 1840 to circa 1940(die-studies and art history);6.From circa 1940 to circa 2000(coins as instruments of exchange);7.Since 2000(cultural shift and digital humanities).展开更多
More than a simple concert pianist,Wilson Chu is an Indonesian musical diplomacy force.As a distinguished performer,composer,and educator,Wilson has left an indelible mark on the international stage by seamlessly blen...More than a simple concert pianist,Wilson Chu is an Indonesian musical diplomacy force.As a distinguished performer,composer,and educator,Wilson has left an indelible mark on the international stage by seamlessly blending Western classical music with Southeast Asian tradition.Since 2019,he has been the youngest Associate Professor of Piano at the College of Chinese and ASEAN Arts(CCAA)at Chengdu University,where he has dedicated himself to shaping the next generation of musicians.展开更多
文摘After the“Ballad Movement”in the early 20th century revealed and systematized the Liang Zhu legend,numerous literary works had created a rich body of classic reinterpretations.This paper argues that Yang Yinshen’s A Storm stands as the earliest modern literary creation that actively embraced the folk Liang Zhu legend.By situating the ancient story of Zhu Yingtai in a contemporary context,the play replaces the traditional core values of“loyalty and righteousness”with modern themes of pursuing free love,amplifying women’s autonomy.Through a modern tragic love story,it achieves a classic reinterpretation of the classical folk legend.The“revised narrative”in A Storm primarily involves derivative adaptations,incorporating contemporary revisions to characters and themes.Its three-act structure also forms the foundational framework for subsequent reinterpretations of the Liang Zhu legend.The play demonstrates a conscious absorption of the rebellious spirit in folk literature,incorporates dialectal speech,and provides valuable insights into how modern literature can utilize oral traditions.
基金the National Institute for Health and Care Research(NHR)Manchester Biomedical Research Centre(BRC)(NIHR203308,NIHR-BRC-1215-20007)Astra-Zeneca(ESR-14-10711)+2 种基金CRUK RadNet(C19941/A27801)TMI and CFF are the recipient of an NIHR Senior Investigator Award(NIHR205054 and NIHR205061)CTH is supported by the NIHR University College London Hospitals NHS Foundation Trust BRC,the City of London CRUK RadNet and the CRUK Lung Cancer Centre of Excellence.
文摘Objectives:The PACIFIC trial established the benefit of durvalumab following chemo-radiotherapy for stage III non-small cell lung cancer(NSCLC).However,the concurrent use of radiotherapy(RT)and durvalumab(PACIFIC-2 trial)showed no additional advantage.The PD-RAD study was set up to understand the immunological effects of RT on the tumor microenvironment(TME)to aid in optimizing sequencing of combination therapies.Methods:The PD-RAD trial(ClinicalTrials.gov identifier:NCT03258788)aimed to enroll thirty NSCLC patients receiving radical-intent RT.Tumor biopsies and blood samples were collected pre-RT and at week 2 during RT and analyzed using multiplex immunohistochemistry(mIHC)and high-dimensional mass cytometry(CyTOF),respectively.Results:Paired biopsies were collected from only three patients(Pts 1,3&4)and blood from four patients(Pts 1-4)before the study was closed early during the COVID-19 pandemic.Programmed Death-Ligand 1(PD-L1)expression in the TME was raised in Patient 1,who responded well to treatment,and unaltered in two patients with progressive disease.CyTOF analysis revealed elevated circulating classical monocytes,highest in the patient with a good response.Conclusions:This study underscores the challenges of integrating advanced immune monitoring during RT delivery and did not meet its primary endpoint.The hypothesis-generating findings highlight PD-L1+macrophages in the TME and classical monocytes in the blood as potential immune biomarkers of RT response,but larger studies are needed to validate these observations and characterize the immune changes following curative-intent RT in patients with NSCLC.
