pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic self-assembly.The morphology,particle size and zeta potential of the nanocomposites were analyzed by transmission electron microsc...pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic self-assembly.The morphology,particle size and zeta potential of the nanocomposites were analyzed by transmission electron microscopy and dynamic light scattering.The synthesis of the polymer was analyzed by^(1)H-NMR.The zeta-potential changes and cellular uptake effects of the nanocomplexes under different pH environments were investigated.The experimental results show that the surface morphology of the nanocomposite is spherical,and the average particle size is about 135 nm.As the pH value of the solution gradually decreases,the surface charge of the nanocomposite reverses from negative charge to positive charge(from-9.4 to+17.1 mV).Cellular uptake mediated by pH-responsive nanocomposite is selective for tumor cells,and the cellular uptake effect in tumor cells at pH 6.5 was approximately 3 times higher than that at pH 7.4.This pH responsive charge reversal nanocomposite has promising application prospects for gene delivery in the weak acid environment of tumors.展开更多
Nanostructured TiO2 with differentiate morphologies has attracted tremendous attention due to its wide band-gap nature as well as outstanding optical and electric properties for solar-driven light-toelectricity conver...Nanostructured TiO2 with differentiate morphologies has attracted tremendous attention due to its wide band-gap nature as well as outstanding optical and electric properties for solar-driven light-toelectricity conversion application. Layered-stacking TiO2 film such as double-layer, tri-layer, quadrupleor quintuplicate-layer, is highly desirable to the design of high-performance semiconductor material photoanodes and the development of advanced photovoltaic devices. In this minireview, we will summarize the recent progress and achievements on proof-of-concept of layered-stacking TiO2 films（LTFs） for solar cells with emphasis on the tailored properties and synergistic functionalization of LTFs, such as optimized sensitizer adsorption, broadened light confinement as well as facilitated electron transport characteristics.Various demonstrations of LTFs photovoltaic systems provide lots of possibilities and flexibilities for more efficient solar energy utilization that a wide variety of TiO2 with distinguished morphologies can be integrated into differently structured photoanodes with synergistic and complementary advantages. This key structure engineering technology will also pave the way for the development of next generation state-ofthe-art electronics and optoelectronics. Finally, from our point of view, we conclude the future research interest and efforts for constructing more efficient LTFs as photoelectrode, which will be highly warranted to advance the solar energy conversion process.展开更多
EHL-2 spherical torus(ST)is one of the key steps of p-^(11)B(proton-boron or hydrogen-boron)fusion energy research in ENN.The fusion produced energy is carried mainly by alpha particles of average energy 3 MeV,which i...EHL-2 spherical torus(ST)is one of the key steps of p-^(11)B(proton-boron or hydrogen-boron)fusion energy research in ENN.The fusion produced energy is carried mainly by alpha particles of average energy 3 MeV,which ideally can be converted to electricity with high efficiency(>80%).However,there exist serious difficulties to realize such conversion in a fusion device,due to the high energy density and high voltage required.To comprehensively describe the progress of the EHL-2 physics design,this work presents preliminary considerations of approaches for achieving energy conversion,highlighting critical issues for further investigation.Specifically,we provide an initial simulation of alpha particle extraction in the EHL-2 ST configuration as a starting point for p-^(11)B fusion energy conversion.展开更多
The two-dimensional electron gas(2DEG)formed at the interface between two oxide insulators provides new opportunities for electronics and spintronics.The broken inversion symmetry at the heterointerface results in a R...The two-dimensional electron gas(2DEG)formed at the interface between two oxide insulators provides new opportunities for electronics and spintronics.The broken inversion symmetry at the heterointerface results in a Rashba spin-orbit coupling(RSOC)effect that enables the conversion between spin and charge currents.However,conducting oxide interfaces that simultaneously exhibit strong RSOC and high carrier mobility-a combination query for achieving high spin-to-charge inter-conversion efficiencies-remain scarce.Herein,we report a correlated 2DEG with giant Rashba splitting and high electron mobility in(111)-oriented EuTiO_(3)/KTaO_(3)(ETO/KTO)heterostructures under light illumination.Upon light modulation,a unique carrier-dependent giant anomalous Hall effect,the signature of spin-polarized 2DEG,emerges with a sign crossover at a carrier density of approximately 5.0×10^(13)cm^(-2),highlighting dramatic changes in the band topology of KTO(111)interface.Furthermore,at 2 K,the carrier mobility is enhanced from 103 cm^(2)·V^(-1)·s^(-1)to 1800 cm^(2)·V^(-1)·s^(-1),a remarkable enhancement of approximately 20 times.Accompanying with a giant Rashba coefficient αR up to 360meV·˚A,this high mobility ferromagnetic 5d oxide 2DEG is predicted to achieve a giant spin-to-charge conversion efficiency ofλ~10 nm,showing great potential for designing low-power spin-orbitronic devices.展开更多
