Heating,Ventilation,andAir Conditioning(HVAC)systems are critical formaintaining thermal comfort in office environments which also crucial for occupant well-being and productivity.This study investigates the impact of...Heating,Ventilation,andAir Conditioning(HVAC)systems are critical formaintaining thermal comfort in office environments which also crucial for occupant well-being and productivity.This study investigates the impact of integrating ceiling fans with higher air conditioning setpoints on thermal comfort and energy efficiency in office environments.Field measurements and questionnaire surveys were conducted to evaluate thermal comfort and energysaving potential under varying conditions.Results show that increasing the AC setpoint from 25○C to 27○C,combined with ceiling fan operation,reduced power consumption by 10%,achieving significant energy savings.Survey data confirmed that 85%of participants reported consistent thermal sensations across all conditions,with ceiling fans effectively compensating for higher setpoints through enhanced air circulation.CFDsimulations revealed that mediumspeed ceiling fan operation produced the most uniformairflowdistribution,with an average air velocity of 0.45 m/s,and minimized temperature variations,ensuring balanced thermal conditions.Temperature analysis showed a reduction in hotspots and cold zones,maintaining an average temperature deviation of less than±0.5○C.Predicted Mean Vote(PMV)evaluations at a 27○C setpoint indicated improved thermal comfort,with average PMV values around−0.3,corresponding to a“neutral”thermal sensation.These findings demonstrate the effectiveness of integrating ceiling fans with HVAC systems in achieving energy efficiency and occupant comfort,offering a sustainable approach to reducing AC energy consumption in office environments.展开更多
Anti-hepatic fibrosis peptide from Carapax Trionycis was purified, characterized, and inhibitory effect was assessed. Carapax Trionycis extract peptide hydrolysates （CTEPHs） were separated by ultrafiltration, Sephad...Anti-hepatic fibrosis peptide from Carapax Trionycis was purified, characterized, and inhibitory effect was assessed. Carapax Trionycis extract peptide hydrolysates （CTEPHs） were separated by ultrafiltration, Sephadex G-15 gel chromatography and RP-HPLC. One novel anti-hepatic fibrosis peptide （CTEPH-I： Asn-Pro-Asn-Pro-Thr） was obtained and identified. MTS assay and enzyme-linked immunosorbent assay were applied to evaluate the anti-fibrotic effect of CTEPH-1 on activated hepatic stellate cells （HSCs） in vitro. CTEPH-1 efficiently inhibited activation and proliferation of cultured HSC-T6 cells via lowering the contents of collagen and TIMP- 1 except for matrix metalloproteinase- 1 （MMP- 1）. The purified peptide might be beneficial as functional food or potential drug for treatment of liver fibrogenesis.展开更多
A non-noble metal oxygen reduction reaction （ORR） catalyst labeled as Co-C-N（800） was synthesized by heat-treating a mixture of urea, cobalt chloride and acetylene black for 2 h at 800 ℃ in an inert nitrogen atmo...A non-noble metal oxygen reduction reaction （ORR） catalyst labeled as Co-C-N（800） was synthesized by heat-treating a mixture of urea, cobalt chloride and acetylene black for 2 h at 800 ℃ in an inert nitrogen atmosphere. X-ray diffraction pattern indicates that a metallic β-Co is generated after the heat-treating process. The results from cyclic voltammograms show that the obtained Co-C-N（800） catalyst has good ORR catalytic activity in 0.5 mol/L H2SO4 solution. The catalyst is also good at methanol tolerance and stability in the acidic solution.展开更多
OBJECTIVE Recent studies have shown that hepsin, a type of transmembrane serine protease, is highly upregulated in prostate cancer, but, little is known about its role in progression and invasion of this cancer. We co...OBJECTIVE Recent studies have shown that hepsin, a type of transmembrane serine protease, is highly upregulated in prostate cancer, but, little is known about its role in progression and invasion of this cancer. We constructed a hepsin-expressing plasmid and transfected it into PC-3 cells to investigate the effect of the hepsin gene on the biological behavior of the PC-3 cells. METHODS Plasmid pHepsin-IRES2 was transfected into prostate cancer PC-3 cells using Fugene6, and the cells with stable hepsin expression were screened and selected with Zeocin (600 mg/L). The hepsin mRNA level was measured by real-time PCR and the growth curve of the PC-3-transfected cells assessed using MTT and BrdU assays. A Boyden chamber was used to examine the difference in invasion and metastases between transfected and non-transfected cells. RESULTS The hepsin mRNA level in pHepsin-IRES2 transfected -PC-3 cells was significantly higher than that found in the control PC -3 cells. While the growth curve of the hepsin gene transfected PC -3 cells showed that there was no significant effect on proliferation, the invasive ability of the pHepsin-IRES2 transfected PC-3 cells, as compared with control cells, was significantly increased (P<0.05). CONCLUSION The results suggest that even though hepsin has no effect on the proliferation of prostate cancer PC-3 cells, it does promote cellular invasion and metastasis.Therefore hepsin may have a role in the development of prostate cancer.展开更多
基金support by the National Science and Technology Council under Grant No.NSTC 112-2221-E-167-017-MY3.
