AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which r...AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance(sLV) and mean defect(MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. RESULTS: Our analysis determined Spearman coefficient is 0.705 for the correlation between sLV and MH stage(P<0.01), 0.877 for the correlation between sLV and postoperative ellipsoid zone disruption(P<0.01) and 0.721 for the correlation between MD and postoperative ellipsoid zone disruption(P<0.01). A significant relationship was also detected between postoperative ellipsoid zone disruption and MH stage(r=0.470, P<0.05). Univariate regression analysis indicated that sLV and MD were associated with postoperative ellipsoid zone disruption(P<0.01, P<0.01, respectively). CONCLUSION: Postoperative cVFD is highly correlated with MH stage and postoperative ellipsoid zone disruption in patients with MH.展开更多
目的:评价益气活血通窍药物对放射性视神经病变晚期患者视功能的改善作用。方法:选择放射性视神经病变(RION)晚期患者12例21眼,应用益气活血通窍药物黄芪注射液、川芎嗪注射液和醒脑静注射液静脉滴注,两周为一疗程。于治疗前、第一疗程...目的:评价益气活血通窍药物对放射性视神经病变晚期患者视功能的改善作用。方法:选择放射性视神经病变(RION)晚期患者12例21眼,应用益气活血通窍药物黄芪注射液、川芎嗪注射液和醒脑静注射液静脉滴注,两周为一疗程。于治疗前、第一疗程结束和第二疗程结束行视力、视野和视觉诱发电位检查,记录最佳矫正视力、中心视野平均光敏度和平均缺损、以及视觉诱发电位振幅值,比较患者治疗前后的视功能改变。结果:第一疗程和第二疗程后视力改善的有效率分别为38.10%和57.14%,两个疗程的疗效差异有统计学意义(P<0.05)。治疗前中心视野平均光敏度(MS)和平均缺损(MD)分别为(12.16±5.20d B)和(15.60±2.39d B),第一疗程后分别为(13.92±4.68d B)和(13.85±1.39 d B),第二疗程后分别为(15.55±5.32d B)和(11.87±2.00 d B),其中第二疗程后的MS值和MD值与治疗前比较有统计学差异(P<0.05)。13眼闪光视觉诱发电位(F-VEP)于治疗前、第一疗程和第二疗程后的P2波平均振幅值分别为(5.08±2.35μv)、(7.36±2.58μv)和(9.25±3.06μv),其中第二疗程后与治疗前比较有统计学差异(P<0.05);6眼图形视觉诱发电位(P-VEP)检查于治疗前、第一疗程和第二疗程后的P100波平均振幅值分别为(3.33±1.45μv)、(4.70±1.42μv)和(6.53±1.94μv),其中第二疗程后平均振幅与治疗前比较有统计学差异(P<0.05)。结论:益气活血通窍法对晚期RION患者具有保持和改善视力、提高中心视野光敏度和视觉诱发电位振幅的作用,对于改善晚期RION患者视功能和提高生活质量有临床应用价值。展开更多
目的:观察玻璃体切割术中不同内界膜剥离方式治疗黄斑裂孔闭合指数(MHCI)<0.7特发性黄斑裂孔(IMH)的临床效果。方法:将2014-05/2017-05收治的MHCI<0.7 IMH患者88例88眼随机分为A组(44眼,行扩大内界膜剥离术)和B组(44眼,行标准内...目的:观察玻璃体切割术中不同内界膜剥离方式治疗黄斑裂孔闭合指数(MHCI)<0.7特发性黄斑裂孔(IMH)的临床效果。方法:将2014-05/2017-05收治的MHCI<0.7 IMH患者88例88眼随机分为A组(44眼,行扩大内界膜剥离术)和B组(44眼,行标准内界膜剥离术),观察两组患者黄斑裂孔闭合情况、最佳矫正视力(BCVA)、中心暗点及并发症发生情况。结果:术后6mo,A组患者黄斑裂孔闭合率明显高于B组(91% vs 75%, P <0.05),BCVA优于B组(0.47±0.05 vs 0.74±0.14, P <0.05),中心暗点眼数占比低于B组(4% vs 23%, P <0.05),且两组患者并发症发生率无明显差异(11% vs 9%, P >0.05)。结论:临床治疗MHCI<0.7的IMH采用扩大内界膜剥离术较标准内界膜剥离术疗效更突出,前者视网膜功能恢复效果更佳。展开更多
基金Supported by National Natural Science Foundation of China(No.81670865 No.81500743)Natural Science Foundation of Tianjin(No.16JCQNJC13000)
