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Striving for the development of biology——The celebration of Biomagnelism formally changed into Progress in Modem Biomedicine 被引量:2
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作者 Editorial Department of Progress in Modern Biomedicine 《现代生物医学进展》 CAS 2006年第6期F0002-F0002,共1页
关键词 Striving for the development of biology The celebration of Biomagnelism formally changed into Progress in Modem Biomedicine
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Both ABO and MN blood groups have changed after Allo-PBSCT
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《中国输血杂志》 CAS CSCD 2001年第S1期379-,共1页
关键词 ABO Both ABO and MN blood groups have changed after Allo-PBSCT
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A CHANGED FACE OF GUANGZHOU TRADE FAIR
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《大经贸》 北大核心 1996年第11期91-91,共1页
FAMOUS-BRAND PRODUCTS ARE WARMLY WELCOMEUPGRADING TECHNOLOGIES ARE HIGHLY CHERISHEDEXQUISITE FINE-ART PRODUCTS RECEIVE SPECIAL ATTENTION.
关键词 HIGH ARE A changed FACE OF GUANGZHOU TRADE FAIR
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Words That Changed a Life
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作者 Bob Greene 方陵生 《语言教育》 1999年第7期24-26,共3页
“Are you too stupid to do anything right?”These words—said by a woman to a little boy who was evidently her son—were spoken because he had walked away from her.Andthey were said at a volume high enough that all th... “Are you too stupid to do anything right?”These words—said by a woman to a little boy who was evidently her son—were spoken because he had walked away from her.Andthey were said at a volume high enough that all the strangersin the vicinity could hear.Chastised,the boy returned quiet-ly to the woman’s side,his eyes downcast.Not a big moment,perhaps.Yet small moments some- 展开更多
关键词 Words That changed a Life
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It was love that changed me
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作者 于莹莹 《疯狂英语(初中天地)》 2002年第47期26-26,共1页
Once I was a conceited girl.I would neveraccept the advice of others.I was never readyto help others.Sometimes when someone wasin trouble,I liked to play a joke on him orher.So many classmates disliked me.My teach-ers... Once I was a conceited girl.I would neveraccept the advice of others.I was never readyto help others.Sometimes when someone wasin trouble,I liked to play a joke on him orher.So many classmates disliked me.My teach-ers often tried to change me,but I wouldn’tlisten. 展开更多
关键词 It was love that changed me
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Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning? 被引量:11
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作者 Bülent Baran Filiz Akyüz 《World Journal of Gastroenterology》 SCIE CAS 2014年第39期14219-14229,共11页
Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often ... Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. Many clinical studies have tried numerous drugs and alternative medicine, however, investigators have failed to identify a safe and effective therapy for patients with NASH. As summarized, the heterogeneity of pathogenic pathways in individual patients with NASH may warrant the development of an individualized treatment according to the underlying pathogenic pathway. The differentiation of pathogenetic targets may require the development of diagnostic and prognostic biomarkers, and the identification of genetic susceptibilities. At present, evidence-based medicine provides only a few options including life-style modifications targeting weight loss, pioglitazone and vitamin E in non-diabetic patients with biopsy-proven NASH. 展开更多
关键词 Non-alcoholic steatohepatitis PATHOGENESIS INFLAMMATION FIBROSIS Life-style changes Pharmacologic treatment
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Simulation of the mixing process in a straight tube with sudden changed cross-section 被引量:3
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作者 Yangcheng LU Shan Zhu +1 位作者 Kai Wang Guangsheng Luo 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2016年第6期711-718,共8页
In this work, we revised the expression of mixing intensity to describe the mixing output through a cross section in a flow system by considering heterogeneity of flow field, and carefully investigated the mixing proc... In this work, we revised the expression of mixing intensity to describe the mixing output through a cross section in a flow system by considering heterogeneity of flow field, and carefully investigated the mixing process along a straight tube with expanding/contracting cross section by simulation method. The simulation results show that a sudden expansion of cross section has remarkable mixing intensification effect within a limited period(on the sub-second scale) or tube-length(on the millimeter scale), corresponding to the generation of considerable local vortices determined by both the flow capacity and the ratio of cross section change; a sudden contraction of cross section has instantaneous but weak mixing intensification effect; through introducing a local expansion structure with proper length, as the combination of sudden expansion and sudden contraction, their mixing intensification effects could be superposed. Besides, the rationality and importance are experimentally verified to explore the time profile of mixing intensity and carry out the vortex analysis by simulation for enhancing the selectivity of a complicated reaction system. These progresses may lead to more meaningful quantitative description of mixing process in a flow microreactor for some specific chemical processes. 展开更多