We investigate the spin to charge conversion phenomena in Y_(3)Fe_(5)O_(12)/Pt/Co_(1-x)Tb_(x)/Pt multilayers by both the spin pumping and spin Seebeck effects.We find that the spin transport efficiency is irrelevant t...We investigate the spin to charge conversion phenomena in Y_(3)Fe_(5)O_(12)/Pt/Co_(1-x)Tb_(x)/Pt multilayers by both the spin pumping and spin Seebeck effects.We find that the spin transport efficiency is irrelevant to magnetization states of the perpendicular magnetized Co;Tb;films,which can be attributed to the symmetry requirement of the inverse transverse spin Hall effect.Furthermore,the spin transmission efficiency is significantly affected by the film concentration,revealing the dominant role of extrinsic impurity scattering caused by Tb impurity.The present results provide further guidance for enhancing the spin transport efficiency and developing spintronic devices.展开更多
A novel method to calculate fuel-electric conversion factor for full hybrid electric vehicle（HEV）equipped with continuously variable transmission（CVT）is proposed.Based on consideration of the efficiency of pivotal...A novel method to calculate fuel-electric conversion factor for full hybrid electric vehicle（HEV）equipped with continuously variable transmission（CVT）is proposed.Based on consideration of the efficiency of pivotal components,electric motor,system efficiency optimization models are developed.According to the target of instantaneous optimization of system efficiency,operating ranges of each mode of power-train are determined,and the corresponding energy management strategies are established.The simulation results demonstrate that the energy management strategy proposed can substantially improve the vehicle fuel economy,and keep battery state of charge（SOC）change in a reasonable variation range.展开更多
Current optical storage technologies utilizing phosphor media face challenges in achieving rapid and precise data recording with visible or infrared light,primarily due to the constraints of traditional charging techn...Current optical storage technologies utilizing phosphor media face challenges in achieving rapid and precise data recording with visible or infrared light,primarily due to the constraints of traditional charging techniques.Here,we introduce a cutting-edge method termed up-conversion charging(UCC)to address these challenges,enabling rapid and high-resolution data storage in phosphors.Our study focuses on the unique two-step ionization and non-linear charging characteristics of UCC in storage phosphors,specifically in a gallate composition Gd3Ga5O12:Cr3+.Remarkably,this technique enables data writing with high solution,requiring only 0.01 s of exposure per bit when utilizing a portable laser engraver equipped with visible-emitting diode lasers.The present strategy not only enhances recording efficiency but also ensures long-term data retention and superior rewritability.Moreover,we illustrate the versatility of UCC storage across various material systems through thermally-and optically-stimulated luminescence.Our outcomes highlight the transformative potential of the UCC method in advancing optical storage applications,offering significant improvements in the development of information storage solutions.展开更多
Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally controlled manner, far-red light-resp...Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally controlled manner, far-red light-responsive nanoclusters (NCs) capable of size shrinkage and charge conversion were developed and co-administered with iRGD to synergistically improve the intratumoral penetration and the anticancer efficacy. The NCs were constructed using the singlet oxygen-sensitive (SOS) polyethylene glycolpolyurethane-polyethylene glycol (PEG-(1O2)PU-PEG) triblock copolymer to encapsulate the doxorubicin (DOX)-loaded, chlorin e6 (Ce6)-conjugated polyamindoamine (PAMAM) dendrimer (DCD) via the double-emulsion method. Co-administration of iRGD notably increased the permeability of NCs within tumor vasculature and tumor tissues. In addition, upon far-red light irradiation (660 nm) of tumors at low optical density (10 mW/cm2), the generated 1O2 could disintegrate the NCs and release the DCD with positive surface charge and ultra-small size (~ 5 nm), which synergized with iRGD to enable deep intratumoral penetration. Consequently, the local 1O2 at lethal concentrations along with the released DOX efficiently and cooperatively eradicated tumor cells. This study provides a convenient approach to spatiotemporally promote the intratumoral penetration of nanomedicine and mediate programmed anticancer therapy.展开更多
