HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibit...HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibitors （NNRTIs）. In this report, a noval class of non-nucleoside compound with potential RT inhibitory activity were found from the traditional Chinese medicines database （TCMD） using a combination of virtual screening, docking, molecular dynamic simulations, where results were ranked by scoring function of the docking tool. The result indicates that M4753 （a compound derived from TCMD） has not only the lowest bonding energy but also the best match in geometric conformation with the forthcoming NNRTIs. Accordingly M4753 might possibly become a promising lead compound of NNRTIs for AIDS therapy.展开更多
Mazu is the most famous goddess of canal transport in China,and one of the three folk beliefs in China.Japan is our neighbor across the sea.As early as 1000 years ago,Japan was influenced by the Mazu ceremonial cultur...Mazu is the most famous goddess of canal transport in China,and one of the three folk beliefs in China.Japan is our neighbor across the sea.As early as 1000 years ago,Japan was influenced by the Mazu ceremonial culture.Through big data analysis,this study conducted database counting,screening,and analysis on the Mazu culture in Diaolong,the full-text database of Chinese and Japanese ancient books.Besides,it explored the hot topics of concern and emotional attitudes,and then analyzed the important role of Mazu culture in the cultural exchange and mutual learning between China and Japan in the new era,with a view to completing the contemporary task of“people-to-people bond”and achieving common development.展开更多
After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in th...After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties.展开更多
The purpose of this paper is to test the applicability of the ＂financial ac- celerator＂ mechanism to China. Using the Chinese Industrial Enterprises Database, we find strong evidence suggesting that the employment a...The purpose of this paper is to test the applicability of the ＂financial ac- celerator＂ mechanism to China. Using the Chinese Industrial Enterprises Database, we find strong evidence suggesting that the employment and investment of leveraged firms are less responsive to aggregate fluctuations. This finding goes against the im- plications of the ＂financial accelerator＂. To make sure our empirical result is reliable, we have done several robustness checks using different estimation methods and sub- samples.展开更多
Well developed continuous speech recognition and synthesis systems demand a high quality continuous speech database which is compact and valid, and whose scientific design would benefit from incorporating linguistic a...Well developed continuous speech recognition and synthesis systems demand a high quality continuous speech database which is compact and valid, and whose scientific design would benefit from incorporating linguistic and phonetic knowledge. It is argued that at the present stage the database should be limited to read speech. To describe those very complex variabilities in continuous speech, the following speech units are proposed: (1) 401syllables without tone; (2) 415 inter-syllabic diphones, (3) 3035 inter-syllabic triphones, (4) 781 inter-syllabic final-initial structures. The 17 basic sefltence patterns in standard Chinese are summarized to cover the most important prosodic phenomena. By using the automatic method,2393 sentences and 388 phrases are selected by above phonetic rules from a large corpus, which includes People's Daily in recent years, TV play scripts and dictionary entries, as the reading text of continuous speech recognition database in standard Chinese. This set of sentences and pbrases covers 99.8% syllables without counting tones, 100% inter-syllable diphones, 99.6% inter-syllable triphones and 100% sentence patterns.展开更多
Database system is the infrastructure of the modern information system. The R＆D in the database system and its technologies is one of the important research topics in the field. The database R＆D in China took off la...Database system is the infrastructure of the modern information system. The R＆D in the database system and its technologies is one of the important research topics in the field. The database R＆D in China took off later but it moves along by giant steps. This report presents the achievements Renmin University of China （RUC） has made in the past 25 years and at the same time addresses some of the research projects we, RUC, are currently working on. The National Natural Science Foundation of China supports and initiates most of our research projects and these successfully conducted projects have produced fruitful results.展开更多
CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is ...CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.展开更多
CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is ...CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.展开更多
CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is ...CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.展开更多