关键词 MixingIntensificationSimulationSudden change in cross-sectionVortex
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Prediction of Changed Faces with HSCNN
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作者 Jinho Han 《Computers, Materials & Continua》 SCIE EI 2022年第5期3747-3759,共13页
Convolutional Neural Networks(CNN)have been successfully employed in the field of image classification.However,CNN trained using images from several years ago may be unable to identify how such images have changed ove... Convolutional Neural Networks(CNN)have been successfully employed in the field of image classification.However,CNN trained using images from several years ago may be unable to identify how such images have changed over time.Cross-age face recognition is,therefore,a substantial challenge.Several efforts have been made to resolve facial changes over time utilizing recurrent neural networks(RNN)with CNN.The structure of RNN contains hidden contextual information in a hidden state to transfer a state in the previous step to the next step.This paper proposes a novel model called Hidden State-CNN(HSCNN).This adds to CNN a convolution layer of the hidden state saved as a parameter in the previous step and requires no more computing resources than CNN.The previous CNN-RNN models perform CNN and RNN,separately and then merge the results.Therefore,their systems consume twice the memory resources and CPU time,compared with the HSCNN system,which works the same as CNN only.HSCNN consists of 3 types of models.All models load hidden state ht−1 from parameters of the previous step and save ht as a parameter for the next step.In addition,modelB adds ht−1 to x,which is the previous output.The summation of ht−1 and x is multiplied by weight W.In model-C the convolution layer has two weights:W1 and W2.Training HSCNN with faces of the previous step is for testing faces of the next step in the experiment.That is,HSCNN trained with past facial data is then used to verify future data.It has been found to exhibit 10 percent greater accuracy than traditional CNN with a celeb face database. 展开更多
关键词 CNN-RNN HSCNN hidden state changing faces
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REDEFINING ENSO EPISODES BASED ON CHANGED CLIMATE REFERENCES
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作者 李晓燕 翟盘茂 任福民 《Journal of Tropical Meteorology》 SCIE 2005年第1期97-103,共7页
Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new ... Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new climate references and new index standards, ENSO episodes and their intensities for the period 1951 -2003 have been classified. Finally, an analysis has been performed comparing the new characteristics with the old ones for ENSO period, peak values and intensities. 展开更多
关键词 change of climate REFERENCE ENSO episodes INDICATORS
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A Study of Soil Nutrients in the Terrace Field Changed from Mountain Slope in Three Gorges Reservoir Region
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作者 Guojian CHEN Chunjuan LI +3 位作者 Chunli LI Juanjuan LI Jie WEI Hongwei DONG 《Asian Agricultural Research》 2016年第8期77-80,共4页
In order to accurately grasp the soil fertility in Three Gorges Reservoir Region after changing mountain slope into terrace field,we take Wushan County for example,and use the spatio-temporal substitution method to an... In order to accurately grasp the soil fertility in Three Gorges Reservoir Region after changing mountain slope into terrace field,we take Wushan County for example,and use the spatio-temporal substitution method to analyze the soil nutrient status and trend about the terrace field changed from mountain slope under different length of implementation.The results show that the soil fertility is generally low in the study area,and according to the soil nutrient grading standards in the second national land survey,the average content of total nitrogen,available potassium,organic matter and available phosphorus reaches Standard III,Standard III,Standard IV and Standard V,respectively,and the spatial heterogeneity of soil nutrients is small.Compared to the sloping land,the terrace field changed from mountain slope has increasing soil nutrients on the whole with the length of farming.The mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 2 years is lower than in the sloping land,and there is the biggest difference in soil fertility,while the mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 14 years shows a linear upward trend,and the difference in soil fertility decreases. 展开更多
关键词 Changing mountain slope into terrace field Soil nutrients Three Gorges Reservoir Region
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Effects of Changed Climate Conditions on Tropospheric Ozone over Three Centuries
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作者 Gitte Brandt Hedegaard Jesper Heile Christensen +5 位作者 Camilla Geels Allan Gross Kaj Mantzius Hansen Wilhelm May Azimeh Zare Jorgen Brandt 《Atmospheric and Climate Sciences》 2012年第4期546-561,共16页
