Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be d...Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.展开更多
Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both g...Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.展开更多
Wind-induced circulation is the main form of lake flow for shallow lakes and plays an important role in algae population distribution.This study constructed a three-dimensional hydrodynamic model(EFDC)of the plateau l...Wind-induced circulation is the main form of lake flow for shallow lakes and plays an important role in algae population distribution.This study constructed a three-dimensional hydrodynamic model(EFDC)of the plateau lake Erhai,China using accuracy wind field observation,runoff data and monthly algae data during 2022–2023.The model successfully reproduced the circulation characteristics of Erhai under prevailing wind directions.The results showed that the lake flow velocity in Lake Erhai is higher in winter than in summer,with lower velocities near shore particularly in the northern and central parts of the lake.There is a negative correlation between algal biomass and flow velocity(FV)in different zones,with lower FV favoring the accumulation of algal biomass,particularly for Microcystis,Dolichospermum,and Peridinium.Additionally,due to buoyancy,cyanobacteria are highly affected by wind direction and tend to accumulate in downwind regions of the prevailing wind direction.This study demonstrates that wind-induced circulation is a crucial factor affecting the spatial distribution of dominant algae populations in shallow plateau lakes with weak hydrodynamic force.Further,the risk of bloom occurrence in Lake Erhai will be higher due to the background of global climate change and the lake’s wind speed decline.In conclusion,we suggest implementing targeted zoning measures to control algal blooms and establishing stricter regulations for nitrogen and phosphorus control to counterbalance the promotion of algal bloom accumulation in low-velocity zones caused by reduced wind speed.展开更多
By reviewing the mechanisms of drilling fluid lost circulation and its control in fractured formations, the applicability and working mechanisms of different kinds of lost circulation materials in plugging fractured f...By reviewing the mechanisms of drilling fluid lost circulation and its control in fractured formations, the applicability and working mechanisms of different kinds of lost circulation materials in plugging fractured formations have been summarized. Meanwhile, based on the types of lost circulation materials, the advantages, disadvantages, and application effects of corresponding plugging technologies have been analyzed to sort out the key problems existing in the current lost circulation control technologies. On this basis, the development direction of plugging technology for severe loss have been pointed out. It is suggested that that the lost circulation control technology should combine different disciplines such as geology, engineering and materials to realize integration, intelligence and systematization in the future. Five research aspects should be focused on:(1) the study on mechanisms of drilling fluid lost circulation and its control to provide basis for scientific selection of lost circulation material formulas, control methods and processes;(2) the research and development of self-adaptive lost circulation materials to improve the matching relationship between lost control materials and fracture scales;(3) the research and development of lost circulation materials with strong retention and strong filling in three-dimensional fracture space, to enhance the retention and filling capacities of materials in fractures and improve the lost circulation control effect;(4) the research and development of lost circulation materials with high temperature tolerance, to ensure the long-term plugging effect of deep high-temperature formations;(5) the study on digital and intelligent lost circulation control technology, to promote the development of lost circulation control technology to digital and intelligent direction.展开更多
Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks...Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks of moderate-intensity aerobic exercise,when compared with a control group,would change inflammation,circulating tumor cells(CTCs),and circulating tumor DNA(ctDNA)in a manner consistent with an improved cancer prognosis.Methods This trial randomized Stages I–III colorectal cancer survivors to 12 weeks of home-based moderate-intensity aerobic exercise or a waitlist control group.The co-primary endpoints were high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6),secondary endpoints were soluble tumor necrosis factor-αreceptor 2(sTNFαR2)and CTCs,and the exploratory endpoint was tumor fraction quantified from ctDNA.Results Sixty subjects were randomized(age=60.6±10.8 years,mean±SD;39(65%)females;46(77%)colonic primary tumor),and 59(98%)subjects completed the study.Over 12 weeks,exercise adherence was 92%(95%confidence interval(95%CI):86‒99).Exercise improved submaximal fitness capacity(0.36 metabolic equivalents;95%CI:0.05‒0.67;p=0.025)and objectively measured moderate-to-vigorous-intensity physical activity(34.8%,95%CI:11.3‒63.1;p=0.002)compared to control.Exercise did not change hs-CRP(20.9%,95%CI:−17.1 to 76.2;p=0.32),IL-6(11.4%,95%CI:−7.5 to 34.0;p=0.25),or sTNFαR2(−3.6%,95%CI:−13.7 to 7.7;p=0.52)compared to control.In the subgroup of subjects with elevated baseline hs-CRP(n=35,58.3%),aerobic exercise reduced hs-CRP(−35.5%,95%CI:−55.3 to−3.8;p=0.031).Exercise did not change CTCs(0.59 cells/mL,95%CI:−0.33 to 1.51;p=0.21)or tumor fraction(0.0005,95%CI:−0.0024 to 0.0034;p=0.73).In exploratory analyses,higher aerobic exercise adherence correlated with a reduction in CTCs(ρ=−0.37,95%CI:−0.66 to−0.08;p=0.013).Conclusion Colorectal cancer survivors achieved high adherence to a home-based moderate-intensity aerobic exercise prescription that improved fitness capacity and physical activity but did not reduce inflammation or change tumor endpoints from a liquid biopsy.展开更多