Objective： To make a bibliometric analysis and evaluation of acupuncture-moxibustion papers on moxibustion therapy published from 1954 to 2007, thus to reflect the diseases spectrum of moxibustion therapy and proper ...Objective： To make a bibliometric analysis and evaluation of acupuncture-moxibustion papers on moxibustion therapy published from 1954 to 2007, thus to reflect the diseases spectrum of moxibustion therapy and proper indications of moxibustion therapy objectively. Methods： Statistics were taken by a bibliometric analysis of the data from China Modern Acupuncture-moxibustion Information Databank. Results and Conclusion： The diseases spectrum of moxibustion therapy has 364 kinds of diseases. The most proper indications of moxibustion therapy are malposition, diarrhea, and colitis. The common proper indications are urinary incontinence and dysmenorrhea. The next common proper indications are knee osteoarthritis, temporomandibular joint disturbance syndrome, soft tissue injury, heel pain, asthma, urinary retention and herpes zoster. Diseases spectrum of moxibustion therapy varies with time.展开更多
Objective:To summarize the clinical application patterns in acupuncture-moxibustion treatment of AD by reviewing the clinical literatures on acupuncture-moxibustion for Alzheimer disease(AD)published between January 2...Objective:To summarize the clinical application patterns in acupuncture-moxibustion treatment of AD by reviewing the clinical literatures on acupuncture-moxibustion for Alzheimer disease(AD)published between January 2009 and December 2019.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),Chinese Medicine Acupuncture-moxibustion Information Database,PubMed Medical Data Retrieval Service System,Springer Database and Ovid Technologies(OVID)were retrieved to screen clinical studies of acupuncture-moxibustion treatment of AD according to the inclusion and exclusion criteria to conduct quantitative,clustering and association analyses.Results:In acupuncture-moxibustion treatment of AD,the frequently used points were Baihui(GV 20),Zusanli(ST 36),Sishencong(EX-HN 1),Taixi(KI 3),Sanyinjiao(SP 6),and Neiguan(PC 6)in the descending order.Regarding meridians,the most frequently used one was the Governor Vessel,followed by the Stomach Meridian of Foot Yangming and Gallbladder Meridian of Foot Shaoyang.From the perspective of body regions,the points in the head-face region and the lower-limb region had the highest frequencies,followed by the upper-limb,back and chest-abdomen regions.The point group,Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Sanyinjiao(SP 6),showed the most significant association,and the group winning the second place was Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Zusanli(ST 36).The clustering analysis showed that the commonly used point pairs included Zusanli(ST 36)-Sishencong(EX-HN 1)and Taixi(KI 3)-Sanyinjiao(SP 6),which were closely associated with Baihui(GV 20).By analyzing the three commonly used acupuncture-moxibustion methods,acupuncture plus medication was found achieving the best result in the total effective rate and mini-mental state examination(MMSE)score,followed by monotherapy of electroacupuncture therapy,and these two methods were superior to acupuncture alone(P<0.05);the scores of MMSE,Alzheimer disease assessment scale-cognitive section(ADAS-cog)and activity of daily living scale(ADL)showed significant improvements after treatment(all P<0.01).Conclusion:In the acupuncture-moxibustion prescriptions for AD,the main points are Baihui(GV 20),Sishencong(EX-HN 1),Neiguan(PC 6),Zusanli(ST 36),Sanyinjiao(SP 6)and Taixi(KI 3).Monotherapy of acupuncture has the highest frequency amongst the treatment methods,but its effective rate is lower than that of acupuncture plus medication and monotherapy of electroacupuncture.展开更多
Objective: To explore the clinical regularities in acupuncture-moxibustion treatment of cancer pain by reviewing the re leva nt studies published betwee n 1985 and 2017. Methods: Based on the Chinese Medicine Acupunct...Objective: To explore the clinical regularities in acupuncture-moxibustion treatment of cancer pain by reviewing the re leva nt studies published betwee n 1985 and 2017. Methods: Based on the Chinese Medicine Acupuncture-moxibustion Information Database, quantitative analysis, correlation an alysis and Chi-square test were applied to an a lyze the comm only used acupoi nts, meridia n affiliatio ns and body regi on distributi ons, comm only used methods and acupoi nt correlati ons, treatme nt method correlati ons, the efficacy of acupuncture- moxibusti on plus the three-step an algesic ladder for can cer pain, and in dicators. Results: Zusanli (ST 36), Ashi point and Sanyinjiao (SP 6) ranked the top on the list of frequency;points from Bladder Meridian of Foot Taiyang and Stomach Meridian of Foot Yangming were often used;points from the lower limbs and back had high frequencies. The most commonly used treatment method was acupuncture-moxibustion plus medication. Acupuncture-moxibusti on plus the three-step an algesic ladder showed certai n adva ntage compared with the two methods used separately, and among the integrated methods, acupoint application plus the three-step analgesic ladder produced the most significant efficacy. It took (44.77±55.54) min for the analgesic effect to act and the effect lasted for (12.81±14.59) h. Numerical rati ng scale (NRS), visual an alog scale (VAS) and Kar nofsky performa nee status (KPS) scores all showed sign ifica nt changes after interventions (all P<0.01);there was no significant change in the score of quality of life (QOL) after interventions (P>0.05). Conclusion: Zusa nli (ST 36), Ashi point and Sanyin jiao (SP 6) are comm only selected in acup un cture-moxibusti on treatment of cancer pain;acupuncture and acupoint application are often used;acupuncture-moxibustion plus the three-step an algesic ladder can boost the treatme nt efficacy.展开更多
