Dear Editor,Crypt base columnar cells(CBCs)are essential for the homeostatic renewal of the gut lining,yet they are susceptible to cytotoxic damage.l In the absence of CBCs,alternative cell populations drive regenerat...Dear Editor,Crypt base columnar cells(CBCs)are essential for the homeostatic renewal of the gut lining,yet they are susceptible to cytotoxic damage.l In the absence of CBCs,alternative cell populations drive regeneration through fetal-like reprogramming and adaptive differentiation.In particular,a rare,slow-cycling cell lineage,referred to as revival stem cell(RSC),is activated by prostaglandin E2(PGE2)secreted from the stromal niche,which subseguently stimulates the YAP pathway to facilitate the regeneration.23 Given the critical role of RSCs in intestinal recovery,regulating cellular plasticity to drive endogenous RSCs could serve as a powerful strategy for regenerative medicine.展开更多
基金supported by the National Research Foundation of Korea(NRF),funded by the Ministry of Science and ICT(MSIT)(RS-2024-00340037,RS-2024-00340063,RS-2024-00347978)by the Bio&Medical Technology Development Program of the NRF funded by the Korean government(MSIT)(RS-2023-00223591,RS-2024-00439078)funded by the Ministry of Science and ICT and the Ministry of Health&Welfare(22A0205L1,23A0205L1)also supported this project.
文摘Dear Editor,Crypt base columnar cells(CBCs)are essential for the homeostatic renewal of the gut lining,yet they are susceptible to cytotoxic damage.l In the absence of CBCs,alternative cell populations drive regeneration through fetal-like reprogramming and adaptive differentiation.In particular,a rare,slow-cycling cell lineage,referred to as revival stem cell(RSC),is activated by prostaglandin E2(PGE2)secreted from the stromal niche,which subseguently stimulates the YAP pathway to facilitate the regeneration.23 Given the critical role of RSCs in intestinal recovery,regulating cellular plasticity to drive endogenous RSCs could serve as a powerful strategy for regenerative medicine.
