提出了1种基于0.18μm CMOS工艺的低压低功耗、宽锁定范围、低复杂度的2分频直接注入锁定分频器.该分频器采用Class-C的LC-tank架构来降低电源电压,同时改善LC振荡器的起振情况.此外还采用双端注入混频技术来扩大锁定范围.仿真结果表明...提出了1种基于0.18μm CMOS工艺的低压低功耗、宽锁定范围、低复杂度的2分频直接注入锁定分频器.该分频器采用Class-C的LC-tank架构来降低电源电压,同时改善LC振荡器的起振情况.此外还采用双端注入混频技术来扩大锁定范围.仿真结果表明该分频器有很好的混频性能,且分频器核心电路(不包括输出buffer)在800 m V电源电压下的功耗仅为0.91 m W.在注入信号的功率为0 d Bm时,该分频器在没有任何调谐单元时的锁定范围为6.4-8.5 GHz.展开更多
The feasibility of utilization of flue gas desulfurization （FGD） gypsum and Class-C fly ash （CFA） to prepare CFA-based geopolymer were studied. The results showed that geopolymer made from 90% CFA and 10% FGD gyps...The feasibility of utilization of flue gas desulfurization （FGD） gypsum and Class-C fly ash （CFA） to prepare CFA-based geopolymer were studied. The results showed that geopolymer made from 90% CFA and 10% FGD gypsum （FGDG） which was thermally treated at 800 ℃ for 1 h obtained the better compressive strength of 37.0 MPa. The micro characteristics and structures of the geopolymer samples of CFA and CFA-FGDG were tested by XRD, FT-IR, and SEM-EDXA after these samples cured at 75 ℃ for 8 h followed by 23 ℃ for 28 d. Both the geopolymer samples of CFA and CFA-FGDG have significant asymmetric stretching of A1-O/Si-O bonds and Si-O-Si / Si-O-A1 bending band. In geopolymer sample of CFA-FGDG, a small quantity of lathy products probably being the ettringite wrapped over the spherical fly ash particle, and the concentration of sulfur is much more than that in geopolymer sample of CFA. It is indicated that FGD gypsum may react during alkali-activated and geopolymeric process.展开更多
A 1.4-2 GHz phase-locked loop （PLL） ∑-△ fraction-N frequency synthesizer with automatic fre- quency control （AFC） for 802.1 lah applications is presented. A class-C voltage control oscillator （VCO） ranging fr...A 1.4-2 GHz phase-locked loop （PLL） ∑-△ fraction-N frequency synthesizer with automatic fre- quency control （AFC） for 802.1 lah applications is presented. A class-C voltage control oscillator （VCO） ranging from 1.4 to 2 GHz is integrated on-chip to save power for the sub-GHz band. A novel AFC algorithm is introduced to maintain the VCO oscillation at the start-up and automatically search for the appropriate control word of the switched-capacitor array to extend the PLL tuning range. A 20-bit third-order ∑-△ modulator is utilized to reduce the fraction spurs while achieving a frequency resolution that is lower than 30 Hz. The measurement results show that the frequency synthesizer has achieved a phase noise of 〈 -120 dBc/Hz at 1 MHz offset and consumes 11.1 mW from a 1.7 V supply. Moreover, compared with the traditional class-A counterparts, the phase noise in class-C mode has been improved by 5 dB under the same power consumption.展开更多
嵌合抗原受体T细胞(chimeric antigen receptor T cells,CAR-T)的出现使得多发性骨髓瘤(multiple myeloma,MM)患者的治疗进入了一个新的阶段,但大多数患者都难逃原发耐药或疾病复发的不良结局。G蛋白偶联受体C类5组成员D(G protein-coup...嵌合抗原受体T细胞(chimeric antigen receptor T cells,CAR-T)的出现使得多发性骨髓瘤(multiple myeloma,MM)患者的治疗进入了一个新的阶段,但大多数患者都难逃原发耐药或疾病复发的不良结局。G蛋白偶联受体C类5组成员D(G protein-coupled receptor class C group 5 member D,GPRC5D)是目前MM患者的一个有前景的治疗靶点,与GPRC5D CAR-T相关的Ⅰ期临床研究也都显示出较高的反应率和疗效。文章将对现有的靶向GPRC5D CAR-T细胞最新研究进行综述,旨在通过总结讨论目前不同GPRC5D CAR-T细胞治疗复发难治性MM的研究现状,对今后的临床治疗提供更多参考。展开更多
文摘提出了1种基于0.18μm CMOS工艺的低压低功耗、宽锁定范围、低复杂度的2分频直接注入锁定分频器.该分频器采用Class-C的LC-tank架构来降低电源电压,同时改善LC振荡器的起振情况.此外还采用双端注入混频技术来扩大锁定范围.仿真结果表明该分频器有很好的混频性能,且分频器核心电路(不包括输出buffer)在800 m V电源电压下的功耗仅为0.91 m W.在注入信号的功率为0 d Bm时,该分频器在没有任何调谐单元时的锁定范围为6.4-8.5 GHz.