For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid tumors.Here,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs...For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid tumors.Here,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs)for enhanced tumor delivery and augmented chemotherapy.CH was first grafted with PPy to form CH-PPy polymers that were used to form CH-PPy NGs through glutaraldehyde cross-linking via a miniemulsion method.The CH-PPy NGs could be finely treated with an alkaline solution to generate ultrafast charge-reversible CH-PPy-OH-4 NGs(R-NGs)with a negative charge at a physiological pH and a positive charge at a slightly acidic pH.The R-NGs display good cytocompatibility,excellent protein resistance,and high doxorubicin(DOX)loading efficiency.Encouragingly,the prepared R-NGs/DOX have prolonged blood circulation time,enhanced tumor accumulation,penetration and tumor cell uptake due to their self-adaptive charge switching to be positively charged,and responsive drug delivery for augmented chemotherapy of ovarian carcinoma in vivo.Notably,the tumor accumulation of R-NGs/DOX(around 4.7%)is much higher than the average tumor accumulation of other nanocarriers(less than 1%)reported elsewhere.The developed self-adaptive PPy-grafted CH NGs represent one of the advanced designs of nanomedicine that could be used for augmented antitumor therapy with low side effects.展开更多
Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobi...Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobilities.Here,we used nanochannels to regulate thermal-driven ion transport properties and described a solar thermoelectric nanofluidic device(STEND).展开更多
基金Funded by the National Key R&D Program of China(No.2023YFC2412300)the Natural Science Foundation of Hubei Province(No.2022CFB386)the National Natural Science Foundation of China(No.52073222)。
文摘pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic self-assembly.The morphology,particle size and zeta potential of the nanocomposites were analyzed by transmission electron microscopy and dynamic light scattering.The synthesis of the polymer was analyzed by^(1)H-NMR.The zeta-potential changes and cellular uptake effects of the nanocomplexes under different pH environments were investigated.The experimental results show that the surface morphology of the nanocomposite is spherical,and the average particle size is about 135 nm.As the pH value of the solution gradually decreases,the surface charge of the nanocomposite reverses from negative charge to positive charge(from-9.4 to+17.1 mV).Cellular uptake mediated by pH-responsive nanocomposite is selective for tumor cells,and the cellular uptake effect in tumor cells at pH 6.5 was approximately 3 times higher than that at pH 7.4.This pH responsive charge reversal nanocomposite has promising application prospects for gene delivery in the weak acid environment of tumors.
基金the financial supports from the NSFC(51472274)the GDUPS(2016)+2 种基金the program of Guangzhou Science and Technology Project(201504010031)the NSF of Guangdong Province(S2013030013474)the Fundamental Research Funds for the Central Universities
文摘Nanostructured TiO2 with differentiate morphologies has attracted tremendous attention due to its wide band-gap nature as well as outstanding optical and electric properties for solar-driven light-toelectricity conversion application. Layered-stacking TiO2 film such as double-layer, tri-layer, quadrupleor quintuplicate-layer, is highly desirable to the design of high-performance semiconductor material photoanodes and the development of advanced photovoltaic devices. In this minireview, we will summarize the recent progress and achievements on proof-of-concept of layered-stacking TiO2 films（LTFs） for solar cells with emphasis on the tailored properties and synergistic functionalization of LTFs, such as optimized sensitizer adsorption, broadened light confinement as well as facilitated electron transport characteristics.Various demonstrations of LTFs photovoltaic systems provide lots of possibilities and flexibilities for more efficient solar energy utilization that a wide variety of TiO2 with distinguished morphologies can be integrated into differently structured photoanodes with synergistic and complementary advantages. This key structure engineering technology will also pave the way for the development of next generation state-ofthe-art electronics and optoelectronics. Finally, from our point of view, we conclude the future research interest and efforts for constructing more efficient LTFs as photoelectrode, which will be highly warranted to advance the solar energy conversion process.