During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to dril...During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to drilling fluids is the most common method for controlling lost circulation.Among these,granular LCMs are widely used,but the application frequency of flaky LCMs has been increasing annually due to their unique morphology.However,the migration and plugging behavior of flaky LCMs within fractures,and the mechanisms enhancing the pressure-bearing capacity of the plugging zone are not well understood.Therefore,this study conducted visual plugging experiments and dynamic fracture plugging experiments to evaluate the plugging mode and pressure-bearing capacity of the plugging slurry with various particle sizes and concentrations of flaky LCMs.The experimental results demonstrate that the fracture plugging process can be divided into four stages:uniform flow stage of the plugging slurry,formation and development stage of the bridging area,formation and development stage of the plugging area,and pressure-bearing stage of the plugging zone.The inclusion of flaky LCMs notably reduces the duration of stages 1 and 2,while simultaneously increasing the proportion of the plugging zone and enhancing its surface porosity.Flaky LCMs reduce the effective fracture width through“interception”and“co-bridging”modes,thus improving plugging zone formation efficiency.Appropriate particle size and concentration of flaky LCMs increase the area and length of the plugging zone.This reduces the fracture width increment caused by injection pressure and enhances frictional force between the plugging zone and fracture surface,thereby improving the pressure-bearing capacity of the plugging zone.However,excessively high concentrations of flaky LCMs result in decreased structural stability of the plugging zone,and excessively large particle sizes increase the risk of plugging outside fracture inlet.The recommended concentration of flaky LCMs in the plugging slurry is 2%–3%,with a particle size 1.2 to 1.5 times that of the bridging granular LCMs and not exceeding twice the fracture width.This study provides a theoretical foundation for selecting LCMs and designing plugging formulations for field applications.展开更多
Lost circulation of drilling fluid is an international engineering problem during drilling.Aiming at the problems of the first-time lost circulation control success rate and poor adaptability of traditional lost circu...Lost circulation of drilling fluid is an international engineering problem during drilling.Aiming at the problems of the first-time lost circulation control success rate and poor adaptability of traditional lost circulation materials,a new self-healing lost circulation material based on dynamic disulfide bonds was prepared and named CKSH.In this paper,the particle size of self-healing lost circulation material was from 0.1 to 5 mm.The structure was analyzed by modern characterization means,and the drilling fluid compatibility,self-healing performance were evaluated.The self-healing and bridging-filling-sealing mechanism of CKSH were revealed.The results showed that the healing rate of CKSH could reach100%after 12 h over 70℃.It showed good compatibility with drilling fluid,with no effect on rheology or filtration loss.It could be stably suspended in drilling fluid,and the temperature resistance reached140℃.Healing by self-healing lost circulation materials of different particle size,the pressure bearing capacity of plugging zone were over 12 MPa for fracture opening of 1–5 mm.It could play a synergistic role with traditional lost circulation materials by chemical bonding,and the repeated loss caused by physical plugging was avoided.The research results of this paper can improve the bridging plugging bearing pressure strength and the first-time lost circulation control success rate,which is of great significance for improving drilling efficiency and reducing non-productive time.展开更多
Molecular profiling of biliary tract cancers(BTCs)has paved the way for a broader range of therapeutic options,leading to improved survival outcomes.Given the challenges of tissue evaluation in BTCs,circulating tumor ...Molecular profiling of biliary tract cancers(BTCs)has paved the way for a broader range of therapeutic options,leading to improved survival outcomes.Given the challenges of tissue evaluation in BTCs,circulating tumor DNA(ct-DNA)has emerged as a promising non-invasive biomarker for genomic profiling.Bile has been proven to be a reliable ctDNA source,demonstrating higher concordance with tumor tissue than plasma.More importantly,ctDNA provides valuable insights into both clonal evolution and treatment response,including the detection of resistance mechanisms and mutation clearance,which are often associated with disease control.Although its role in recurrence monitoring remains investigational,early studies suggest that ctDNA detection may precede radiological recurrences.This review examines recent advancements in ctDNA analysis for patients with BTC,highlighting key developments,current clinical implications,and ongoing challenges.Large-scale prospective studies are needed to validate the clinical utility of ctDNA and to support its integration into BTC management.展开更多
Circulating plasma cells(CPCs)in patients of plasma cell neoplasm have been an area of intense research in recent decades.Circulating tumor plasma cells(CTPCs)might represent a sub-clone of tumor cells that have exite...Circulating plasma cells(CPCs)in patients of plasma cell neoplasm have been an area of intense research in recent decades.Circulating tumor plasma cells(CTPCs)might represent a sub-clone of tumor cells that have exited into peripheral blood as a result of the dynamic interactions between the bone marrow(BM)microenvironment and neoplastic plasma cells.Chemokine receptors like chemokine receptor 4(CXCR4)and integrins are known to play a role in homing and migration of plasma cells(PCs).The hypoxic microenvironment in the BM niche also contributes to their circulation through various mechanisms.In addition,the CCL3–CCR1 axis probably competes with the retention signals from the CXCR4–α4β1(VLA-4)interaction and actively promotes the exit of PCs from the BM.CTPCs,even in extremely low numbers,can be detected and quantified by high-sensitivity techniques like multi-color flow cytometry and next-generation sequencing.High load of CTPCs noted in patients of plasma cell neoplasm;monoclonal gammopathy of undetermined significance(MGUS),smoldering multiple myeloma(SMM),multiple myeloma(MM)is a strong predictor of shorter progression free survival(PFS)as well as overall survival(OS).In newly diagnosed patients of MM,a load of CTPCs correlates with the outcomes,i.e.,OS and PFS.With more studies collaborating on the results of previous reports,assessment of the burden of CTPCs may become a complimentary approach for non-invasive risk stratification of MM patients and evaluating the response to therapy.Future research on larger cohorts and longer follow-ups may help to improve the existing staging system by incorporating the load of CTPCs as one of the prognostic indicators.Further studies based on isolation and genetic characterization of CTPCs may help in understanding the pathophysiology of the progression of the disease and may open avenues for newer treatment modalities.This review discusses the pathobiological aspects leading to circulation of neoplastic/tumor plasma cells in peripheral blood and provides a summary of research work done in last two decades on its prognostic importance in various plasma cells neoplasms.展开更多