The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danis... The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danish Eulerian Hemispheric Model (DEHM) forced with meteorology projected by theECHAM5/MPI-OM coupled Atmosphere-Ocean General Circulation Model. The largest changes in meteorology, ozone and its precursors are found in the 21st century, however, also significant changes are found in the 22nd century. At surface level the ozone concentration is projected to increase due to climate change in the areas where substantial amounts of ozone precursors are emitted. Elsewhere a significant decrease is projected at the surface. In the free troposphere a general increase is found in the entire Northern Hemisphere except in the tropics, where the ozone concentration is decreasing. In the Arctic the ozone concentration will increase in the entire air column, which most likely is due to changes in atmospheric transport. Changes in temperature, humidity and the naturally emitted Volatile Organic Compounds (VOCs) are governing the changes in ozone both in the past, present and future century. 展开更多
关键词 OZONE Climate Change Air Quality MODELLING
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Brief Introduction to“Journal of Jilin University(Science Edition)”
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《吉林大学学报(理学版)》 北大核心 2026年第1期F0003-F0003,共1页
“Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of Chin... “Journal of Jilin University(Science Edition)”is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the Peoples Republic of China.The journal started publication in 1955.The original name at starting publication was “Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis”in 1958owing to the name change of the university.The present journal name has been begun since the beginning of 2002after a new Jilin University was set up,which comes from the amalgamation of the original Jilin University,Jilin University of Technology,Bethune Medicine University,Changchun University of Science and Technology and Changchun Post and Telecommunication Institute on June 12,2000.The domestic journal number is CN 22-1340/O,and the international journal number is ISSN 1671-5489. 展开更多
关键词 comprehensive academic journal Science Fields name change SCIENCE Academic Journal scientiarum naturalium Journal natural science
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Current status and recent changes of glaciers in Tajikistan
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作者 XU Chunhai LI Zhongqin +6 位作者 HE Zhonghua WANG Feiteng MU Jianxin CHEN Yaning Sheralizoda NAZRIALO Farhod NASRULLOEV Aminjon GULAHMADZODA 《Regional Sustainability》 2026年第1期75-90,共16页
Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monito... Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management. 展开更多
关键词 Glacier inventory Glacier change Glacier mass balance Climate change TAJIKISTAN
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Recent advances in the properties,synthesis,and applications of oriented composite phase change materials
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作者 Jun Tong Zui Tao +5 位作者 Wenjie Hou Chaoxing Yang Tiantian Yuan Huimin Liao Xiubing Huang Ge Wang 《Journal of Energy Chemistry》 2026年第1期902-944,I0020,共44页
In the context of the global energy low-carbon transition,phase change energy storage technology becomes a key technology to solve the problem of intermittent renewable energy.Oriented phase change composites(OCPCMs)r... In the context of the global energy low-carbon transition,phase change energy storage technology becomes a key technology to solve the problem of intermittent renewable energy.Oriented phase change composites(OCPCMs)receive widespread attention in practical energy storage applications due to their unique oriented thermally conductive structure,which achieves significant thermal conductivity enhancement in specific directions while retaining the high energy storage capacity of the phase change components.This review systematically summarizes the overall analysis of OCPCMs from synthesis and preparation to application scenarios in recent years.Herein,we introduce the analysis of the heat transfer mechanism of the materials and explore the advantages of the oriented structure in OCPCMs in the heat transfer behavior from a bionic perspective.We then focus on summarizing and generalizing the methods for preparing OCPCMs,giving suggestions for suitable methods according to different scenarios.Besides,we discuss the application of finite element simulation methods to the monitoring of the thermal management behavior of OCPCMs,and look into the potential future application areas of such materials.Finally,it is hoped that this review will provide guidance for the academic community in developing high-performance OCPCMs. 展开更多
关键词 Phase change materials Oriented phase change composites Oriented thermal conduction Thermal conductivity enhancements
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When clothing learns to"think",temperature changes will no longer be a problem in outdoor activities
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作者 Xiao Ying Qiu Shuchen 《China Textile》 2026年第1期12-13,共2页
