Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(AN...Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed.展开更多
Objective To investigate the distribution and antimicrobial susceptibility of causative microorganisms recovered from patients with intra-abdominal infections(IAIs).Methods A total of 2,926 bacterial and fungal strain...Objective To investigate the distribution and antimicrobial susceptibility of causative microorganisms recovered from patients with intra-abdominal infections(IAIs).Methods A total of 2,926 bacterial and fungal strains were identified in samples collected from 1,679 patients with IAIs at the Peking Union Medical College Hospital between 2011 and 2021.Pathogenic bacteria and fungi were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Antimicrobial susceptibility testing(AST)was performed using the VITEK 2 compact system and the Kirby–Bauer method.AST results were interpreted based on the M100-Ed31 clinical breakpoints of the Clinical and Laboratory Standards Institute.Results Of the 2,926 strains identified,49.2%,40.8%,and 9.5%were gram-negative bacteria,gram-positive bacteria,and fungi,respectively.Escherichia coli was the most prevalent pathogen in intensive care unit(ICU)and non-ICU patients;however,a significant decrease was observed in the isolation of E.coli between 2011 and 2021.Specifically,significant decreases were observed between 2011 and 2021 in the levels of extended-spectrumβ-lactamase(ESBL)-producing E.coli(from 76.9%to 14.3%)and Klebsiella pneumoniae(from 45.8%to 4.8%).Polymicrobial infections,particularly those involving co-infection with gram-positive and gram-negative bacteria,were commonly observed in IAI patients.Moreover,Candida albicans was more commonly isolated from hospital-associated IAI samples,while Staphylococcus epidermidis had a higher ratio in community-associated IAIs.Additionally,AST results revealed that most antimicrobial agents performed better in non-ESBL-producers than in ESBL-producers,while the overall resistance rates(56.9%–76.8%)of Acinetobacter baumanmii were higher against all antimicrobial agents than those of other common gram-negative bacteria.Indeed,Enterococcus faecium,Enterococcus faecalis,S.epidermidis,and S.aureus were consistently found to be susceptible to vancomycin,teicoplanin,and linezolid.Similarly,C.albicans exhibited high susceptibility to all the tested antifungal drugs.Conclusion The distribution and antimicrobial susceptibility of the causative microorganisms from patients with IAls were altered between 2011 and 2021.This finding is valuable for the implementation of evidence-based antimicrobial therapy and provides guidance for the control of hospital infections.展开更多
On the basis of the textual research on the historical earthquake data and the field investigation of Wudu earthquake occurred in 186 B.C., we suggest that the earthquake parameters drawn from the present earthquake c...On the basis of the textual research on the historical earthquake data and the field investigation of Wudu earthquake occurred in 186 B.C., we suggest that the earthquake parameters drawn from the present earthquake catalogs are not definite and amendments should be made. The heavily-damaged area of this earthquake should be located between Jugan township of Wudu County and Pingding township of Zhouqu County. Its epicenter should be in the vicinity of Lianghekou in Wudu County with a magnitude of about 7-7 1/4 and an intensity of about IX-X. The major axis direction of the heavily-damaged area should be in the WNW direction that is approximately consistent with the strike of the middle-east segment of Diebu-Bailongjiang active fault zone, and the origin time should match up to that of the latest paleoearthquake event [before （83±46） B.C.] obtained by the trench investigation. Certain seismic rupture evidences are still preserved on this fault segment. Therefore, we propose on the basis of comprehensive analysis that the causative structure of the M 7-7 1/4 Wudu earthquake in 186 B.C. should be in the middle-east segment of Diebu-Bailongjiang active fault zone.展开更多
The traditional Japanese grammar teaching often only pays attention to the interpretation of syntax and the integrity of grammar structure. This violates the cultivation of communicative competence, and is not in conf...The traditional Japanese grammar teaching often only pays attention to the interpretation of syntax and the integrity of grammar structure. This violates the cultivation of communicative competence, and is not in conformity with the society’s requirements of applied foreign language talents. Cognitive linguistics theory, which links language form with semantic concept, reveals the internal relation of man’s thinking and language. If we can subtly apply cognitive linguistic theory into Japanese grammar teaching to explore the cognitive process in the speakers’ brain while expressing, we can get a good understanding of diffi cult points and “special case”. This paper explores the introductory methods and efficacy of the cognitive linguistics theory applied in Japanese grammar teaching method, by lecturing causative sentences an example.展开更多