文摘AIM: To investigate the characteristics of postoperative central visual field defect(cVFD) in patients with macular hole(MH).METHODS: Eighteen eyes from 18 MH patients were involved in this retrospective study which reviewed square root of loss variance(sLV) and mean defect(MD) of the visual field test in all subjects. The relationship between cVFD and MH stage, as well as the postoperative ellipsoid zone disruption were evaluated using Spearman's correlation test. RESULTS: Our analysis determined Spearman coefficient is 0.705 for the correlation between sLV and MH stage(P<0.01), 0.877 for the correlation between sLV and postoperative ellipsoid zone disruption(P<0.01) and 0.721 for the correlation between MD and postoperative ellipsoid zone disruption(P<0.01). A significant relationship was also detected between postoperative ellipsoid zone disruption and MH stage(r=0.470, P<0.05). Univariate regression analysis indicated that sLV and MD were associated with postoperative ellipsoid zone disruption(P<0.01, P<0.01, respectively). CONCLUSION: Postoperative cVFD is highly correlated with MH stage and postoperative ellipsoid zone disruption in patients with MH.
文摘目的:评价益气活血通窍药物对放射性视神经病变晚期患者视功能的改善作用。方法:选择放射性视神经病变(RION)晚期患者12例21眼,应用益气活血通窍药物黄芪注射液、川芎嗪注射液和醒脑静注射液静脉滴注,两周为一疗程。于治疗前、第一疗程结束和第二疗程结束行视力、视野和视觉诱发电位检查,记录最佳矫正视力、中心视野平均光敏度和平均缺损、以及视觉诱发电位振幅值,比较患者治疗前后的视功能改变。结果:第一疗程和第二疗程后视力改善的有效率分别为38.10%和57.14%,两个疗程的疗效差异有统计学意义(P<0.05)。治疗前中心视野平均光敏度(MS)和平均缺损(MD)分别为(12.16±5.20d B)和(15.60±2.39d B),第一疗程后分别为(13.92±4.68d B)和(13.85±1.39 d B),第二疗程后分别为(15.55±5.32d B)和(11.87±2.00 d B),其中第二疗程后的MS值和MD值与治疗前比较有统计学差异(P<0.05)。13眼闪光视觉诱发电位(F-VEP)于治疗前、第一疗程和第二疗程后的P2波平均振幅值分别为(5.08±2.35μv)、(7.36±2.58μv)和(9.25±3.06μv),其中第二疗程后与治疗前比较有统计学差异(P<0.05);6眼图形视觉诱发电位(P-VEP)检查于治疗前、第一疗程和第二疗程后的P100波平均振幅值分别为(3.33±1.45μv)、(4.70±1.42μv)和(6.53±1.94μv),其中第二疗程后平均振幅与治疗前比较有统计学差异(P<0.05)。结论:益气活血通窍法对晚期RION患者具有保持和改善视力、提高中心视野光敏度和视觉诱发电位振幅的作用,对于改善晚期RION患者视功能和提高生活质量有临床应用价值。
文摘目的:观察玻璃体切割术中不同内界膜剥离方式治疗黄斑裂孔闭合指数(MHCI)<0.7特发性黄斑裂孔(IMH)的临床效果。方法:将2014-05/2017-05收治的MHCI<0.7 IMH患者88例88眼随机分为A组(44眼,行扩大内界膜剥离术)和B组(44眼,行标准内界膜剥离术),观察两组患者黄斑裂孔闭合情况、最佳矫正视力(BCVA)、中心暗点及并发症发生情况。结果:术后6mo,A组患者黄斑裂孔闭合率明显高于B组(91% vs 75%, P <0.05),BCVA优于B组(0.47±0.05 vs 0.74±0.14, P <0.05),中心暗点眼数占比低于B组(4% vs 23%, P <0.05),且两组患者并发症发生率无明显差异(11% vs 9%, P >0.05)。结论:临床治疗MHCI<0.7的IMH采用扩大内界膜剥离术较标准内界膜剥离术疗效更突出,前者视网膜功能恢复效果更佳。
