“Are you too stupid to do anything right?”These words—said by a woman to a little boy who was evidently her son—were spoken because he had walked away from her.Andthey were said at a volume high enough that all th...“Are you too stupid to do anything right?”These words—said by a woman to a little boy who was evidently her son—were spoken because he had walked away from her.Andthey were said at a volume high enough that all the strangersin the vicinity could hear.Chastised,the boy returned quiet-ly to the woman’s side,his eyes downcast.Not a big moment,perhaps.Yet small moments some-展开更多
Once I was a conceited girl.I would neveraccept the advice of others.I was never readyto help others.Sometimes when someone wasin trouble,I liked to play a joke on him orher.So many classmates disliked me.My teach-ers...Once I was a conceited girl.I would neveraccept the advice of others.I was never readyto help others.Sometimes when someone wasin trouble,I liked to play a joke on him orher.So many classmates disliked me.My teach-ers often tried to change me,but I wouldn’tlisten.展开更多
Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often ...Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. Many clinical studies have tried numerous drugs and alternative medicine, however, investigators have failed to identify a safe and effective therapy for patients with NASH. As summarized, the heterogeneity of pathogenic pathways in individual patients with NASH may warrant the development of an individualized treatment according to the underlying pathogenic pathway. The differentiation of pathogenetic targets may require the development of diagnostic and prognostic biomarkers, and the identification of genetic susceptibilities. At present, evidence-based medicine provides only a few options including life-style modifications targeting weight loss, pioglitazone and vitamin E in non-diabetic patients with biopsy-proven NASH.展开更多
In this work, we revised the expression of mixing intensity to describe the mixing output through a cross section in a flow system by considering heterogeneity of flow field, and carefully investigated the mixing proc...In this work, we revised the expression of mixing intensity to describe the mixing output through a cross section in a flow system by considering heterogeneity of flow field, and carefully investigated the mixing process along a straight tube with expanding/contracting cross section by simulation method. The simulation results show that a sudden expansion of cross section has remarkable mixing intensification effect within a limited period(on the sub-second scale) or tube-length(on the millimeter scale), corresponding to the generation of considerable local vortices determined by both the flow capacity and the ratio of cross section change; a sudden contraction of cross section has instantaneous but weak mixing intensification effect; through introducing a local expansion structure with proper length, as the combination of sudden expansion and sudden contraction, their mixing intensification effects could be superposed. Besides, the rationality and importance are experimentally verified to explore the time profile of mixing intensity and carry out the vortex analysis by simulation for enhancing the selectivity of a complicated reaction system. These progresses may lead to more meaningful quantitative description of mixing process in a flow microreactor for some specific chemical processes.展开更多
Convolutional Neural Networks(CNN)have been successfully employed in the field of image classification.However,CNN trained using images from several years ago may be unable to identify how such images have changed ove...Convolutional Neural Networks(CNN)have been successfully employed in the field of image classification.However,CNN trained using images from several years ago may be unable to identify how such images have changed over time.Cross-age face recognition is,therefore,a substantial challenge.Several efforts have been made to resolve facial changes over time utilizing recurrent neural networks(RNN)with CNN.The structure of RNN contains hidden contextual information in a hidden state to transfer a state in the previous step to the next step.This paper proposes a novel model called Hidden State-CNN(HSCNN).This adds to CNN a convolution layer of the hidden state saved as a parameter in the previous step and requires no more computing resources than CNN.The previous CNN-RNN models perform CNN and RNN,separately and then merge the results.Therefore,their systems consume twice the memory resources and CPU time,compared with the HSCNN system,which works the same as CNN only.HSCNN consists of 3 types of models.All models load hidden state ht−1 from parameters of the previous step and save ht as a parameter for the next step.In addition,modelB adds ht−1 to x,which is the previous output.The summation of ht−1 and x is multiplied by weight W.In model-C the convolution layer has two weights:W1 and W2.Training HSCNN with faces of the previous step is for testing faces of the next step in the experiment.That is,HSCNN trained with past facial data is then used to verify future data.It has been found to exhibit 10 percent greater accuracy than traditional CNN with a celeb face database.展开更多
Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new ...Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new climate references and new index standards, ENSO episodes and their intensities for the period 1951 -2003 have been classified. Finally, an analysis has been performed comparing the new characteristics with the old ones for ENSO period, peak values and intensities.展开更多