The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic...The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic field has not been previously estimated or incorporated into geomagnetic field models,potentially causing leakage into the core field model.Here,we present a method to account for the circulation-induced magnetic field during geomagnetic field modeling.First,a forward model of the circulation-induced magnetic field is constructed by numerically solving electromagnetic induction equations based on a realistic ocean circulation model.Then,this forward model is subtracted from the observed data.Finally,the core and lithospheric fields,magnetospheric and Earth’s mantle-induced fields,and the ocean tide-induced magnetic field are co-estimated.Applying our method to over 20 years of MSS-1,Swarm,CryoSat-2,and CHAMP satellite magnetic data,we derive a new multisource geomagnetic field model(MGFM).We find that incorporating a forward model of the circulation-induced magnetic field marginally improves the fit to the data.Furthermore,we demonstrate that neglecting the circulation-induced magnetic field in geomagnetic field modeling results in leakage into the core field model.The highlights of the MGFM model include:(i)a good agreement with the widely used CHAOS model series;(ii)the incorporation of magnetic fields induced by both ocean tides and circulation;and(iii)the suppression of leakage of the circulation-induced magnetic field into the core field model.展开更多
BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma me...BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma methylation and circulating tumor cells were detected.METHODS Plasma samples were collected from Hubei Cancer Hospital(n=156).Plasma DNA was tested to detect SHOX2,HOXA9,SEPTIN9,and RASSF1A methylation using TaqMan PCR.Circulating tumor cells(CTCs)were detected in the peripheral blood of patients using the United States Food and Drug Administration-approved cell search system before and after clinical therapy.The CCA diagnostic value was estimated using the area under the curve.The independent prognosis risk factors for patients with CCA were estimated using Cox and logistic regression analyses.RESULTS The sensitivity and specificity of the four DNA plasma methylations exhibited 64.74%sensitivity and 93.88%specificity for detecting CCA.The receiver operating characteristic curve of the combined value for CCA diagnosis in plasma was 0.828±0.032.RASSF1A plasma methylation was related to the prognosis of patients with CCA.We determined the prognostic hazard ratio for CCA using CTC count,tumor stage,methylation,and carbohydrate antigen 19-9 levels as key factors.Our overall survival nomogram achieved a C-index of 0.705(0.605-0.805).CONCLUSION SHOX2,HOXA9,SEPTIN9,and RASSF1A plasma methylation demonstrated increased sensitivity for diagnosing CCA.RASSF1A plasma methylation and CTCs were valuable predictors to assess CCA prognosis and recurrence.展开更多
Given the growing burden of colorectal cancer(CRC)as a global health challenge,it becomes imperative to focus on strategies that can mitigate its impact.Posttreatment surveillance has emerged as essential for early de...Given the growing burden of colorectal cancer(CRC)as a global health challenge,it becomes imperative to focus on strategies that can mitigate its impact.Posttreatment surveillance has emerged as essential for early detection of recurrence,significantly improving patient outcomes.However,intensive surveillance strategies have shown mixed results compared to less intensive methods,emphasizing the necessity for personalized,risk-adapted approaches.The observed suboptimal adherence to existing surveillance protocols underscores the urgent need for more tailored and efficient strategies.In this context,circulating tumor DNA(ctDNA)emerges as a promising biomarker with significant potential to revolutionize post-treatment surveillance,demonstrating high specificity[0.95,95%confidence interval(CI):0.91-0.97]and robust diagnostic odds(37.6,95%CI:20.8-68.0)for recurrence detection.Furthermore,artificial intelligence and machine learning models integrating patient-specific and tumor features can enhance risk stratification and optimize surveillance strategies.The reported area under the receiver operating characteristic curve,measuring artificial intelligence model performance in predicting CRC recurrence,ranged from 0.581 and 0.593 at the lowest to 0.979 and 0.978 at the highest in training and validation cohorts,respectively.Despite this promise,addressing cost,accessibility,and extensive validation remains crucial for equitable integration into clinical practice.展开更多
Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited...Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups.Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate,while Group B received only Betahistine Mesylate.The efficacy,syndrome scores,hemodynamics,and quality of life indicators were compared between the two groups.Results:The efficacy of PCI treatment in Group A was higher than that in Group B(P<0.05).The syndrome scores in Group A were lower than those in Group B(P<0.05).The peak systolic velocity(PSV)of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B(P<0.05).The quality of life(SF-36)score in Group A was higher than that in Group B(P<0.05).Conclusion:Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI,with improved hemodynamic indicators and reduced disease scores.展开更多
Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration a...Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration and development.Predicting LC risks enables the targeted implementation of mitigation strategies,thereby reducing the frequency of such incidents.To address the limitations of existing 3D geomechanical modeling in predicting LC,such as arbitrary factor selection,subjective weight assignment,and the inability to achieve pre-drilling prediction along the entire well section,an improved prediction method is proposed.This method integrates multi-source data and incorporates three LC-related sensitivity factors:fracture characteristics,rock brittleness,and in-situ stress conditions.A quantitative risk assessment model for LC is developed by combining the subjective analytic hierarchy process with the objective entropy weight method(EWM)to assign weights.Subsequently,3D geomechanical modeling is applied to identify regional risk zones,enabling digital visualization for pre-drilling risk prediction.The developed 3D LC risk prediction model was validated using actual LC incidents from drilled wells.Results were generally consistent with field-identified LC zones,with an average relative error of 19.08%,confirming its reliability.This method provides practical guidance for mitigating potential LC risks and optimizing drilling program designs in fractured formations.展开更多
Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical...Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical frameworks to systematically examine the evolution,performance,and influencing factors of governance mechanisms within these organizations.Using both quantitative and inductive analytical methods,the paper proposes innovative designs and supporting measures for improving governance mechanisms.The findings reveal that,amid large-scale farmland circulation,the governance mechanisms of agricultural production organizations in Daqing City are evolving from traditional to modern structures.However,challenges remain in areas such as decision-making efficiency,benefit distribution,and supervision mechanisms.In response,this study proposes innovative governance designs focusing on decision-making processes,profit-sharing mechanisms,and risk prevention.Corresponding policy recommendations are also provided to support the sustainable development of agricultural modernization in China.展开更多
