Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-r...Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,展开更多
Objective To evaluate the value of autofluorescence bronchoscope (AFB) in airway examination in central type lung cancer. Methods From Sep 2009 to Mar 2010,29 patients (23 men,6 women,median age 62. 2 years,range from...Objective To evaluate the value of autofluorescence bronchoscope (AFB) in airway examination in central type lung cancer. Methods From Sep 2009 to Mar 2010,29 patients (23 men,6 women,median age 62. 2 years,range from 34 to 81 years) underwent AFB procedure. There were 3 lesions located at trachea,1 at展开更多
Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for m...Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for multiple complications. The objective of this study was to characterize clinically and biologically type 2 diabetic patients followed at the National Center for Diabetology and Arterial Hypertension of the Central Hospital of Yaoundé. Method: This prospective, cross-sectional, and analytical study took place from April 5 to July 31, 2023 (4 months) on 100 diabetic patients of both sexes (61 women and 39 men), aged from 31 to 88 years. Body Mass Index, systolic and diastolic blood pressure, and cardiac frequency were measured on each of the patients. Subsequently, blood was collected from the patients for the determination of the complete blood count, HBA1c, lipid profile, serum albumin, TNF-α, and IL-6 levels. The data were analyzed using SPSS 17.0 software. Results: The age average of our population was 56.99 ± 11.51 years, the population was primarily female (61%) and primarily between the ages of 55 and 88. 67% of respondents were married. 59% went to secondary school. 73% of them lived in urban areas. 30% were obese and 40% were overweight, with an average BMI of 28.75 kg/m2. 76% of patients took oral antidiabetic medications. HbA1c level average was 8.65%, with 60% having readings above 6.5%. Low hemoglobin and hypochromia were among the abnormalities of red blood cells observed. Lipid profiles revealed low HDL-cholesterol and high triglycerides and cholesterol. Elevated levels of TNF-α and IL-6 indicated inflammation and cardiovascular risk. Conclusion: These results indicate the necessity of focused diabetic care and management on diabetic patients attending the central hospital of Yaoundé, Cameroon.展开更多
Type 2 diabetes （T2D） is an important risk factor for developing dementias, including Alzheimer＇s disease （AD）. Hyperinsulin- emia and glucose intolerance, as features of T2D, might increase the neurodegeneration...Type 2 diabetes （T2D） is an important risk factor for developing dementias, including Alzheimer＇s disease （AD）. Hyperinsulin- emia and glucose intolerance, as features of T2D, might increase the neurodegeneration process, synaptic loss and brain atrophy, leading to cognitive impairment observed in AD. Also, adult neurogenesis seems to be impaired in AD models. Therefore, we have studied morphological alterations, cell proliferation and neurogenesis in the central nervous system （CNS） from a classical model of T2D, the db/db mouse, and in a prediabetes insulin-resistant model, obtained after long-term high fat diet （HFD） administration to C57B1/6 mice. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. Neurogen- esis and cell proliferation were increased in young db/db mice, when compared with control mice, whereas no differences were detected in the prediabetic model. We also detected significant correlations between metabolic parameters and central atrophy, altered proliferation and neurogenesis in the central nervous system. Altogether these data support that glycaemia control in elderly patients, could help to control central alterations and improve dementia prognosis.展开更多
The alkali feldspar granite of Gabal El Atawi is post orogenic granite originated from subalkaline magma in extensional suite. It is developed within plate tectonic setting and has A2-type character which generated fr...The alkali feldspar granite of Gabal El Atawi is post orogenic granite originated from subalkaline magma in extensional suite. It is developed within plate tectonic setting and has A2-type character which generated from apparent crustal source. The petrographic, geochemical and radioactive characteristics of El Atawi granite meet and fulfill the requirements of being fertile granite and it can be considered as promising uraniferous granite. Fluid inclusion studies of the altered granite elucidated two different solutions acting on the host granitic pluton. The first is NaCl-CaCl low temperature fluid with a wide range of salinity. The second is high temperature and salinity Fe-Mg-Na chloride solution. Different fractures in the granite acted as good channels for the hydrothermal fluids that leached uranium from its bearing minerals disseminated all over the host granite and redeposited it in the alteration zones.展开更多
Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an ...Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an Andeantype active continent margin during the early to middle Paleozoic. The Qiganmiao accretionary prism is characterized by a mélange that consists of gabbro, two-mica quartz schist and basic volcanic rock blocks and heterogeneously deformed marble matrix. Two zircon U-Pb ages of 446.0±6.3 Ma and 1104±27 Ma have been acquired and been interpreted as the metamorphic and forming ages for the gabbro and two-mica quartz schist, respectively. The prism formed during the early to middle Paleozoic southward subduction of the Paleo Asian Ocean(PAO) and represents a suture between the North China craton(NCC) and Central Asian Orogenic Belt(CAOB). The Jiefangyingzi arc belt consists of pluton complex and volcanic rocks of the Xibiehe and Badangshan Formations, and Geochronology analysis indicates that the development of it can be divided into two stages. The first stage is represented by the Xibiehe Formation volcanic rocks, which belong to the subalkaline series, enriched LREE and LILE and depleted HFSE, with negative Eu anomalies, and plot in the volcanic arc field in discrimination diagrams. These characters indicate that the Xibiehe Formation results from to the continental arc magmatic activity related to the subduction of the PAO during 400–420 Ma. Magmatism of the second stage in 380–390 Ma consists of the Badangshan Formation volcanic rocks. Geochemistry analysis reveals that rhyolite, basaltic andesite and basalt of the Badangshan Formation were developed in continental margin arc setting. Moreover, the basaltic andesite and basalt display positive Sr anomalies, and the basalt have very low Nb/La values, suggesting that fluid is involved in magma evolution and the basalts were contaminated by continental crust. The sequence of Sidaozhangpeng molasse basin is characterized by proximity, coarseness and large thickness, similar to the proximity molasses basin. According to our field investigation, geochronological and geochemical data, combined with previous research in this area, a tectonic evolutionary model for Andes-type active continental margin of the CAOB has been proposed, including a development of the subduction-free PAO before 446 Ma, a subduction of the PAO and arc-related magmatism during 446–380 Ma, and formation of a molasse basin during 380–360 Ma.展开更多
Behavioral and molecular characterization of cell-type specific populations governing fear learning and behavior is a promising avenue for the rational identification of potential therapeutics for fear-related disorde...Behavioral and molecular characterization of cell-type specific populations governing fear learning and behavior is a promising avenue for the rational identification of potential therapeutics for fear-related disorders.Identification of cell-type specific changes in neuronal translation following fear learning allows for targeted pharmacological intervention during fear extinction learning,mirroring possible treatment strategies in humans.Here we identify the central amygdala(Ce A)Drd2-expressing population as a fear-supporting population that is molecularly distinct from other,previously identified fear-supporting CeA populations.Sequencing of actively translating transcripts of Drd2 neurons identifies m RNAs that are differentially regulated following fear learning including Npy5r,Rxrg,Sst5r,Fgf3,Erb B4,Fkbp14,Dlk1,Ssh3 and Adora2a.Direct pharmacological manipulation of NPY5R,RXR,and ADORA2A confirms their importance in fear behavior and validates the present approach of identifying pharmacological targets for the modulation of emotional learning.展开更多
This study uses the Climate Forecast System Reanalysis(CFSR) to investigate the responses of the Southern Hemisphere(SH) extratropical climate to two types of El Nino–Southern Oscillation(ENSO)-the eastern Pacific(EP...This study uses the Climate Forecast System Reanalysis(CFSR) to investigate the responses of the Southern Hemisphere(SH) extratropical climate to two types of El Nino–Southern Oscillation(ENSO)-the eastern Pacific(EP) type and the central Pacific(CP) type in different seasons. The responses are denoted by the anomalies of climate variables associated with one-standard-deviation increase in the Nino3 or Nino4 index. The results show that in austral spring the differences in the ENSO-related anomaly(ERA) patterns of atmospheric circulation between the EP ENSO period(1979–1998) and CP ENSO period(1999–2010) are mainly associated with the change in the ENSO-PSA2 relationship. Such differences affect the ERA fields of surface air temperature and mixed layer temperature, and finally result in significant differences in sea-ice concentration anomalies in the Atlantic sector. In austral summer, significant correlation exists between the variations of SAM and both of the variations of Nino3 and Nino4 in 1979–1998, while the correlation between SAM and Nino4 disappears in 1999–2010. For all seasons, the strength of the climate ERAs depend on if there are close relationship between ENSO and the major climate variation modes of the SH extratropics. For the climate variables, the ERA patterns of surface air temperature are generally controlled by surface wind anomalies and mirrored by the mixed layer temperature anomalies. The mixed layer depth anomalies are primarily modulated by surface heat flux anomalies and occasionally by anomalous wind. There are strikingly strong anomalies of surface heat flux in the autumn of 1979–1998 related to the Nino3 variation, the period when there is only significant correlation between ENSO and PSA2. There are no evidence that the SH extratropical climate variability induced by Nino3 variations are stronger in the EP-ENSO period, and that variability induced by Nino4 variations are stronger in the CP-ENSO period.展开更多
We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with d...We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for age.In the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.展开更多
We obtain the expansion of Renyi divergence of order α （0 〈 α 〈 1） between the normalized sum of IID continuous random variables and the Caussian limit under minimal moment conditions via Edgeworth-type expansio...We obtain the expansion of Renyi divergence of order α （0 〈 α 〈 1） between the normalized sum of IID continuous random variables and the Caussian limit under minimal moment conditions via Edgeworth-type expansion. The rate is faster than that of Shannon case, which can be used to improve the rate of convergence in total variance norm.展开更多
In this paper, the boundedness of mulitilinear commutator [-b,T] on Herz-type space is considered, where T is a standard Calderon-Zygmund singular operator and -b ∈ （BMO（Rn））m.