Handwriting expertise,as a form of forensic evidence,was once considered by most courts under the Anglo-American law system to be infallible,but this position was significantly challenged by the Daubert case(1993)and ...Handwriting expertise,as a form of forensic evidence,was once considered by most courts under the Anglo-American law system to be infallible,but this position was significantly challenged by the Daubert case(1993)and further by the President’s Council of Advisors on Science and Technology report published in 2016.In China,handwriting expertise has often been accepted as forensic evidence.However,this does not mean that there is no need to review the reliability of handwriting expertise.In this study,we analyze the current situation in China regarding the reliability of handwriting identification using cases from China’s judicial judgment database.We intend to identify the reasons for rejection of handwriting expertise,analyze the outcomes of applications for re-examination,and examine the court’s evaluation of different forensic opinions in relation to a given case.We also propose ways to strengthen the reliability of handwriting identification in China.展开更多
Background:The Ebola virus is highly pathogenic and destructive to humans and other primates.The Ebola virus encodes viral protein 40(VP40),which is highly expressed and regulates the assembly and release of viral par...Background:The Ebola virus is highly pathogenic and destructive to humans and other primates.The Ebola virus encodes viral protein 40(VP40),which is highly expressed and regulates the assembly and release of viral particles in the host cell.Because VP40 plays a prominent role in the life cycle of the Ebola virus,it is considered as a key target for antiviral treatment.However,there is currently no FDA-approved drug for treating Ebola virus infection,resulting in an urgent need to develop effective antiviral inhibitors that display good safety profiles in a short duration.Methods:This study aimed to screen the effective lead candidate against Ebola infection.First,the lead molecules were filtered based on the docking score.Second,Lipinski rule of five and the other drug likeliness properties are predicted to assess the safety profile of the lead candidates.Finally,molecular dynamics simulations was performed to validate the lead compound.Results:Our results revealed that emodin-8-beta-D-glucoside from the Traditional Chinese Medicine Database(TCMD)represents an active lead candidate that targets the Ebola virus by inhibiting the activity of VP40,and displays good pharmacokinetic properties.Conclusion:This report will considerably assist in the development of the competitive and robust antiviral agents against Ebola infection.展开更多
基金supported by the grants from Chinese National Science Foundation(No.30472166)the Tianjin Commission of Sciences and Technology under the Contract(No.06YFGZSH07000)
文摘HIV- 1 RT is an important target for the treatment of AIDS. There are two major classes of antiviral agents that inhibit HIV- 1 RT have been identified, nucleoside RT inhibitors （NRTIs） and non-nucleoside RT inhibitors （NNRTIs）. In this report, a noval class of non-nucleoside compound with potential RT inhibitory activity were found from the traditional Chinese medicines database （TCMD） using a combination of virtual screening, docking, molecular dynamic simulations, where results were ranked by scoring function of the docking tool. The result indicates that M4753 （a compound derived from TCMD） has not only the lowest bonding energy but also the best match in geometric conformation with the forthcoming NNRTIs. Accordingly M4753 might possibly become a promising lead compound of NNRTIs for AIDS therapy.
文摘Mazu is the most famous goddess of canal transport in China,and one of the three folk beliefs in China.Japan is our neighbor across the sea.As early as 1000 years ago,Japan was influenced by the Mazu ceremonial culture.Through big data analysis,this study conducted database counting,screening,and analysis on the Mazu culture in Diaolong,the full-text database of Chinese and Japanese ancient books.Besides,it explored the hot topics of concern and emotional attitudes,and then analyzed the important role of Mazu culture in the cultural exchange and mutual learning between China and Japan in the new era,with a view to completing the contemporary task of“people-to-people bond”and achieving common development.
基金supported by the Fundamental Research Funds for the Central Universities[Grant No:3332019163]the Beijing Municipal Science and Technology Commission Medicine Collaborative Science and Technology Innovation Research Project[Grant No:Z191100007719001].
文摘After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties.
文摘The purpose of this paper is to test the applicability of the ＂financial ac- celerator＂ mechanism to China. Using the Chinese Industrial Enterprises Database, we find strong evidence suggesting that the employment and investment of leveraged firms are less responsive to aggregate fluctuations. This finding goes against the im- plications of the ＂financial accelerator＂. To make sure our empirical result is reliable, we have done several robustness checks using different estimation methods and sub- samples.
