Preterm birth(PTB),defined as delivery before 37 weeks of gestation,is the most common adverse pregnancy outcome[1].PTB is a global health concern,with an estimated 13.4 million cases in 2020[1],accounting for more th...Preterm birth(PTB),defined as delivery before 37 weeks of gestation,is the most common adverse pregnancy outcome[1].PTB is a global health concern,with an estimated 13.4 million cases in 2020[1],accounting for more than one in 10 births worldwide.Compared to full-term births,PTBs are associated with a higher risk of short-and long-term complications,including bronchopulmonary dysplasia,necrotizing enterocolitis,visual impairment,and cerebral injuries[2].Despite substantial research efforts to prevent PTB,the global PTB rate has shown little improvement over the past decade[1].Therefore,identifying additional risk factors remains a critical goal in preventing PTB.展开更多
Korla fragrant pears are one of the“famous,excellent,and special”fruits in Xinjiang.They belong to the white pear variety in the genus Pyrus of the Rosaceae family.With a long-standing planting history and strong re...Korla fragrant pears are one of the“famous,excellent,and special”fruits in Xinjiang.They belong to the white pear variety in the genus Pyrus of the Rosaceae family.With a long-standing planting history and strong regional characteristics,they are mainly produced in southern Xinjiang.Due to unique natural conditions such as large temperature differences between day and night and sufficient sunlight,Korla fragrant pears have a crispy texture,a sweet but not cloying taste,and their flesh is delicate and juicy,with excellent quality.Korla fragrant pears contain a variety of bioactive substances,mainly including polysaccharides,polyphenolic compounds,flavonoid compounds,triterpenoids,and sterols.They have medical effects such as“moistening the lungs,calming the heart,reducing phlegm,anti-inflammation,relieving cough,and resolving carbuncle toxins”.Uyghur and Mongolian medicine often use them as a good dietary therapy product.Based on recent literature reports,this paper reviews the main chemical constituents and pharmacological effects of Korla fragrant pears,aiming to provide references for the research and utilization of the deep processing of Korla fragrant pears.展开更多
Besides its ornamental value, Hotan rose is widely used in medicine, health products, cosmetics, food, essential oil and other fields. It is necessary to conduct in-depth research on its chemical constituents and phar...Besides its ornamental value, Hotan rose is widely used in medicine, health products, cosmetics, food, essential oil and other fields. It is necessary to conduct in-depth research on its chemical constituents and pharmacological effects. This paper mainly discusses the application value and chemical constituents of Hotan rose, aiming at providing a certain basis for enhancing its application value and expanding its application fields.展开更多
Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blu...Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blumenol A （2）, （3S,5R,6S,7E,9R）-5,6-epoxy-3,9-dihydroxy-7-megastigmene （3）, 3β-hydroxy-5a,6a-epoxy-γ-megastigmen-9-one （4）, ixerol B （5）, （-）-dehydrovomifoliol （6）, 3S,5R-dihydroxy-6S,7-megastigmadien-9-one （7）, loliotide （8）, （＋）-dehydrololiolide （9）, （＋）-medioresinol （10）, 4-oxopinoresinol （11）, tormentic acid （12）, and indole-3-carboxylic acid （13）. Compounds 2-13 described above were isolated from this genus for the first time.展开更多
Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial pa...Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial parts and the roots are used in traditional Chinese medicine for differentmedications. The roots are often used to treat inflammation, snake bite, bruises and injuries,tonsillitis, mastitis, scrofula, and cancer for their antibacterial, anti-inflammatory, andantineoplastic activities. The aerial parts are used for the treatment of mastitis, bruises, andheart diseases, such as endomyocarditis. The medicinal usage of this plant prompted us toinvestigate its chemical constituents. As a result, nine compounds 1-9 ( see Figure 1) were isolatedfrom the roots of S. adoxoides. Among them, compounds 1-7 and 9 were isolated from the genusSemiaquilegia for the first time.展开更多