Co-infections of the central nervous system (CNS) caused by bacterial and viral pathogens are considered to be rare. Herpes simplex virus type-1 (HSV-1) reactivation following Streptococcus pneumoniae infection is wel...Co-infections of the central nervous system (CNS) caused by bacterial and viral pathogens are considered to be rare. Herpes simplex virus type-1 (HSV-1) reactivation following Streptococcus pneumoniae infection is well described but most cases are related to oral or cutaneous lesions or in respiratory samples. HSV-1 CNS reactivation after Streptococcus pneumoniae meningitis is a very rare event and may have significant morbidity and mortality. In this case report, we describe a 71-year-old female patient that presented with a history of abdominal pain and confusion/disorientation that had tonic-clonic seizures while in the Emergency Department. The diagnostic work-up confirmed CNS co-infection caused by Streptococcus pneumoniae and HSV-1. Of note, beyond age, the patient had no known risk factors for both entities and recovered fully after antibiotic and antiviral therapy. This case underlines that clinicians must be aware of CNS co-infection despite being a rare diagnosis. This should be suspected particularly in patients who present an unusual clinical course of CNS infection.展开更多
The Late Cretaceous Uckapth Granitoid including mafic microgranular enclaves intruded into metapelitic and metabasic rocks, and overlain unconformably by Neogene ignimbrites in the Ni^de area of Turkey. It is mostly g...The Late Cretaceous Uckapth Granitoid including mafic microgranular enclaves intruded into metapelitic and metabasic rocks, and overlain unconformably by Neogene ignimbrites in the Ni^de area of Turkey. It is mostly granite and minor granodiorite in composition, whereas its enclaves are dominantly gabbro with a few diorites in composition. The Uckapdl Granitoid is composed mainly of quartz, K-feldspar, plagioclase, biotite, muscovite and minor amphibole while its enclaves contain mostly plagioclase, amphibole, minor pyroxene and biotite. The Uckapth Granitoid has calcalkaline and peraluminous （AJCNK= 1.0-1.3） geochemical characteristics. It is characterized by high LILE/HFSE and LREE/HREE ratios （（La/Lu）N 3-33）, and has negative Ba, Ta, Nb and Eu anomalies, resembling those of comsion granitoids. The {）fkaplh Granitoid has relatively high STSr/S6Sr0） ratios （0.711189--0.716061） and low eNd（t） values （-5.13 to -7.13）, confirming crustal melting. In contrast, the enclaves are tholeiitic and metaluminous, and slightly enriched in LILEs （K, Rb） and Th, and have negative Ta, Nb and Ti anomalies; propose that they were derived from a subduction-modified mantle source. Based on mineral and whole rock chemistry data, the Uckapth granitoid is H-（hybrid） type, post-collision granitoid developed by mixing/mingllng processes between crustal melts and mantle-derived mafic magmas.展开更多
Objective: Investigate how pregnancy-induced hormonal and hemodynamic changes affect retinal vessels caliber dynamic and the course of diabetic retinopathy. Methods: Retinopathy grading and vessel diameter measurement...Objective: Investigate how pregnancy-induced hormonal and hemodynamic changes affect retinal vessels caliber dynamic and the course of diabetic retinopathy. Methods: Retinopathy grading and vessel diameter measurement using digital fundus photographs in women with diabetes type 1 taken no more than one year before conception, during week 10 and/or 22, week 34, and within one year after delivery. Calibers were measured