In order to accurately grasp the soil fertility in Three Gorges Reservoir Region after changing mountain slope into terrace field,we take Wushan County for example,and use the spatio-temporal substitution method to an...In order to accurately grasp the soil fertility in Three Gorges Reservoir Region after changing mountain slope into terrace field,we take Wushan County for example,and use the spatio-temporal substitution method to analyze the soil nutrient status and trend about the terrace field changed from mountain slope under different length of implementation.The results show that the soil fertility is generally low in the study area,and according to the soil nutrient grading standards in the second national land survey,the average content of total nitrogen,available potassium,organic matter and available phosphorus reaches Standard III,Standard III,Standard IV and Standard V,respectively,and the spatial heterogeneity of soil nutrients is small.Compared to the sloping land,the terrace field changed from mountain slope has increasing soil nutrients on the whole with the length of farming.The mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 2 years is lower than in the sloping land,and there is the biggest difference in soil fertility,while the mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 14 years shows a linear upward trend,and the difference in soil fertility decreases.展开更多
The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danis...The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danish Eulerian Hemispheric Model (DEHM) forced with meteorology projected by theECHAM5/MPI-OM coupled Atmosphere-Ocean General Circulation Model. The largest changes in meteorology, ozone and its precursors are found in the 21st century, however, also significant changes are found in the 22nd century. At surface level the ozone concentration is projected to increase due to climate change in the areas where substantial amounts of ozone precursors are emitted. Elsewhere a significant decrease is projected at the surface. In the free troposphere a general increase is found in the entire Northern Hemisphere except in the tropics, where the ozone concentration is decreasing. In the Arctic the ozone concentration will increase in the entire air column, which most likely is due to changes in atmospheric transport. Changes in temperature, humidity and the naturally emitted Volatile Organic Compounds (VOCs) are governing the changes in ozone both in the past, present and future century.展开更多
This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signa...This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning accuracy.Managed by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude regions.Ina-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast Asia.We provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this network.We generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific research.Two preliminary findings from the ROTI maps of Ina-CORS are noteworthy.First,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther eastward.Second,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East Asia.We have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,2024.We observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities post-midnight.By sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionospheric research.展开更多
In the practice of healthcare,patient-reported outcomes(PROs)and PRO measures(PROMs)are used as an attempt to observe the changes in complex clinical situations.They guide us in making decisions based on the evidence ...In the practice of healthcare,patient-reported outcomes(PROs)and PRO measures(PROMs)are used as an attempt to observe the changes in complex clinical situations.They guide us in making decisions based on the evidence regarding patient care by recording the change in outcomes for a particular treatment to a given condition and finally to understand whether a patient will benefit from a particular treatment and to quantify the treatment effect.For any PROM to be usable in health care,we need it to be reliable,encapsulating the points of interest with the potential to detect any real change.Using structured outcome measures routinely in clinical practice helps the physician to understand the functional limitation of a patient that would otherwise not be clear in an office interview,and this allows the physician and patient to have a meaningful conver-sation as well as a customized plan for each patient.Having mentioned the rationale and the benefits of PROMs,understanding the quantification process is crucial before embarking on management decisions.A better interpretation of change needs to identify the treatment effect based on clinical relevance for a given condition.There are a multiple set of measurement indices to serve this effect and most of them are used interchangeably without clear demarcation on their differences.This article details the various quantification metrics used to evaluate the treatment effect using PROMs,their limitations and the scope of usage and implementation in clinical practice.展开更多
Latent heat thermal energy storage(TES)effectively reduces the mismatch between energy supply and demand of renewable energy sources by the utilization of phase change materials(PCMs).However,the low thermal conductiv...Latent heat thermal energy storage(TES)effectively reduces the mismatch between energy supply and demand of renewable energy sources by the utilization of phase change materials(PCMs).However,the low thermal conductivity and poor shape stability are the main drawbacks in realizing the large-scale application of PCMs.Promisingly,developing composite PCM(CPCM)based on porous supporting mate-rial provides a desirable solution to obtain performance-enhanced PCMs with improved effective thermal conductivity and shape stability.Among all the porous matrixes as supports for PCM,three-dimensional carbon-based porous supporting material has attracted considerable attention ascribing to its high ther-mal conductivity,desirable loading capacity of PCMs,and excellent chemical compatibility with various PCMs.Therefore,this work systemically reviews the CPCMs with three-dimensional carbon-based porous supporting materials.First,a concise rule for the fabrication of CPCMs is illustrated in detail.Next,the experimental and computational research of carbon nanotube-based support,graphene-based support,graphite-based support and amorphous carbon-based support are reviewed.Then,the applications of the shape-stabilized CPCMs including thermal management and thermal conversion are illustrated.Last but not least,the challenges and prospects of the CPCMs are discussed.To conclude,introducing carbon-based porous materials can solve the liquid leakage issue and essentially improve the thermal conductivity of PCMs.However,there is still a long way to further develop a desirable CPCM with higher latent heat capacity,higher thermal conductivity,and more excellent shape stability.展开更多
BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic im...BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.展开更多
Ecological conservation is at a crossroad as environmental stresses around the world intensify and traditional models of conservation exhibit intrinsic weaknesses in their response to present and future problems.In th...Ecological conservation is at a crossroad as environmental stresses around the world intensify and traditional models of conservation exhibit intrinsic weaknesses in their response to present and future problems.In the project,we evaluated novel approaches integrating adaptive management,technological innovations,and community-based action towards more efficient sustainable conservation results and ecosystem resilience.The multi-site experimental design was based on comparison between conventional reserve management and novel integrative models implemented in diverse ecological zones.Data were collected over a period of three years employing remote sensing technologies,in situ biodiversity assessments,and large socioeconomic surveys.These instruments enabled a robust and multi-dimensional measurement of variables such as species diversity,ecological resilience,community engagement,and stakeholder engagement.The results indicate that adaptive strategies significantly enhance real-time decision-making abilities and enhance long-term ecosystem resilience.Further,technology-driven monitoring greatly enhances data accuracy,responsiveness,and early warning capabilities.Besides that,community-based conservation initiatives were found to be pivotal in facilitating local stewardship,enhancing participatory governance,and enabling more adaptive and adaptive policy systems.This research rejects mainstream conservation paradigms by placing importance on flexibility,interdisciplinarity,and inclusivity of governance systems in effectively mitigating the impacts of climate change and loss of biodiversity.Our findings offer strong evidence that emerging paradigms of conservation can provide greater ecological and social sustainability than traditional methods.These results support the need for a paradigm shift towards conservation strategies that are dynamic,collaborative,and technologically integrated,with significant implications for policy formulation as well as operational environmental management.展开更多
1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Int...1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Intergovernmental Panel on Climate Change(IPCC)—consistently predict the widespread implementation of CO_(2)geological storage on a global scale.展开更多
Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what exten...Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what extent CO_(2)fertilization affects vegetation changes in such regions remains unclear.In this study,we investigated the degree to which CO_(2)fertilization influences vegetation changes,along with their spatial and temporal differences,in the subtropical humid karst region using time-lag effect analysis,a random forest model,and multiple regression analysis.Results showed that CO_(2)fertilization plays an important role in vegetation changes,exhibiting clear spatial variations across different geomorphological zones,with its degree of influence ranging mainly between 11%and 25%.The highest contribution of CO_(2)fertilization was observed in the karst basin and non-karstic region,whereas the lowest contribution was found in the karst plateau region.Previous studies have primarily attributed vegetation changes in subtropical humid karst region to ecological engineering,leading to an overestimation of its contribution to these changes.The findings of this study enhance the understanding of the mechanism of vegetation changes in humid karst region and provide theoretical and practical insights for ecological and environmental protection in these regions.展开更多
文摘“Are you too stupid to do anything right?”These words—said by a woman to a little boy who was evidently her son—were spoken because he had walked away from her.Andthey were said at a volume high enough that all the strangersin the vicinity could hear.Chastised,the boy returned quiet-ly to the woman’s side,his eyes downcast.Not a big moment,perhaps.Yet small moments some-
文摘Once I was a conceited girl.I would neveraccept the advice of others.I was never readyto help others.Sometimes when someone wasin trouble,I liked to play a joke on him orher.So many classmates disliked me.My teach-ers often tried to change me,but I wouldn’tlisten.
文摘Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. Many clinical studies have tried numerous drugs and alternative medicine, however, investigators have failed to identify a safe and effective therapy for patients with NASH. As summarized, the heterogeneity of pathogenic pathways in individual patients with NASH may warrant the development of an individualized treatment according to the underlying pathogenic pathway. The differentiation of pathogenetic targets may require the development of diagnostic and prognostic biomarkers, and the identification of genetic susceptibilities. At present, evidence-based medicine provides only a few options including life-style modifications targeting weight loss, pioglitazone and vitamin E in non-diabetic patients with biopsy-proven NASH.