文摘Well developed continuous speech recognition and synthesis systems demand a high quality continuous speech database which is compact and valid, and whose scientific design would benefit from incorporating linguistic and phonetic knowledge. It is argued that at the present stage the database should be limited to read speech. To describe those very complex variabilities in continuous speech, the following speech units are proposed: (1) 401syllables without tone; (2) 415 inter-syllabic diphones, (3) 3035 inter-syllabic triphones, (4) 781 inter-syllabic final-initial structures. The 17 basic sefltence patterns in standard Chinese are summarized to cover the most important prosodic phenomena. By using the automatic method,2393 sentences and 388 phrases are selected by above phonetic rules from a large corpus, which includes People's Daily in recent years, TV play scripts and dictionary entries, as the reading text of continuous speech recognition database in standard Chinese. This set of sentences and pbrases covers 99.8% syllables without counting tones, 100% inter-syllable diphones, 99.6% inter-syllable triphones and 100% sentence patterns.
基金Supported by the National Natural Science Foundation of China. Acknowledgements The National Science Foundation of China supported these works. Thanks to NSFC and all the members of the research groups in Renmin University of China.
文摘Database system is the infrastructure of the modern information system. The R＆D in the database system and its technologies is one of the important research topics in the field. The database R＆D in China took off later but it moves along by giant steps. This report presents the achievements Renmin University of China （RUC） has made in the past 25 years and at the same time addresses some of the research projects we, RUC, are currently working on. The National Natural Science Foundation of China supports and initiates most of our research projects and these successfully conducted projects have produced fruitful results.
文摘CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.
文摘CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.
文摘CSEE Journal of Power and Energy Systems(JPES)is dedicated to reporting cutting-edge theories,methods,technologies and applications that will shape the development of power systems in energy transition.The journal is indexed by Science Citation Index Expanded(SCIE),Ei,INSPEC,DOAJ,ProQuest,Scopus,and Chinese Science Abstract Database(CSAD).It aims to provide an international platform for authors to maximize the reach and influence of their contributions,and present the latest research achievements,which have significant impacts on the advancement of knowledge in the fields.
基金supported by National Basic Research Program of China (973 Program, 2009CB522900)Shanghai Leading Academic Discipline Project
文摘Objective： To make a bibliometric analysis and evaluation of acupuncture-moxibustion papers on moxibustion therapy published from 1954 to 2007, thus to reflect the diseases spectrum of moxibustion therapy and proper indications of moxibustion therapy objectively. Methods： Statistics were taken by a bibliometric analysis of the data from China Modern Acupuncture-moxibustion Information Databank. Results and Conclusion： The diseases spectrum of moxibustion therapy has 364 kinds of diseases. The most proper indications of moxibustion therapy are malposition, diarrhea, and colitis. The common proper indications are urinary incontinence and dysmenorrhea. The next common proper indications are knee osteoarthritis, temporomandibular joint disturbance syndrome, soft tissue injury, heel pain, asthma, urinary retention and herpes zoster. Diseases spectrum of moxibustion therapy varies with time.
文摘Objective:To summarize the clinical application patterns in acupuncture-moxibustion treatment of AD by reviewing the clinical literatures on acupuncture-moxibustion for Alzheimer disease(AD)published between January 2009 and December 2019.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP),Chinese Medicine Acupuncture-moxibustion Information Database,PubMed Medical Data Retrieval Service System,Springer Database and Ovid Technologies(OVID)were retrieved to screen clinical studies of acupuncture-moxibustion treatment of AD according to the inclusion and exclusion criteria to conduct quantitative,clustering and association analyses.Results:In acupuncture-moxibustion treatment of AD,the frequently used points were Baihui(GV 20),Zusanli(ST 36),Sishencong(EX-HN 1),Taixi(KI 3),Sanyinjiao(SP 6),and Neiguan(PC 6)in the descending order.Regarding meridians,the most frequently used one was the Governor Vessel,followed by the Stomach Meridian of Foot Yangming and Gallbladder Meridian of Foot Shaoyang.From the perspective of body regions,the points in the head-face region and the lower-limb region had the highest frequencies,followed by the upper-limb,back and chest-abdomen regions.The point group,Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Sanyinjiao(SP 6),showed the most significant association,and the group winning the second place was Baihui(GV 20)and Sishencong(EX-HN 1)-Neiguan(PC 6)-Zusanli(ST 36).The clustering analysis showed that the commonly used point pairs included Zusanli(ST 36)-Sishencong(EX-HN 1)and Taixi(KI 3)-Sanyinjiao(SP 6),which were closely associated with Baihui(GV 20).By analyzing the three commonly used acupuncture-moxibustion methods,acupuncture plus medication was found achieving the best result in the total effective rate and mini-mental state examination(MMSE)score,followed by monotherapy of electroacupuncture therapy,and these two methods were superior to acupuncture alone(P<0.05);the scores of MMSE,Alzheimer disease assessment scale-cognitive section(ADAS-cog)and activity of daily living scale(ADL)showed significant improvements after treatment(all P<0.01).Conclusion:In the acupuncture-moxibustion prescriptions for AD,the main points are Baihui(GV 20),Sishencong(EX-HN 1),Neiguan(PC 6),Zusanli(ST 36),Sanyinjiao(SP 6)and Taixi(KI 3).Monotherapy of acupuncture has the highest frequency amongst the treatment methods,but its effective rate is lower than that of acupuncture plus medication and monotherapy of electroacupuncture.
