This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course o...This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course of two years and identified statistically significant improvement in penile curvature and erectile function with a tolerable complication rate in response to a tri-modal protocol of intralesional clostridium collagenase histolyticum(CCH),tadalafil,and vacuum treatment.Despite lack of controls,it does serve to confirm the safety,efficacy,and clinical utility of their nonsurgical approach and supports the growing body of literature on combined therapy for this difficult disorder.Based on results in multiple"real world"studies following the Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies(IMPRESS)Trial,^(2) it is encouraging to see that both chronic-and acute-phase patients were included.展开更多
Peyronie's disease(PD)is a challenging condition that significantly impacts male sexual health,often leading to penile curvature,pain,and erectile dysfunction.Treatment options range from conservative pharmacologi...Peyronie's disease(PD)is a challenging condition that significantly impacts male sexual health,often leading to penile curvature,pain,and erectile dysfunction.Treatment options range from conservative pharmacologic approaches to more invasive surgical interventions,with collagenase clostridium histolyticum(CCH)being the only U.S.Food and Drug Administration(FDA)-approved intralesional therapy.However,optimizing treatment strategies to enhance efficacy while minimizing patient burden remains an area of ongoing investigation.^(1,2)展开更多
The reaction of N-n-Bu4MnO4 with Mn(Oac) 2 · 4H2O and butenoic acid in nonaqueous solvents leads to the formation of the complex [Mn3O(O2CCH = CHCH3) 6(py) 3] ClO4 · py (1). The crystal structure was determi...The reaction of N-n-Bu4MnO4 with Mn(Oac) 2 · 4H2O and butenoic acid in nonaqueous solvents leads to the formation of the complex [Mn3O(O2CCH = CHCH3) 6(py) 3] ClO4 · py (1). The crystal structure was determined.The complex crystallizes in hexagonal, space group P63/m, unit cell parameters, a = 1. 2456(1)nm, b = 1. 2456(1) nm, c = 1. 8741(1) nm, V=2. 5181(3) nm3, Z =2, and final R1 =0. 0565, wR2 =0. 1465. Variable tem-perature solid tate magnetic susceptibility study shows that the complex [Mn3O(O2CCH = CHCH3)6(py)3] ClO4 (2) has an antiferromagnetic exchange interaction.展开更多
The title complex Cu[C5H3N(CCH3=N-C6H5)2]2(PF6)2 has been synthesized by r eaction of Schiff base C5H3N(CCH3=N-C6H5)2 and cupric sulfate in toluene solut ion. The crystal structure was determined by X-ray diffraction ...The title complex Cu[C5H3N(CCH3=N-C6H5)2]2(PF6)2 has been synthesized by r eaction of Schiff base C5H3N(CCH3=N-C6H5)2 and cupric sulfate in toluene solut ion. The crystal structure was determined by X-ray diffraction method and the chemical formula weight of the complex is 1041.85. The crystal structure belongs to triclinic system with spacegroup and cell parameters: a=12.6470(10) , b=14. 123(2) , c=15.613(2);á=66.150(10)a=79.470(10)?=78.290(10)穖-3 and F(000)=1064. The final R:R1=0.0668, wR 2=0.1927; R(all data): R1=0.1133, wR2=0.2357. The Cu was coordinated by six nitrogen, at the same time the Cu formed a distorted octahedron, besides the angles and pl anes of this compound were discussed . The result of kinetics of the thermal dec omposition indicated that the first step of it is 2 series chemical reactions, t he function of machanism is f(a)=(1-a)2, and the activation energy is 144.64E/ kJ. CCDC: 180872.展开更多
文摘This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course of two years and identified statistically significant improvement in penile curvature and erectile function with a tolerable complication rate in response to a tri-modal protocol of intralesional clostridium collagenase histolyticum(CCH),tadalafil,and vacuum treatment.Despite lack of controls,it does serve to confirm the safety,efficacy,and clinical utility of their nonsurgical approach and supports the growing body of literature on combined therapy for this difficult disorder.Based on results in multiple"real world"studies following the Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies(IMPRESS)Trial,^(2) it is encouraging to see that both chronic-and acute-phase patients were included.
文摘Peyronie's disease(PD)is a challenging condition that significantly impacts male sexual health,often leading to penile curvature,pain,and erectile dysfunction.Treatment options range from conservative pharmacologic approaches to more invasive surgical interventions,with collagenase clostridium histolyticum(CCH)being the only U.S.Food and Drug Administration(FDA)-approved intralesional therapy.However,optimizing treatment strategies to enhance efficacy while minimizing patient burden remains an area of ongoing investigation.^(1,2)
文摘The reaction of N-n-Bu4MnO4 with Mn(Oac) 2 · 4H2O and butenoic acid in nonaqueous solvents leads to the formation of the complex [Mn3O(O2CCH = CHCH3) 6(py) 3] ClO4 · py (1). The crystal structure was determined.The complex crystallizes in hexagonal, space group P63/m, unit cell parameters, a = 1. 2456(1)nm, b = 1. 2456(1) nm, c = 1. 8741(1) nm, V=2. 5181(3) nm3, Z =2, and final R1 =0. 0565, wR2 =0. 1465. Variable tem-perature solid tate magnetic susceptibility study shows that the complex [Mn3O(O2CCH = CHCH3)6(py)3] ClO4 (2) has an antiferromagnetic exchange interaction.
文摘The title complex Cu[C5H3N(CCH3=N-C6H5)2]2(PF6)2 has been synthesized by r eaction of Schiff base C5H3N(CCH3=N-C6H5)2 and cupric sulfate in toluene solut ion. The crystal structure was determined by X-ray diffraction method and the chemical formula weight of the complex is 1041.85. The crystal structure belongs to triclinic system with spacegroup and cell parameters: a=12.6470(10) , b=14. 123(2) , c=15.613(2);á=66.150(10)a=79.470(10)?=78.290(10)穖-3 and F(000)=1064. The final R:R1=0.0668, wR 2=0.1927; R(all data): R1=0.1133, wR2=0.2357. The Cu was coordinated by six nitrogen, at the same time the Cu formed a distorted octahedron, besides the angles and pl anes of this compound were discussed . The result of kinetics of the thermal dec omposition indicated that the first step of it is 2 series chemical reactions, t he function of machanism is f(a)=(1-a)2, and the activation energy is 144.64E/ kJ. CCDC: 180872.