Dear Editor,Dengue virus(DENV)is a positive-sense single-stranded RNA virus belonging to the Flaviviridae family,which causes dengue—a disease affecting over 400 million people annually worldwide.DENV is transmitted ...Dear Editor,Dengue virus(DENV)is a positive-sense single-stranded RNA virus belonging to the Flaviviridae family,which causes dengue—a disease affecting over 400 million people annually worldwide.DENV is transmitted through the bite of mosquitoes from the Aedes genus,primarily Aedes aegypti,and has a wide distribution in tropical and subtropical areas(de Souza et al.,2022).展开更多
Background:Aortic atherosclerosis increases the risk of embolic events under extracorporeal circulation(ECC).To evaluate the hemodynamic impact of ECC on atheromatous plaques,an atherosclerosis animal model,which is a...Background:Aortic atherosclerosis increases the risk of embolic events under extracorporeal circulation(ECC).To evaluate the hemodynamic impact of ECC on atheromatous plaques,an atherosclerosis animal model,which is also eligible for ECC,is required.Methods:Twenty-nine New Zealand White rabbits received a pro-atherosclerotic diet(group diet,n=10),a pro-atherosclerotic diet and additional intraaortic balloon insufflation injury(group BI,n=9),or served as controls(n=10).After 3 or 6 months,aortic explants were analyzed by(immuno-)histology and RT-PCR.Results:Blood serum analyses revealed increased cholesterol-levels in groups diet and BI compared to controls(3 months:p=0.03 each,6 months:p<0.0001 each).Aortic inflammatory infiltration was significantly enhanced in groups diet(CD3 at 3 months:p<0.0001,6 months:p=0.02;CD68 at 3 months:p=0.01)and BI(CD3 at 3 months:p<0.0001,6 months:p=0.03;CD68 at 3 months:p=0.04,6 months:p=0.02).Increased intima hyperplasia occurred in both groups(p<0.0001 each).Macroscopic analyses after 3 and 6 months showed ubiquitous lumen-narrowing aortic plaques.Calcification of the intima and media was increased in groups diet(intima:p<0.0001 at 3 and 6 months;media at 3 months:p<0.0001,6 months:p=0.01)and BI(intima:p<0.0001 at 3 and 6 months;media at 3 months:p<0.0001,6 months:p=0.02).Extensive lipid accumulation was found in the intima in both treatment groups(p<0.0001 each).Conclusions:A rabbit model with high aortic calcific plaque burden—diet-induced with no implicit need of an additional intimal injury by an intraaortic balloon insufflation due to comparable outcome—exhibiting multiple pathophysiological aspects of human atherosclerosis has been designed and thoroughly characterized.It is suitable for use in future studies on the interaction between atherosclerotic plaques and the arterial blood flow under ECC.展开更多
As a pyrometallurgical process,circulating fluidized bed(CFB) roasting has good potential for application in desulfurization of high-sulfur bauxite.The gas-solid distribution and reaction during CFB roasting of high-s...As a pyrometallurgical process,circulating fluidized bed(CFB) roasting has good potential for application in desulfurization of high-sulfur bauxite.The gas-solid distribution and reaction during CFB roasting of high-sulfur bauxite were simulated using the computational particle fluid dynamics(CPFD) method.The effect of primary air flow velocity on particle velocity,particle volume distribution,furnace temperature distribution and pressure distribution were investigated.Under the condition of the same total flow of natural gas,the impact of the number of inlets on the desulfurization efficiency,atmosphere mass fraction distribution and temperature distribution in the furnace was further investigated.展开更多
Sintering is the process that emits the most pollutants in ironmaking,including CO,SO_(2),NO_(x),and dioxins.Flue gas circulation sintering technology can not only reduce the emissions of various pollutants but also d...Sintering is the process that emits the most pollutants in ironmaking,including CO,SO_(2),NO_(x),and dioxins.Flue gas circulation sintering technology can not only reduce the emissions of various pollutants but also decrease the consumption of solid fuels.Therefore,it is necessary to summarize and discuss the research status of flue gas circulation technology.Firstly,the research status,advantages,and disadvantages of five typical flue gas circulation processes and their effects on the emission of different pollutants were analyzed.Then,the impact of O_(2),CO,SO_(2),and temperature in the circulating gas during the sintering flue gas circulation process on the quality of sinter and their reasonable ranges was summarized,and the formation mechanisms of CO_(x),NO_(x),SO_(2),and dioxins during the sintering process were discussed.Furthermore,the optimization and improvement of flue gas circulation technology in recent years were introduced.Finally,issues related to element enrichment,equipment improvements,and fine particulate matter emissions in the flue gas circulation process were reviewed,providing a reference for the optimal application of flue gas circulation sintering technology in the future.展开更多
Spin waves,quantized as magnons,constitute a fundamental class of excitations and serve as one of the primary angular momentum carriers in magnetic systems.Devoid of Joule heating,a magnonic device that routes spin wa...Spin waves,quantized as magnons,constitute a fundamental class of excitations and serve as one of the primary angular momentum carriers in magnetic systems.Devoid of Joule heating,a magnonic device that routes spin waves between different ports holds promise for an energy-efficient information infrastructure.Here,we systematically investigate the transport behavior of a magnetic skyrmion-based magnon circulator,a representative device that directs spin wave flow in a non-reciprocal manner.Particularly,a ballistic transport model is established,where the scattering of spin waves by magnetic skyrmions is simplified as magnon deflection by fictitious electromagnetic fields within the skyrmions.Through the combination of ballistic analyses and micromagnetic simulations,the circulation performance is rigorously evaluated for multiple magnon circulators.展开更多
文摘Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2342210 and 42275043)the National Institute of Natural Hazards,Ministry of Emergency Management of China(Grant Nos.J2223806,ZDJ2024-25 and ZDJ2025-34)。
文摘Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.
基金supported by the Open Research Fund of Key Laboratory for Lake Pollution Control of the Ministry of Ecology and Environment(No.2024HPYKFZD04)the Fundamental Research Funds for the Central Publicinterest Scientific Institution(No.2025YSKY-04)the National Natural Science Foundation of China(Nos.U1902207 and 42207265).
