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Pathological quality control chips for tuberculosis
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作者 Enru Ye Jing He +5 位作者 Lingna Zhang Chaofan He Qiuju Zhou Juan Xu Meifu Gan Yong He 《Bio-Design and Manufacturing》 2025年第6期962-975,I0024-I0027,共18页
Globally,approximately 10 million new tuberculosis(TB)cases are reported annually.Delayed diagnosis due to low detection rates is the primary cause of mortality.Although pathological examination is commonly used for d... Globally,approximately 10 million new tuberculosis(TB)cases are reported annually.Delayed diagnosis due to low detection rates is the primary cause of mortality.Although pathological examination is commonly used for diagnosing TB,5%-30%of cases remain undiagnosed,emphasizing the urgent need to establish quality control(QC)standards to reduce rates of misdiagnosis and missed diagnoses.To address this,we introduced a novel QC chip for detecting Mycobacterium tuberculosis(MTB).A quantitative pathological QC model was constructed by precisely and uniformly integrating MTB and HeLa cells into a photocurable hydrogel.This model was then sliced into uniform sections to create QC chips.It demonstrated that the QC chips exhibited no significant differences in intra-batch or inter-batch variation(coefficient of variation<5%),and remained stable at−80°C for one year.Furthermore,these chips were found to be 100%effective when tested with 240 clinical samples(200 with special staining and 40 with polymerase chain reaction).In addition to enhancing TB detection rates,this approach offers visualization,quantification,and sustainable production.Overall,this work provides a novel framework for developing QC chips for pathological testing,offering a reliable solution to enhance clinical diagnostic workflows. 展开更多
关键词 Mycobacterium tuberculosis(MTB) Pathological model Quality control(QC)chip
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Use of single chip microcomputer in hydraulic digital adaptive control system 被引量:1
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作者 吴振顺 袁建光 +1 位作者 汲永涛 熊汉文 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2001年第2期196-198,共3页
Presents a one grade adaptive controller with one reference model which is built according to δ MRACS adaptive control theory and used to control an actual high order hydraulic system, and the whole hardware system u... Presents a one grade adaptive controller with one reference model which is built according to δ MRACS adaptive control theory and used to control an actual high order hydraulic system, and the whole hardware system used, which includes a AT89C51 single chip microcomputer, 74Ls373 flip latch, 6116 store, eight bit ADC0809, and so on, and the satisfactory results obtained in study on hydraulic control system. 展开更多
关键词 Adaptive control single chip microcomputer
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SF VECTOR CONTROL SYSTEM WITH TWO SINGLE CHIP MICROPROCESSORS
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作者 XU Yinquan Cui Gejin (Automation and Computer Science Department) 《Journal of China Textile University(English Edition)》 EI CAS 1990年第2期73-78,共6页
This paper introduces a SF vector control system of a slip frequency controlled induction mo-tor with simple structure,fair performance and convenient operation.It is realized by two singlechip microprocessors and fed... This paper introduces a SF vector control system of a slip frequency controlled induction mo-tor with simple structure,fair performance and convenient operation.It is realized by two singlechip microprocessors and fed from SPWM-GTR inverter.The whole system is combined by twosubsystems,both of them are 8031 single chip microprocessors.The communication between themis coordinated by the full duplex serial port within the chip and ask-and-answer communicationmanner.The error-corrected means adopted has improved the operation reliability of the system.A series of experimental results on a 3 kW induction motor are given at the end of this paper. 展开更多
关键词 VECTOR control SINGLE chip MICROPROCESSOR SPWM WAVES
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An Implanted Closed-loop Chip System for Heart Rate Control:System Design and Effects in Conscious Rats 被引量:3
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作者 Yuxuan Zhou Yuan Yuan +4 位作者 Juan Gao Ling Yang Feng Zhang Guoqing Zhu Xingya Gao 《The Journal of Biomedical Research》 CAS 2010年第2期107-114,共8页
