OBJECTIVE:To evaluate the effect of this plant as adjunctive therapy on Helicobacter pylori(H.pylori)eradication.METHODS:The plant capsules were prepared and their physicochemical properties were assessed.In this clin...OBJECTIVE:To evaluate the effect of this plant as adjunctive therapy on Helicobacter pylori(H.pylori)eradication.METHODS:The plant capsules were prepared and their physicochemical properties were assessed.In this clinical trial,99 patients with H.pylori infection were randomized to receive Salvia mirzayanii Rech.f.&Esfand(S.mirzayanii)or placebo capsules for two weeks.All the patients in both groups received clarithromycin-based triple therapy.Both intention to treat and per protocol analyses were performed.Eradication rates,treatment side effects,and medication compliance were evaluated in both groups.RESULTS:H.pylori eradication rate of all the randomized participants was 59.59%.The eradication rate of H.pylori was significantly higher in S.mirzayanii group compared with that in the placebo group for per protocol analysis(84.62%,P=0.026)but not for intention to treat one(65.31%,P=0.252).There were no significant differences between the two groups regarding the frequencies of the medications side effects and the patients with poor compliance.CONCLUSION:The use of S.mirzayanii as adjunctive therapy to 14-day clarithromycin-based triple therapy might improve H.pylori eradication rate.展开更多
基金Kerman University of Medical Sciences Project:Evaluating the Effects of Marmotti(Salvia mirzayanii Rech.f.&Esfand)Capsules as Adjunctive Treatment in Patients with Helicobacter Pylori Infection(No.98000128)。
文摘OBJECTIVE:To evaluate the effect of this plant as adjunctive therapy on Helicobacter pylori(H.pylori)eradication.METHODS:The plant capsules were prepared and their physicochemical properties were assessed.In this clinical trial,99 patients with H.pylori infection were randomized to receive Salvia mirzayanii Rech.f.&Esfand(S.mirzayanii)or placebo capsules for two weeks.All the patients in both groups received clarithromycin-based triple therapy.Both intention to treat and per protocol analyses were performed.Eradication rates,treatment side effects,and medication compliance were evaluated in both groups.RESULTS:H.pylori eradication rate of all the randomized participants was 59.59%.The eradication rate of H.pylori was significantly higher in S.mirzayanii group compared with that in the placebo group for per protocol analysis(84.62%,P=0.026)but not for intention to treat one(65.31%,P=0.252).There were no significant differences between the two groups regarding the frequencies of the medications side effects and the patients with poor compliance.CONCLUSION:The use of S.mirzayanii as adjunctive therapy to 14-day clarithromycin-based triple therapy might improve H.pylori eradication rate.