文摘Wind-induced circulation is the main form of lake flow for shallow lakes and plays an important role in algae population distribution.This study constructed a three-dimensional hydrodynamic model(EFDC)of the plateau lake Erhai,China using accuracy wind field observation,runoff data and monthly algae data during 2022–2023.The model successfully reproduced the circulation characteristics of Erhai under prevailing wind directions.The results showed that the lake flow velocity in Lake Erhai is higher in winter than in summer,with lower velocities near shore particularly in the northern and central parts of the lake.There is a negative correlation between algal biomass and flow velocity(FV)in different zones,with lower FV favoring the accumulation of algal biomass,particularly for Microcystis,Dolichospermum,and Peridinium.Additionally,due to buoyancy,cyanobacteria are highly affected by wind direction and tend to accumulate in downwind regions of the prevailing wind direction.This study demonstrates that wind-induced circulation is a crucial factor affecting the spatial distribution of dominant algae populations in shallow plateau lakes with weak hydrodynamic force.Further,the risk of bloom occurrence in Lake Erhai will be higher due to the background of global climate change and the lake’s wind speed decline.In conclusion,we suggest implementing targeted zoning measures to control algal blooms and establishing stricter regulations for nitrogen and phosphorus control to counterbalance the promotion of algal bloom accumulation in low-velocity zones caused by reduced wind speed.
基金Supported by National Natural Science Foundation of China(51991361,52074327,U1762212)Major Engineering Technology Field Tes Project of CNPC(2020F-45)。
文摘By reviewing the mechanisms of drilling fluid lost circulation and its control in fractured formations, the applicability and working mechanisms of different kinds of lost circulation materials in plugging fractured formations have been summarized. Meanwhile, based on the types of lost circulation materials, the advantages, disadvantages, and application effects of corresponding plugging technologies have been analyzed to sort out the key problems existing in the current lost circulation control technologies. On this basis, the development direction of plugging technology for severe loss have been pointed out. It is suggested that that the lost circulation control technology should combine different disciplines such as geology, engineering and materials to realize integration, intelligence and systematization in the future. Five research aspects should be focused on:(1) the study on mechanisms of drilling fluid lost circulation and its control to provide basis for scientific selection of lost circulation material formulas, control methods and processes;(2) the research and development of self-adaptive lost circulation materials to improve the matching relationship between lost control materials and fracture scales;(3) the research and development of lost circulation materials with strong retention and strong filling in three-dimensional fracture space, to enhance the retention and filling capacities of materials in fractures and improve the lost circulation control effect;(4) the research and development of lost circulation materials with high temperature tolerance, to ensure the long-term plugging effect of deep high-temperature formations;(5) the study on digital and intelligent lost circulation control technology, to promote the development of lost circulation control technology to digital and intelligent direction.
基金supported by the National Cancer Institute of the National Institutes of Health under Award Number R00CA218603
文摘Background The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood.This trial tested the hypothesis that 12 weeks of moderate-intensity aerobic exercise,when compared with a control group,would change inflammation,circulating tumor cells(CTCs),and circulating tumor DNA(ctDNA)in a manner consistent with an improved cancer prognosis.Methods This trial randomized Stages I–III colorectal cancer survivors to 12 weeks of home-based moderate-intensity aerobic exercise or a waitlist control group.The co-primary endpoints were high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6),secondary endpoints were soluble tumor necrosis factor-αreceptor 2(sTNFαR2)and CTCs,and the exploratory endpoint was tumor fraction quantified from ctDNA.Results Sixty subjects were randomized(age=60.6±10.8 years,mean±SD;39(65%)females;46(77%)colonic primary tumor),and 59(98%)subjects completed the study.Over 12 weeks,exercise adherence was 92%(95%confidence interval(95%CI):86‒99).Exercise improved submaximal fitness capacity(0.36 metabolic equivalents;95%CI:0.05‒0.67;p=0.025)and objectively measured moderate-to-vigorous-intensity physical activity(34.8%,95%CI:11.3‒63.1;p=0.002)compared to control.Exercise did not change hs-CRP(20.9%,95%CI:−17.1 to 76.2;p=0.32),IL-6(11.4%,95%CI:−7.5 to 34.0;p=0.25),or sTNFαR2(−3.6%,95%CI:−13.7 to 7.7;p=0.52)compared to control.In the subgroup of subjects with elevated baseline hs-CRP(n=35,58.3%),aerobic exercise reduced hs-CRP(−35.5%,95%CI:−55.3 to−3.8;p=0.031).Exercise did not change CTCs(0.59 cells/mL,95%CI:−0.33 to 1.51;p=0.21)or tumor fraction(0.0005,95%CI:−0.0024 to 0.0034;p=0.73).In exploratory analyses,higher aerobic exercise adherence correlated with a reduction in CTCs(ρ=−0.37,95%CI:−0.66 to−0.08;p=0.013).Conclusion Colorectal cancer survivors achieved high adherence to a home-based moderate-intensity aerobic exercise prescription that improved fitness capacity and physical activity but did not reduce inflammation or change tumor endpoints from a liquid biopsy.
基金support from the National Natural Science Foundation of China(Grant No.52274009).