The aim of current study was to investigate the chemical constituents from the flowers of Rhododendron molle G. Don. The isolation and purification of components were achieved by a series of chromatography including s...The aim of current study was to investigate the chemical constituents from the flowers of Rhododendron molle G. Don. The isolation and purification of components were achieved by a series of chromatography including silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were identified based on 1D, 2D NMR, and mass spectral analysis. Fifteen known compounds were isolated and their structures were identified as 2E,4Z-abscisic acid（1）, 2α-hydroxy-oleanolic acid（2）, oleanic acid（3）, asiatic acid（4）, benzyl glucoside（5）, dibutyl phthalate（6）, β-sitosterol（7）, vitexin（8）, quercetin（9）, steraric acid（10）, rhodomollein I（11）, rhodojaponin VI（12）, rhodomollein XI（13）, rhodojaponin II（14）, kalmanol（15）. Compounds 1–10 were isolated from Rhododendron molle for the first time.展开更多
Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column...Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy.Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-(4'- methoxyphenylethyl)ether(1),1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose(2),4-ethoxy-phenylethanol acetate(3),p-hydroxyacetophenone (4),p-hydroxy-benzoic acid ethylester(5),4-hydroxybenzoic acid(6),4-hydroxybenzaldehyde(7),R(-)-mellein (8),stigmasterol(9),4-methoxy-phenylethanol(10),and methylgallate(11).Among them,1 and 2 are new compounds; compounds 3,5,7,8,and 10 were isolated from Rhodiola genus for the first time;and compounds 4,6,9,and 11 were isolated from Rhodiola kirilowii(Regl) Maxim.for the first time.展开更多
Abstract： To investigate the chemical constituents of the roots of Polygala wattersii Hance, the separation and purification were performed by solvent extraction and repeated column chromatography （CC） on silica ge...Abstract： To investigate the chemical constituents of the roots of Polygala wattersii Hance, the separation and purification were performed by solvent extraction and repeated column chromatography （CC） on silica gel, Sephadex LH-20 and macroporous resin D101, preparative TLC and semi-preparative HPLC. The structures were identified by spectroscopic analysis and comparison of their 1H and 13C NMR data with those reported in literatures. Twenty-three known compounds, including eleven xanthones （1-11）, nine sugar esters （12-20）, two triterpenoid saponins （21 and 22） and one phenylpropanoid （23） were isolated and their structures were identified as 1,3-dihydroxyxanthone （1）, 1-hydroxy-3-methoxyxanthone （2）, 1,3-dihydroxy-2-methoxyxanthone （3）, 1,3,7-trihydroxy-2- methoxyxanthone （4）, 1,3,6-trihydroxy-2,7-dimethoxyxanthone （5）, 1,6,7-trihydroxy-2,3-dimethoxyxanthone （6）, 1,7-dihydroxy- 2,3-methylenedioxyxanthone （7）, 1,7-dimethoxyxanthone （8）, 1,2,3-trimethoxyxanthone （9）, 1-methoxy-2,3-methylenedioxyxanthone （10）, 6-hydroxy-0-methoxy-2,3-methylenedioxyxanthone （11）, 3＇-O-feruloyl-6-O-acetyl sucrose （12）, arillatose B （13）, sibricose A5 （14）, sibricose A6 （15）, 3＇,6-di-O-sinapoyl sucrose （16）, tenufoliside A （17）, 3＇-O-3,4,5-trimethoxycinnamoyl-6-O-p-methoxybenzoyl sucrose （18）, glomeratose A （19）, 1-O-p-coumaroyl-D-glucopyranose （20）, bayogenin-3-O-glucoside （21）, tenufolin （22）, and sinapic acid （23）. Among them, compounds 2 and 12 were obtained from genus Polygala for the first time, and except compound 16, all others were isolated from this species for the first time.展开更多
Fructus corni is the dried sarcocarp of Cornus officinalis Sieb.et Zucc.It has been used as an important traditional Chinese medicine.Its action is to protect liver and kidney and regulate the essence of human body.In...Fructus corni is the dried sarcocarp of Cornus officinalis Sieb.et Zucc.It has been used as an important traditional Chinese medicine.Its action is to protect liver and kidney and regulate the essence of human body.In this paper,the research progress on the chemical ingredients and pharmacological activities of Fructus corni are reviewed.According to its pharmacological activities,some suggestions for future research and development have been made.展开更多
To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidate...To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidated based on spectro- scopic data. Fourteen compounds were isolated and their structures were identified as brazilin （1）, sappanone B （2）, （E）-3-（3,4- dihydroxybenzylidene）-7-hydroxychroman-4-one （3）, 3-deoxysappanone B （4）, brazilide A （5）, euxanthone （6）, quercetin （7）, rhamnetin （8）, sappanchalcone （9）, 3-deoxysappanchalcone （10）, butein （11）, 2,4,5-trihydroxybenzaldehyde （12）, 3,8,9-trihydroxy- 6H-benzo[c]chromen-6-one （13） and 13-sitosterol （14）. Compounds 12 and 13 were two new natural compounds, and the ^13C NMR data of compound 13 were reported for the first time. Compound 6 was the first xanthone isolated from the genus Caesalpinia.展开更多
