The study objectives were to analyze the epidemiological characteristics of pertussis in Henan Province,China,and to evaluate the impact of pertussis vaccination strategy adjustments on population infection rates.A re...The study objectives were to analyze the epidemiological characteristics of pertussis in Henan Province,China,and to evaluate the impact of pertussis vaccination strategy adjustments on population infection rates.A retrospective analysis was conducted on the reported pertussis cases in Henan Province from 2012 to 2024.The concentration of IgG antibodies against pertussis toxin(anti-PT IgG)was measured in 18,528 healthy individuals from 2022 to 2024.The positive rate(≥20 IU/mL)and median concentration(MC)were calculated,and the infection rate was estimated based on anti-PT IgG≥40 IU/mL,using the susceptible-exposed-infec tious-recovered-vaccinated(SEIRV)model to predict the effect of adding a pertussis booster dose at 6 years.The average annual incidence of pertussis in Henan Province from 2012 to 2024 was 2.21 per 100,000 population.The overall anti-PT IgG positivity rate was 16.42%,and the MC was 4.66 IU/mL.The antibody concentration is influenced by age,gender,and vaccine type.The population that completed the full course of vaccination had the highest anti-PT IgG positive rate(17.81%)and the highest MC(4.97 IU/mL).The population that vaccinated the diphtheria-tetanus-acellular pertussis-inactivated polio vaccine-haemophilus influenzae type b(DTaP-IPV/Hib)had the highest MC(14.83 IU/mL).The total estimated infection rate of pertussis was 7,833.45 per 100,000,peaking in the 6-year age group(10,809.72 per 100,000).When the estimated coverage rate of the pertussis booster vaccination reaches 83.21%,the infection rate could be decreased by 71.41%.The incidence of pertussis in Henan Province has increased,and the infection rate is higher than anticipated.Booster immunization at age six can significantly lower the risk of infection.展开更多
基金approved by the Medical Ethics Committee of the Henan Provincial Center for Disease Control and Prevention(2022-KY-009-02)written informed consent was obtained from all participants.
文摘The study objectives were to analyze the epidemiological characteristics of pertussis in Henan Province,China,and to evaluate the impact of pertussis vaccination strategy adjustments on population infection rates.A retrospective analysis was conducted on the reported pertussis cases in Henan Province from 2012 to 2024.The concentration of IgG antibodies against pertussis toxin(anti-PT IgG)was measured in 18,528 healthy individuals from 2022 to 2024.The positive rate(≥20 IU/mL)and median concentration(MC)were calculated,and the infection rate was estimated based on anti-PT IgG≥40 IU/mL,using the susceptible-exposed-infec tious-recovered-vaccinated(SEIRV)model to predict the effect of adding a pertussis booster dose at 6 years.The average annual incidence of pertussis in Henan Province from 2012 to 2024 was 2.21 per 100,000 population.The overall anti-PT IgG positivity rate was 16.42%,and the MC was 4.66 IU/mL.The antibody concentration is influenced by age,gender,and vaccine type.The population that completed the full course of vaccination had the highest anti-PT IgG positive rate(17.81%)and the highest MC(4.97 IU/mL).The population that vaccinated the diphtheria-tetanus-acellular pertussis-inactivated polio vaccine-haemophilus influenzae type b(DTaP-IPV/Hib)had the highest MC(14.83 IU/mL).The total estimated infection rate of pertussis was 7,833.45 per 100,000,peaking in the 6-year age group(10,809.72 per 100,000).When the estimated coverage rate of the pertussis booster vaccination reaches 83.21%,the infection rate could be decreased by 71.41%.The incidence of pertussis in Henan Province has increased,and the infection rate is higher than anticipated.Booster immunization at age six can significantly lower the risk of infection.