using a custom-developed semi-automated computer algorithm which identified the six largest arteries and six largest veins and calculated the central retinal artery equivalent (CRAE) and central vein equivalent (CRVE) diameters. Glycemic control was assessed quarterly by HbA1c. Systolic and diastolic blood pressure was assessed at week 10, 22 and 34. Results: Photographs at baseline, weeks 10, 22, 34 and after delivery were available in 28 patients, of whom 24 did not progress in retinopathy. For those whose level of retinopathy remained stable CRAE constricted from 138.80 ± 21.27 μm at baseline to 129.88 ± 13.97 μm at week 10 (p = 0.0379) CRVE constricted from 195.16 ± 24.98 μm at baseline to 185.97 ± 21.96 μm at week 10 (p = 0.0400). The patients with retinopathy progression had a CRAE of 131.67 ± 13.37 μm at baseline and 132.08 ± 11.07 μm at week 10 (p = 0.34) while CRVE was 195.33 ± 24.92 μm at baseline and 204.27 ± 10.18 μm at week 10 (p = 0.16). Progressors had higher blood pressures at week 10. Conclusion: Retinal vessels constricted between prepregnancy and first trimester in women who did not experience diabetic retinopathy progression. The study suggests that the vessels constriction seen in early pregnancy contributes to reduce the risk of gestational microvascular complications and progression of diabetes in the eye.展开更多
文摘Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,
文摘Objective To evaluate the value of autofluorescence bronchoscope (AFB) in airway examination in central type lung cancer. Methods From Sep 2009 to Mar 2010,29 patients (23 men,6 women,median age 62. 2 years,range from 34 to 81 years) underwent AFB procedure. There were 3 lesions located at trachea,1 at
文摘Introduction: Diabetes remains a real public health problem today, due to its associated morbidity and mortality. It induces numerous metabolic, biochemical, hematological, and immunological changes, responsible for multiple complications. The objective of this study was to characterize clinically and biologically type 2 diabetic patients followed at the National Center for Diabetology and Arterial Hypertension of the Central Hospital of Yaoundé. Method: This prospective, cross-sectional, and analytical study took place from April 5 to July 31, 2023 (4 months) on 100 diabetic patients of both sexes (61 women and 39 men), aged from 31 to 88 years. Body Mass Index, systolic and diastolic blood pressure, and cardiac frequency were measured on each of the patients. Subsequently, blood was collected from the patients for the determination of the complete blood count, HBA1c, lipid profile, serum albumin, TNF-α, and IL-6 levels. The data were analyzed using SPSS 17.0 software. Results: The age average of our population was 56.99 ± 11.51 years, the population was primarily female (61%) and primarily between the ages of 55 and 88. 67% of respondents were married. 59% went to secondary school. 73% of them lived in urban areas. 30% were obese and 40% were overweight, with an average BMI of 28.75 kg/m2. 76% of patients took oral antidiabetic medications. HbA1c level average was 8.65%, with 60% having readings above 6.5%. Low hemoglobin and hypochromia were among the abnormalities of red blood cells observed. Lipid profiles revealed low HDL-cholesterol and high triglycerides and cholesterol. Elevated levels of TNF-α and IL-6 indicated inflammation and cardiovascular risk. Conclusion: These results indicate the necessity of focused diabetic care and management on diabetic patients attending the central hospital of Yaoundé, Cameroon.