Objective: To evaluate the efficiency of an implanted chip system for the control of heart rate (HR). Methods: The HR was recorded in six conscious Sprague-Dawley (SD) rats. An implanted chip system was designed... Objective: To evaluate the efficiency of an implanted chip system for the control of heart rate (HR). Methods: The HR was recorded in six conscious Sprague-Dawley (SD) rats. An implanted chip system was designed to regulate the HR by stimulating the right cervical vagus nerve according to the feedback of real time HR. Each rat was subjected to 30-min regulation and 30-min recovery. The change of HR during the regulation period was compared with the control. The ECG was recorded during the experiment for 24 h. Results: The ECG signals were successfully recorded during the experiment. The HR was significantly decreased during the period of regulation compared with control (-79.3 ± 34.5, P 〈 0.01, n = 6) and then recovered to normal after regulation. Conclusion: The described implanted chip system can regulate the HR to a designated set point. 展开更多
关键词 closed-loop regulation implanted chip system set point heart rate vagus nerve stimulation Remote-controlled animal
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DESIGNOFMULTI┐SLOTANDUNEQUAL┐TEMPERATUREPIDCONTROLLERBASEDONSINGLECHIPMICROCOMPUTER
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作者 Ma Weihua He Hai Department of Computer Science and Engineering, NUAA29 Yudao Street, Nanjing 210016, P.R.China 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1996年第1期121-124,共4页
Taking a specific production process as an example, this paper introduces the design of multi slot and unequal temperature PID controller based on single chip microcomputer. The mathematical implementation method... Taking a specific production process as an example, this paper introduces the design of multi slot and unequal temperature PID controller based on single chip microcomputer. The mathematical implementation method of PID algorithm and the design method of the hardware and software are discussed, The principle diagram of the hardware circuit implementing the control algorithm and the features of the software possessed are also presented. 展开更多
关键词 real time control temperature measurement HARDWARE SOFTWARE single chip microcomputer
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PRESSURE FORCE CONTROL FOR FABRICATION OF PLASTIC MICROFLUIDIC CHIPS WITH HOT EMBOSSING METHOD
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作者 LIU Chong LIAO Junfeng +1 位作者 WANG Xiaodong WANG Liding 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2007年第1期107-110,共4页
A pressure force control system for hot embossing of microfluidic chips is designed with a moment motor and a ball bearing lead screw. Based on the numeric PID technique, the algorithm of pulsant integral accelerated ... A pressure force control system for hot embossing of microfluidic chips is designed with a moment motor and a ball bearing lead screw. Based on the numeric PID technique, the algorithm of pulsant integral accelerated PID control is presented and the negative effects of nonlinearity from friction, clearance and saturation are eliminated. In order to improve the quick-resixmse characteristic, independent thread technique is adopted. The method of pressure force control based on pulsant integral accelerated PID control and independent thread technique is applied with satisfactory control performance. 展开更多
关键词 Microfluidic chip Hot embossing Pressure force control Nonlinearity
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The Temperature Intelligence Control System Based on Single Chip-Microprocessor
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作者 (changchun Institute of Technology ,changchun 130012) Liu, Shurong Ding,Lujun 《微计算机信息》 2003年第7期31-32,共2页
The paper introduces a temperature control systembased on AT89C51 single-chip-microprocessor, and discussesthe principle , hardware structure, and software design of thissystem in detail.
关键词 单片机 温度智能控制系统 AT89C51 软件设计 硬件设计
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On-Chip Degeneracy Breaking of Wood’s Anomaly for Vibrational Strong Coupling
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作者 Xing Liu Shu Chen +3 位作者 Hao Wang Chengxiao Song Tinghui Xiao Chongxin Shan 《Chinese Physics Letters》 2025年第9期34-49,共16页
Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infr... Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infrared spectroscopy,modification of chemical reactions,and exploration of nonlinear quantum effects.Surface plasmon resonance,excited on simple plasmonic resonators in the infrared,has been demonstrated as a means to realize VSC,but suffers from either limited quality factor for realizing large Rabi splitting or poor reconfigurability for precise detuning control.Here we propose and experimentally demonstrate,for the first time,an on-chip plasmonic resonator based on degeneracy breaking of Wood’s anomaly for VSC.Leveraging the low damping rate of the surface state induced by this degeneracy breaking,we achieve a plasmonic resonance with a high-Q factor exceeding~110,resulting in a Rabi splitting up to~112 cm^(-1) with a subwavelength molecular layer.Additionally,the dispersion of the surface state allows for precise control over VSC detuning by simply adjusting the incident angle of excitation light,even in the absence of photons,enabling a broad detuning range up to 300 cm^(-1).These experimental results align well with our analytical model and numerical simulation.This work provides a promising integrated platform for VSC,with various potential applications in on-chip spectroscopy,polariton chemistry,and polariton devices. 展开更多
关键词 plasmonic resonators exploration nonlinear quantum effectssurface plasmon resonanceexcited vibrational strong coupling vsc provides vibrational strong coupling ultrasensitive infrared spectroscopymodification chemical reactionsand chip degeneracy breaking reshaping molecular propertieswhich enhanced control infrared light
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利用四环素调控系统研究CHIP对TGF-β信号通路的抑制性调节 被引量:2
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作者 徐夏莲 辛宏 +3 位作者 张新军 任芳丽 王银银 常智杰 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2005年第6期557-561,共5页
为了研究伴侣分子相互作用蛋白CHIP对TGF-β信号通路的调控,利用四环素基因表达调控系统,建立四环素调控表达CHIP的稳定细胞系(Mv1Lu-Tetoff-CHIP).利用此细胞模型,发现CHIP的过量表达可显著降低细胞内Smad2/3蛋白水平;荧光素酶报告分... 为了研究伴侣分子相互作用蛋白CHIP对TGF-β信号通路的调控,利用四环素基因表达调控系统,建立四环素调控表达CHIP的稳定细胞系(Mv1Lu-Tetoff-CHIP).利用此细胞模型,发现CHIP的过量表达可显著降低细胞内Smad2/3蛋白水平;荧光素酶报告分析也表明开启CHIP蛋白表达可明显降低Smads介导的基因转录活性;进一步的免疫印迹结果显示CHIP蛋白可明显下调TGF-β所诱导的下游基因JunB的表达.上述结果提示CHIP可以作为一种新的蛋白质分子抑制性调节TGF-β信号通路. 展开更多
关键词 四环素调控 chip TGF-Β SMAD2/3 JUNB 抑制
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INTELLIGENT PRECISION CONTROL IN CNC GRINDING
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作者 田新诚 王宁生 袁信 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2000年第1期95-99,共5页
The development of intelligent control techniques provides powerful means for the control of machine tools. In this paper, a intelligent control technique and an algorithm for precision control of CNC grinding of cera... The development of intelligent control techniques provides powerful means for the control of machine tools. In this paper, a intelligent control technique and an algorithm for precision control of CNC grinding of ceramic chips are introduced. In the process of ceramic chip CNC grinding, the dimension of the chips tends to get larger and the dimensional error to exceed the tolerance as the number of the chips increases which are machined on the same part program. There are many factors leading to the occurrence of the error and the law of error variation is very complicated. With the introduced intelligent self learning error compensation technique, the CNC system can improve the control strategy to compensate the error automatically. The simulational result is also given. 展开更多
关键词 intelligent control self learning precision control ceramic chip
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基于双L形探测区域的片上网络近似通信方法
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作者 袁江涛 黎思越 +3 位作者 高亨粤 范文杰 李丽 傅玉祥 《计算机工程与设计》 北大核心 2026年第1期82-87,共6页
为解决现有片上网络近似通信技术在高通信负载下无法有效缓解拥塞的问题,提出了一种基于双L形探测区域的近似通信方法(dual L-shaped region-based approximate communication,DLAC)。该方法通过实时监测双L形探测区域内路由节点的缓冲... 为解决现有片上网络近似通信技术在高通信负载下无法有效缓解拥塞的问题,提出了一种基于双L形探测区域的近似通信方法(dual L-shaped region-based approximate communication,DLAC)。该方法通过实时监测双L形探测区域内路由节点的缓冲区占用率,对潜在拥塞节点进行分级管理,并在数据包传输过程中根据节点的实时拥塞等级动态调整近似通信策略。实验结果显示,与传统方法相比,DLAC在高负载情况下显著提升了片上网络的通信效率,同时保证了数据传输的可靠性,为高负载片上网络的拥塞控制提供了新的解决方案。 展开更多
关键词 片上网络 近似通信 拥塞控制 路由算法 高负载通信 通信延迟 多核系统
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组织芯片取样枪在免疫组织化学对照制作中的应用
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作者 王冬冬 冯映业 +1 位作者 黄珠珠 吴坤河 《实用医技杂志》 2026年第1期61-64,I0006,共5页