The aim of this study is to perform a phytochemical investigation of the aerial parts of Murraya tetramera Huang. Nine compounds were isolated by silica gel and Sephadex LH-20 chromatography, together with preparative...The aim of this study is to perform a phytochemical investigation of the aerial parts of Murraya tetramera Huang. Nine compounds were isolated by silica gel and Sephadex LH-20 chromatography, together with preparative TLC and HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these nine compounds were identified as 3,3＇-[oxybis（methylene）]bis（9-methoxy-9H-carbazole）（1）, murrastifoline B（2）, murrayaquinone A（3）, 2,4-dimethoxyphenol（4）, 1,2-dimethoxy-4-nitrobenzene（5）, 3-methylanisole（6）,（–）-syringaresinol-4-O-β-D-glucopyranoside（7）, β-sitosterol（8）, and octadecanyl-3-methoxy-4-hydroxylbenzeneacrylate（9）, respectively. Among them, compounds 4–6 and 9 were described from the genus Murraya for the first time, and compounds 2–9 were isolated from M. tetramera for the first time.展开更多
Phytochemical investigation of the decoction of Urtica fissa rhizomes led to the isolation of 23 known compounds. Their structures were identified as medioresinol dimethyl ether （1）, L-pyroglutamic acid methyl ester...Phytochemical investigation of the decoction of Urtica fissa rhizomes led to the isolation of 23 known compounds. Their structures were identified as medioresinol dimethyl ether （1）, L-pyroglutamic acid methyl ester （2）, nicotinic acid （3）, L-pyroglutamic acid （4）, erythritol （5）, 6-methyl-2＇-deoxy thymidine （6）, 2-methyl-6-（2＇,3＇,4＇-trihydroxybutyl）-pyrazine （7）, 5-hydroxyl-2-hydroxymethyl pyridine （8）, adenine （9）, uracil （10）, thymine （11）, adenosine （12）, inosine （13）, 2＇-deoxyadenosine （14）, 2＇-deoxyguanosine （15）, 2＇-deoxyinosine （16）, uridine （17）, n-butyl-O-β-D-fructopyranoside （18）, di-D-fructose （19）, β-D-fructofuranosyl- α-D-galactopyranoside （20）, his （5-formyl-furfuryl） ether （21）, chlorogenic acid （22）, and 5-hydroxymethyl furaldehyde （23） by spectroscopic methods. In addition, a total of 20 compounds （1-20） were isolated from U. fissa for the first time. Meanwhile, compounds 1, 6, 7, 8, 19 and 20 were isolated from the Urticaceae plants for the first time.展开更多
To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eigh...To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eight compounds were isolated from Hedysarumgmelinii, including three triteipenoids, two flavonoids and two other compounds. Their structureswere identified as squasapogenol (1), soyasapogenol (2), lupeol (3), 3, 9-dihydroxy coumestan (4),3-hydroxy-9-me-thoxy pterocarpan (5), β-sitosterol (6), palmatic acid (7), and hexadecanoic acid 2,3-dihydroxypropyl ester (8). Conclusion All the compounds have been isolated from this plant forthe first time. Compounds 1 — 4 and 8 were obtained from this genus for the first time. The NMRdata of 1 are reported for the first time.展开更多
Fifteen compounds were isolated from the processed seeds of Strychnos nux-vomica and were identified as follows：strychnine（1）,brucine（2）,pseudostrychnine（3）,pseudobrucine（4）,secoxyloganin（5）,caffeic acid（6...Fifteen compounds were isolated from the processed seeds of Strychnos nux-vomica and were identified as follows：strychnine（1）,brucine（2）,pseudostrychnine（3）,pseudobrucine（4）,secoxyloganin（5）,caffeic acid（6）,p-hydroxybenzoic acid（7）,p-hydroxyphenylacetic acid（8）,uvaol（9）,stigmasta-7,22,25-triene-3-ol（10）,lupeol（11）,11-oxo-α-amyrin palmitate（12）,catechol（13）,maltol（14）,adenosine（15）.Compounds 5-15 were isolated from genus Strychnos for the first time.展开更多
Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterp...Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include： anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.展开更多
Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The cons...Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The constituents were separated and purified by different chromatographic methods, and their structures were elucidated by IR, MS and NMR techniques. Results Twenty eight compounds were isolated from the flower buds of T. farfara. Their structures were identified as n- heptacosane （1）, bis（2-ethylhexyl）phthalate （2）, 7β-[3＇-ethylcrotonoyloxy]-1α-[2＇-methylbutyryloxy]-3,14-dehydro-Z-notonipetranone （3）, 7β-[3＇-ethylcrotonoyloxy]-1α-[2＇-methylbutyryloxy]-3,14-dehydro-E-notonipetranone （4）, tussilagone （5）, dibutyl phthalate （6）, bauer-7-ene-3β,16α-diol （7）, isobauerenol （8）, stigmasterol （9）, β-sitosterol （10）, 2,2-dimethyl-6-acetylchromanone （11）, n- hexadecanoic acid （12）, 7β-hydroxysitosterol （13）, 7α-hydroxysitosterol （14）, 7,14-bisdesacylnotonipetrone （15）, 2,3- dihydroxypropylpalmitate （16）, daucosterol （17）, 6-hydroxy-2,6-dimethylhept-2-en-4-one （18）, ferulic acid （19）, isoferulic acid （20）, caffeic acid （21）, α-D-glucose （22）, sucrose （23）, phthalic acid （24）, p-hydroxybenzoic acid （25）, gallic acid （26）, uridine （27）, and adenosine （28）. Conclusion Compounds 1, 12-16, 18 and 20 were obtained from the genus Tussilago for the first time.展开更多
Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 colu...Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 columns. The structures were elucidated by spectral analysis. Results Thirteen compounds were isolated and their structures were identified as （-）-syringaresinol （1）, syringaresinol-4-O-β-D-glucopyranoside （2）, syringaresinol-4,4′-bis-O-β-D-glucopyranoside （3）, （±）-catechin （4）, catechin-3-O- β-D-glucopyranoside （5）, catechin-5-O-β-D-glucopyranoside （6）, 1,3-bis-（4-hydroxy-3,5-dimethoxyphenyl）-1,3-propanediol （7）, （R）-（＋）-chaulmoogric acid （8）, friedelin （9）, uracile （10）, benzoic acid （11）, vaniUic acid （12）, and 4-hydroxybenzoic acid （13）. Conclusion All the compounds described above were isolated from this genus for the first time.展开更多
Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spe...Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.展开更多
To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS column...To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS columns, and semiprep. HPLC. The structures were elucidated by spectral analysis. Twelve known compounds were isolated and identified as tenuifoliside A （1）, tenuifoliside B （2）, glomeratose A （3）, 3＇,6-disinapoyl sucrose （4）, sibiricose A5 （5）, sibiricose A6 （6）, sibiricose A1 （7）, sibiricose A2 （8）, polygalatenoside E （9）, 1-O-L-arabinopyranosyl-O-（6→1）-β-D-glucopyranosyl-salicylate （10）, canthoside A （11）, and methyl- 3,4,5-trimethoxycinnamate （12）. Compound 11 was obtained from genus Polygala for the first time, and compounds 2, 9, 10 and 12 were isolated from this plant for the first time.展开更多
In the present research, in order to study the chemical constituents ofPaliurus ramosissimus （Lour.） Poir., the isolation of its ingredients was performed by repeated chromatography on silica gel, Sephadex LH-20, OD...In the present research, in order to study the chemical constituents ofPaliurus ramosissimus （Lour.） Poir., the isolation of its ingredients was performed by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were elucidated on the basis of combination of mass spectrometry and 1D, 2D NMR spectroscopy. A total of 8 compounds were obtained, and their structures were identified as 313-hydroxy-27-（3,4-dihydroxybenzoyl）oxylup-20（29）-en- 28-oic acid （1）, betulinic acid （2）, lupeol （3）, 27-O-trans-caffeoylcylicodiscic acid （4）, ceanothic acid （5）, 24-hydroxyceanothic acid （6）, dihydrokaempferol （7）, eriodictyol （8）. Among them, compound 1 was a new compound. Compounds 3-4, 7-8 were isolated from Paliurus ramosissimus （Lour.） Poir. for the first time.展开更多
基金supported by the National Natural Science Foundation of China(8200340181972981)+1 种基金the Scientific and Technological Project of Henan Province(222102310150,China)the Open Research Fund of the National Health Commission Key Laboratory of Birth Defects Prevention(NHCKLBDP202504,China).
文摘Preterm birth(PTB),defined as delivery before 37 weeks of gestation,is the most common adverse pregnancy outcome[1].PTB is a global health concern,with an estimated 13.4 million cases in 2020[1],accounting for more than one in 10 births worldwide.Compared to full-term births,PTBs are associated with a higher risk of short-and long-term complications,including bronchopulmonary dysplasia,necrotizing enterocolitis,visual impairment,and cerebral injuries[2].Despite substantial research efforts to prevent PTB,the global PTB rate has shown little improvement over the past decade[1].Therefore,identifying additional risk factors remains a critical goal in preventing PTB.
基金Science and Technology Achievements Transformation Project of the Autonomous Prefecture(Project No.:202401)National College Students'Innovation and Entrepreneurship Training Program(Project Title:"Li Zhiyun·Ku Li Chun"-Pioneer in Promoting National Geographic Brand,Project Number:202513561005).