Lin Wei is a hiking enthusiast.At six o'clock on the last Saturday morning,the temperature at the foot of the mountain was only 2℃,so she put on her thickest fleece jacket.However,after only half an hour of climb... Lin Wei is a hiking enthusiast.At six o'clock on the last Saturday morning,the temperature at the foot of the mountain was only 2℃,so she put on her thickest fleece jacket.However,after only half an hour of climbing,the heat left her drenched in sweat,making her feel very cold.By midday,the temperature was approaching 20℃,and her heavy jacket had to be tied around her waist,becoming a burden during her hike.This outdoor adventure allowed her to appreciate the beautiful scenery,but also subjected her to repeated changes in temperature. 展开更多
关键词 HIKING temperature changes outdoor activities CLOTHING temperature regulation
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Spatiotemporal evolution of net ecosystem productivity and the driving mechanisms in Horqin Sandy Land,China
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作者 XU Xiaona ZHANG Huayong 《Journal of Arid Land》 2026年第1期34-55,共22页
Vegetation in terrestrial ecosystems as a carbon sink is a crucial factor in mitigating global warming and reaching carbon neutrality targets,although the drivers of net ecosystem productivity(NEP)under combined human... Vegetation in terrestrial ecosystems as a carbon sink is a crucial factor in mitigating global warming and reaching carbon neutrality targets,although the drivers of net ecosystem productivity(NEP)under combined human and environmental pressures remain poorly understood.In this study,we analyzed the spatiotemporal evolution of NEP in the Horqin Sandy Land,China from 2000 to 2020,and observed the variation in NEP across different land use types.We further identified and quantified the effects of human activities,topographical features,climatic conditions,and soil properties on NEP through the application of structural equation modeling(SEM)and boosted regression trees(BRT).The results showed that the multi-year average NEP ranged from–137.79 to 461.96 g C/m^(2) in the Horqin Sandy Land,with 88.21%of the area showing a significant increasing trend.Among different land use types,forestland exhibited the highest NEP values,followed by cropland,grassland,impervious land,and unused land.The NEP in carbon sink areas was primarily regulated by potential evapotranspiration(negatively correlated)and precipitation(positively correlated).Slope was identified as the most significant positive determinant in carbon source areas.Forestland exhibited climate–topography interactions driving NEP,whereas cropland and grassland relied on temperature;unused land and impervious land were susceptible to land use/cover change and human footprint.This study has significant implications for maintaining the carbon sink function and promoting ecological engineering programs that aim to enhance the capacity of terrestrial carbon sinks in the semi-arid agro-pastoral ecotone. 展开更多
关键词 net ecosystem productivity(NEP) land use/cover change(LUCC) carbon sink climate change human activities structural equation modeling(SEM) semi-arid agro-pastoral ecotone
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MewCDNet: A Wavelet-Based Multi-Scale Interaction Network for Efficient Remote Sensing Building Change Detection
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作者 Jia Liu Hao Chen +5 位作者 Hang Gu Yushan Pan Haoran Chen Erlin Tian Min Huang Zuhe Li 《Computers, Materials & Continua》 2026年第1期687-710,共24页
Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectra... Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability. 展开更多
关键词 Remote sensing change detection deep learning wavelet transform MULTI-SCALE
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Simulating silver fir provenance responses to climate change:A forest modelling approach in the Northern Apennines
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作者 Silvio Daniele Oggioni Lorenzo Matteo Walter Rossi +2 位作者 Silvia Terzago Friedrich J.Bohn Giorgio Vacchiano 《Forest Ecosystems》 2026年第1期44-56,共13页
Understanding how genetic variation within forest species influences growth responses under climate change is essential for improving the accuracy of forest models and guiding adaptive management strategies.This study... Understanding how genetic variation within forest species influences growth responses under climate change is essential for improving the accuracy of forest models and guiding adaptive management strategies.This study models the dynamics of Italian silver fir(Abies alba)forests under varying climate change scenarios using the forest gap model FORMIND.Focusing on three distinct silver fir provenances(Western Alps,Northern Apennines,and Southern Apennines),the study simulates forest growth in the Tuscan-Emilian Apennine National Park under different representative concentration pathways(RCPs).The individual-based model FORMIND was parameterized and validated with field data for each of the provenances,demonstrating its ability to accurately reproduce key forest metrics and dynamics.Our results reveal significant differences in expected growth patterns,productivity,metabolism,and carbon storage capacity among the silver fir provenances in pure and mixed stands.In the simulations,the Northern Apennines provenance showed higher biomass production(biomass>10%±1%)and carbon uptake(net primary productivity,NPP>8%±1%)at the end of the century compared to the Western Alps provenance in the pure provenance(PP)and no regeneration scenario.Conversely,the Southern Apennines provenance showed higher biomass(biomass>5%–10%)and NPP(>15%–18%)in mixed provenance(MP)and regeneration scenarios.These results show that genetic diversity strongly affects forest growth and resilience to environmental changes.Hence,it should be included as a predictor variable in forest models.The study also demonstrates the resilience of silver fir to climatic stressors,emphasizing its potential as a robust species in multiple forest contexts.The integration of forest provenance data into the FORMIND model represents a significant advancement in forest modelling,enabling more accurate and reliable predictions under climate change scenarios.The study's findings advocate for a greater understanding and consideration of genetic diversity in forest management and conservation strategies,in support of assisted migration strategies aiming to enhance the resilience of forest ecosystems in a changing climate. 