The electrochemical behavior of nitrofurazone in dimethylformamide has been studied by cyclic voltammetry and in-situ thin-layer spectroelectrochemistry.The redox reactions are complicated at platinium electrode,and a...The electrochemical behavior of nitrofurazone in dimethylformamide has been studied by cyclic voltammetry and in-situ thin-layer spectroelectrochemistry.The redox reactions are complicated at platinium electrode,and a possible electrochemical mechanism of nitrofurazone is proposed.展开更多
Objective Qing Fu Juan Bi Tang(QFJBT)is an anti-arthritic Chinese medicine formula consisting of five herbs:Aconiti Lateralis Radix Praeparata(Fu Zi,附子),Sinomenii Caulis(Qing Feng Teng,青风藤),Astragali Radix(Huang ...Objective Qing Fu Juan Bi Tang(QFJBT)is an anti-arthritic Chinese medicine formula consisting of five herbs:Aconiti Lateralis Radix Praeparata(Fu Zi,附子),Sinomenii Caulis(Qing Feng Teng,青风藤),Astragali Radix(Huang Qi,黄芪),Paeoniae Radix Alba(Bai Shao,白芍)and Moutan Cortex(Mu Dan Pi,牡丹皮),which have well-established histories of use for treatment of rheumatic and arthritic diseases.We intended to establish the optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT to develop it as a novel botanical drug product for treatment of rheumatoid arthritis(RA).Methods The combinative approaches of chemical assessment,toxicological and pharmacological evaluation were explored to define the pharmaceutical preparation of QFJBT.Results The optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT were established in terms of greatest chemical contents of bioactive constituents,potent anti-inflammatory and antinociceptive activities,and favorable safety profile.Quality analysis of the pilot product of QFJBT by high-performance liquid chromatography(HPLC)demonstrated that the chromatographic fingerprint profiles of three batches of QFJBT were basically identical and the contents of four characteristic and bioactive markers were relatively consistent.General toxicological studies showed a favorable safety profile of QFJBT.The maximum tolerated single dose of QFJBT was determined in both sexes of rats to be 33.63 g/kg body weight which is equivalent to 346 times of clinical dose.In the chronic oral toxicity study,the results of laboratory investigation showed that QFJBT at doses of 3.89,6.80 and 9.72 g/kg body weight(equivalent to 40,70 and 100-fold clinical doses,respectively)caused no changes in all hematological parameters and blood biochemical parameters of rats.No mortality or specific toxic responses were observed in animals after three months of repeated dosing with QFJBT.Conclusion The optimized and standardized pharmaceutical and manufacturing processes for the production of QFJBT have been successfully screened and identified through established rigorous in-process controls.展开更多
The 2017 Chinese Medicinal Chemistry Symposium was successfully held on Aug. 27-30 at the Beijing National Conference Center. The theme of this conference is Global New Drug Research and Development： New molecules, N...The 2017 Chinese Medicinal Chemistry Symposium was successfully held on Aug. 27-30 at the Beijing National Conference Center. The theme of this conference is Global New Drug Research and Development： New molecules, New Technologies, and New Therapies. This symposium collected a very impressive list of scientists who are highly active in drug discovery. The symposium delivered 179 presentations and 135 posters on the topics of： 1） Progression of cell therapy research （including immune, stem ceils, etc.）; 2） New frontiers and trends in medicinal chemistry; 3） Latest developments in critical diseases; 4） New theories and methods of drug molecular design; 5） New methods and technologies in medicinal materials and drug synthesis; 6） Chemical biology and related fields; 7） Frontiers of natural medicine and traditional Chinese medicine. Among them, 11 invited speakers are come from School of Pharmaceutical Sciences, PKU.展开更多
Micropeptin EI-964 is a cyclic peptide compound isolated from a marine cyanobacterium with potent inhibitory activity against serine proteases, particularly chymotrypsin and trypsin. It has shown promising activity ag...Micropeptin EI-964 is a cyclic peptide compound isolated from a marine cyanobacterium with potent inhibitory activity against serine proteases, particularly chymotrypsin and trypsin. It has shown promising activity against various cancer cell lines, making it a candidate for drug development. The unique structure and activity of Micropeptin EI-964 make it a promising lead compound for the development of novel serine protease inhibitors and anti-cancer drugs. Computational Chemistry and Molecular Modeling techniques can provide valuable insights into the chemical reactivity and pharmaceutical properties of Micropeptin EI-964, guiding the design and development of new compounds with enhanced bioactivity and improved drug-like properties.展开更多
In order to effectively cultivate applied pharmaceutical talents,aiming at the current teaching situation of organic chemistry,the basic course of pharmaceutical specialty,including the problems of curriculum setting,...In order to effectively cultivate applied pharmaceutical talents,aiming at the current teaching situation of organic chemistry,the basic course of pharmaceutical specialty,including the problems of curriculum setting,experimental teaching,and the integration of classroom and professional knowledge,it is proposed to overcome the problem of curriculum setting by combining"online+offline"in teaching.It should overcome the problems in experimental teaching with the help of virtual simulation platform.By cultivating students organic chemistry thinking and paying attention to the integration of subject and professional knowledge,students recognition of organic chemistry course can be improved,and the quality of training can be improved.展开更多