基金Supported by the National Natural Science Foundation of China(21176136,21422603)the National Science and Technology Support Program of China(2011BAC06B01)
文摘In this work, we revised the expression of mixing intensity to describe the mixing output through a cross section in a flow system by considering heterogeneity of flow field, and carefully investigated the mixing process along a straight tube with expanding/contracting cross section by simulation method. The simulation results show that a sudden expansion of cross section has remarkable mixing intensification effect within a limited period(on the sub-second scale) or tube-length(on the millimeter scale), corresponding to the generation of considerable local vortices determined by both the flow capacity and the ratio of cross section change; a sudden contraction of cross section has instantaneous but weak mixing intensification effect; through introducing a local expansion structure with proper length, as the combination of sudden expansion and sudden contraction, their mixing intensification effects could be superposed. Besides, the rationality and importance are experimentally verified to explore the time profile of mixing intensity and carry out the vortex analysis by simulation for enhancing the selectivity of a complicated reaction system. These progresses may lead to more meaningful quantitative description of mixing process in a flow microreactor for some specific chemical processes.
基金This work was supported by the National Research Foundation of Korea(NRF)grant in 2019(NRF-2019R1G1A1004773).
文摘Convolutional Neural Networks(CNN)have been successfully employed in the field of image classification.However,CNN trained using images from several years ago may be unable to identify how such images have changed over time.Cross-age face recognition is,therefore,a substantial challenge.Several efforts have been made to resolve facial changes over time utilizing recurrent neural networks(RNN)with CNN.The structure of RNN contains hidden contextual information in a hidden state to transfer a state in the previous step to the next step.This paper proposes a novel model called Hidden State-CNN(HSCNN).This adds to CNN a convolution layer of the hidden state saved as a parameter in the previous step and requires no more computing resources than CNN.The previous CNN-RNN models perform CNN and RNN,separately and then merge the results.Therefore,their systems consume twice the memory resources and CPU time,compared with the HSCNN system,which works the same as CNN only.HSCNN consists of 3 types of models.All models load hidden state ht−1 from parameters of the previous step and save ht as a parameter for the next step.In addition,modelB adds ht−1 to x,which is the previous output.The summation of ht−1 and x is multiplied by weight W.In model-C the convolution layer has two weights:W1 and W2.Training HSCNN with faces of the previous step is for testing faces of the next step in the experiment.That is,HSCNN trained with past facial data is then used to verify future data.It has been found to exhibit 10 percent greater accuracy than traditional CNN with a celeb face database.
基金Core project in the key research of the 9th five-year economic development plan of China - "Study on Prediction System for Short-term Climate in China"(96-908-06-1-2-2)
文摘Through studying changes in ENSO indices relative to change of climate reference from 1961~1990 to 1971~2000, the study generated new standards to define ENSO episodes and their intensities. Then according to the new climate references and new index standards, ENSO episodes and their intensities for the period 1951 -2003 have been classified. Finally, an analysis has been performed comparing the new characteristics with the old ones for ENSO period, peak values and intensities.
基金Supported by National Natural Science Foundation of China(41001168)National Science and Technology Support Program(2011BAD31B03)+2 种基金Chongqing Natural Science Foundation(CSTC2010BB0326)Social Sciences Project of Chongqing Municipal Education Commission(08JWSK043)Doctoral Fund Project of Chongqing Normal University(05XLB)
文摘In order to accurately grasp the soil fertility in Three Gorges Reservoir Region after changing mountain slope into terrace field,we take Wushan County for example,and use the spatio-temporal substitution method to analyze the soil nutrient status and trend about the terrace field changed from mountain slope under different length of implementation.The results show that the soil fertility is generally low in the study area,and according to the soil nutrient grading standards in the second national land survey,the average content of total nitrogen,available potassium,organic matter and available phosphorus reaches Standard III,Standard III,Standard IV and Standard V,respectively,and the spatial heterogeneity of soil nutrients is small.Compared to the sloping land,the terrace field changed from mountain slope has increasing soil nutrients on the whole with the length of farming.The mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 2 years is lower than in the sloping land,and there is the biggest difference in soil fertility,while the mean of various indicators about soil nutrients in the terrace field changed from mountain slope for 14 years shows a linear upward trend,and the difference in soil fertility decreases.
基金partly funded by the Centre for Energy,Environment and Health(CEEH),financed by The Danish Strategic Research Program on Sustainable Energy under contract no 2104-06-0027(www.ceeh.dk).