文摘EHL-2 spherical torus(ST)is one of the key steps of p-^(11)B(proton-boron or hydrogen-boron)fusion energy research in ENN.The fusion produced energy is carried mainly by alpha particles of average energy 3 MeV,which ideally can be converted to electricity with high efficiency(>80%).However,there exist serious difficulties to realize such conversion in a fusion device,due to the high energy density and high voltage required.To comprehensively describe the progress of the EHL-2 physics design,this work presents preliminary considerations of approaches for achieving energy conversion,highlighting critical issues for further investigation.Specifically,we provide an initial simulation of alpha particle extraction in the EHL-2 ST configuration as a starting point for p-^(11)B fusion energy conversion.
基金supported by the Science Center of the National Science Foundation of China(Grant No.52088101)the National Key Research and Development Program of China(Grant Nos.2023YFA1406400,2021YFA1400300,and 2023YFA1607403)the National Natural Science Foundation of China(Grant Nos.T2394472 and T2394470).
文摘The two-dimensional electron gas(2DEG)formed at the interface between two oxide insulators provides new opportunities for electronics and spintronics.The broken inversion symmetry at the heterointerface results in a Rashba spin-orbit coupling(RSOC)effect that enables the conversion between spin and charge currents.However,conducting oxide interfaces that simultaneously exhibit strong RSOC and high carrier mobility-a combination query for achieving high spin-to-charge inter-conversion efficiencies-remain scarce.Herein,we report a correlated 2DEG with giant Rashba splitting and high electron mobility in(111)-oriented EuTiO_(3)/KTaO_(3)(ETO/KTO)heterostructures under light illumination.Upon light modulation,a unique carrier-dependent giant anomalous Hall effect,the signature of spin-polarized 2DEG,emerges with a sign crossover at a carrier density of approximately 5.0×10^(13)cm^(-2),highlighting dramatic changes in the band topology of KTO(111)interface.Furthermore,at 2 K,the carrier mobility is enhanced from 103 cm^(2)·V^(-1)·s^(-1)to 1800 cm^(2)·V^(-1)·s^(-1),a remarkable enhancement of approximately 20 times.Accompanying with a giant Rashba coefficient αR up to 360meV·˚A,this high mobility ferromagnetic 5d oxide 2DEG is predicted to achieve a giant spin-to-charge conversion efficiency ofλ~10 nm,showing great potential for designing low-power spin-orbitronic devices.
基金supported by the National Key Basic Research Project of China(Grant No.2016YFA0300600)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB33020300)the National Natural Science Foundation of China(Grant Nos.11604375 and 11874416)。
文摘We investigate the spin to charge conversion phenomena in Y_(3)Fe_(5)O_(12)/Pt/Co_(1-x)Tb_(x)/Pt multilayers by both the spin pumping and spin Seebeck effects.We find that the spin transport efficiency is irrelevant to magnetization states of the perpendicular magnetized Co;Tb;films,which can be attributed to the symmetry requirement of the inverse transverse spin Hall effect.Furthermore,the spin transmission efficiency is significantly affected by the film concentration,revealing the dominant role of extrinsic impurity scattering caused by Tb impurity.The present results provide further guidance for enhancing the spin transport efficiency and developing spintronic devices.
基金Supported by the National Science and Technology Support Program(2013BAG12B01)Foundational and Advanced Research Program General Project of Chongqing City(cstc2013jcyjjq60002)
文摘A novel method to calculate fuel-electric conversion factor for full hybrid electric vehicle（HEV）equipped with continuously variable transmission（CVT）is proposed.Based on consideration of the efficiency of pivotal components,electric motor,system efficiency optimization models are developed.According to the target of instantaneous optimization of system efficiency,operating ranges of each mode of power-train are determined,and the corresponding energy management strategies are established.The simulation results demonstrate that the energy management strategy proposed can substantially improve the vehicle fuel economy,and keep battery state of charge（SOC）change in a reasonable variation range.
基金supported by the National Natural Science Foundation of China(11774046,12074373,52072361,51732003,52172083)the Key Research and Department of Science and Technology of Jilin Province(20230101012JC).
文摘Current optical storage technologies utilizing phosphor media face challenges in achieving rapid and precise data recording with visible or infrared light,primarily due to the constraints of traditional charging techniques.Here,we introduce a cutting-edge method termed up-conversion charging(UCC)to address these challenges,enabling rapid and high-resolution data storage in phosphors.Our study focuses on the unique two-step ionization and non-linear charging characteristics of UCC in storage phosphors,specifically in a gallate composition Gd3Ga5O12:Cr3+.Remarkably,this technique enables data writing with high solution,requiring only 0.01 s of exposure per bit when utilizing a portable laser engraver equipped with visible-emitting diode lasers.The present strategy not only enhances recording efficiency but also ensures long-term data retention and superior rewritability.Moreover,we illustrate the versatility of UCC storage across various material systems through thermally-and optically-stimulated luminescence.Our outcomes highlight the transformative potential of the UCC method in advancing optical storage applications,offering significant improvements in the development of information storage solutions.