The demand for sustainable energy storage has accelerated the development of cellulose-based materials(CBMs)for flexible supercapacitors(FSCs).However,widespread commercialization of FSCs remains challenged by their l...The demand for sustainable energy storage has accelerated the development of cellulose-based materials(CBMs)for flexible supercapacitors(FSCs).However,widespread commercialization of FSCs remains challenged by their low gravimetric energy density(approximately 35 Wh kg^(-1)),far below lithium-ion batteries(exceeding 200 Wh kg^(-1)),and a limited operational temperature range(from-20℃ to 60℃),restricting their use in extreme environments.To date,no comprehensive review has elucidated the crucial role of the chemistry and structure-property relationships of CBMs in advancing FSC technology.This review fills this gap by examining the chemical attributes and versatility of cellulose and its derivatives,including their physicochemical characteris-tics,assembly methodologies,and functional modifications such as oxidation,esterification,etherification,grafting polymerization,nucleophilic substitution,and crosslinking reactions.We further provide an overview of the chemistry and structure-function correlations of various cellulose forms used in advanced electrodes,solid electrolytes,separators,binders,current collectors,and substrate/encapsulation materials,alongside relevant microelectrode processing technologies.Given that large-scale application of FSCs is still in its early stages,we offer insightful design principles for guiding future development of cellulose-based FSCs.By proposing a“chemistry-performance-sustainability”design framework,this review not only addresses existing limitations but also outlines a roadmap for next-generation eco-friendly FSCs.展开更多
While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest fre...While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest freshwater system,and in many ways resemble marine ecosystems.However,unlike the open ocean and coastal waters where pH has declined due to rising atmospheric CO_(2),no significant pH trends have been observed in the Laurentian Great Lakes,despite significant ecosystem changes driven partly by the invasion of dreissenid mussels.This study examined 41 years of field observations from Lake Michigan to investigate the long-term carbonate chemistry dynamics.Observational results revealed substantial declines in both total alkalinity(TA)and dissolved inorganic carbon(DIC)over the four decades.Mussel shell calcification emerged as the primary mechanism behind these declines,accounting for 97%and 47%of the observed changes in TA and DIC,respectively,lowering water column pH by 0.24 units.Elevated carbon accumulation in soft mussel tissues,coupled with long-term changes in the air-water pCO_(2)gradient during summer,significantly contributed to long-term DIC variations,explaining 18%and 28%of the lake-wide DIC loss.These two mechanisms also resulted in an overall pH increase of 0.09 and 0.12 units,largely offsetting the calcification-driven pH decrease.These findings bridge a gap in acidification research for large freshwater systems and provide valuable insights for comprehensive lake-wide management strategies.展开更多
China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co....China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.展开更多
Ion migration capability and interfacial chemistry of solid polymer electrolytes(SPEs)in all-solid-state sodium metal batteries(ASSMBs)are closely related to the Na^(+)coordination environment.Herein,an electrostatic ...Ion migration capability and interfacial chemistry of solid polymer electrolytes(SPEs)in all-solid-state sodium metal batteries(ASSMBs)are closely related to the Na^(+)coordination environment.Herein,an electrostatic engineering strategy is proposed to regulate the Na^(+)coordinated structure by employing a fluorinated metal–organic framework as an electron-rich model.Theoretical and experimental results revealed that the abundant electron-rich F sites can accelerate the disassociation of Na-salt through electrostatic attraction to release free Na^(+),while forcing anions into a Na^(+)coordination structure though electrostatic repulsion to weaken the Na^(+)coordination with polymer,thus promoting rapid Na^(+)transport.The optimized anion-rich weak solvation structure fosters a stable inorganic-dominated solid–electrolyte interphase,significantly enhancing the interfacial stability toward Na anode.Consequently,the Na/Na symmetric cell delivered stable Na plating/stripping over 2500 h at 0.1 mA cm^(−2).Impressively,the assembled ASSMBs demonstrated stable performance of over 2000 cycles even under high rate of 2 C with capacity retention nearly 100%,surpassing most reported ASSMBs using various solid-state electrolytes.This work provides a new avenue for regulating the Na^(+)coordination structure of SPEs by exploration of electrostatic effect engineering to achieve high-performance all-solid-state alkali metal batteries.展开更多
