Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB...Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10 μmol·L -1 the lead compound CAPE possessed anticancer activities against human HL 60, Bel 7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel 7402 and Hela cell lines.展开更多
Side reaction pathways are observed to occur between antioxidants and peroxide during the processing of multiple resin grades mediated by controlled peroxide-induced degradation of impact polypropylene.In the present ...Side reaction pathways are observed to occur between antioxidants and peroxide during the processing of multiple resin grades mediated by controlled peroxide-induced degradation of impact polypropylene.In the present work,the reaction mechanism and main by-products between antioxidants and peroxides were investigated.The results demonstrate that peroxides greatly accelerate the decomposition reactions,and the free radicals formed from peroxide decomposition react with,for example,the antioxidant AO1010 to produce dehydrogenation of phenyl propionic unit(s)at the a position(cinnamic acid ester moiety),which generates a conjugated system leading to the increased color of the product.It is the first time to confirm the cinnamic acid moiety's existence and report its NMR data.Further,this work confirms the dehydrogenation mechanism by comparison with different sterically hindered phenolic antioxidants.It also systematically summarizes the oxidation and degradation mechanism of AO168 and AO1010 under air and peroxide environments,respectively.Based on present study,clear guidelines are obtained to improve the quality of polymeric products,especially the appearance and stability,during product development.展开更多
The intermolecular reductive coupling of 1,1-diaryl-2,2-dicya-noethylenes with cinnamic esters promoted by samarium(II) iodide was studied. Functionalized cyclopentenylamine derivatives were prepared in good yields ...The intermolecular reductive coupling of 1,1-diaryl-2,2-dicya-noethylenes with cinnamic esters promoted by samarium(II) iodide was studied. Functionalized cyclopentenylamine derivatives were prepared in good yields under neutral and mild conditions.展开更多
文摘Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10 μmol·L -1 the lead compound CAPE possessed anticancer activities against human HL 60, Bel 7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel 7402 and Hela cell lines.
文摘Side reaction pathways are observed to occur between antioxidants and peroxide during the processing of multiple resin grades mediated by controlled peroxide-induced degradation of impact polypropylene.In the present work,the reaction mechanism and main by-products between antioxidants and peroxides were investigated.The results demonstrate that peroxides greatly accelerate the decomposition reactions,and the free radicals formed from peroxide decomposition react with,for example,the antioxidant AO1010 to produce dehydrogenation of phenyl propionic unit(s)at the a position(cinnamic acid ester moiety),which generates a conjugated system leading to the increased color of the product.It is the first time to confirm the cinnamic acid moiety's existence and report its NMR data.Further,this work confirms the dehydrogenation mechanism by comparison with different sterically hindered phenolic antioxidants.It also systematically summarizes the oxidation and degradation mechanism of AO168 and AO1010 under air and peroxide environments,respectively.Based on present study,clear guidelines are obtained to improve the quality of polymeric products,especially the appearance and stability,during product development.
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 0 72 0 33)andtheNaturalScienceFoundationofZhejiangProvince,China .
文摘The intermolecular reductive coupling of 1,1-diaryl-2,2-dicya-noethylenes with cinnamic esters promoted by samarium(II) iodide was studied. Functionalized cyclopentenylamine derivatives were prepared in good yields under neutral and mild conditions.
