Metal nanomaterials have garnered significant attention due to their distinctive physical and chemical properties,which present promising applications in sensing,catalysis,and energy.However,chromium-based nanomateria...Metal nanomaterials have garnered significant attention due to their distinctive physical and chemical properties,which present promising applications in sensing,catalysis,and energy.However,chromium-based nanomaterials have been relatively overlooked in terms of their synthesis,properties,and applications.This research presents a rapid and efficient method for synthesizing chromium-based nanoparticles(Cr NPs)with tunable fluorescence capability to detect tumor-derived exosomes(TDEs)and implement information security at the molecular level.The synthesis process involved a straightforward procedure of mixing pre-cooled Cr6+and NaBH4 solutions for 30 min.The resultant spherical Cr NPs displayed unique fluorescence modulation(including quenching or enhancing)for various dyes and DNA with different compositions.Leveraging these fluorescence characteristics,a CD63 aptamer-Cr NPs sensing system was constructed for detecting CD63-positive TDEs even in real samples while encoding and protecting information.In this system,fluorescence-labeled CD63 aptamers functioned as recognition probes and information carriers,forming a stego object by adsorbing onto the Cr NPs.The specific binding of the CD63 aptamer-Cr NPs to CD63 or TDEs elicited distinct fluorescence responses,thereby enabling precise quantitative detection alongside data encryption and protection.This study provides a new extension for the preparation and application of novel metal nanomaterials,offers a new platform for the rapid detection of tumor biomarkers,and opens up a direction for the integration of sensing and information science based on molecular systems.展开更多
Magnetization,specific heat,and muon spin relaxation(μSR)experiments have been carried out on the Cr-based nitride superconductor La_(3)Cr_(10-x)N_(11),which exhibits a number of unconventional superconducting proper...Magnetization,specific heat,and muon spin relaxation(μSR)experiments have been carried out on the Cr-based nitride superconductor La_(3)Cr_(10-x)N_(11),which exhibits a number of unconventional superconducting properties.The susceptibilityχ(T)shows nearly perfect superconducting diamagnetism(4πχ(T=0)≈-1)and a remarkably high upper critical fieldμ_(0)Hc_(2)=11.2 T.The specific heat displays activated exponential behavior exp(-Δ0/kBT),together with a large and field-dependent residual Sommerfeld coefficient.Transverse-field muon spin relaxation(μSR)measurements suggest s+s-wave or p-wave pairing symmetry,ruling out single s-wave pairing.Zero-fieldμSR yields no statistically significant evidence for time reversal symmetry breaking(TRSB),and places an upper bound of 1.5(1.3)ms-1 on any TRSB-induced muon relaxation rate at T=0.Our results suggest that the unconventional superconductivity in Ln_(3)Cr_(10-x)N_(11),Ln=La and Pr,is mainly due to Cr 3d electrons and is similar in both compounds,whereas Pr 4f electrons are primarily responsible for the TRSB superconductivity observed in Pr_(3)Cr_(10-x)N_(11).展开更多
基金supported by National Key Research and Development Program of China(No.2024YFD2401105)the National Natural Science Foundation of China(No.32201108)+3 种基金the Science and Technology Inno-vation Program of Hunan Province(No.2022RC1167)Hunan Provincial Natural Science Foundation of China(Nos.2024JJ5251 and 2024JJ5053)the Research Foundation of Education Bureau of Hunan Province(Nos.24A0048 and 24B0893)Hunan Province College Students Research Learning and Innovative Experiment Project(S202310542099).
文摘Metal nanomaterials have garnered significant attention due to their distinctive physical and chemical properties,which present promising applications in sensing,catalysis,and energy.However,chromium-based nanomaterials have been relatively overlooked in terms of their synthesis,properties,and applications.This research presents a rapid and efficient method for synthesizing chromium-based nanoparticles(Cr NPs)with tunable fluorescence capability to detect tumor-derived exosomes(TDEs)and implement information security at the molecular level.The synthesis process involved a straightforward procedure of mixing pre-cooled Cr6+and NaBH4 solutions for 30 min.The resultant spherical Cr NPs displayed unique fluorescence modulation(including quenching or enhancing)for various dyes and DNA with different compositions.Leveraging these fluorescence characteristics,a CD63 aptamer-Cr NPs sensing system was constructed for detecting CD63-positive TDEs even in real samples while encoding and protecting information.In this system,fluorescence-labeled CD63 aptamers functioned as recognition probes and information carriers,forming a stego object by adsorbing onto the Cr NPs.The specific binding of the CD63 aptamer-Cr NPs to CD63 or TDEs elicited distinct fluorescence responses,thereby enabling precise quantitative detection alongside data encryption and protection.This study provides a new extension for the preparation and application of novel metal nanomaterials,offers a new platform for the rapid detection of tumor biomarkers,and opens up a direction for the integration of sensing and information science based on molecular systems.
基金funded by the National Key Research and Development Program of China(Grant No.2022YFA1402203)the National Natural Science Foundations of China(Grant No.12174065)+1 种基金the Innovation Program for Quantum Science and Technology(Grant No.2024ZD0300104)the Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX01).
文摘Magnetization,specific heat,and muon spin relaxation(μSR)experiments have been carried out on the Cr-based nitride superconductor La_(3)Cr_(10-x)N_(11),which exhibits a number of unconventional superconducting properties.The susceptibilityχ(T)shows nearly perfect superconducting diamagnetism(4πχ(T=0)≈-1)and a remarkably high upper critical fieldμ_(0)Hc_(2)=11.2 T.The specific heat displays activated exponential behavior exp(-Δ0/kBT),together with a large and field-dependent residual Sommerfeld coefficient.Transverse-field muon spin relaxation(μSR)measurements suggest s+s-wave or p-wave pairing symmetry,ruling out single s-wave pairing.Zero-fieldμSR yields no statistically significant evidence for time reversal symmetry breaking(TRSB),and places an upper bound of 1.5(1.3)ms-1 on any TRSB-induced muon relaxation rate at T=0.Our results suggest that the unconventional superconductivity in Ln_(3)Cr_(10-x)N_(11),Ln=La and Pr,is mainly due to Cr 3d electrons and is similar in both compounds,whereas Pr 4f electrons are primarily responsible for the TRSB superconductivity observed in Pr_(3)Cr_(10-x)N_(11).
