To analyse the risk factors of relapse before bone marrow transplantation (BMT) and to present the prognostic information as good as possible.Methods A total of 3142 patients, who underwent the allogeneic blood or b...To analyse the risk factors of relapse before bone marrow transplantation (BMT) and to present the prognostic information as good as possible.Methods A total of 3142 patients, who underwent the allogeneic blood or bone marrow tran sp lantation between 1989 and 1997 and were documented in the European Group for Bl ood and Marrow transplantation (EBMT), were included. Six possible risk factors including type of donor, stage of disease, age, gender, donor? recipient sex co mbination and the waiting time from diagnosis to transplation of relapse were co nsidered. The time to relapse was analysed by Kaplan Meier curves and Cox regre ssion with stratification on prognostic factors that did not satisfy the Proport ional Hazard Assumption.Results An amount of 447 patients relapsed out of all 3142 patients. The relapse rate wa s 14.2%. Type of donor and stage of disease showed a clear prognostic effect, bu t failed the proportional hazard assumption. Therefore, the data were stratified on the combination of type of donor and stage of disease. Within these strata a n additional significant effect of age could be observed. Relative risk of age ≥40 vs age <40 was 1.32 (95% confidence interval 1.09-1.59). The prognostic model is summarized graphically.Conclusions The combination of type of donor, stage of disease and age of recipient at tr ansplantation are important prognostic factors for relapse after BMT.展开更多
Objectives:This review aims to evaluate the utility of nonmedicated middle meatal packing compared to no packing on synechia formation up to 12 weeks after endoscopic sinus surgery(ESS)for chronic rhinosinusitis(CRS)....Objectives:This review aims to evaluate the utility of nonmedicated middle meatal packing compared to no packing on synechia formation up to 12 weeks after endoscopic sinus surgery(ESS)for chronic rhinosinusitis(CRS).Methods:We conducted a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A literature search was performed on Medline(PubMed),EBSCO CINAHL plus,CENTRAL,and Clinicaltrials.org and included randomized controlled trials in the English language only.We extracted all relevant data and conducted quality assessment using the Cochrane risk of Bias tool(version 2).We also performed the quality assessment of the outcomes using Grading of Recommendations Assessment,Development and Evaluation.Results:Our search identified 390 articles of which four met our eligibility criteria.A total of 139 patients were randomized to receive middle meatal pack in either of the nostrils.At 4 weeks of follow-up,there was no difference in the risk of synechia formation on either the packed side or the unpacked side,with a relative risk(RR)of 0.77(95%confidence interval[CI]:0.48-1.25).Similarly,no difference was seen at either 8-12 weeks of follow-up,with an RR of 0.68(95%CI:0.42-1.20).Nasal congestion was reported to be less on the packed side on the follow-up in one of the trials.Conclusions:Our systematic review,with limited evidence,indicates no difference in synechia formation between the nonmedicated packed and unpacked middle meatus at four and eight or 12 weeks after ESS for CRS.Further studies are required to ascertain the true effect of packing the middle meatus with different materials and its long-term sequelae.展开更多
文摘To analyse the risk factors of relapse before bone marrow transplantation (BMT) and to present the prognostic information as good as possible.Methods A total of 3142 patients, who underwent the allogeneic blood or bone marrow tran sp lantation between 1989 and 1997 and were documented in the European Group for Bl ood and Marrow transplantation (EBMT), were included. Six possible risk factors including type of donor, stage of disease, age, gender, donor? recipient sex co mbination and the waiting time from diagnosis to transplation of relapse were co nsidered. The time to relapse was analysed by Kaplan Meier curves and Cox regre ssion with stratification on prognostic factors that did not satisfy the Proport ional Hazard Assumption.Results An amount of 447 patients relapsed out of all 3142 patients. The relapse rate wa s 14.2%. Type of donor and stage of disease showed a clear prognostic effect, bu t failed the proportional hazard assumption. Therefore, the data were stratified on the combination of type of donor and stage of disease. Within these strata a n additional significant effect of age could be observed. Relative risk of age ≥40 vs age <40 was 1.32 (95% confidence interval 1.09-1.59). The prognostic model is summarized graphically.Conclusions The combination of type of donor, stage of disease and age of recipient at tr ansplantation are important prognostic factors for relapse after BMT.
文摘Objectives:This review aims to evaluate the utility of nonmedicated middle meatal packing compared to no packing on synechia formation up to 12 weeks after endoscopic sinus surgery(ESS)for chronic rhinosinusitis(CRS).Methods:We conducted a systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.A literature search was performed on Medline(PubMed),EBSCO CINAHL plus,CENTRAL,and Clinicaltrials.org and included randomized controlled trials in the English language only.We extracted all relevant data and conducted quality assessment using the Cochrane risk of Bias tool(version 2).We also performed the quality assessment of the outcomes using Grading of Recommendations Assessment,Development and Evaluation.Results:Our search identified 390 articles of which four met our eligibility criteria.A total of 139 patients were randomized to receive middle meatal pack in either of the nostrils.At 4 weeks of follow-up,there was no difference in the risk of synechia formation on either the packed side or the unpacked side,with a relative risk(RR)of 0.77(95%confidence interval[CI]:0.48-1.25).Similarly,no difference was seen at either 8-12 weeks of follow-up,with an RR of 0.68(95%CI:0.42-1.20).Nasal congestion was reported to be less on the packed side on the follow-up in one of the trials.Conclusions:Our systematic review,with limited evidence,indicates no difference in synechia formation between the nonmedicated packed and unpacked middle meatus at four and eight or 12 weeks after ESS for CRS.Further studies are required to ascertain the true effect of packing the middle meatus with different materials and its long-term sequelae.