Dear Editors,This letter,reflecting on my research career,is dedi-cated to Professor Qingshi Zhu for his 80th Birthday.Part of this letter is based on my comment“A 20-year journey on the invention of vibrational phot...Dear Editors,This letter,reflecting on my research career,is dedi-cated to Professor Qingshi Zhu for his 80th Birthday.Part of this letter is based on my comment“A 20-year journey on the invention of vibrational photothermal microscopy”published in the May 2025 Nature Meth-ods Focus Issue on Bond-Selective Imaging[1].展开更多
The remarkable power of chemistry over description and trans-formation of matters has been significantly enhanced through the development of dynamic chemistry and condensed matter chemistry[1].This progress has furthe...The remarkable power of chemistry over description and trans-formation of matters has been significantly enhanced through the development of dynamic chemistry and condensed matter chemistry[1].This progress has further elevated chemistry to a creative science and a thriving industry.The development of dynamic chemistry,span-ning from supramolecular chemistry to constitutional dynamic chem-istry,has witnessed significant advancements towards adaptive chemistry,which is characterized primarily by its self-adaption to external stimuli.This is particularly achieved in two-or three-dimensional dynamic frameworks.Meanwhile,the multi-phase evolution resulting from the emerging of solid-to-liquid transition plat-form is assuming an increasingly crucial role in condensed matter chemistry[2].展开更多
The recent emergence of pollutants of concern in the water bodies is becoming a challenge for the water treatment community.In such a scenario,the deployment of the polyamide(PA)nanofiltration(NF)has proved to be a su...The recent emergence of pollutants of concern in the water bodies is becoming a challenge for the water treatment community.In such a scenario,the deployment of the polyamide(PA)nanofiltration(NF)has proved to be a successful solution.Hence,the current study focused on applying a set of PA NF membranes for their potential to treat saline water containing organic pharmaceutical pollutants of emerging concern.The membranes have a varied active layer chemistry owing to the use of a set of aliphatic amines of varying chain lengths during interfacial polymerization(IP).Five membranes,ranging from M1 to M5[M1(2%w/v PIP+0.15%w/v TMC),M2(1.8%w/v PIP and 0.2%w/v EDA+0.15%w/v TMC),M3(1.8%w/v PIP and 0.2%w/v DETA+0.15%w/v TMC),M4(1.8%w/v PIP and 0.2%w/v BAEP+0.15%w/v TMC),and M5(1.8%w/v PIP and 0.2%w/v TEPA+0.15%w/v TMC)],were fabricated,exhibiting varied physical and chemical features,including different surface charges,roughness,and wettability.The M4 membrane was found to be the best-performing membrane for rejecting the majority of pharmaceutical pollutant drugs and having higher permeate flux compared to other membranes.The M4 membrane has an entirely different surface morphology of larger-sized PA globules observed in the scanning electron microscopy(SEM)analysis of the M4 membrane.In addition,the M4 membrane possessed a hydrophilic surface with a water contact angle of 24.5°,resulting in higher clean water permeability compared to other membranes.It was observed that the rejection of the pharmaceutical pollutant drugs was mainly governed by size exclusion,augmented by the Donnan effect,where the positively charged drugs were rejected almost entirely by the membranes.The M4 membrane rejected 66.9%of 4-hydroxyacetanilide,82.0% of sulfamethoxazole,96.9%of caffeine,and>99%of amitriptyline and ranolazine,where amitriptyline and ranolazine have positive charges.The presence of monovalent and divalent salts affected the rejection of the drugs,where the rejection of the drugs increased with increasing concentration of the salts.Moreover,the long-term stability tests revealed that the membranes exhibited stable rejection performance and a stable permeate flux,with only slight variations.The ultrahigh-performance liquid chromatography(UHPLC)analyses confirmed rejection of drugs from the water.This study demonstrated that variations in the chemistry of the PA active layer can yield promising membranes for removing organic pharmaceutical pollutants from saline water bodies,enabling safe reuse of treated water.展开更多
Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field face...Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.展开更多
The preparation,functionalization,and investigations in host-vip properties of high-level pillararene macrocycles have long been a big challenge because of the lack of efficient synthetic methods.Herein,a novel type...The preparation,functionalization,and investigations in host-vip properties of high-level pillararene macrocycles have long been a big challenge because of the lack of efficient synthetic methods.Herein,a novel type of pillararene derivative,namely desymmetrized pillar[8]arene(DP[8]A),has been successfully synthesized via a facile two-step strategy with high yield.Compared with its pillar[8]arene counterpart,DP[8]A is composed of four alkoxy-substituted benzene units and four bare benzene rings.Single crystal analysis has been performed in order to unveil the molecular conformation and packing mode of DP[8]A,which indicated that DP[8]A possesses a unique chair-like structure and much smaller steric hindrance.Density functional theory(DFT)calculations and electrostatic potential map suggested the inhomogeneous electronic distribution in the DP[8]A cavity.Water-soluble carboxylate-modified DP[8]A,that is,CDP[8]A,was also prepared to investigate the host-vip properties in aqueous solution with methyl viologen(MV),where the binding constant and morphologies of the formed host-vip complexes have been studied.In all,this new version of eight-membered pillararene derivative might potentially serve as a powerful macrocycle candidate for further applications in supramolecular chemistry.展开更多