展开更多
关键词 Silver fir Genetic diversity Climate change Forest modelling FORMIND
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Preliminary Study on the Theory of Environmentally Adaptive Changes in Flue-Cured Tobacco during Growth
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作者 Liuping DENG Ajuan ZHAO +13 位作者 Guoqiang HUANG Liangjiao Jiongling ZHAO Li LI Shaoxiang ZHANG Shimin ZHOU Jianyong LI Qiongfeng LIU Huan FAN Dewu ZENG Xinchao LI Liangrui PENG Sicheng CAI Dongcheng LI 《Asian Agricultural Research》 2026年第2期30-34,共5页
Starting from the foundational static traits underlying the growth and development of flue-cured tobacco, this research conducts a systematic examination of the phenomena and theoretical principles associated with env... Starting from the foundational static traits underlying the growth and development of flue-cured tobacco, this research conducts a systematic examination of the phenomena and theoretical principles associated with environment-driven adaptive changes during its cultivation. It was found that environmental variables-including temperature, light, and moisture-elicit directional shifts in static traits ( e.g. , chemical composition, morphological architecture, and leaf tissue structure) toward enhanced environmental adaptation, characterized by graduality, juvenility, similarity, and correlativity. Upon alterations in ambient conditions, flue-cured tobacco modulates its static traits through integrated physical, chemical, and biological-genetic mechanisms, aiming to optimize resource utilization, mitigate environmental constraints, and preserve internal homeostasis alongside metabolic balance. The investigation further reveals that the adaptive scope of flue-cured tobacco to field environments is malleable and can be extended and elevated via adaptive conditioning commencing at the juvenile stage. In addition, the adaptive alignment between static traits and environmental parameters exerts a substantial impact on the plant s growth dynamics, yield performance, and quality attributes. Beyond its relevance to flue-cured tobacco, the proposed theory offers a meaningful framework for elucidating the pervasive adaptive strategies employed by plants and broader biological systems in response to environmental contingencies. 展开更多
关键词 Flue-cured tobacco Static trait Environment Adaptive change
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Time-and dose-related pathological changes in knee osteoarthritis rat model induced by monosodium iodoacetate
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作者 Wei Pu Qi Liu +4 位作者 Shuyan Xue Siyuan Li Nan Nan Yang Liu Huiqin Hao 《Animal Models and Experimental Medicine》 2026年第1期21-30,共10页
Knee osteoarthritis(KOA)is a chronic degenerative disease.Monosodium iodoac-etate(MIA)induction is the most commonly used therapeutic effect evaluation and mechanism of action research model;we observed a lack of stan... Knee osteoarthritis(KOA)is a chronic degenerative disease.Monosodium iodoac-etate(MIA)induction is the most commonly used therapeutic effect evaluation and mechanism of action research model;we observed a lack of standardization and uni-formity in current model building methods,which led us to conduct this study.Background:The aim was to investigate the time-and dose-related changes in the behavioral and pathological characteristics in the MIA-induced KOA model rat.Methods:MIA(40,50,and 60 mg/mL)was injected into the left joint of male Sprague-Dawley rats.After 2 weeks,the changes in the KOA rat model were observed by be-havioral evaluation,imaging-level evaluation,and histological-level evaluation.The changes were also compared after 40-mg/mL MIA injection for 2 and 6 weeks.Results:MIA-induced bone surface defects,osteophyte hyperplasia around the artic-ular rim,increased subchondral bone density,thinning of the sparse trabecular bone,structural disorder,and local clustering were observed.The degree of injury gradually increased with the increase in MIA concentration.After 6 weeks,subchondral bone density and sparse trabecular bone increased in the KOA model.Conclusions:The severity of the model also increased significantly with the changes in dose and time.In dose-dependent experiments,this study revealed that 40 mg/mL was the optimal dose to induce significant pathological changes without causing undue discomfort or death in animals.This dose may induce pathological changes stably and is suitable for long-term observation. 展开更多
关键词 knee osteoarthritis MICRO-CT monosodium iodoacetate pathological change
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