基金funded by Ramon y Cajal program RYC-2008-02333,Junta de Andalucia,Proyectos de Excelencia,Consejería de Economía,Innovación,Ciencia y Empleo(P11-CTS-7847)ISCIII–Subdirección General de Evaluación y Fomento de la Investigacióncofinanced by the European Union(Fondo Europeo de Desarrollo Regional,FEDER)"Una manera de hacer Europa"PI12/00675(Monica Garcia-Alloza)
文摘Type 2 diabetes （T2D） is an important risk factor for developing dementias, including Alzheimer＇s disease （AD）. Hyperinsulin- emia and glucose intolerance, as features of T2D, might increase the neurodegeneration process, synaptic loss and brain atrophy, leading to cognitive impairment observed in AD. Also, adult neurogenesis seems to be impaired in AD models. Therefore, we have studied morphological alterations, cell proliferation and neurogenesis in the central nervous system （CNS） from a classical model of T2D, the db/db mouse, and in a prediabetes insulin-resistant model, obtained after long-term high fat diet （HFD） administration to C57B1/6 mice. Db/db mice showed an age-dependent cortical and hippocampal atrophy, whereas in HFD mice cortex and hippocampus were preserved. Neurogen- esis and cell proliferation were increased in young db/db mice, when compared with control mice, whereas no differences were detected in the prediabetic model. We also detected significant correlations between metabolic parameters and central atrophy, altered proliferation and neurogenesis in the central nervous system. Altogether these data support that glycaemia control in elderly patients, could help to control central alterations and improve dementia prognosis.
文摘The alkali feldspar granite of Gabal El Atawi is post orogenic granite originated from subalkaline magma in extensional suite. It is developed within plate tectonic setting and has A2-type character which generated from apparent crustal source. The petrographic, geochemical and radioactive characteristics of El Atawi granite meet and fulfill the requirements of being fertile granite and it can be considered as promising uraniferous granite. Fluid inclusion studies of the altered granite elucidated two different solutions acting on the host granitic pluton. The first is NaCl-CaCl low temperature fluid with a wide range of salinity. The second is high temperature and salinity Fe-Mg-Na chloride solution. Different fractures in the granite acted as good channels for the hydrothermal fluids that leached uranium from its bearing minerals disseminated all over the host granite and redeposited it in the alteration zones.
基金supported by grants from National Key R&D Program of China (2017YFC0601302)the NSF of China (41672214)Geological Survey Project of China Geological Survey (DD20189612, DD20190004).
文摘Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an Andeantype active continent margin during the early to middle Paleozoic. The Qiganmiao accretionary prism is characterized by a mélange that consists of gabbro, two-mica quartz schist and basic volcanic rock blocks and heterogeneously deformed marble matrix. Two zircon U-Pb ages of 446.0±6.3 Ma and 1104±27 Ma have been acquired and been interpreted as the metamorphic and forming ages for the gabbro and two-mica quartz schist, respectively. The prism formed during the early to middle Paleozoic southward subduction of the Paleo Asian Ocean(PAO) and represents a suture between the North China craton(NCC) and Central Asian Orogenic Belt(CAOB). The Jiefangyingzi arc belt consists of pluton complex and volcanic rocks of the Xibiehe and Badangshan Formations, and Geochronology analysis indicates that the development of it can be divided into two stages. The first stage is represented by the Xibiehe Formation volcanic rocks, which belong to the subalkaline series, enriched LREE and LILE and depleted HFSE, with negative Eu anomalies, and plot in the volcanic arc field in discrimination diagrams. These characters indicate that the Xibiehe Formation results from to the continental arc magmatic activity related to the subduction of the PAO during 400–420 Ma. Magmatism of the second stage in 380–390 Ma consists of the Badangshan Formation volcanic rocks. Geochemistry analysis reveals that rhyolite, basaltic andesite and basalt of the Badangshan Formation were developed in continental margin arc setting. Moreover, the basaltic andesite and basalt display positive Sr anomalies, and the basalt have very low Nb/La values, suggesting that fluid is involved in magma evolution and the basalts were contaminated by continental crust. The sequence of Sidaozhangpeng molasse basin is characterized by proximity, coarseness and large thickness, similar to the proximity molasses basin. According to our field investigation, geochronological and geochemical data, combined with previous research in this area, a tectonic evolutionary model for Andes-type active continental margin of the CAOB has been proposed, including a development of the subduction-free PAO before 446 Ma, a subduction of the PAO and arc-related magmatism during 446–380 Ma, and formation of a molasse basin during 380–360 Ma.
文摘Behavioral and molecular characterization of cell-type specific populations governing fear learning and behavior is a promising avenue for the rational identification of potential therapeutics for fear-related disorders.Identification of cell-type specific changes in neuronal translation following fear learning allows for targeted pharmacological intervention during fear extinction learning,mirroring possible treatment strategies in humans.Here we identify the central amygdala(Ce A)Drd2-expressing population as a fear-supporting population that is molecularly distinct from other,previously identified fear-supporting CeA populations.Sequencing of actively translating transcripts of Drd2 neurons identifies m RNAs that are differentially regulated following fear learning including Npy5r,Rxrg,Sst5r,Fgf3,Erb B4,Fkbp14,Dlk1,Ssh3 and Adora2a.Direct pharmacological manipulation of NPY5R,RXR,and ADORA2A confirms their importance in fear behavior and validates the present approach of identifying pharmacological targets for the modulation of emotional learning.