文摘During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to drilling fluids is the most common method for controlling lost circulation.Among these,granular LCMs are widely used,but the application frequency of flaky LCMs has been increasing annually due to their unique morphology.However,the migration and plugging behavior of flaky LCMs within fractures,and the mechanisms enhancing the pressure-bearing capacity of the plugging zone are not well understood.Therefore,this study conducted visual plugging experiments and dynamic fracture plugging experiments to evaluate the plugging mode and pressure-bearing capacity of the plugging slurry with various particle sizes and concentrations of flaky LCMs.The experimental results demonstrate that the fracture plugging process can be divided into four stages:uniform flow stage of the plugging slurry,formation and development stage of the bridging area,formation and development stage of the plugging area,and pressure-bearing stage of the plugging zone.The inclusion of flaky LCMs notably reduces the duration of stages 1 and 2,while simultaneously increasing the proportion of the plugging zone and enhancing its surface porosity.Flaky LCMs reduce the effective fracture width through“interception”and“co-bridging”modes,thus improving plugging zone formation efficiency.Appropriate particle size and concentration of flaky LCMs increase the area and length of the plugging zone.This reduces the fracture width increment caused by injection pressure and enhances frictional force between the plugging zone and fracture surface,thereby improving the pressure-bearing capacity of the plugging zone.However,excessively high concentrations of flaky LCMs result in decreased structural stability of the plugging zone,and excessively large particle sizes increase the risk of plugging outside fracture inlet.The recommended concentration of flaky LCMs in the plugging slurry is 2%–3%,with a particle size 1.2 to 1.5 times that of the bridging granular LCMs and not exceeding twice the fracture width.This study provides a theoretical foundation for selecting LCMs and designing plugging formulations for field applications.
基金supported by National Natural Science Foundation of China(52304006,52274032,and 51774062)the General Project of the Chongqing Natural Science Foundation(CSTB2022NSCQ-MSX1554 and CSTB2022NSCQ-MSX0349)Shaanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields and Engineering Research Center of Oil and Gas Field Chemistry,Universities of Shaanxi Province(XSYU-CCCE-2402).
文摘Lost circulation of drilling fluid is an international engineering problem during drilling.Aiming at the problems of the first-time lost circulation control success rate and poor adaptability of traditional lost circulation materials,a new self-healing lost circulation material based on dynamic disulfide bonds was prepared and named CKSH.In this paper,the particle size of self-healing lost circulation material was from 0.1 to 5 mm.The structure was analyzed by modern characterization means,and the drilling fluid compatibility,self-healing performance were evaluated.The self-healing and bridging-filling-sealing mechanism of CKSH were revealed.The results showed that the healing rate of CKSH could reach100%after 12 h over 70℃.It showed good compatibility with drilling fluid,with no effect on rheology or filtration loss.It could be stably suspended in drilling fluid,and the temperature resistance reached140℃.Healing by self-healing lost circulation materials of different particle size,the pressure bearing capacity of plugging zone were over 12 MPa for fracture opening of 1–5 mm.It could play a synergistic role with traditional lost circulation materials by chemical bonding,and the repeated loss caused by physical plugging was avoided.The research results of this paper can improve the bridging plugging bearing pressure strength and the first-time lost circulation control success rate,which is of great significance for improving drilling efficiency and reducing non-productive time.
文摘Molecular profiling of biliary tract cancers(BTCs)has paved the way for a broader range of therapeutic options,leading to improved survival outcomes.Given the challenges of tissue evaluation in BTCs,circulating tumor DNA(ct-DNA)has emerged as a promising non-invasive biomarker for genomic profiling.Bile has been proven to be a reliable ctDNA source,demonstrating higher concordance with tumor tissue than plasma.More importantly,ctDNA provides valuable insights into both clonal evolution and treatment response,including the detection of resistance mechanisms and mutation clearance,which are often associated with disease control.Although its role in recurrence monitoring remains investigational,early studies suggest that ctDNA detection may precede radiological recurrences.This review examines recent advancements in ctDNA analysis for patients with BTC,highlighting key developments,current clinical implications,and ongoing challenges.Large-scale prospective studies are needed to validate the clinical utility of ctDNA and to support its integration into BTC management.
文摘Circulating plasma cells(CPCs)in patients of plasma cell neoplasm have been an area of intense research in recent decades.Circulating tumor plasma cells(CTPCs)might represent a sub-clone of tumor cells that have exited into peripheral blood as a result of the dynamic interactions between the bone marrow(BM)microenvironment and neoplastic plasma cells.Chemokine receptors like chemokine receptor 4(CXCR4)and integrins are known to play a role in homing and migration of plasma cells(PCs).The hypoxic microenvironment in the BM niche also contributes to their circulation through various mechanisms.In addition,the CCL3–CCR1 axis probably competes with the retention signals from the CXCR4–α4β1(VLA-4)interaction and actively promotes the exit of PCs from the BM.CTPCs,even in extremely low numbers,can be detected and quantified by high-sensitivity techniques like multi-color flow cytometry and next-generation sequencing.High load of CTPCs noted in patients of plasma cell neoplasm;monoclonal gammopathy of undetermined significance(MGUS),smoldering multiple myeloma(SMM),multiple myeloma(MM)is a strong predictor of shorter progression free survival(PFS)as well as overall survival(OS).In newly diagnosed patients of MM,a load of CTPCs correlates with the outcomes,i.e.,OS and PFS.With more studies collaborating on the results of previous reports,assessment of the burden of CTPCs may become a complimentary approach for non-invasive risk stratification of MM patients and evaluating the response to therapy.Future research on larger cohorts and longer follow-ups may help to improve the existing staging system by incorporating the load of CTPCs as one of the prognostic indicators.Further studies based on isolation and genetic characterization of CTPCs may help in understanding the pathophysiology of the progression of the disease and may open avenues for newer treatment modalities.This review discusses the pathobiological aspects leading to circulation of neoplastic/tumor plasma cells in peripheral blood and provides a summary of research work done in last two decades on its prognostic importance in various plasma cells neoplasms.
基金supported by the National Natural Science Foundation of China(42250101,42250102)the Macao Foundation.
