There is a contradiction between the evolution rate of materials and the time resolution of SR-CT characterization in the in situ synchrotron radiation computed tomography(SR-CT)characterization of ultrafast evolution...There is a contradiction between the evolution rate of materials and the time resolution of SR-CT characterization in the in situ synchrotron radiation computed tomography(SR-CT)characterization of ultrafast evolution process.The sampling strategy of the ultra-sparse angle is an effective method for improving time resolution.Accurate reconstruction under sparse sampling conditions has always been a bottleneck problem.In recent years,convolutional neural networks have shown outstanding advantages in sparse-angle CT reconstruction given the development of deep learning.However,existing ideas did not consider the expression of high-frequency details in neural networks,limiting their application in accurate SR-CT characterization.A novel high-frequency information-constrained deep learning network(HFIC-Net)is proposed in response to this problem.Additional high-frequency information constraints are added to improve the accuracy of the reconstruction results.Further,a series of numerical reconstruction experiments are conducted to verify this new method,and the results indicate that the reconstruction results of HFIC-Net method effectively improve reconstruction quality.This new method uses only eight-angle projections to achieve the reconstruction effect of the filtered backprojection method(FBP)method in 360 projections.The results of the HFIC-Net method demonstrate clear boundaries and accurate detailed structures,correcting the misinformation caused by using other methods.For quantitative evaluation,the SSIM used to evaluate image structure similarity is increased from 0.1951,0.9212,and 0.9308 for FBP,FBP-Conv,and DDC-Net,respectively,to 0.9620 for HFIC-Net.Finally,the results of actual SR-CT experimental data indicate that the new method can suppress artifacts and achieve accurate reconstruction,and it is suitable for the in situ SR-CT accurate characterization of ultxafast evolution process.展开更多
This paper aims to examine the characterizational shift of C.Auguste Dupin in Edgar Allan Poe’s detective stories.First,Poe’s detective stories were written when the Enlightenment,which emphasizes Reason,was being e...This paper aims to examine the characterizational shift of C.Auguste Dupin in Edgar Allan Poe’s detective stories.First,Poe’s detective stories were written when the Enlightenment,which emphasizes Reason,was being embedded in the fabric of American culture.Meanwhile,beneath the Enlightenment was also an undercurrent of irrationality.In Poe’s“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Dupin typifies a flat character standing for Reason/Good.However,in Poe’s“The Purloined Letter,”Dupin has been depicted as a round character;not only is he characterized a lot more vividly but also he bears striking resemblance to his opponent,Minister D.Namely,the dichotomous relationship between them has been erased,and Dupin has been portrayed more like a real person walking on the thin line between Good and Evil.Speaking of dissecting this characterizational shift of Dupin,I believe the key lies in the fact that Poe actually has taken an attitude of openness about Reason and Unreason,and that he has a way with opposing elements.In“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Poe intends for Reason,represented by Dupin,to keep under control Unreason,represented by the criminals.In such a case,Dupin only needs to be a flat character representing Good/Reason.But in“The Purloined Letter,”Poe intends for Reason/Good and Unreason/Evil to be merged.Under such circumstances,Dupin will conveniently evolve into a round character.展开更多
Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the preven...Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.展开更多
基金supported by the National Nature Science Foundation of China(Nos.12027901 and 12041202)Synchrotron Radiation Joint Fund of University of Science and Technology of China(Nos.KY2090000059 and KY2090000054)。
文摘There is a contradiction between the evolution rate of materials and the time resolution of SR-CT characterization in the in situ synchrotron radiation computed tomography(SR-CT)characterization of ultrafast evolution process.The sampling strategy of the ultra-sparse angle is an effective method for improving time resolution.Accurate reconstruction under sparse sampling conditions has always been a bottleneck problem.In recent years,convolutional neural networks have shown outstanding advantages in sparse-angle CT reconstruction given the development of deep learning.However,existing ideas did not consider the expression of high-frequency details in neural networks,limiting their application in accurate SR-CT characterization.A novel high-frequency information-constrained deep learning network(HFIC-Net)is proposed in response to this problem.Additional high-frequency information constraints are added to improve the accuracy of the reconstruction results.Further,a series of numerical reconstruction experiments are conducted to verify this new method,and the results indicate that the reconstruction results of HFIC-Net method effectively improve reconstruction quality.This new method uses only eight-angle projections to achieve the reconstruction effect of the filtered backprojection method(FBP)method in 360 projections.The results of the HFIC-Net method demonstrate clear boundaries and accurate detailed structures,correcting the misinformation caused by using other methods.For quantitative evaluation,the SSIM used to evaluate image structure similarity is increased from 0.1951,0.9212,and 0.9308 for FBP,FBP-Conv,and DDC-Net,respectively,to 0.9620 for HFIC-Net.Finally,the results of actual SR-CT experimental data indicate that the new method can suppress artifacts and achieve accurate reconstruction,and it is suitable for the in situ SR-CT accurate characterization of ultxafast evolution process.