目的探讨组织芯片取样枪在免疫组织化学对照制作中的应用价值。方法用组织芯片取样枪对空白蜡块进行打孔(采用1.5 mm孔径枪头),选取抗体阳性组织块取样(采用2.0 mm孔径枪头),打入预打孔的空白蜡块中,经加热平整、融合、修整及重新包埋... 目的探讨组织芯片取样枪在免疫组织化学对照制作中的应用价值。方法用组织芯片取样枪对空白蜡块进行打孔(采用1.5 mm孔径枪头),选取抗体阳性组织块取样(采用2.0 mm孔径枪头),打入预打孔的空白蜡块中,经加热平整、融合、修整及重新包埋等步骤完成对照芯片制作,制作10块多组织组合的免疫组化对照芯片。对对照芯片进行切片,采用全自动免疫组织化学染色机检测蛋白、Ki-67核抗原、雌激素受体(ER)、人表皮生长因子受体2(HER-2)、广谱细胞角蛋白CK-pan(CK-pan)5种常见抗体,观察染色效果和统计10块对照芯片的可切质控切片数量,计算均值与标准差。结果对照芯片免疫组织化学染色结果清晰,定位准确,背景干净,P63、Ki-67、ER为细胞核阳性,HER-2为细胞膜阳性,CK-pan为细胞质阳性。平均每块对照芯片可切质控切片206.90张(标准差14.58张),可常温或4℃保存,便于随时取用。结论基于组织芯片取样枪的免疫组织化学对照制作方法操作简便、组织利用率高、可实现多抗体集成对照,染色结果稳定可靠,适用于病理科日常质控,具备良好的临床推广价值。 展开更多
关键词 组织芯片取样枪 免疫组化 对照芯片 病理诊断 质量控制
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基于Fuzzy-control的工业温度控制器的设计 被引量:2
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作者 王瑞兰 《微计算机信息》 2009年第13期67-68,97,共3页
传统PID控制是建立在被控对象的精确数学模型基础上,而实际控制对象的数学模型是难以建立的。模糊控制是在模糊数学基础上的一种模糊语言规则的控制,它不需要建立被控对象的精确数学模型。本文阐述的是将模糊控制理论应用于温度控制系统... 传统PID控制是建立在被控对象的精确数学模型基础上,而实际控制对象的数学模型是难以建立的。模糊控制是在模糊数学基础上的一种模糊语言规则的控制,它不需要建立被控对象的精确数学模型。本文阐述的是将模糊控制理论应用于温度控制系统,设计一个以MSC1211为核心的模糊控制器。 展开更多
关键词 模糊控制 PID控制 单片机
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基于A1000芯片的高国产化率行泊一体域控制器设计
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作者 徐志刚 王鹏 张洋 《汽车电器》 2026年第2期76-78,共3页
随着智能汽车技术的快速发展,行泊一体域控制器作为自动驾驶技术的关键组成部分,正逐渐成为行业焦点。本文旨在探讨基于A1000芯片的高国产化率行泊一体域控制器设计方案,分析其在智能汽车领域的应用前景与技术优势,并展望其对未来汽车... 随着智能汽车技术的快速发展,行泊一体域控制器作为自动驾驶技术的关键组成部分,正逐渐成为行业焦点。本文旨在探讨基于A1000芯片的高国产化率行泊一体域控制器设计方案,分析其在智能汽车领域的应用前景与技术优势,并展望其对未来汽车产业的影响。 展开更多
关键词 行泊一体域控制器 芯片 传感器
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基于技术突破、应用场景与国产替代前景的新能源汽车MCU研究分析
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作者 陆建鹏 周书荣 《专用汽车》 2026年第2期9-12,共4页
系统分析了新能源汽车MCU的最新技术突破、应用场景特点、国产化现状及未来发展趋势。研究表明,在800 V高压平台、智能驾驶等技术推动下,车规级MCU正加速向16/18 nm先进制程、RISC-V开源架构及域控集成方向演进;国产MCU在电池管理、车... 系统分析了新能源汽车MCU的最新技术突破、应用场景特点、国产化现状及未来发展趋势。研究表明,在800 V高压平台、智能驾驶等技术推动下,车规级MCU正加速向16/18 nm先进制程、RISC-V开源架构及域控集成方向演进;国产MCU在电池管理、车身控制等领域已实现批量应用,但在动力域控等高端市场占有率仍低于10%。随着政策支持与技术成熟,2025年中国车规级MCU市场规模将突破500亿元,新能源汽车贡献约60%需求,国产替代率有望提升至22%以上。研究结论为把握汽车半导体产业发展趋势、推动供应链自主可控提供了重要参考。 展开更多
关键词 新能源汽车 微控制器 车规级芯片 电池管理系统 智能驾驶 国产替代
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Development of FPGA Based NURBS Interpolator and Motion Controller with Multiprocessor Technique 被引量:2
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作者 ZHAO Huan ZHU Limin +1 位作者 XIONG Zhenhua DING Han 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第5期940-947,共8页
The high-speed computational performance is gained at the cost of huge hardware resource,which restricts the application of high-accuracy algorithms because of the limited hardware cost in practical use.To solve the p... The high-speed computational performance is gained at the cost of huge hardware resource,which restricts the application of high-accuracy algorithms because of the limited hardware cost in practical use.To solve the problem,a novel method for designing the field programmable gate array(FPGA)-based non-uniform rational B-spline(NURBS) interpolator and motion controller,which adopts the embedded multiprocessor technique,is proposed in this study.The hardware and software design for the multiprocessor,one of which is for NURBS interpolation and the other for position servo control,is presented.Performance analysis and experiments on an X-Y table are carried out,hardware cost as well as consuming time for interpolation and motion control is compared with the existing methods.The experimental and comparing results indicate that,compared with the existing methods,the proposed method can reduce the hardware cost by 97.5% using higher-accuracy interpolation algorithm within the period of 0.5 ms.A method which ensures the real-time performance and interpolation accuracy,and reduces the hardware cost significantly is proposed,and it’s practical in the use of industrial application. 展开更多
关键词 NURBS interpolator FPGA-based interpolation MULTIPROCESSOR system on a programmable chip (SOPC) motion controller
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The Design of PSM-Based ECRH Power Supply Control System 被引量:4
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作者 Jian Zhang Xu Hao +1 位作者 Wei Wei Yiyun Huang 《Journal of Power and Energy Engineering》 2016年第4期91-102,共12页