文摘The movement of global ocean circulation in the Earth’s main magnetic field generates a measurable induced magnetic field(about 2 nT at geomagnetic satellite altitudes).However,this ocean circulation-induced magnetic field has not been previously estimated or incorporated into geomagnetic field models,potentially causing leakage into the core field model.Here,we present a method to account for the circulation-induced magnetic field during geomagnetic field modeling.First,a forward model of the circulation-induced magnetic field is constructed by numerically solving electromagnetic induction equations based on a realistic ocean circulation model.Then,this forward model is subtracted from the observed data.Finally,the core and lithospheric fields,magnetospheric and Earth’s mantle-induced fields,and the ocean tide-induced magnetic field are co-estimated.Applying our method to over 20 years of MSS-1,Swarm,CryoSat-2,and CHAMP satellite magnetic data,we derive a new multisource geomagnetic field model(MGFM).We find that incorporating a forward model of the circulation-induced magnetic field marginally improves the fit to the data.Furthermore,we demonstrate that neglecting the circulation-induced magnetic field in geomagnetic field modeling results in leakage into the core field model.The highlights of the MGFM model include:(i)a good agreement with the widely used CHAOS model series;(ii)the incorporation of magnetic fields induced by both ocean tides and circulation;and(iii)the suppression of leakage of the circulation-induced magnetic field into the core field model.
基金Supported by the Medical Talents of Wuhan Health and Family Planning Commission,No.2017[51](to Yu J)the Medical Talents of Wuhan Hospital of Traditional Chinese and Western Medicine(to Yu J)+1 种基金the Hubei Natural Science Foundation,No.2023AFB1091Wuhan Medical Research Project,No.WX23A36(to Yu J).
文摘BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma methylation and circulating tumor cells were detected.METHODS Plasma samples were collected from Hubei Cancer Hospital(n=156).Plasma DNA was tested to detect SHOX2,HOXA9,SEPTIN9,and RASSF1A methylation using TaqMan PCR.Circulating tumor cells(CTCs)were detected in the peripheral blood of patients using the United States Food and Drug Administration-approved cell search system before and after clinical therapy.The CCA diagnostic value was estimated using the area under the curve.The independent prognosis risk factors for patients with CCA were estimated using Cox and logistic regression analyses.RESULTS The sensitivity and specificity of the four DNA plasma methylations exhibited 64.74%sensitivity and 93.88%specificity for detecting CCA.The receiver operating characteristic curve of the combined value for CCA diagnosis in plasma was 0.828±0.032.RASSF1A plasma methylation was related to the prognosis of patients with CCA.We determined the prognostic hazard ratio for CCA using CTC count,tumor stage,methylation,and carbohydrate antigen 19-9 levels as key factors.Our overall survival nomogram achieved a C-index of 0.705(0.605-0.805).CONCLUSION SHOX2,HOXA9,SEPTIN9,and RASSF1A plasma methylation demonstrated increased sensitivity for diagnosing CCA.RASSF1A plasma methylation and CTCs were valuable predictors to assess CCA prognosis and recurrence.
文摘Given the growing burden of colorectal cancer(CRC)as a global health challenge,it becomes imperative to focus on strategies that can mitigate its impact.Posttreatment surveillance has emerged as essential for early detection of recurrence,significantly improving patient outcomes.However,intensive surveillance strategies have shown mixed results compared to less intensive methods,emphasizing the necessity for personalized,risk-adapted approaches.The observed suboptimal adherence to existing surveillance protocols underscores the urgent need for more tailored and efficient strategies.In this context,circulating tumor DNA(ctDNA)emerges as a promising biomarker with significant potential to revolutionize post-treatment surveillance,demonstrating high specificity[0.95,95%confidence interval(CI):0.91-0.97]and robust diagnostic odds(37.6,95%CI:20.8-68.0)for recurrence detection.Furthermore,artificial intelligence and machine learning models integrating patient-specific and tumor features can enhance risk stratification and optimize surveillance strategies.The reported area under the receiver operating characteristic curve,measuring artificial intelligence model performance in predicting CRC recurrence,ranged from 0.581 and 0.593 at the lowest to 0.979 and 0.978 at the highest in training and validation cohorts,respectively.Despite this promise,addressing cost,accessibility,and extensive validation remains crucial for equitable integration into clinical practice.
文摘Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups.Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate,while Group B received only Betahistine Mesylate.The efficacy,syndrome scores,hemodynamics,and quality of life indicators were compared between the two groups.Results:The efficacy of PCI treatment in Group A was higher than that in Group B(P<0.05).The syndrome scores in Group A were lower than those in Group B(P<0.05).The peak systolic velocity(PSV)of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B(P<0.05).The quality of life(SF-36)score in Group A was higher than that in Group B(P<0.05).Conclusion:Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI,with improved hemodynamic indicators and reduced disease scores.
基金supported by the National Natural Science Foundation of China(No.52074312)the CNPC Science and Technology Innovation Foundation(No.2021DQ02-0505)+1 种基金the Open Fund Project of the National Key Laboratory for the Enrichment Mechanism and Efficient Development of Shale Oil and Gas(No.36650000-24-ZC0609-0006)the Major Science and Technology Project of Karamay City(No.20232023zdzx0003).
文摘Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration and development.Predicting LC risks enables the targeted implementation of mitigation strategies,thereby reducing the frequency of such incidents.To address the limitations of existing 3D geomechanical modeling in predicting LC,such as arbitrary factor selection,subjective weight assignment,and the inability to achieve pre-drilling prediction along the entire well section,an improved prediction method is proposed.This method integrates multi-source data and incorporates three LC-related sensitivity factors:fracture characteristics,rock brittleness,and in-situ stress conditions.A quantitative risk assessment model for LC is developed by combining the subjective analytic hierarchy process with the objective entropy weight method(EWM)to assign weights.Subsequently,3D geomechanical modeling is applied to identify regional risk zones,enabling digital visualization for pre-drilling risk prediction.The developed 3D LC risk prediction model was validated using actual LC incidents from drilled wells.Results were generally consistent with field-identified LC zones,with an average relative error of 19.08%,confirming its reliability.This method provides practical guidance for mitigating potential LC risks and optimizing drilling program designs in fractured formations.
基金Supported by Daqing City Philosophy and Social Sciences Planning Research Project(DSGB 2025011)the Heilongjiang Province Education Science Planning Key Project(GJB1320229).