文摘The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danish Eulerian Hemispheric Model (DEHM) forced with meteorology projected by theECHAM5/MPI-OM coupled Atmosphere-Ocean General Circulation Model. The largest changes in meteorology, ozone and its precursors are found in the 21st century, however, also significant changes are found in the 22nd century. At surface level the ozone concentration is projected to increase due to climate change in the areas where substantial amounts of ozone precursors are emitted. Elsewhere a significant decrease is projected at the surface. In the free troposphere a general increase is found in the entire Northern Hemisphere except in the tropics, where the ozone concentration is decreasing. In the Arctic the ozone concentration will increase in the entire air column, which most likely is due to changes in atmospheric transport. Changes in temperature, humidity and the naturally emitted Volatile Organic Compounds (VOCs) are governing the changes in ozone both in the past, present and future century.
基金JSPS KAKENHI Grant Number16H06286 supports global GNSS ionospheric maps (TEC,ROTI,and detrended TEC maps) developed by the Institute for SpaceEarth Environmental Research (ISEE) of Nagoya Universitysupport of the 2024 JASSO Follow-up Research Fellowship Program for a 90-day visiting research at the Institute for Space-Earth Environmental Research (ISEE),Nagoya University+3 种基金the support received from Telkom University under the“Skema Penelitian Terapan Periode I Tahun Anggaran 2024”the Memorandum of Understanding for Research Collaboration on Regional Ionospheric Observation (No:092/SAM3/TE-DEK/2021)the National Institute of Information and Communications Technology (NICT) International Exchange Program 2024-2025(No.2024-007)support for a one-year visiting research at Hokkaido University
文摘This paper highlights the crucial role of Indonesia’s GNSS receiver network in advancing Equatorial Plasma Bubble(EPB)studies in Southeast and East Asia,as ionospheric irregularities within EPB can disrupt GNSS signals and degrade positioning accuracy.Managed by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference Station(Ina-CORS)network comprises over 300 GNSS receivers spanning equatorial to southern low-latitude regions.Ina-CORS is uniquely situated to monitor EPB generation,zonal drift,and dissipation across Southeast Asia.We provide a practical tool for EPB research,by sharing two-dimensional rate of Total Electron Content(TEC)change index(ROTI)derived from this network.We generate ROTI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific research.Two preliminary findings from the ROTI maps of Ina-CORS are noteworthy.First,the Ina-CORS ROTI maps reveal that the irregularities within a broader EPB structure persist longer,increasing the potential for these irregularities to migrate farther eastward.Second,we demonstrate that combined ROTI maps from Ina-CORS and GNSS receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in Southeast and East Asia.We have demonstrated the combined ROTI maps to capture the development of ionospheric irregularities in the Southeast/East Asian sector during the G5 Geomagnetic Storm on May 11,2024.We observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas Southeast Asia’s equatorial and low-latitude regions exhibited irregularities post-midnight.By sharing ROTI maps from Indonesia and integrating them with regional GNSS networks,researchers can conduct comprehensive EPB studies,enhancing the understanding of EPB behavior across Southeast and East Asia and contributing significantly to ionospheric research.
文摘In the practice of healthcare,patient-reported outcomes(PROs)and PRO measures(PROMs)are used as an attempt to observe the changes in complex clinical situations.They guide us in making decisions based on the evidence regarding patient care by recording the change in outcomes for a particular treatment to a given condition and finally to understand whether a patient will benefit from a particular treatment and to quantify the treatment effect.For any PROM to be usable in health care,we need it to be reliable,encapsulating the points of interest with the potential to detect any real change.Using structured outcome measures routinely in clinical practice helps the physician to understand the functional limitation of a patient that would otherwise not be clear in an office interview,and this allows the physician and patient to have a meaningful conver-sation as well as a customized plan for each patient.Having mentioned the rationale and the benefits of PROMs,understanding the quantification process is crucial before embarking on management decisions.A better interpretation of change needs to identify the treatment effect based on clinical relevance for a given condition.There are a multiple set of measurement indices to serve this effect and most of them are used interchangeably without clear demarcation on their differences.This article details the various quantification metrics used to evaluate the treatment effect using PROMs,their limitations and the scope of usage and implementation in clinical practice.
基金supported by the National Natural Science Foundation of China(No.52127816),the National Key Research and Development Program of China(No.2020YFA0715000)the National Natural Science and Hong Kong Research Grant Council Joint Research Funding Project of China(No.5181101182)the NSFC/RGC Joint Research Scheme sponsored by the Research Grants Council of Hong Kong and the National Natural Science Foundation of China(No.N_PolyU513/18).