基金The General Program of the National Natural Science Foundation of China under contract Nos 41876221 and 41861134040
文摘This study uses the Climate Forecast System Reanalysis(CFSR) to investigate the responses of the Southern Hemisphere(SH) extratropical climate to two types of El Nino–Southern Oscillation(ENSO)-the eastern Pacific(EP) type and the central Pacific(CP) type in different seasons. The responses are denoted by the anomalies of climate variables associated with one-standard-deviation increase in the Nino3 or Nino4 index. The results show that in austral spring the differences in the ENSO-related anomaly(ERA) patterns of atmospheric circulation between the EP ENSO period(1979–1998) and CP ENSO period(1999–2010) are mainly associated with the change in the ENSO-PSA2 relationship. Such differences affect the ERA fields of surface air temperature and mixed layer temperature, and finally result in significant differences in sea-ice concentration anomalies in the Atlantic sector. In austral summer, significant correlation exists between the variations of SAM and both of the variations of Nino3 and Nino4 in 1979–1998, while the correlation between SAM and Nino4 disappears in 1999–2010. For all seasons, the strength of the climate ERAs depend on if there are close relationship between ENSO and the major climate variation modes of the SH extratropics. For the climate variables, the ERA patterns of surface air temperature are generally controlled by surface wind anomalies and mirrored by the mixed layer temperature anomalies. The mixed layer depth anomalies are primarily modulated by surface heat flux anomalies and occasionally by anomalous wind. There are strikingly strong anomalies of surface heat flux in the autumn of 1979–1998 related to the Nino3 variation, the period when there is only significant correlation between ENSO and PSA2. There are no evidence that the SH extratropical climate variability induced by Nino3 variations are stronger in the EP-ENSO period, and that variability induced by Nino4 variations are stronger in the CP-ENSO period.
文摘We sought to evaluate central corneal thickness（CCT）,corneal endothelial cell density（ECD）and intraocular pressure（IOP）in patients with type 2 diabetes mellitus（DM）and to associate potential differences with diabetes duration and treatment modality in a prospective,randomized study.We measured ECD,CCT and IOP of125 patients with type 2 DM（mean age 57.1±11.5 years）and compared them with 90 age-matched controls.Measured parameters were analyzed for association with diabetes duration and glucose control modalities（insulin injection or oral medication）while controlling for age.In the diabetic group,the mean ECD（2511±252 cells/mm^2）,mean CCT（539.7±33.6μm）and mean IOP（18.3±2.5 mmHg）varied significantly from those the control group[ECD：2713±132 cells/mm^2（P〈0.0001）,CCT：525.0±45.3μm（P=0.003）and IOP：16.7±1.8 mmHg（P〈0.0001）].ECD was significantly reduced by about 32 cell/mm^2 for diabetics with duration of〉10 years when compared with those with duration of〈10 years（P〈0.05）.CCT was thicker and IOP was higher for diabetics with duration of〉10 years than those with duration of〈10 years（P〉0.05）.None of the measured parameters was significantly associated with diabetes duration and treatment modality（P〉0.05）.In conclusion,subjects with type 2DM exhibit significant changes in ECD,IOP and CCT,which,however,are not correlated with disease duration or if the patients receive on insulin injection or oral medications.
基金supported by National Basic Research Program of China(973 Program)(2011CB707802,2013CB910200)Natural Science Foundation of China Grant(11126180)
文摘We obtain the expansion of Renyi divergence of order α （0 〈 α 〈 1） between the normalized sum of IID continuous random variables and the Caussian limit under minimal moment conditions via Edgeworth-type expansion. The rate is faster than that of Shannon case, which can be used to improve the rate of convergence in total variance norm.
基金Supported by the National Natural Science Foundation of China(10771054, 10861010)the Scientific Re-search Program of Institutions of Higher Education of XinJiang(2008S58)the Natural Science Fund of Xinjiang University(YX080106, BS090101)
文摘In this paper, the boundedness of mulitilinear commutator [-b,T] on Herz-type space is considered, where T is a standard Calderon-Zygmund singular operator and -b ∈ （BMO（Rn））m.