基金Funded by the National Natural Science Foundation of China(Nos.51208370,51172164)the Specialized Research Fund for the Doctoral Program of Higher Education(Nos.20110072120046,20090072110010)of China
文摘The feasibility of utilization of flue gas desulfurization （FGD） gypsum and Class-C fly ash （CFA） to prepare CFA-based geopolymer were studied. The results showed that geopolymer made from 90% CFA and 10% FGD gypsum （FGDG） which was thermally treated at 800 ℃ for 1 h obtained the better compressive strength of 37.0 MPa. The micro characteristics and structures of the geopolymer samples of CFA and CFA-FGDG were tested by XRD, FT-IR, and SEM-EDXA after these samples cured at 75 ℃ for 8 h followed by 23 ℃ for 28 d. Both the geopolymer samples of CFA and CFA-FGDG have significant asymmetric stretching of A1-O/Si-O bonds and Si-O-Si / Si-O-A1 bending band. In geopolymer sample of CFA-FGDG, a small quantity of lathy products probably being the ettringite wrapped over the spherical fly ash particle, and the concentration of sulfur is much more than that in geopolymer sample of CFA. It is indicated that FGD gypsum may react during alkali-activated and geopolymeric process.
文摘A 1.4-2 GHz phase-locked loop （PLL） ∑-△ fraction-N frequency synthesizer with automatic fre- quency control （AFC） for 802.1 lah applications is presented. A class-C voltage control oscillator （VCO） ranging from 1.4 to 2 GHz is integrated on-chip to save power for the sub-GHz band. A novel AFC algorithm is introduced to maintain the VCO oscillation at the start-up and automatically search for the appropriate control word of the switched-capacitor array to extend the PLL tuning range. A 20-bit third-order ∑-△ modulator is utilized to reduce the fraction spurs while achieving a frequency resolution that is lower than 30 Hz. The measurement results show that the frequency synthesizer has achieved a phase noise of 〈 -120 dBc/Hz at 1 MHz offset and consumes 11.1 mW from a 1.7 V supply. Moreover, compared with the traditional class-A counterparts, the phase noise in class-C mode has been improved by 5 dB under the same power consumption.
文摘嵌合抗原受体T细胞(chimeric antigen receptor T cells,CAR-T)的出现使得多发性骨髓瘤(multiple myeloma,MM)患者的治疗进入了一个新的阶段,但大多数患者都难逃原发耐药或疾病复发的不良结局。G蛋白偶联受体C类5组成员D(G protein-coupled receptor class C group 5 member D,GPRC5D)是目前MM患者的一个有前景的治疗靶点,与GPRC5D CAR-T相关的Ⅰ期临床研究也都显示出较高的反应率和疗效。文章将对现有的靶向GPRC5D CAR-T细胞最新研究进行综述,旨在通过总结讨论目前不同GPRC5D CAR-T细胞治疗复发难治性MM的研究现状,对今后的临床治疗提供更多参考。