基金The research was financially supported by the National Natural Science Foundation of China(Nos.51873142,51722305,and 81903068)the Ministry of Science and Technology of China(No.2016YFA0201200)111 project,and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally controlled manner, far-red light-responsive nanoclusters (NCs) capable of size shrinkage and charge conversion were developed and co-administered with iRGD to synergistically improve the intratumoral penetration and the anticancer efficacy. The NCs were constructed using the singlet oxygen-sensitive (SOS) polyethylene glycolpolyurethane-polyethylene glycol (PEG-(1O2)PU-PEG) triblock copolymer to encapsulate the doxorubicin (DOX)-loaded, chlorin e6 (Ce6)-conjugated polyamindoamine (PAMAM) dendrimer (DCD) via the double-emulsion method. Co-administration of iRGD notably increased the permeability of NCs within tumor vasculature and tumor tissues. In addition, upon far-red light irradiation (660 nm) of tumors at low optical density (10 mW/cm2), the generated 1O2 could disintegrate the NCs and release the DCD with positive surface charge and ultra-small size (~ 5 nm), which synergized with iRGD to enable deep intratumoral penetration. Consequently, the local 1O2 at lethal concentrations along with the released DOX efficiently and cooperatively eradicated tumor cells. This study provides a convenient approach to spatiotemporally promote the intratumoral penetration of nanomedicine and mediate programmed anticancer therapy.
基金This research was financially supported by the Sino-German Center for Research Promotion(GZ1505)National Natural Science Foundation of China(81801704 and 81761148028)+5 种基金the Science and Technology Commission of Shanghai Municipality(19XD1400100)Shanghai Sailing Program(18YF1415300)the China Scholarship Council(for X.Li)X.Shi also thanks the support by FCT-Fundaçao para a Ciencia e a Tecnologia through the CQM Base Fund-UIDB/00674/2020Programmatic Fund-UIDP/00674/2020by ARDITI-Agencia Regional para o Desenvolvimento da Investigaçao Tecnologia e Inovaçao,through the project M1420-01-0145-FEDER-000005-Centro de Química da Madeira-CQM+(Madeira 14-20 Program).
文摘For cancer nanomedicine,the main goal is to deliver therapeutic agents effectively to solid tumors.Here,we report the unique design of self-adaptive ultrafast charge-reversible chitosan-polypyrrole nanogels(CH-PPy NGs)for enhanced tumor delivery and augmented chemotherapy.CH was first grafted with PPy to form CH-PPy polymers that were used to form CH-PPy NGs through glutaraldehyde cross-linking via a miniemulsion method.The CH-PPy NGs could be finely treated with an alkaline solution to generate ultrafast charge-reversible CH-PPy-OH-4 NGs(R-NGs)with a negative charge at a physiological pH and a positive charge at a slightly acidic pH.The R-NGs display good cytocompatibility,excellent protein resistance,and high doxorubicin(DOX)loading efficiency.Encouragingly,the prepared R-NGs/DOX have prolonged blood circulation time,enhanced tumor accumulation,penetration and tumor cell uptake due to their self-adaptive charge switching to be positively charged,and responsive drug delivery for augmented chemotherapy of ovarian carcinoma in vivo.Notably,the tumor accumulation of R-NGs/DOX(around 4.7%)is much higher than the average tumor accumulation of other nanocarriers(less than 1%)reported elsewhere.The developed self-adaptive PPy-grafted CH NGs represent one of the advanced designs of nanomedicine that could be used for augmented antitumor therapy with low side effects.
基金supported by the National Natural Science Foundation of China(nos.21635004,21775066,and 21974058).
文摘Harvesting the low-grade(<100°C)solar thermal energy with ionic heat-to-electricity conversion shows great promise but low efficiencies due to the challenges encountered in regulating ionic thermophoretic mobilities.Here,we used nanochannels to regulate thermal-driven ion transport properties and described a solar thermoelectric nanofluidic device(STEND).