文摘Co-infections of the central nervous system (CNS) caused by bacterial and viral pathogens are considered to be rare. Herpes simplex virus type-1 (HSV-1) reactivation following Streptococcus pneumoniae infection is well described but most cases are related to oral or cutaneous lesions or in respiratory samples. HSV-1 CNS reactivation after Streptococcus pneumoniae meningitis is a very rare event and may have significant morbidity and mortality. In this case report, we describe a 71-year-old female patient that presented with a history of abdominal pain and confusion/disorientation that had tonic-clonic seizures while in the Emergency Department. The diagnostic work-up confirmed CNS co-infection caused by Streptococcus pneumoniae and HSV-1. Of note, beyond age, the patient had no known risk factors for both entities and recovered fully after antibiotic and antiviral therapy. This case underlines that clinicians must be aware of CNS co-infection despite being a rare diagnosis. This should be suspected particularly in patients who present an unusual clinical course of CNS infection.
基金financially supported by the Seluk University Scientific Research Projects Coordination (Project No: 2004/37)
文摘The Late Cretaceous Uckapth Granitoid including mafic microgranular enclaves intruded into metapelitic and metabasic rocks, and overlain unconformably by Neogene ignimbrites in the Ni^de area of Turkey. It is mostly granite and minor granodiorite in composition, whereas its enclaves are dominantly gabbro with a few diorites in composition. The Uckapdl Granitoid is composed mainly of quartz, K-feldspar, plagioclase, biotite, muscovite and minor amphibole while its enclaves contain mostly plagioclase, amphibole, minor pyroxene and biotite. The Uckapth Granitoid has calcalkaline and peraluminous （AJCNK= 1.0-1.3） geochemical characteristics. It is characterized by high LILE/HFSE and LREE/HREE ratios （（La/Lu）N 3-33）, and has negative Ba, Ta, Nb and Eu anomalies, resembling those of comsion granitoids. The {）fkaplh Granitoid has relatively high STSr/S6Sr0） ratios （0.711189--0.716061） and low eNd（t） values （-5.13 to -7.13）, confirming crustal melting. In contrast, the enclaves are tholeiitic and metaluminous, and slightly enriched in LILEs （K, Rb） and Th, and have negative Ta, Nb and Ti anomalies; propose that they were derived from a subduction-modified mantle source. Based on mineral and whole rock chemistry data, the Uckapth granitoid is H-（hybrid） type, post-collision granitoid developed by mixing/mingllng processes between crustal melts and mantle-derived mafic magmas.
文摘Objective: Investigate how pregnancy-induced hormonal and hemodynamic changes affect retinal vessels caliber dynamic and the course of diabetic retinopathy. Methods: Retinopathy grading and vessel diameter measurement using digital fundus photographs in women with diabetes type 1 taken no more than one year before conception, during week 10 and/or 22, week 34, and within one year after delivery. Calibers were measured using a custom-developed semi-automated computer algorithm which identified the six largest arteries and six largest veins and calculated the central retinal artery equivalent (CRAE) and central vein equivalent (CRVE) diameters. Glycemic control was assessed quarterly by HbA1c. Systolic and diastolic blood pressure was assessed at week 10, 22 and 34. Results: Photographs at baseline, weeks 10, 22, 34 and after delivery were available in 28 patients, of whom 24 did not progress in retinopathy. For those whose level of retinopathy remained stable CRAE constricted from 138.80 ± 21.27 μm at baseline to 129.88 ± 13.97 μm at week 10 (p = 0.0379) CRVE constricted from 195.16 ± 24.98 μm at baseline to 185.97 ± 21.96 μm at week 10 (p = 0.0400). The patients with retinopathy progression had a CRAE of 131.67 ± 13.37 μm at baseline and 132.08 ± 11.07 μm at week 10 (p = 0.34) while CRVE was 195.33 ± 24.92 μm at baseline and 204.27 ± 10.18 μm at week 10 (p = 0.16). Progressors had higher blood pressures at week 10. Conclusion: Retinal vessels constricted between prepregnancy and first trimester in women who did not experience diabetic retinopathy progression. The study suggests that the vessels constriction seen in early pregnancy contributes to reduce the risk of gestational microvascular complications and progression of diabetes in the eye.