Electron cyclotron resonance heating (ECRH) system is one of the most important Tokamak auxiliary heating methods. However, there are growing demands for ECRH system as the physical experiments progress which meanwhil... Electron cyclotron resonance heating (ECRH) system is one of the most important Tokamak auxiliary heating methods. However, there are growing demands for ECRH system as the physical experiments progress which meanwhile adds the difficulty of designing and building the control system of its power source. In this paper, the method of designing a control system based on Single Chip Microcomputer (SCM) and Field Programmable Gate Array (FPGA) is introduced according to its main requirements. The experimental results show that the control system in this paper achieves the conversion of different working modes, gets exact timing, and realizes the failure protection in 10us thus can be used in the ECRH system. 展开更多
关键词 ECRH PSM High Voltage Power Supply control System Field Programmable Gate Array (FPGA) Single chip Microcomputer (SCM)
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Plasma spraying system with distributed controlling
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作者 李春旭 陈克选 张成 《China Welding》 EI CAS 2003年第2期133-136,共4页
A distributed control system is designed for plasma spraying equipment and the configurations of system software and hardware is discussed. Through founding an expert database, the spraying process parameters are work... A distributed control system is designed for plasma spraying equipment and the configurations of system software and hardware is discussed. Through founding an expert database, the spraying process parameters are worked out and the initialization and control of spraying process are realized. The plasma spraying system with this control configuration can simplify the spraying operation, improve automation level of spray process, and approach the experience criterion as soon as possible. 展开更多
关键词 distributed control plasma spraying single chip communication criterion approach
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Fuzzy control of carbon dioxide short circuit transfer welding based on reducing dependence of operating skills
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作者 王雅生 蔡洪能 +1 位作者 张庆 曲海英 《China Welding》 EI CAS 2002年第1期46-50,共5页
In order to reduce dependence of operating skill ,fuzzy control system is developed, the core of which is a 16 bit Single Chip Microcomputer of Intel 80C196KC.It is realized by software programming. In this system two... In order to reduce dependence of operating skill ,fuzzy control system is developed, the core of which is a 16 bit Single Chip Microcomputer of Intel 80C196KC.It is realized by software programming. In this system two fuzzy controller are designed. The PID parameter self adjusting fuzzy controller is used to compensate welding current deviation in the process of arc voltage optimized control. To obtain the optimum result of ultimate frequency of short circuit transfer, the self optimizing fuzzy controller carries out the arc voltage self optimizing by under the condition of the given welding current. Arc voltage and welding current are kept the optimum matching relationship by two fuzzy controllers. 展开更多
关键词 fuzzy control carbon dioxide welding single chip microcomputer operating skill
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Low-Cost Embedded Controller for Complex Control Systems 被引量:1
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作者 Long-Hua Ma Xiao-Long Shi +2 位作者 Hui Li Zhe-Ming Lu Meng Shao 《Journal of Electronic Science and Technology》 CAS 2013年第1期89-95,共7页
Because of limited resource of embedded platforms, the computational complexity of advanced control algorithms raises significant challenges for the use of embedded systems in complex control field. A Scilab/Scicos ba... Because of limited resource of embedded platforms, the computational complexity of advanced control algorithms raises significant challenges for the use of embedded systems in complex control field. A Scilab/Scicos based embedded controller is developed on which various control software can be easily modeled, simulated, implemented, and evaluated to meet the ever-expanding requirements of industrial control applications. Built on the Cirrus Logic EP9315 ARM systems-on-chip board, this embedded controller is possible to develop complex embedded control systems that employ advanced control strategies in a rapid and cost-efficient fashion. Due to the free and open source nature of the software packages used, the cost of the embedded controller is minimized. 展开更多
关键词 Complex control embedded systems SCILAB system optimization system-on-chip.
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