基金funded by the Macao Science and Technology Development Fund(FDCT Nos.001/2023/ALC,0123/2022/A,0006/2020/AKP,and 005/2023/SKL)the Natural Science Foundation of Guangdong Province,China(No.2020A1515010922)+1 种基金the Shenzhen-Hong Kong-Macao S&T Program(Category C,No.SGDX2020110309420200)the Research Fund of University of Macao(Nos.MYRG-GRG2023-00198-ICMS,CPG2024-00038-ICMS and SRG2022-00052-ICMS)。
文摘Pinelliae Rhizoma(PR),known as Banxia in Chinese,Hange in Japanese,and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.)Breit.(PT).It is extensively utilized in dispensing granules,classical prescriptions,and herbal formulas to treat various conditions,including cough,infection,phlegm,nausea,asthma,and inflammation.Despite numerous studies on PR and its classical prescriptions over recent decades,a comprehensive synthesis of available evidence regarding its multifunctional roles and therapeutic potential is lacking.This review aims to address this gap by examining emerging evidence from metabonomics,preclinical studies,and clinical trials,while exploring potential trends and prospects for future research.A systematic literature search was conducted across six electronic databases,including Pub Med,Web of Science,Scopus,Science Direct,Wanfang,and China National Knowledge Infrastructure,to identify relevant articles on PR published until March 2023.PR contains 107 compounds with diverse pharmacological activities,including anti-inflammatory,immune regulatory,anti-viral,anti-cancer,anti-asthma,antitussive and expectorant,antioxidant,anti-obesity,anti-atherosclerosis,antimicrobial,emetic and anti-emetic,anti-convulsant and anti-epileptic,sedative and hypnotic,learning and memory enhancement,and anti-depressant effects.Metabonomic studies suggest that raw PR may exhibit cardiotoxicity and pregnancy toxicity while showing no apparent hepatorenal toxicity.However,limited pharmacokinetic investigations on PR constrain its clinical translation.Furthermore,clinical safety data on PR is scarce,with only four clinical trials assessing its positive effects in pediatric epilepsy,nausea and vomiting,soft tissue injury,and chronic sinus tract.This review aims to enhance understanding of PR and provide valuable information and recommendations for further research and development of herbal medicine.
文摘Angiomyolipomas(AMLs)represent the most common benign solid renal tumors.The frequency of their detection in the general population is increasing owing to advances in imaging technology.The objective of this review is to discuss computed tomography(CT)and magnetic resonance imaging findings for both typical and atypical renal AMLs,along with their associated complications.AMLs are typically defined as solid triphasic tumors composed of varying amounts of dysmorphic and tortuous blood vessels,smooth muscle components and adipose tissue.In an adult,a classical renal AML appears as a solid,heterogeneous renal cortical mass with macroscopic fat.However,up to 5%of AMLs contain minimal fat and cannot be reliably diagnosed by imaging.Fat-poor AMLs can appear as hyperattenuating masses on unenhanced CT and as hypointense masses on T2WI;other AMLs may be isodense or exhibit cystic components.Hemorrhage is the most common complication,and AMLs with hemorrhage can mimic other tumors,making their diagnosis challenging.Understanding the variable and heterogeneous nature of this neoplasm to correctly classify renal AMLs and to avoid misdiagnosis of other renal lesions is crucial.
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
基金supported by the National Social Science Fund of China(Grand No.21XTJ001).
文摘A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment effect and interim result.For hypotheses and reversed hypotheses under normal models,we obtain analytical expressions of the ROC curves of the CCP,find optimal ROC curves of the CCP,investigate the superiority of the ROC curves of the CCP,calculate critical values of the False Positive Rate(FPR),True Positive Rate(TPR),and cutoff of the optimal CCP,and give go/no go decisions at the interim of the optimal CCP.In addition,extensive numerical experiments are carried out to exemplify our theoretical results.Finally,a real data example is performed to illustrate the go/no go decisions of the optimal CCP.