文摘Heating,Ventilation,andAir Conditioning(HVAC)systems are critical formaintaining thermal comfort in office environments which also crucial for occupant well-being and productivity.This study investigates the impact of integrating ceiling fans with higher air conditioning setpoints on thermal comfort and energy efficiency in office environments.Field measurements and questionnaire surveys were conducted to evaluate thermal comfort and energysaving potential under varying conditions.Results show that increasing the AC setpoint from 25○C to 27○C,combined with ceiling fan operation,reduced power consumption by 10%,achieving significant energy savings.Survey data confirmed that 85%of participants reported consistent thermal sensations across all conditions,with ceiling fans effectively compensating for higher setpoints through enhanced air circulation.CFDsimulations revealed that mediumspeed ceiling fan operation produced the most uniformairflowdistribution,with an average air velocity of 0.45 m/s,and minimized temperature variations,ensuring balanced thermal conditions.Temperature analysis showed a reduction in hotspots and cold zones,maintaining an average temperature deviation of less than±0.5○C.Predicted Mean Vote(PMV)evaluations at a 27○C setpoint indicated improved thermal comfort,with average PMV values around−0.3,corresponding to a“neutral”thermal sensation.These findings demonstrate the effectiveness of integrating ceiling fans with HVAC systems in achieving energy efficiency and occupant comfort,offering a sustainable approach to reducing AC energy consumption in office environments.
基金The Foundation of the Education Department of Hubei Province(Grant No.D20162004)
文摘Anti-hepatic fibrosis peptide from Carapax Trionycis was purified, characterized, and inhibitory effect was assessed. Carapax Trionycis extract peptide hydrolysates （CTEPHs） were separated by ultrafiltration, Sephadex G-15 gel chromatography and RP-HPLC. One novel anti-hepatic fibrosis peptide （CTEPH-I： Asn-Pro-Asn-Pro-Thr） was obtained and identified. MTS assay and enzyme-linked immunosorbent assay were applied to evaluate the anti-fibrotic effect of CTEPH-1 on activated hepatic stellate cells （HSCs） in vitro. CTEPH-1 efficiently inhibited activation and proliferation of cultured HSC-T6 cells via lowering the contents of collagen and TIMP- 1 except for matrix metalloproteinase- 1 （MMP- 1）. The purified peptide might be beneficial as functional food or potential drug for treatment of liver fibrogenesis.
文摘A non-noble metal oxygen reduction reaction （ORR） catalyst labeled as Co-C-N（800） was synthesized by heat-treating a mixture of urea, cobalt chloride and acetylene black for 2 h at 800 ℃ in an inert nitrogen atmosphere. X-ray diffraction pattern indicates that a metallic β-Co is generated after the heat-treating process. The results from cyclic voltammograms show that the obtained Co-C-N（800） catalyst has good ORR catalytic activity in 0.5 mol/L H2SO4 solution. The catalyst is also good at methanol tolerance and stability in the acidic solution.
文摘OBJECTIVE Recent studies have shown that hepsin, a type of transmembrane serine protease, is highly upregulated in prostate cancer, but, little is known about its role in progression and invasion of this cancer. We constructed a hepsin-expressing plasmid and transfected it into PC-3 cells to investigate the effect of the hepsin gene on the biological behavior of the PC-3 cells. METHODS Plasmid pHepsin-IRES2 was transfected into prostate cancer PC-3 cells using Fugene6, and the cells with stable hepsin expression were screened and selected with Zeocin (600 mg/L). The hepsin mRNA level was measured by real-time PCR and the growth curve of the PC-3-transfected cells assessed using MTT and BrdU assays. A Boyden chamber was used to examine the difference in invasion and metastases between transfected and non-transfected cells. RESULTS The hepsin mRNA level in pHepsin-IRES2 transfected -PC-3 cells was significantly higher than that found in the control PC -3 cells. While the growth curve of the hepsin gene transfected PC -3 cells showed that there was no significant effect on proliferation, the invasive ability of the pHepsin-IRES2 transfected PC-3 cells, as compared with control cells, was significantly increased (P<0.05). CONCLUSION The results suggest that even though hepsin has no effect on the proliferation of prostate cancer PC-3 cells, it does promote cellular invasion and metastasis.Therefore hepsin may have a role in the development of prostate cancer.
