Chikungunya fever(CHIKF)is an acute mosquito-borne disease caused by the Chikungunya virus(CHIKV),primarily transmitted by Aedes aegypti mosquitoes[1-3].With its expanding global prevalence and the significant burden ...Chikungunya fever(CHIKF)is an acute mosquito-borne disease caused by the Chikungunya virus(CHIKV),primarily transmitted by Aedes aegypti mosquitoes[1-3].With its expanding global prevalence and the significant burden of chronic complications,CHIKF has become a major public health threat.CHIKV is a member of the Togaviridae family,belonging to the Alphavirus genus.Its genome is a single-stranded,positive-sense RNA of about 11-12 kb,encoding four non-structural proteins(nsPl-4)and five structural proteins(capsid protein C,envelope proteins E1,E2,E3,and ion channel protein 6 K)[2].展开更多
With the global warming, the expansion of transportation networks, a tremendous increase in international travel and exchange, and the ongoing evolution of viruses, chikungunya virus (CHIKV) has spread beyond its Afri...With the global warming, the expansion of transportation networks, a tremendous increase in international travel and exchange, and the ongoing evolution of viruses, chikungunya virus (CHIKV) has spread beyond its African origins and achieved global distribution, posing a significant threat to public health worldwide. Under such circumstances, animal models serve as indispensable tools for elucidating CHIKV pathogenesis and developing antiviral strategies. The currently established animal models of CHIKV infection can recapitulate various aspects of the clinical disease at different levels of complexity. However, each model possesses distinct advantages and limitations, rendering them suitable for rather specific research applications. Furthermore, the clinical realities of CHIKV infection in patients with comorbidities or coinfections with other viruses, coupled with emerging initiatives to reduce animal model reliance, present substantial challenges for the future development and application of these models. This review summarizes the natural history and susceptible host of CHIKV, recent advances in understanding the pathogenesis and animal model development, and prospects for animal models of CHIKV infection. The aim is to provide a reference for the selection, utilization, and development of appropriate animal models for CHIKV research.展开更多
基金supported by the Key Research and Development Program,Ministry of Science and Technology of China(2023YFC2606500)the Taishan Scholar Project of Shandong Province(tstp20240852)the Young Talent of Lifting Engineering for Science and Technology in Shandong,China(SDAST2025QTB057)。
文摘Chikungunya fever(CHIKF)is an acute mosquito-borne disease caused by the Chikungunya virus(CHIKV),primarily transmitted by Aedes aegypti mosquitoes[1-3].With its expanding global prevalence and the significant burden of chronic complications,CHIKF has become a major public health threat.CHIKV is a member of the Togaviridae family,belonging to the Alphavirus genus.Its genome is a single-stranded,positive-sense RNA of about 11-12 kb,encoding four non-structural proteins(nsPl-4)and five structural proteins(capsid protein C,envelope proteins E1,E2,E3,and ion channel protein 6 K)[2].
文摘With the global warming, the expansion of transportation networks, a tremendous increase in international travel and exchange, and the ongoing evolution of viruses, chikungunya virus (CHIKV) has spread beyond its African origins and achieved global distribution, posing a significant threat to public health worldwide. Under such circumstances, animal models serve as indispensable tools for elucidating CHIKV pathogenesis and developing antiviral strategies. The currently established animal models of CHIKV infection can recapitulate various aspects of the clinical disease at different levels of complexity. However, each model possesses distinct advantages and limitations, rendering them suitable for rather specific research applications. Furthermore, the clinical realities of CHIKV infection in patients with comorbidities or coinfections with other viruses, coupled with emerging initiatives to reduce animal model reliance, present substantial challenges for the future development and application of these models. This review summarizes the natural history and susceptible host of CHIKV, recent advances in understanding the pathogenesis and animal model development, and prospects for animal models of CHIKV infection. The aim is to provide a reference for the selection, utilization, and development of appropriate animal models for CHIKV research.