文摘Korla fragrant pears are one of the“famous,excellent,and special”fruits in Xinjiang.They belong to the white pear variety in the genus Pyrus of the Rosaceae family.With a long-standing planting history and strong regional characteristics,they are mainly produced in southern Xinjiang.Due to unique natural conditions such as large temperature differences between day and night and sufficient sunlight,Korla fragrant pears have a crispy texture,a sweet but not cloying taste,and their flesh is delicate and juicy,with excellent quality.Korla fragrant pears contain a variety of bioactive substances,mainly including polysaccharides,polyphenolic compounds,flavonoid compounds,triterpenoids,and sterols.They have medical effects such as“moistening the lungs,calming the heart,reducing phlegm,anti-inflammation,relieving cough,and resolving carbuncle toxins”.Uyghur and Mongolian medicine often use them as a good dietary therapy product.Based on recent literature reports,this paper reviews the main chemical constituents and pharmacological effects of Korla fragrant pears,aiming to provide references for the research and utilization of the deep processing of Korla fragrant pears.
基金Supported by Scientific Research Project of Central Asia Drug Research and Development Center, Chinese Academy of Sciences (CAM202204).
文摘Besides its ornamental value, Hotan rose is widely used in medicine, health products, cosmetics, food, essential oil and other fields. It is necessary to conduct in-depth research on its chemical constituents and pharmacological effects. This paper mainly discusses the application value and chemical constituents of Hotan rose, aiming at providing a certain basis for enhancing its application value and expanding its application fields.
基金National Natural Science Foundation of China(Grant No.31270390)Program for New Century Excellent Talents in University(Grant No.NCET-08-0224)
文摘Phytochemical investigation of the leaves of Premna microphylla Turcz led to the isolation of 13 known compounds. Based on spectroscopic and chemical evidences, their structures were identified as diosmetin （1）, blumenol A （2）, （3S,5R,6S,7E,9R）-5,6-epoxy-3,9-dihydroxy-7-megastigmene （3）, 3β-hydroxy-5a,6a-epoxy-γ-megastigmen-9-one （4）, ixerol B （5）, （-）-dehydrovomifoliol （6）, 3S,5R-dihydroxy-6S,7-megastigmadien-9-one （7）, loliotide （8）, （＋）-dehydrololiolide （9）, （＋）-medioresinol （10）, 4-oxopinoresinol （11）, tormentic acid （12）, and indole-3-carboxylic acid （13）. Compounds 2-13 described above were isolated from this genus for the first time.
基金Ministry of Science and Technology of People'sRepublic of China (No. 2004AA2Z3730)
文摘Semiaquilegia adoxoides ( DC. ) Makino ( Chinese name ''Tian-Kui-Zi'' ) , theonly species of genus Semiaquilegia, belongs to the Ranunculaceae family. As a perennial herbaceousplant, both the aerial parts and the roots are used in traditional Chinese medicine for differentmedications. The roots are often used to treat inflammation, snake bite, bruises and injuries,tonsillitis, mastitis, scrofula, and cancer for their antibacterial, anti-inflammatory, andantineoplastic activities. The aerial parts are used for the treatment of mastitis, bruises, andheart diseases, such as endomyocarditis. The medicinal usage of this plant prompted us toinvestigate its chemical constituents. As a result, nine compounds 1-9 ( see Figure 1) were isolatedfrom the roots of S. adoxoides. Among them, compounds 1-7 and 9 were isolated from the genusSemiaquilegia for the first time.
基金National Natural Science Foundation of China(Grant No.81172943)
文摘The aim of current study was to investigate the chemical constituents from the flowers of Rhododendron molle G. Don. The isolation and purification of components were achieved by a series of chromatography including silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were identified based on 1D, 2D NMR, and mass spectral analysis. Fifteen known compounds were isolated and their structures were identified as 2E,4Z-abscisic acid（1）, 2α-hydroxy-oleanolic acid（2）, oleanic acid（3）, asiatic acid（4）, benzyl glucoside（5）, dibutyl phthalate（6）, β-sitosterol（7）, vitexin（8）, quercetin（9）, steraric acid（10）, rhodomollein I（11）, rhodojaponin VI（12）, rhodomollein XI（13）, rhodojaponin II（14）, kalmanol（15）. Compounds 1–10 were isolated from Rhododendron molle for the first time.
基金National Natural Science Foundation of China (Grant No.30973628).
