The proximal small intestine,encompassing the duodenum and jejunum,is widely recognized as the primary site for nutrient digestion and absorption in humans.[1]Notably,its luminal environment exhibits diverse histologi...The proximal small intestine,encompassing the duodenum and jejunum,is widely recognized as the primary site for nutrient digestion and absorption in humans.[1]Notably,its luminal environment exhibits diverse histological and physiological characteristics,including a longitudinal pH gradient,variations in oxygen pressure,and differing concentrations of antimicrobial peptides.[2]In addition,the small intestine is a highly organized structure composed of repeated crypt-villous units.In mice,epithelial,immune,and mesenchymal cells have been identified to exhibit significant spatial variability in the gene expression patterns along the crypt-villus axis.However,the spatial expression heterogeneity of the small intestine in humans remains largely unexplored.展开更多
基金funded by grants from the National Natural Science Foundation of China(Nos.82070562,82370532,and 82341219).
文摘The proximal small intestine,encompassing the duodenum and jejunum,is widely recognized as the primary site for nutrient digestion and absorption in humans.[1]Notably,its luminal environment exhibits diverse histological and physiological characteristics,including a longitudinal pH gradient,variations in oxygen pressure,and differing concentrations of antimicrobial peptides.[2]In addition,the small intestine is a highly organized structure composed of repeated crypt-villous units.In mice,epithelial,immune,and mesenchymal cells have been identified to exhibit significant spatial variability in the gene expression patterns along the crypt-villus axis.However,the spatial expression heterogeneity of the small intestine in humans remains largely unexplored.
