We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and re-laxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyper...We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and re-laxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyperlipidemia in im-potent patients; 2) erection response to intracavemous injection of papaverine in impotent patients with hyperlipidemia;3) relaxation responses of isolated cavemosal smooth muscles to endothelium-independent and endothelium-dependentvasodilators in impotent patients with hypercholesterolemia or hypertriglyceridemia; 4) involvement of superoxide radi-cal in the impaired endothelium-dependent relaxation of cavemous smooth muscle in hypercholesterolemic rabbits; S)effects of isolated lipoproteins and triglyceride, combined oxidized LDL plus triglyceride, and combined oxidized LDLplus HDL on contractile and relaxation response of rabbit cavemous smooth muscles; 6) involvement of e-NOS in theimpaired endothelium-dependent relaxation of cavemous smooth muscle in hypercholesterolemic rabbit. Hypercholes-terolemia may cause impairment of endothelium-dependent relaxation. Oxidized LDL is the major causative cholesterolof the impaired relaxation response. A chain reaction, the production of superoxide radicals and functional impairmentof eNOS may be a major cause of the functional impairment in the early stages of hypercholesterolemia.展开更多
The measured data of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting were analyzed by Fourier Transform and Wavelet Transform,and the characteristics of vibrations ind...The measured data of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting were analyzed by Fourier Transform and Wavelet Transform,and the characteristics of vibrations induced under these two circumstances were studied.It is concluded that with the similar rock condition and drilling-blasting parameters,vibration induced by bench blasting in deep-buried cavern has a higher main frequency and more scattered energy distribution than that in open pit.The vibration induced by bench blasting in open pit is mainly originated from the blast load,while the vibration induced by bench blasting in deep-buried cavern is the superposition of vibrations induced by blast load and transient release of in-situ stress.The vibration induced by transient release of in-situ stress increases with the stress level.展开更多
文摘We have done consecutive studies to investigate the effects of impaired lipid metabolism on the contractile and re-laxation response of cavernous smooth muscles and to elucidate its pathogenesis: 1) incidence of hyperlipidemia in im-potent patients; 2) erection response to intracavemous injection of papaverine in impotent patients with hyperlipidemia;3) relaxation responses of isolated cavemosal smooth muscles to endothelium-independent and endothelium-dependentvasodilators in impotent patients with hypercholesterolemia or hypertriglyceridemia; 4) involvement of superoxide radi-cal in the impaired endothelium-dependent relaxation of cavemous smooth muscle in hypercholesterolemic rabbits; S)effects of isolated lipoproteins and triglyceride, combined oxidized LDL plus triglyceride, and combined oxidized LDLplus HDL on contractile and relaxation response of rabbit cavemous smooth muscles; 6) involvement of e-NOS in theimpaired endothelium-dependent relaxation of cavemous smooth muscle in hypercholesterolemic rabbit. Hypercholes-terolemia may cause impairment of endothelium-dependent relaxation. Oxidized LDL is the major causative cholesterolof the impaired relaxation response. A chain reaction, the production of superoxide radicals and functional impairmentof eNOS may be a major cause of the functional impairment in the early stages of hypercholesterolemia.
基金Project(2010CB732003) supported by the National Basic Research Program of ChinaProjects(50725931,50779050 and 50909077) supported by the National Natural Science Foundation of China
文摘The measured data of vibrations induced by excavation of deep-buried cavern and open pit with method of bench blasting were analyzed by Fourier Transform and Wavelet Transform,and the characteristics of vibrations induced under these two circumstances were studied.It is concluded that with the similar rock condition and drilling-blasting parameters,vibration induced by bench blasting in deep-buried cavern has a higher main frequency and more scattered energy distribution than that in open pit.The vibration induced by bench blasting in open pit is mainly originated from the blast load,while the vibration induced by bench blasting in deep-buried cavern is the superposition of vibrations induced by blast load and transient release of in-situ stress.The vibration induced by transient release of in-situ stress increases with the stress level.