A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection...A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.展开更多
Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal...Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal monitoring and adjustment strategies,achieving high quality and efficiency remains a challenge.In this work,we proposed an artificial intelligence(AI)-based robot platform for the multi-objective optimization of the extraction process.First,a perception intelligence method for multimodal process monitoring was established to track active ingredient transfer and production changes during the extraction process.Second,a digital twin model was developed to reconstruct the field information,which interacted with real-time monitoring data.Furthermore,the model performed real-time inference to predict future production process states by using the reconstructing information.Finally,according to the predicted process states,the autonomous decision-making robot implemented multi-objective optimization,ensuring efficient process adjustments for global optimization.Experimental and industrial results demonstrated that the platform could effectively infer component transfer dynamics,monitor temperature variations,and identify boiling states,ensuring product quality while reducing energy consumption.This pharmaceutical robot could promote the integration of AI and pharmaceutical engineering,thereby accelerating the iterative development and improvement of China’s pharmaceutical industry.展开更多
Metal-carbon dioxide(CO_(2))batteries hold great promise for reducing greenhouse gas emissions and are regarded as one of the most promising energy storage techniques due to their efficiency advantages in CO_(2)recove...Metal-carbon dioxide(CO_(2))batteries hold great promise for reducing greenhouse gas emissions and are regarded as one of the most promising energy storage techniques due to their efficiency advantages in CO_(2)recovery and conversion.Moreover,rechargeable nonaqueous metal-CO_(2)batteries have attracted much attention due to their high theoretical energy density.However,the stability issues of the electrode-electrolyte interfaces of nonaqueous metal-CO_(2)(lithium(Li)/sodium(Na)/potassium(K)-CO_(2))batteries have been troubling its development,and a large number of related research in the field of electrolytes have conducted in recent years.This review retraces the short but rapid research history of nonaqueous metal-CO_(2)batteries with a detailed electrochemical mechanism analysis.Then it focuses on the basic characteristics and design principles of electrolytes,summarizes the latest achievements of various types of electrolytes in a timely manner and deeply analyzes the construction strategies of stable electrode-electrolyte interfaces for metal-CO_(2)batteries.Finally,the key issues related to electrolytes and interface engineering are fully discussed and several potential directions for future research are proposed.This review enriches a comprehensive understanding of electrolytes and interface engineering toward the practical applications of next-generation metal-CO_(2)batteries.展开更多
AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to i...AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we organized this special issue entitled"Innovative Pharmaceutical Research Driven by AI",and collected Original research articles,Reviewpapers.展开更多
Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before ...Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before fully understanding their molecular mechanisms,yeast systems now provide valuable insights for drug discovery and personalized medicine.Recent advancements in genetic engineering,metabolic engineering,and synthetic biology have improved the efficiency and scalability of yeast-based production systems,enabling more sustainable and cost-effective manufacturing processes.This paper reviews the latest developments in yeast-based technologies,focusing on their use as model organisms to study disease mechanisms,identify drug targets,and develop novel therapies.We highlight key platforms such as the yeast two-hybrid system,surface display technologies,and optimized expression systems.Additionally,we explore the future integration of yeast engineering with artificial intelligence(AI),machine learning(ML),and advanced genome editing technologies like CRISPR/Cas9,which are expected to accelerate drug discovery and enable personalized therapies.Furthermore,yeast-based systems are increasingly employed in largescale drug production,vaccine development,and therapeutic protein expression,offering promising applications in clinical and industrial settings.This paper discusses the practical implications of these systems and their potential to revolutionize drug development,paving the way for safer,more effective therapies.展开更多
文摘The electrochemical behavior of nitrofurazone in dimethylformamide has been studied by cyclic voltammetry and in-situ thin-layer spectroelectrochemistry.The redox reactions are complicated at platinium electrode,and a possible electrochemical mechanism of nitrofurazone is proposed.
