To the Editor,We read with interest the article by Lehrer et al.on an in silico molecular docking and molecular dynamics simulation study with Cx43 channels,which investigated whether insulin or metformin can dock wit...To the Editor,We read with interest the article by Lehrer et al.on an in silico molecular docking and molecular dynamics simulation study with Cx43 channels,which investigated whether insulin or metformin can dock within the Cx43 channel and effectively block it,thereby reducing the risk of amyotrophic lateral sclerosis(ALS)[1].Based on data from the FDA Med Watch,it was found that the insulin heterodimer docks in the center of the Cx43 channel and effectively blocks it,and that this blockade is very stable,thereby achieving a protective effect on ALS[1].It has been found that metformin also docks in the Cx43 channel,but due to the small size of the molecule,it does not impede the passage of toxic waste products from astrocytes[1].The study is impressive,but some points should be discussed.展开更多
文摘To the Editor,We read with interest the article by Lehrer et al.on an in silico molecular docking and molecular dynamics simulation study with Cx43 channels,which investigated whether insulin or metformin can dock within the Cx43 channel and effectively block it,thereby reducing the risk of amyotrophic lateral sclerosis(ALS)[1].Based on data from the FDA Med Watch,it was found that the insulin heterodimer docks in the center of the Cx43 channel and effectively blocks it,and that this blockade is very stable,thereby achieving a protective effect on ALS[1].It has been found that metformin also docks in the Cx43 channel,but due to the small size of the molecule,it does not impede the passage of toxic waste products from astrocytes[1].The study is impressive,but some points should be discussed.