文摘Latent heat thermal energy storage(TES)effectively reduces the mismatch between energy supply and demand of renewable energy sources by the utilization of phase change materials(PCMs).However,the low thermal conductivity and poor shape stability are the main drawbacks in realizing the large-scale application of PCMs.Promisingly,developing composite PCM(CPCM)based on porous supporting mate-rial provides a desirable solution to obtain performance-enhanced PCMs with improved effective thermal conductivity and shape stability.Among all the porous matrixes as supports for PCM,three-dimensional carbon-based porous supporting material has attracted considerable attention ascribing to its high ther-mal conductivity,desirable loading capacity of PCMs,and excellent chemical compatibility with various PCMs.Therefore,this work systemically reviews the CPCMs with three-dimensional carbon-based porous supporting materials.First,a concise rule for the fabrication of CPCMs is illustrated in detail.Next,the experimental and computational research of carbon nanotube-based support,graphene-based support,graphite-based support and amorphous carbon-based support are reviewed.Then,the applications of the shape-stabilized CPCMs including thermal management and thermal conversion are illustrated.Last but not least,the challenges and prospects of the CPCMs are discussed.To conclude,introducing carbon-based porous materials can solve the liquid leakage issue and essentially improve the thermal conductivity of PCMs.However,there is still a long way to further develop a desirable CPCM with higher latent heat capacity,higher thermal conductivity,and more excellent shape stability.
文摘BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.
基金supported by the Lebanese International University(LIU)with a funding amount of$500.
文摘Ecological conservation is at a crossroad as environmental stresses around the world intensify and traditional models of conservation exhibit intrinsic weaknesses in their response to present and future problems.In the project,we evaluated novel approaches integrating adaptive management,technological innovations,and community-based action towards more efficient sustainable conservation results and ecosystem resilience.The multi-site experimental design was based on comparison between conventional reserve management and novel integrative models implemented in diverse ecological zones.Data were collected over a period of three years employing remote sensing technologies,in situ biodiversity assessments,and large socioeconomic surveys.These instruments enabled a robust and multi-dimensional measurement of variables such as species diversity,ecological resilience,community engagement,and stakeholder engagement.The results indicate that adaptive strategies significantly enhance real-time decision-making abilities and enhance long-term ecosystem resilience.Further,technology-driven monitoring greatly enhances data accuracy,responsiveness,and early warning capabilities.Besides that,community-based conservation initiatives were found to be pivotal in facilitating local stewardship,enhancing participatory governance,and enabling more adaptive and adaptive policy systems.This research rejects mainstream conservation paradigms by placing importance on flexibility,interdisciplinarity,and inclusivity of governance systems in effectively mitigating the impacts of climate change and loss of biodiversity.Our findings offer strong evidence that emerging paradigms of conservation can provide greater ecological and social sustainability than traditional methods.These results support the need for a paradigm shift towards conservation strategies that are dynamic,collaborative,and technologically integrated,with significant implications for policy formulation as well as operational environmental management.
基金supported by the National Key Research and Development Program of China(2022YFE0206700)。
文摘1.Introduction Climate change mitigation pathways aimed at limiting global anthropogenic carbon dioxide(CO_(2))emissions while striving to constrain the global temperature increase to below 2℃—as outlined by the Intergovernmental Panel on Climate Change(IPCC)—consistently predict the widespread implementation of CO_(2)geological storage on a global scale.
基金National Natural Science Foundation of China,No.41761003The Karst Science Research Center of Guizhou Province,No.U1812401。
文摘Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what extent CO_(2)fertilization affects vegetation changes in such regions remains unclear.In this study,we investigated the degree to which CO_(2)fertilization influences vegetation changes,along with their spatial and temporal differences,in the subtropical humid karst region using time-lag effect analysis,a random forest model,and multiple regression analysis.Results showed that CO_(2)fertilization plays an important role in vegetation changes,exhibiting clear spatial variations across different geomorphological zones,with its degree of influence ranging mainly between 11%and 25%.The highest contribution of CO_(2)fertilization was observed in the karst basin and non-karstic region,whereas the lowest contribution was found in the karst plateau region.Previous studies have primarily attributed vegetation changes in subtropical humid karst region to ecological engineering,leading to an overestimation of its contribution to these changes.The findings of this study enhance the understanding of the mechanism of vegetation changes in humid karst region and provide theoretical and practical insights for ecological and environmental protection in these regions.