基金support from the National Natural Science Foundation of China(No.81704065)China Postdoctoral Science Foundation(No.2016M600632 and No.2017T100604)+3 种基金Hunan Provincial Natural Science Foundation(No.2017JJ3239 and No.2018JJ2293)Hunan Education Department’s Science&Research Project(No.17K069)Hunan Provincial Science&Research Project of Chinese Medicine(No.201790)National First-class Disciple Construction Project of Chinese Medicine of Hunan University of Chinese Medicine
文摘Objective Qing Fu Juan Bi Tang(QFJBT)is an anti-arthritic Chinese medicine formula consisting of five herbs:Aconiti Lateralis Radix Praeparata(Fu Zi,附子),Sinomenii Caulis(Qing Feng Teng,青风藤),Astragali Radix(Huang Qi,黄芪),Paeoniae Radix Alba(Bai Shao,白芍)and Moutan Cortex(Mu Dan Pi,牡丹皮),which have well-established histories of use for treatment of rheumatic and arthritic diseases.We intended to establish the optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT to develop it as a novel botanical drug product for treatment of rheumatoid arthritis(RA).Methods The combinative approaches of chemical assessment,toxicological and pharmacological evaluation were explored to define the pharmaceutical preparation of QFJBT.Results The optimized and standardized pharmaceutical procedures and manufacturing processes for the pilot production of QFJBT were established in terms of greatest chemical contents of bioactive constituents,potent anti-inflammatory and antinociceptive activities,and favorable safety profile.Quality analysis of the pilot product of QFJBT by high-performance liquid chromatography(HPLC)demonstrated that the chromatographic fingerprint profiles of three batches of QFJBT were basically identical and the contents of four characteristic and bioactive markers were relatively consistent.General toxicological studies showed a favorable safety profile of QFJBT.The maximum tolerated single dose of QFJBT was determined in both sexes of rats to be 33.63 g/kg body weight which is equivalent to 346 times of clinical dose.In the chronic oral toxicity study,the results of laboratory investigation showed that QFJBT at doses of 3.89,6.80 and 9.72 g/kg body weight(equivalent to 40,70 and 100-fold clinical doses,respectively)caused no changes in all hematological parameters and blood biochemical parameters of rats.No mortality or specific toxic responses were observed in animals after three months of repeated dosing with QFJBT.Conclusion The optimized and standardized pharmaceutical and manufacturing processes for the production of QFJBT have been successfully screened and identified through established rigorous in-process controls.
文摘The 2017 Chinese Medicinal Chemistry Symposium was successfully held on Aug. 27-30 at the Beijing National Conference Center. The theme of this conference is Global New Drug Research and Development： New molecules, New Technologies, and New Therapies. This symposium collected a very impressive list of scientists who are highly active in drug discovery. The symposium delivered 179 presentations and 135 posters on the topics of： 1） Progression of cell therapy research （including immune, stem ceils, etc.）; 2） New frontiers and trends in medicinal chemistry; 3） Latest developments in critical diseases; 4） New theories and methods of drug molecular design; 5） New methods and technologies in medicinal materials and drug synthesis; 6） Chemical biology and related fields; 7） Frontiers of natural medicine and traditional Chinese medicine. Among them, 11 invited speakers are come from School of Pharmaceutical Sciences, PKU.
文摘Micropeptin EI-964 is a cyclic peptide compound isolated from a marine cyanobacterium with potent inhibitory activity against serine proteases, particularly chymotrypsin and trypsin. It has shown promising activity against various cancer cell lines, making it a candidate for drug development. The unique structure and activity of Micropeptin EI-964 make it a promising lead compound for the development of novel serine protease inhibitors and anti-cancer drugs. Computational Chemistry and Molecular Modeling techniques can provide valuable insights into the chemical reactivity and pharmaceutical properties of Micropeptin EI-964, guiding the design and development of new compounds with enhanced bioactivity and improved drug-like properties.
基金Supported by No.2022-79 Teaching Reform Project of Guangzhou Huashang College(HS2022ZLGC58)No.2022-79 Quality Engineering Project of Guangzhou Huashang College(HS2022ZLGC04).
文摘In order to effectively cultivate applied pharmaceutical talents,aiming at the current teaching situation of organic chemistry,the basic course of pharmaceutical specialty,including the problems of curriculum setting,experimental teaching,and the integration of classroom and professional knowledge,it is proposed to overcome the problem of curriculum setting by combining"online+offline"in teaching.It should overcome the problems in experimental teaching with the help of virtual simulation platform.By cultivating students organic chemistry thinking and paying attention to the integration of subject and professional knowledge,students recognition of organic chemistry course can be improved,and the quality of training can be improved.
基金support from the National Key R&D Program of China(Grant No.2023YFB4005204)the National Natural Science Foundation of China(Grant No.22125903,U24A20553,22579025,52502038)+2 种基金Fundamental Research Funds for the Central Universities(No.2572023CT06)Key Joint Project of the Natural Science Foundation of Heilongjiang Province,China(No.ZL2024E007)the Innovation Foundation for Doctoral Program of Forestry Engineering of Northeast Forestry University(No.LYGC202220).