文摘Based on questionnaire surveys and field interviews conducted with various types of agricultural production organizations across five districts and four counties in Daqing City,this study combines relevant theoretical frameworks to systematically examine the evolution,performance,and influencing factors of governance mechanisms within these organizations.Using both quantitative and inductive analytical methods,the paper proposes innovative designs and supporting measures for improving governance mechanisms.The findings reveal that,amid large-scale farmland circulation,the governance mechanisms of agricultural production organizations in Daqing City are evolving from traditional to modern structures.However,challenges remain in areas such as decision-making efficiency,benefit distribution,and supervision mechanisms.In response,this study proposes innovative governance designs focusing on decision-making processes,profit-sharing mechanisms,and risk prevention.Corresponding policy recommendations are also provided to support the sustainable development of agricultural modernization in China.
文摘Dear Editor,Dengue virus(DENV)is a positive-sense single-stranded RNA virus belonging to the Flaviviridae family,which causes dengue—a disease affecting over 400 million people annually worldwide.DENV is transmitted through the bite of mosquitoes from the Aedes genus,primarily Aedes aegypti,and has a wide distribution in tropical and subtropical areas(de Souza et al.,2022).
基金German Heart Foundation/German Foundation of Heart Research。
文摘Background:Aortic atherosclerosis increases the risk of embolic events under extracorporeal circulation(ECC).To evaluate the hemodynamic impact of ECC on atheromatous plaques,an atherosclerosis animal model,which is also eligible for ECC,is required.Methods:Twenty-nine New Zealand White rabbits received a pro-atherosclerotic diet(group diet,n=10),a pro-atherosclerotic diet and additional intraaortic balloon insufflation injury(group BI,n=9),or served as controls(n=10).After 3 or 6 months,aortic explants were analyzed by(immuno-)histology and RT-PCR.Results:Blood serum analyses revealed increased cholesterol-levels in groups diet and BI compared to controls(3 months:p=0.03 each,6 months:p<0.0001 each).Aortic inflammatory infiltration was significantly enhanced in groups diet(CD3 at 3 months:p<0.0001,6 months:p=0.02;CD68 at 3 months:p=0.01)and BI(CD3 at 3 months:p<0.0001,6 months:p=0.03;CD68 at 3 months:p=0.04,6 months:p=0.02).Increased intima hyperplasia occurred in both groups(p<0.0001 each).Macroscopic analyses after 3 and 6 months showed ubiquitous lumen-narrowing aortic plaques.Calcification of the intima and media was increased in groups diet(intima:p<0.0001 at 3 and 6 months;media at 3 months:p<0.0001,6 months:p=0.01)and BI(intima:p<0.0001 at 3 and 6 months;media at 3 months:p<0.0001,6 months:p=0.02).Extensive lipid accumulation was found in the intima in both treatment groups(p<0.0001 each).Conclusions:A rabbit model with high aortic calcific plaque burden—diet-induced with no implicit need of an additional intimal injury by an intraaortic balloon insufflation due to comparable outcome—exhibiting multiple pathophysiological aspects of human atherosclerosis has been designed and thoroughly characterized.It is suitable for use in future studies on the interaction between atherosclerotic plaques and the arterial blood flow under ECC.
基金supported by the National Key Research and Development Program of China(2022YFC2904400)Guangxi Science and Technology Major Project(Gui Ke AA23023033)。
文摘As a pyrometallurgical process,circulating fluidized bed(CFB) roasting has good potential for application in desulfurization of high-sulfur bauxite.The gas-solid distribution and reaction during CFB roasting of high-sulfur bauxite were simulated using the computational particle fluid dynamics(CPFD) method.The effect of primary air flow velocity on particle velocity,particle volume distribution,furnace temperature distribution and pressure distribution were investigated.Under the condition of the same total flow of natural gas,the impact of the number of inlets on the desulfurization efficiency,atmosphere mass fraction distribution and temperature distribution in the furnace was further investigated.
基金the financial support provided by the National Natural Science Foundation of China(52204335,52374319,52174291)the National Youth Talent Support Program(GJRC2023008)+2 种基金the Beijing New-Star Plan of Science and Technology(Z211100002121115)the Central Universities Foundation of China(06500170)Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(FRF-IDRY-22-004).
文摘Sintering is the process that emits the most pollutants in ironmaking,including CO,SO_(2),NO_(x),and dioxins.Flue gas circulation sintering technology can not only reduce the emissions of various pollutants but also decrease the consumption of solid fuels.Therefore,it is necessary to summarize and discuss the research status of flue gas circulation technology.Firstly,the research status,advantages,and disadvantages of five typical flue gas circulation processes and their effects on the emission of different pollutants were analyzed.Then,the impact of O_(2),CO,SO_(2),and temperature in the circulating gas during the sintering flue gas circulation process on the quality of sinter and their reasonable ranges was summarized,and the formation mechanisms of CO_(x),NO_(x),SO_(2),and dioxins during the sintering process were discussed.Furthermore,the optimization and improvement of flue gas circulation technology in recent years were introduced.Finally,issues related to element enrichment,equipment improvements,and fine particulate matter emissions in the flue gas circulation process were reviewed,providing a reference for the optimal application of flue gas circulation sintering technology in the future.
基金supported by the National Natural Science Foundation of China(Grant Nos.12374117 and 11904260)the Natural Science Foundation of Tianjin(Grant No.20JCQNJC02020)。
文摘Spin waves,quantized as magnons,constitute a fundamental class of excitations and serve as one of the primary angular momentum carriers in magnetic systems.Devoid of Joule heating,a magnonic device that routes spin waves between different ports holds promise for an energy-efficient information infrastructure.Here,we systematically investigate the transport behavior of a magnetic skyrmion-based magnon circulator,a representative device that directs spin wave flow in a non-reciprocal manner.Particularly,a ballistic transport model is established,where the scattering of spin waves by magnetic skyrmions is simplified as magnon deflection by fictitious electromagnetic fields within the skyrmions.Through the combination of ballistic analyses and micromagnetic simulations,the circulation performance is rigorously evaluated for multiple magnon circulators.