文摘Exploring Greco-Roman and Chinese classics reveals timeless insights for navigating modern crises.THE enduring wisdom of ancient Greece and China–often found in their classics–holds profound potential to address today’s pressing global challenges.This vital connection was powerfully underscored at the Second Global Forum on Mutual Learning among Civilizations.
文摘1 When we immerse ourselves in the pages of a book,we are transported to worlds beyond our own,gaining insights into the human experience and expanding our understanding of ourselves and others.2 Reading can fill our lives and purify our souls.I enjoy reading and I love life.I enjoy reading Chinese classics such as the Four Great Classical Novels of Chinese literature.I explore the mythical and wonderful stories of demons and monsters in Journey to the West and experience the boldness of martial art heroes in Water Margin.
基金the European Union’s Horizon 2020 research and innovation programme.
文摘AI applications have already-irreversibly-entered the fields of Humanities,Classics,and archaeological research,but are rarely taught in class.This paper attempts to encourage teachers and students of Classical Archaeology,Classics,Art History,and related fields,to practically explore,evaluate,and critically discuss pattern recognition(here focusing on Greek vase-painting),without requiring previously acquired coding skills.For this task,I will outline the potential of the open access program“Orange Data Mining”for academic teaching,based on a seminar taught by myself at Heidelberg University in the winter semester of 2024/25.I will introduce four different pattern recognition exercises(“Image Grid,”“Image Clustering,”“Image Classification,”and“Prediction”)that are easily accessible for classicists(please,try this at home!)and report the results and experiences which came out of our seminar.Furthermore,I will evaluate how the“hands-on”use of Orange Data Mining in class enables students to access the current debate on the chances and limitations of AI for research in ancient studies.
基金Supported by the 2024 Guangxi Provincial College Students Innovation and Entrepreneurship Training Program(S202411354155)Guangxi Zhuang Autonomous Region Philosophy and Social Science Planning Research Project(23FWY028)Wuzhou University Research Project(2024QN013)。
文摘Foshan Liang Garden,as a unique cultural heritage in the Lingnan region,possesses high artistic,scientific,and cultural value.Through field surveys and literature research,this paper sorts out the current problems in the protection and utilization of Foshan Liang Garden,establishes the basic principles of emphasizing both protection and revitalization and implementing them simultaneously,and summarizes methods for protection and utilization,including expanding funding channels,strengthening dynamic monitoring and scientific protection,exploring cultural connotations,and encouraging multi-stakeholder participation in joint construction.Furthermore,it proposes revitalization strategies such as empowering garden services with digital technology,integrating cultural resources to innovate cultural and creative products,promoting the museumization of idle functional spaces,and using cultural and educational activities for inheritance and dissemination.It is hoped that these measures will help Foshan Liang Garden better integrate into modern life,meet people’s diverse needs,and provide new ideas and methods for the protection and utilization of garden cultural heritage.
基金supported by the Science and Technology Project of State Grid Corporation of China(5419-202199552A-0-5-ZN).
文摘Explorations into new electrolytes have highlighted the critical impact of solvation structure on battery performance,Classical molecular dynamics(CMD)using semi-empirical force fields has become an essential tool for simulating solvation structures.However,mainstream force fields often lack accuracy in describing strong ion-solvent interactions,causing disparities between CMD simulations and experimental observations.Although some empirical methods have been employed in some of the studies to address this issue,their effectiveness has been limited.Our CMD research,supported by quantum chemical calculations and experimental data,reveals that the solvation structure is influenced not only by the charge model but also by the polarization description.Previous empirical approaches that focused solely on adjusting ion-solvent interaction strengths overlooked the importance of polarization effects.Building on this insight,we propose integrating the Drude polarization model into mainstream force fields and verify its feasibility in carbonate,ether,and nitrile electrolytes.Our experimental results demonstrate that this approach significantly enhances the accuracy of CMD-simulated solvation structures.This work is expected to provide a more reliable CMD method for electrolyte design,shielding researchers from the pitfalls of erroneous simulation outcomes.