文摘The demand for sustainable energy storage has accelerated the development of cellulose-based materials(CBMs)for flexible supercapacitors(FSCs).However,widespread commercialization of FSCs remains challenged by their low gravimetric energy density(approximately 35 Wh kg^(-1)),far below lithium-ion batteries(exceeding 200 Wh kg^(-1)),and a limited operational temperature range(from-20℃ to 60℃),restricting their use in extreme environments.To date,no comprehensive review has elucidated the crucial role of the chemistry and structure-property relationships of CBMs in advancing FSC technology.This review fills this gap by examining the chemical attributes and versatility of cellulose and its derivatives,including their physicochemical characteris-tics,assembly methodologies,and functional modifications such as oxidation,esterification,etherification,grafting polymerization,nucleophilic substitution,and crosslinking reactions.We further provide an overview of the chemistry and structure-function correlations of various cellulose forms used in advanced electrodes,solid electrolytes,separators,binders,current collectors,and substrate/encapsulation materials,alongside relevant microelectrode processing technologies.Given that large-scale application of FSCs is still in its early stages,we offer insightful design principles for guiding future development of cellulose-based FSCs.By proposing a“chemistry-performance-sustainability”design framework,this review not only addresses existing limitations but also outlines a roadmap for next-generation eco-friendly FSCs.
基金Supported by the National Natural Science Foundation of China(No.43277051)the Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education(No.B230203006).
文摘While oceanic and coastal acidification has gained increased attention,long-term pH trends and their drivers in large freshwater systems remain poorly understood.The Laurentian Great Lakes are the world’s largest freshwater system,and in many ways resemble marine ecosystems.However,unlike the open ocean and coastal waters where pH has declined due to rising atmospheric CO_(2),no significant pH trends have been observed in the Laurentian Great Lakes,despite significant ecosystem changes driven partly by the invasion of dreissenid mussels.This study examined 41 years of field observations from Lake Michigan to investigate the long-term carbonate chemistry dynamics.Observational results revealed substantial declines in both total alkalinity(TA)and dissolved inorganic carbon(DIC)over the four decades.Mussel shell calcification emerged as the primary mechanism behind these declines,accounting for 97%and 47%of the observed changes in TA and DIC,respectively,lowering water column pH by 0.24 units.Elevated carbon accumulation in soft mussel tissues,coupled with long-term changes in the air-water pCO_(2)gradient during summer,significantly contributed to long-term DIC variations,explaining 18%and 28%of the lake-wide DIC loss.These two mechanisms also resulted in an overall pH increase of 0.09 and 0.12 units,largely offsetting the calcification-driven pH decrease.These findings bridge a gap in acidification research for large freshwater systems and provide valuable insights for comprehensive lake-wide management strategies.
文摘China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.
基金supported by the National Natural Science Foundation of China(No.52473213 and No.52203261)。
文摘Ion migration capability and interfacial chemistry of solid polymer electrolytes(SPEs)in all-solid-state sodium metal batteries(ASSMBs)are closely related to the Na^(+)coordination environment.Herein,an electrostatic engineering strategy is proposed to regulate the Na^(+)coordinated structure by employing a fluorinated metal–organic framework as an electron-rich model.Theoretical and experimental results revealed that the abundant electron-rich F sites can accelerate the disassociation of Na-salt through electrostatic attraction to release free Na^(+),while forcing anions into a Na^(+)coordination structure though electrostatic repulsion to weaken the Na^(+)coordination with polymer,thus promoting rapid Na^(+)transport.The optimized anion-rich weak solvation structure fosters a stable inorganic-dominated solid–electrolyte interphase,significantly enhancing the interfacial stability toward Na anode.Consequently,the Na/Na symmetric cell delivered stable Na plating/stripping over 2500 h at 0.1 mA cm^(−2).Impressively,the assembled ASSMBs demonstrated stable performance of over 2000 cycles even under high rate of 2 C with capacity retention nearly 100%,surpassing most reported ASSMBs using various solid-state electrolytes.This work provides a new avenue for regulating the Na^(+)coordination structure of SPEs by exploration of electrostatic effect engineering to achieve high-performance all-solid-state alkali metal batteries.
文摘Dear Editors,This letter,reflecting on my research career,is dedi-cated to Professor Qingshi Zhu for his 80th Birthday.Part of this letter is based on my comment“A 20-year journey on the invention of vibrational photothermal microscopy”published in the May 2025 Nature Meth-ods Focus Issue on Bond-Selective Imaging[1].
基金the BAGUI talent program(No.2019AC26001)the National Natural Science Foundation of China(Nos.U23A2080,22371173,22171075).