文摘This paper aims to examine the characterizational shift of C.Auguste Dupin in Edgar Allan Poe’s detective stories.First,Poe’s detective stories were written when the Enlightenment,which emphasizes Reason,was being embedded in the fabric of American culture.Meanwhile,beneath the Enlightenment was also an undercurrent of irrationality.In Poe’s“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Dupin typifies a flat character standing for Reason/Good.However,in Poe’s“The Purloined Letter,”Dupin has been depicted as a round character;not only is he characterized a lot more vividly but also he bears striking resemblance to his opponent,Minister D.Namely,the dichotomous relationship between them has been erased,and Dupin has been portrayed more like a real person walking on the thin line between Good and Evil.Speaking of dissecting this characterizational shift of Dupin,I believe the key lies in the fact that Poe actually has taken an attitude of openness about Reason and Unreason,and that he has a way with opposing elements.In“The Murders in the Rue Morgue”and“The Mystery of Marie Rogêt,”Poe intends for Reason,represented by Dupin,to keep under control Unreason,represented by the criminals.In such a case,Dupin only needs to be a flat character representing Good/Reason.But in“The Purloined Letter,”Poe intends for Reason/Good and Unreason/Evil to be merged.Under such circumstances,Dupin will conveniently evolve into a round character.
基金supported by Public Health Talent Training and Surport Plan(National Administration of Disease Prevention and Control)Research and application of new technology for rapid monitoring and tracing of emergent infectious diseases among entry-exit population(2024YFFK0056)Monitoring,Early warning and Response of Major Infectious Diseases(2022ZDZX0017).
文摘Objective This study reports the first imported case of Lassa fever(LF)in China.Laboratory detection and molecular epidemiological analysis of the Lassa virus(LASV)from this case offer valuable insights for the prevention and control of LF.Methods Samples of cerebrospinal fluid(CSF),blood,urine,saliva,and environmental materials were collected from the patient and their close contacts for LASV nucleotide detection.Whole-genome sequencing was performed on positive samples to analyze the genetic characteristics of the virus.Results LASV was detected in the patient’s CSF,blood,and urine,while all samples from close contacts and the environment tested negative.The virus belongs to the lineage IV strain and shares the highest homology with strains from Sierra Leone.The variability in the glycoprotein complex(GPC)among different strains ranged from 3.9%to 15.1%,higher than previously reported for the seven known lineages.Amino acid mutation analysis revealed multiple mutations within the GPC immunogenic epitopes,increasing strain diversity and potentially impacting immune response.Conclusion The case was confirmed through nucleotide detection,with no evidence of secondary transmission or viral spread.The LASV strain identified belongs to lineage IV,with broader GPC variability than previously reported.Mutations in the immune-related sites of GPC may affect immune responses,necessitating heightened vigilance regarding the virus.