文摘Objective: To explore the clinical regularities in acupuncture-moxibustion treatment of cancer pain by reviewing the re leva nt studies published betwee n 1985 and 2017. Methods: Based on the Chinese Medicine Acupuncture-moxibustion Information Database, quantitative analysis, correlation an alysis and Chi-square test were applied to an a lyze the comm only used acupoi nts, meridia n affiliatio ns and body regi on distributi ons, comm only used methods and acupoi nt correlati ons, treatme nt method correlati ons, the efficacy of acupuncture- moxibusti on plus the three-step an algesic ladder for can cer pain, and in dicators. Results: Zusanli (ST 36), Ashi point and Sanyinjiao (SP 6) ranked the top on the list of frequency;points from Bladder Meridian of Foot Taiyang and Stomach Meridian of Foot Yangming were often used;points from the lower limbs and back had high frequencies. The most commonly used treatment method was acupuncture-moxibustion plus medication. Acupuncture-moxibusti on plus the three-step an algesic ladder showed certai n adva ntage compared with the two methods used separately, and among the integrated methods, acupoint application plus the three-step analgesic ladder produced the most significant efficacy. It took (44.77±55.54) min for the analgesic effect to act and the effect lasted for (12.81±14.59) h. Numerical rati ng scale (NRS), visual an alog scale (VAS) and Kar nofsky performa nee status (KPS) scores all showed sign ifica nt changes after interventions (all P<0.01);there was no significant change in the score of quality of life (QOL) after interventions (P>0.05). Conclusion: Zusa nli (ST 36), Ashi point and Sanyin jiao (SP 6) are comm only selected in acup un cture-moxibusti on treatment of cancer pain;acupuncture and acupoint application are often used;acupuncture-moxibustion plus the three-step an algesic ladder can boost the treatme nt efficacy.
基金This research was funded by the Youth Scientist Program of the CUPL Science Research Project(2016),Grant No.16ZFQ82009.
文摘Handwriting expertise,as a form of forensic evidence,was once considered by most courts under the Anglo-American law system to be infallible,but this position was significantly challenged by the Daubert case(1993)and further by the President’s Council of Advisors on Science and Technology report published in 2016.In China,handwriting expertise has often been accepted as forensic evidence.However,this does not mean that there is no need to review the reliability of handwriting expertise.In this study,we analyze the current situation in China regarding the reliability of handwriting identification using cases from China’s judicial judgment database.We intend to identify the reasons for rejection of handwriting expertise,analyze the outcomes of applications for re-examination,and examine the court’s evaluation of different forensic opinions in relation to a given case.We also propose ways to strengthen the reliability of handwriting identification in China.
基金supported by the Research Grants Council of Hong Kong[212613]Faculty Research Grant[FRG2/14-15/063].
文摘Background:The Ebola virus is highly pathogenic and destructive to humans and other primates.The Ebola virus encodes viral protein 40(VP40),which is highly expressed and regulates the assembly and release of viral particles in the host cell.Because VP40 plays a prominent role in the life cycle of the Ebola virus,it is considered as a key target for antiviral treatment.However,there is currently no FDA-approved drug for treating Ebola virus infection,resulting in an urgent need to develop effective antiviral inhibitors that display good safety profiles in a short duration.Methods:This study aimed to screen the effective lead candidate against Ebola infection.First,the lead molecules were filtered based on the docking score.Second,Lipinski rule of five and the other drug likeliness properties are predicted to assess the safety profile of the lead candidates.Finally,molecular dynamics simulations was performed to validate the lead compound.Results:Our results revealed that emodin-8-beta-D-glucoside from the Traditional Chinese Medicine Database(TCMD)represents an active lead candidate that targets the Ebola virus by inhibiting the activity of VP40,and displays good pharmacokinetic properties.Conclusion:This report will considerably assist in the development of the competitive and robust antiviral agents against Ebola infection.