文摘The remarkable power of chemistry over description and trans-formation of matters has been significantly enhanced through the development of dynamic chemistry and condensed matter chemistry[1].This progress has further elevated chemistry to a creative science and a thriving industry.The development of dynamic chemistry,span-ning from supramolecular chemistry to constitutional dynamic chem-istry,has witnessed significant advancements towards adaptive chemistry,which is characterized primarily by its self-adaption to external stimuli.This is particularly achieved in two-or three-dimensional dynamic frameworks.Meanwhile,the multi-phase evolution resulting from the emerging of solid-to-liquid transition plat-form is assuming an increasingly crucial role in condensed matter chemistry[2].
文摘The recent emergence of pollutants of concern in the water bodies is becoming a challenge for the water treatment community.In such a scenario,the deployment of the polyamide(PA)nanofiltration(NF)has proved to be a successful solution.Hence,the current study focused on applying a set of PA NF membranes for their potential to treat saline water containing organic pharmaceutical pollutants of emerging concern.The membranes have a varied active layer chemistry owing to the use of a set of aliphatic amines of varying chain lengths during interfacial polymerization(IP).Five membranes,ranging from M1 to M5[M1(2%w/v PIP+0.15%w/v TMC),M2(1.8%w/v PIP and 0.2%w/v EDA+0.15%w/v TMC),M3(1.8%w/v PIP and 0.2%w/v DETA+0.15%w/v TMC),M4(1.8%w/v PIP and 0.2%w/v BAEP+0.15%w/v TMC),and M5(1.8%w/v PIP and 0.2%w/v TEPA+0.15%w/v TMC)],were fabricated,exhibiting varied physical and chemical features,including different surface charges,roughness,and wettability.The M4 membrane was found to be the best-performing membrane for rejecting the majority of pharmaceutical pollutant drugs and having higher permeate flux compared to other membranes.The M4 membrane has an entirely different surface morphology of larger-sized PA globules observed in the scanning electron microscopy(SEM)analysis of the M4 membrane.In addition,the M4 membrane possessed a hydrophilic surface with a water contact angle of 24.5°,resulting in higher clean water permeability compared to other membranes.It was observed that the rejection of the pharmaceutical pollutant drugs was mainly governed by size exclusion,augmented by the Donnan effect,where the positively charged drugs were rejected almost entirely by the membranes.The M4 membrane rejected 66.9%of 4-hydroxyacetanilide,82.0% of sulfamethoxazole,96.9%of caffeine,and>99%of amitriptyline and ranolazine,where amitriptyline and ranolazine have positive charges.The presence of monovalent and divalent salts affected the rejection of the drugs,where the rejection of the drugs increased with increasing concentration of the salts.Moreover,the long-term stability tests revealed that the membranes exhibited stable rejection performance and a stable permeate flux,with only slight variations.The ultrahigh-performance liquid chromatography(UHPLC)analyses confirmed rejection of drugs from the water.This study demonstrated that variations in the chemistry of the PA active layer can yield promising membranes for removing organic pharmaceutical pollutants from saline water bodies,enabling safe reuse of treated water.
基金supported by Nanjing Science and Technology Bureau International,Hong Kong,Macao,and Taiwan Science and Technology Cooperation Program(No.202401042)。
文摘Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.
基金the Natural Science Foundation of Jilin Province(No.20230101052JC)he National Natural Science Foundation of China(Nos.52173200 and 52203138)the Jilin Province Science and Technology Development Plan Project(No.#YDZJ202201ZYTS523)for financial support。
文摘The preparation,functionalization,and investigations in host-vip properties of high-level pillararene macrocycles have long been a big challenge because of the lack of efficient synthetic methods.Herein,a novel type of pillararene derivative,namely desymmetrized pillar[8]arene(DP[8]A),has been successfully synthesized via a facile two-step strategy with high yield.Compared with its pillar[8]arene counterpart,DP[8]A is composed of four alkoxy-substituted benzene units and four bare benzene rings.Single crystal analysis has been performed in order to unveil the molecular conformation and packing mode of DP[8]A,which indicated that DP[8]A possesses a unique chair-like structure and much smaller steric hindrance.Density functional theory(DFT)calculations and electrostatic potential map suggested the inhomogeneous electronic distribution in the DP[8]A cavity.Water-soluble carboxylate-modified DP[8]A,that is,CDP[8]A,was also prepared to investigate the host-vip properties in aqueous solution with methyl viologen(MV),where the binding constant and morphologies of the formed host-vip complexes have been studied.In all,this new version of eight-membered pillararene derivative might potentially serve as a powerful macrocycle candidate for further applications in supramolecular chemistry.