文摘Chemical constituents of the whole herb of Rhodiola kirilowii(Regl) Maxim.were investigated.The separation of the constituents was achieved by using a combination of various chromatographic techniques including column chromatography over silica gel,ODS,Sephadex LH-20 and reversed-phase HPLC.Their structures were elucidated by spectroscopic techniques including 1D and 2D NMR spectroscopy.Eleven compounds were obtained and identified as 4-hydroxyphenylethyl-(4'- methoxyphenylethyl)ether(1),1-(2-hydroxy-2-methylbutanoate)-β-D-glucopyranose(2),4-ethoxy-phenylethanol acetate(3),p-hydroxyacetophenone (4),p-hydroxy-benzoic acid ethylester(5),4-hydroxybenzoic acid(6),4-hydroxybenzaldehyde(7),R(-)-mellein (8),stigmasterol(9),4-methoxy-phenylethanol(10),and methylgallate(11).Among them,1 and 2 are new compounds; compounds 3,5,7,8,and 10 were isolated from Rhodiola genus for the first time;and compounds 4,6,9,and 11 were isolated from Rhodiola kirilowii(Regl) Maxim.for the first time.
基金The National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09301002-002-002,2012ZX09304-005)special funds for scientific research on traditional Chinese medicine(Grant No.201307002)National Science Fund for Excellent Young Scholars(Grant No.81222051)
文摘Abstract： To investigate the chemical constituents of the roots of Polygala wattersii Hance, the separation and purification were performed by solvent extraction and repeated column chromatography （CC） on silica gel, Sephadex LH-20 and macroporous resin D101, preparative TLC and semi-preparative HPLC. The structures were identified by spectroscopic analysis and comparison of their 1H and 13C NMR data with those reported in literatures. Twenty-three known compounds, including eleven xanthones （1-11）, nine sugar esters （12-20）, two triterpenoid saponins （21 and 22） and one phenylpropanoid （23） were isolated and their structures were identified as 1,3-dihydroxyxanthone （1）, 1-hydroxy-3-methoxyxanthone （2）, 1,3-dihydroxy-2-methoxyxanthone （3）, 1,3,7-trihydroxy-2- methoxyxanthone （4）, 1,3,6-trihydroxy-2,7-dimethoxyxanthone （5）, 1,6,7-trihydroxy-2,3-dimethoxyxanthone （6）, 1,7-dihydroxy- 2,3-methylenedioxyxanthone （7）, 1,7-dimethoxyxanthone （8）, 1,2,3-trimethoxyxanthone （9）, 1-methoxy-2,3-methylenedioxyxanthone （10）, 6-hydroxy-0-methoxy-2,3-methylenedioxyxanthone （11）, 3＇-O-feruloyl-6-O-acetyl sucrose （12）, arillatose B （13）, sibricose A5 （14）, sibricose A6 （15）, 3＇,6-di-O-sinapoyl sucrose （16）, tenufoliside A （17）, 3＇-O-3,4,5-trimethoxycinnamoyl-6-O-p-methoxybenzoyl sucrose （18）, glomeratose A （19）, 1-O-p-coumaroyl-D-glucopyranose （20）, bayogenin-3-O-glucoside （21）, tenufolin （22）, and sinapic acid （23）. Among them, compounds 2 and 12 were obtained from genus Polygala for the first time, and except compound 16, all others were isolated from this species for the first time.
基金National Natural Science Foundation of China (Grant No.30873438/c190801).
文摘Fructus corni is the dried sarcocarp of Cornus officinalis Sieb.et Zucc.It has been used as an important traditional Chinese medicine.Its action is to protect liver and kidney and regulate the essence of human body.In this paper,the research progress on the chemical ingredients and pharmacological activities of Fructus corni are reviewed.According to its pharmacological activities,some suggestions for future research and development have been made.
文摘To study the chemical constituents of Sappan Lignum. Chemical constituents were isolated by method of solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and ODS. The structures were elucidated based on spectro- scopic data. Fourteen compounds were isolated and their structures were identified as brazilin （1）, sappanone B （2）, （E）-3-（3,4- dihydroxybenzylidene）-7-hydroxychroman-4-one （3）, 3-deoxysappanone B （4）, brazilide A （5）, euxanthone （6）, quercetin （7）, rhamnetin （8）, sappanchalcone （9）, 3-deoxysappanchalcone （10）, butein （11）, 2,4,5-trihydroxybenzaldehyde （12）, 3,8,9-trihydroxy- 6H-benzo[c]chromen-6-one （13） and 13-sitosterol （14）. Compounds 12 and 13 were two new natural compounds, and the ^13C NMR data of compound 13 were reported for the first time. Compound 6 was the first xanthone isolated from the genus Caesalpinia.