基金supported by the Natural Science Foundation of Shandong Province of China(ZR2024MA033ZR2021QA049).
文摘This paper concerns the Cauchy problem of 3D compressible micropolar fluids in the whole space R^(3). For regular initial data with m0E0 is suitable small, where m0 and E0 represent the upper bound of initial density and initial energy, we prove that if ρ0 ∈ Lγ ∩ H3 with γ ∈ (1, 6), then the problem possesses a unique global classical solution on R^(3) × [0, T] with any T ∈ (0, ∞). It’s worth noting that both the vacuum states and possible random largeness of initial energy are allowed.
文摘The article examines the diverse musical environments for older adults on the West Coast of North America,ranging from descriptions of regional variations in senior community living presented in a variety of sources,including fiction,and the place of music in institutional settings to various musical activities designed for older adults.Given that people living on the West Coast have diverse ethno-religious backgrounds,may or may not be sensitive to the music that surrounded them in their formative years at the local and national levels,and have different habits regarding listening to the radio or attending various musical events,additional aspects were taken into account,such as 1980s and 1990s music styles;ethnic musical heritage relevant to the West Coast population;classical,popular,and religious music on the radio;and affordable symphony orchestra programs.The article provides an overview that opens avenues for further exploration of its sub-topics.
文摘Compilation ofSagya Classics Editor-in-chief of this book is Sagya Palden Donyu,a researcher at the High-level Tibetan Buddhism College of China and the Director of the Sagya Culture Research Office.This volume systematically compiles the academic achievements of the Sagya Dharma Kings.The contents in elude a wide range of topics,including religious philosophy.
文摘Grass constitutes a vital poetic imagery in classical Chinese poetry,embodying multifaceted symbolic connotations ranging from the tenacity of life to sentiments of separation and nostalgic longing.The translation of this botanical motif necessitates not merely lexical equivalence,but more importantly,the transmission of its profound cultural resonance and aesthetic essence.This study posits that effective rendition of grass imagery should adopt an integrative approach synthesizing the objectives of cultural translation with the intrinsic aesthetic characteristics of classical poetry.Through systematic analysis of the cultural semiotics embedded in grass symbolism,the research investigates practical translation techniques at lexical,syntactic,and stylistic dimensions.The findings aim to contribute to the theoretical framework of cultural image translation in Chinese poetic tradition while providing methodological references for cross-cultural interpretation of classical verse.By bridging cultural semiotics with translation praxis,this investigation seeks to advance the intercultural communication of Chinese poetic heritage through nuanced treatment of its botanical symbolism.
文摘This concise paper,delivered at a conference,addresses a broad topic with the goal of providing a condensed and inevitably subjective perspective.Initially,it outlines the primary characteristics that distinguish coins from other historical sources.Subsequently,it provides a succinct overview of numismatics,categorized into seven phases:1.Pre-1550(coins as reflections of vice and virtue);2.From circa 1550 to circa 1620(coins as testimony of authentic history);3.From circa 1650 to circa 1730(the heyday of the“Republic of Medals”);4.From circa 1730 to circa 1840(the decline of the“Republic of Medals”and the emergence of scientific practices by Viennese Jesuits);5.From circa 1840 to circa 1940(die-studies and art history);6.From circa 1940 to circa 2000(coins as instruments of exchange);7.Since 2000(cultural shift and digital humanities).
文摘More than a simple concert pianist,Wilson Chu is an Indonesian musical diplomacy force.As a distinguished performer,composer,and educator,Wilson has left an indelible mark on the international stage by seamlessly blending Western classical music with Southeast Asian tradition.Since 2019,he has been the youngest Associate Professor of Piano at the College of Chinese and ASEAN Arts(CCAA)at Chengdu University,where he has dedicated himself to shaping the next generation of musicians.