基金Undergraduate Teaching Quality and Teaching Reform Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2024]No.9)Graduate Education Innovation Plan Project,Guangdong Province(Project No.:Yue Jiao Tong Han[2024]No.1)+2 种基金First-Class Undergraduate Course Construction Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2022]No.10)Undergraduate Curriculum Ideological and Political Reform Demonstration Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2021]No.22)Higher Education Research Project,Guangdong Pharmaceutical University(Project No.:GGP202402).
文摘A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.
基金funded by the National Key Research and Development Program of China(2024YFC3506900)the Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines(24ZXZKSY00010 and 24ZXZKSY00040)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202002)。
文摘Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal monitoring and adjustment strategies,achieving high quality and efficiency remains a challenge.In this work,we proposed an artificial intelligence(AI)-based robot platform for the multi-objective optimization of the extraction process.First,a perception intelligence method for multimodal process monitoring was established to track active ingredient transfer and production changes during the extraction process.Second,a digital twin model was developed to reconstruct the field information,which interacted with real-time monitoring data.Furthermore,the model performed real-time inference to predict future production process states by using the reconstructing information.Finally,according to the predicted process states,the autonomous decision-making robot implemented multi-objective optimization,ensuring efficient process adjustments for global optimization.Experimental and industrial results demonstrated that the platform could effectively infer component transfer dynamics,monitor temperature variations,and identify boiling states,ensuring product quality while reducing energy consumption.This pharmaceutical robot could promote the integration of AI and pharmaceutical engineering,thereby accelerating the iterative development and improvement of China’s pharmaceutical industry.
基金supports from the Beijing Laboratory of New Energy Storage Technology, North China Electric Power Universitythe Program of the National Energy Storage Industry-Education Platformthe Interdisciplinary Innovation Program of North China Electric Power University (No. XM2212315)
文摘Metal-carbon dioxide(CO_(2))batteries hold great promise for reducing greenhouse gas emissions and are regarded as one of the most promising energy storage techniques due to their efficiency advantages in CO_(2)recovery and conversion.Moreover,rechargeable nonaqueous metal-CO_(2)batteries have attracted much attention due to their high theoretical energy density.However,the stability issues of the electrode-electrolyte interfaces of nonaqueous metal-CO_(2)(lithium(Li)/sodium(Na)/potassium(K)-CO_(2))batteries have been troubling its development,and a large number of related research in the field of electrolytes have conducted in recent years.This review retraces the short but rapid research history of nonaqueous metal-CO_(2)batteries with a detailed electrochemical mechanism analysis.Then it focuses on the basic characteristics and design principles of electrolytes,summarizes the latest achievements of various types of electrolytes in a timely manner and deeply analyzes the construction strategies of stable electrode-electrolyte interfaces for metal-CO_(2)batteries.Finally,the key issues related to electrolytes and interface engineering are fully discussed and several potential directions for future research are proposed.This review enriches a comprehensive understanding of electrolytes and interface engineering toward the practical applications of next-generation metal-CO_(2)batteries.
文摘AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we organized this special issue entitled"Innovative Pharmaceutical Research Driven by AI",and collected Original research articles,Reviewpapers.
基金funded by 2024 Scientific Research Project of Chongqing Medical and Pharmaceutical College(No.ygzrc2024101)Chongqing Education Commission Natural Science Foundation(No.KJQN202402821)+2 种基金Chongqing Shapingba District Science and Technology Bureau Project(No.2024071)2024 Chongqing Medical and Pharmaceutical College Innovation Research Group Project(No.ygz2024401)Chongqing Science and Health Joint Medical Research Project(No.2024SQKWLHMS051),respectively.
文摘Yeast-based models have become a powerful platform in pharmaceutical research,offering significant potential for producing complex drugs,vaccines,and therapeutic agents.While many current drugs were discovered before fully understanding their molecular mechanisms,yeast systems now provide valuable insights for drug discovery and personalized medicine.Recent advancements in genetic engineering,metabolic engineering,and synthetic biology have improved the efficiency and scalability of yeast-based production systems,enabling more sustainable and cost-effective manufacturing processes.This paper reviews the latest developments in yeast-based technologies,focusing on their use as model organisms to study disease mechanisms,identify drug targets,and develop novel therapies.We highlight key platforms such as the yeast two-hybrid system,surface display technologies,and optimized expression systems.Additionally,we explore the future integration of yeast engineering with artificial intelligence(AI),machine learning(ML),and advanced genome editing technologies like CRISPR/Cas9,which are expected to accelerate drug discovery and enable personalized therapies.Furthermore,yeast-based systems are increasingly employed in largescale drug production,vaccine development,and therapeutic protein expression,offering promising applications in clinical and industrial settings.This paper discusses the practical implications of these systems and their potential to revolutionize drug development,paving the way for safer,more effective therapies.