基金National Science Fund for Excellent Young Scholars(Grant No.81222051)National Key Technology R&D Program “New Drug Innovation” of China(Grant Nos.2012ZX09301002-002-002 and 2012ZX09304-005)
文摘The aim of this study is to perform a phytochemical investigation of the aerial parts of Murraya tetramera Huang. Nine compounds were isolated by silica gel and Sephadex LH-20 chromatography, together with preparative TLC and HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these nine compounds were identified as 3,3＇-[oxybis（methylene）]bis（9-methoxy-9H-carbazole）（1）, murrastifoline B（2）, murrayaquinone A（3）, 2,4-dimethoxyphenol（4）, 1,2-dimethoxy-4-nitrobenzene（5）, 3-methylanisole（6）,（–）-syringaresinol-4-O-β-D-glucopyranoside（7）, β-sitosterol（8）, and octadecanyl-3-methoxy-4-hydroxylbenzeneacrylate（9）, respectively. Among them, compounds 4–6 and 9 were described from the genus Murraya for the first time, and compounds 2–9 were isolated from M. tetramera for the first time.
基金National Natural Science Foundation of China(G rant No.81374067)
文摘Phytochemical investigation of the decoction of Urtica fissa rhizomes led to the isolation of 23 known compounds. Their structures were identified as medioresinol dimethyl ether （1）, L-pyroglutamic acid methyl ester （2）, nicotinic acid （3）, L-pyroglutamic acid （4）, erythritol （5）, 6-methyl-2＇-deoxy thymidine （6）, 2-methyl-6-（2＇,3＇,4＇-trihydroxybutyl）-pyrazine （7）, 5-hydroxyl-2-hydroxymethyl pyridine （8）, adenine （9）, uracil （10）, thymine （11）, adenosine （12）, inosine （13）, 2＇-deoxyadenosine （14）, 2＇-deoxyguanosine （15）, 2＇-deoxyinosine （16）, uridine （17）, n-butyl-O-β-D-fructopyranoside （18）, di-D-fructose （19）, β-D-fructofuranosyl- α-D-galactopyranoside （20）, his （5-formyl-furfuryl） ether （21）, chlorogenic acid （22）, and 5-hydroxymethyl furaldehyde （23） by spectroscopic methods. In addition, a total of 20 compounds （1-20） were isolated from U. fissa for the first time. Meanwhile, compounds 1, 6, 7, 8, 19 and 20 were isolated from the Urticaceae plants for the first time.
基金National Natural Science Foundation of China (20432030)
文摘To study the chemical constituents of Hedysarum gmelinii. Methods Theconstituents were separated and purified by different methods of chromatography, and theirstructures were elucidated by DR, MS and NMR. Results Eight compounds were isolated from Hedysarumgmelinii, including three triteipenoids, two flavonoids and two other compounds. Their structureswere identified as squasapogenol (1), soyasapogenol (2), lupeol (3), 3, 9-dihydroxy coumestan (4),3-hydroxy-9-me-thoxy pterocarpan (5), β-sitosterol (6), palmatic acid (7), and hexadecanoic acid 2,3-dihydroxypropyl ester (8). Conclusion All the compounds have been isolated from this plant forthe first time. Compounds 1 — 4 and 8 were obtained from this genus for the first time. The NMRdata of 1 are reported for the first time.
基金Research Platform for Quality Standard of TCM and Information System Building(Grant No.2009ZX09308-04)National S&T Major Project-Created Major New Drugs Projects(Grant No.2009ZX09311-004)
文摘Fifteen compounds were isolated from the processed seeds of Strychnos nux-vomica and were identified as follows：strychnine（1）,brucine（2）,pseudostrychnine（3）,pseudobrucine（4）,secoxyloganin（5）,caffeic acid（6）,p-hydroxybenzoic acid（7）,p-hydroxyphenylacetic acid（8）,uvaol（9）,stigmasta-7,22,25-triene-3-ol（10）,lupeol（11）,11-oxo-α-amyrin palmitate（12）,catechol（13）,maltol（14）,adenosine（15）.Compounds 5-15 were isolated from genus Strychnos for the first time.
基金Supported by the State Key Development Program for Basic Research of ChinaScientific and Technological Development Project of Shandong Province(2008GG2NS02022)~~
文摘Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include： anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.
基金The National High-Tech"863"Project(Grant No.2004AA2Z3730-07)State Projects of the Tenth-Five-year Plan(Grant No.2001-BA701A62-11).
文摘Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The constituents were separated and purified by different chromatographic methods, and their structures were elucidated by IR, MS and NMR techniques. Results Twenty eight compounds were isolated from the flower buds of T. farfara. Their structures were identified as n- heptacosane （1）, bis（2-ethylhexyl）phthalate （2）, 7β-[3＇-ethylcrotonoyloxy]-1α-[2＇-methylbutyryloxy]-3,14-dehydro-Z-notonipetranone （3）, 7β-[3＇-ethylcrotonoyloxy]-1α-[2＇-methylbutyryloxy]-3,14-dehydro-E-notonipetranone （4）, tussilagone （5）, dibutyl phthalate （6）, bauer-7-ene-3β,16α-diol （7）, isobauerenol （8）, stigmasterol （9）, β-sitosterol （10）, 2,2-dimethyl-6-acetylchromanone （11）, n- hexadecanoic acid （12）, 7β-hydroxysitosterol （13）, 7α-hydroxysitosterol （14）, 7,14-bisdesacylnotonipetrone （15）, 2,3- dihydroxypropylpalmitate （16）, daucosterol （17）, 6-hydroxy-2,6-dimethylhept-2-en-4-one （18）, ferulic acid （19）, isoferulic acid （20）, caffeic acid （21）, α-D-glucose （22）, sucrose （23）, phthalic acid （24）, p-hydroxybenzoic acid （25）, gallic acid （26）, uridine （27）, and adenosine （28）. Conclusion Compounds 1, 12-16, 18 and 20 were obtained from the genus Tussilago for the first time.
基金Program for Changjiang Scholar and InnovativeTeam in Peking University (Grant number: 985-2-063-112).
文摘Aim To study the chemical constituents from the stems of Xylosma controversum Clos. Methods The constituents were isolated by solvent extraction, repeated chromatography with silica gel, Sephadex LH-20, and RP-18 columns. The structures were elucidated by spectral analysis. Results Thirteen compounds were isolated and their structures were identified as （-）-syringaresinol （1）, syringaresinol-4-O-β-D-glucopyranoside （2）, syringaresinol-4,4′-bis-O-β-D-glucopyranoside （3）, （±）-catechin （4）, catechin-3-O- β-D-glucopyranoside （5）, catechin-5-O-β-D-glucopyranoside （6）, 1,3-bis-（4-hydroxy-3,5-dimethoxyphenyl）-1,3-propanediol （7）, （R）-（＋）-chaulmoogric acid （8）, friedelin （9）, uracile （10）, benzoic acid （11）, vaniUic acid （12）, and 4-hydroxybenzoic acid （13）. Conclusion All the compounds described above were isolated from this genus for the first time.
文摘Aim To investigate the chemical constituents from Potentilla multifida L..Methods Chromatographic technique was employed for the isolation and purification of theconstituents, and the structures were identified by spectral evidence. Results Four compounds wereisolated involving ade-nosine (1), apigenin-6-C-arabinopyranosyl-8-C-glucopyranoside (2),apigenin-7-O-β-D-glucuronide (3) and luteolin-7-O-β-D-glucuronide (4). Conclusion The fourcompounds were obtained from the genus Potentilla for the first time.
基金Program for Changjiang Scholar and Innovative Team in University(Grant No.985-2-063-112)Program for New Century Excellent Talents in University(Grant No.985-2-102-113).
文摘To investigate the chemical constituents of the roots ofPolygala sibirica L. The separation and purification were performed by solvent extraction and repeated chromatography with silica gel, Sephadex LH-20, ODS columns, and semiprep. HPLC. The structures were elucidated by spectral analysis. Twelve known compounds were isolated and identified as tenuifoliside A （1）, tenuifoliside B （2）, glomeratose A （3）, 3＇,6-disinapoyl sucrose （4）, sibiricose A5 （5）, sibiricose A6 （6）, sibiricose A1 （7）, sibiricose A2 （8）, polygalatenoside E （9）, 1-O-L-arabinopyranosyl-O-（6→1）-β-D-glucopyranosyl-salicylate （10）, canthoside A （11）, and methyl- 3,4,5-trimethoxycinnamate （12）. Compound 11 was obtained from genus Polygala for the first time, and compounds 2, 9, 10 and 12 were isolated from this plant for the first time.
基金National Natural Science Foundation of China(Grant No.81172943)
文摘In the present research, in order to study the chemical constituents ofPaliurus ramosissimus （Lour.） Poir., the isolation of its ingredients was performed by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were elucidated on the basis of combination of mass spectrometry and 1D, 2D NMR spectroscopy. A total of 8 compounds were obtained, and their structures were identified as 313-hydroxy-27-（3,4-dihydroxybenzoyl）oxylup-20（29）-en- 28-oic acid （1）, betulinic acid （2）, lupeol （3）, 27-O-trans-caffeoylcylicodiscic acid （4）, ceanothic acid （5）, 24-hydroxyceanothic acid （6）, dihydrokaempferol （7）, eriodictyol （8）. Among them, compound 1 was a new compound. Compounds 3-4, 7-8 were isolated from Paliurus ramosissimus （Lour.） Poir. for the first time.