This work interrogates why certain real-world events that meet criteria for being considered causative events cannot be expressed using Hupa’s morphological or syntactic causative constructions,but must be encoded us...This work interrogates why certain real-world events that meet criteria for being considered causative events cannot be expressed using Hupa’s morphological or syntactic causative constructions,but must be encoded using one of two periphrastic constructions in which the Causer or cause is not marked as an argument.Based on fieldwork with a native speaker,I probe into these two periphrastic constructions in depth,accounting for their distributions through an appeal to Næss’s(2007)account of semantic transitivity.展开更多
This paper aims at investigating the morphophonological make-up of derived causatives in Moroccan Arabic within the framework of Optimality Theory (Prince &Smolensky, 2004). Causative verbs in MA are characterized...This paper aims at investigating the morphophonological make-up of derived causatives in Moroccan Arabic within the framework of Optimality Theory (Prince &Smolensky, 2004). Causative verbs in MA are characterized by the systematic gemination of their medial consonants. However, it is not easy to determine the morphological nature of the causative morpheme involved in this derivation. Also, it is not clearly known why the causative morpheme gets realized exactly on the second segment of the base form.Therefore, we seek to achieve the following goals. First, we intend to determine the nature of the causative morpheme. Second, we aim to explain why the causative morpheme is realized on the second segment of the base form. In this respect, we show that the causative morpheme is represented by a featureless consonantal mora that targets the second segment of the base root, turning it into a geminate. We also show that the causative morpheme gets infixed thanks to the privileged status of root-initial segments.展开更多
The main objective of this study is to give descriptions of formal and functional aspects of causative constructions in Afaan Oromoo.To achieve the objective,written texts,native speaker informants and introspections ...The main objective of this study is to give descriptions of formal and functional aspects of causative constructions in Afaan Oromoo.To achieve the objective,written texts,native speaker informants and introspections are predominantly used as sources of data.The findings reveal that the three structural aspects of causatives-morphological,lexical and syntactic-are used in the language.Morphological causatives are highly productive,and affixes with-s and-i in several combinations as well as-eess are employed for such purposes.Causative Morphemes are detected to derive causatives of basic verb stems of different semantic categories and to involve causations in word-class changing.There are also simple and complex causations in which there are several causatives suffixes,causers and micro-events indicated morphologically and syntactically.Semantically,direct,indirect,and assistive/cooperative causatives are identified.Pseudo-causatives are uncovered as peculiar futures of the language too.There are,even,structures with explicit causative affixes which are called subjectless causatives,but they do not show any causal relations between the participants in the structure.展开更多
This paper explores the nature of the post-syntactic operations responsible for the representations of the linear order of terminal nodes.In particular,it argues in favor of a unified model of the morphosyntax and mor...This paper explores the nature of the post-syntactic operations responsible for the representations of the linear order of terminal nodes.In particular,it argues in favor of a unified model of the morphosyntax and morphophonology,wherein the theory of Distributed Morphology and Optimality Theory operate in a single module.The testing ground is an investigation of the formation of morphological causatives in Moroccan Arabic.Herein,the process of realizing causatives is morphological gemination,whereby the second consonant of the root is doubled.Investigating the question of what triggers the infixal process,I argue against the linearization algorithm suggested in Embick&Noyer(2001),Embick&Marantz(2008),and Embick(2006,2010).Instead,the claim I defend here is that the onus of the linearization process falls on the prosody in Arabic,the central assumption being that the morphosyntactic structure,the output of the syntactic derivation,is the input to OT morphophonological constraints.These constraints are responsible for the linearization of the terminal nodes of the syntactic derivation.I show that adopting one theory over others misses important generalizations about the language.展开更多
This paper will make an investigation on the properties of lexical causatives from the cross-linguistic perspective. Specifically, we shall contrast the lexical causatives in English, Japanese and Chinese. We adopt Py...This paper will make an investigation on the properties of lexical causatives from the cross-linguistic perspective. Specifically, we shall contrast the lexical causatives in English, Japanese and Chinese. We adopt Pylkk^inen＇s （2008） minimalist model as the framework. According to this model, the similarity of cross-linguistic causatives is attributed to the presence of the functional head vCAUSE. Variations of causatives in different languages can be attributed to two parameters： （i） whether vCAUSE obligatorily requires the presence of an external argument or not; （ii） the complement of vCAUSE is root-selecting, verb-selecting or phase-selecting. Causatives in languages can be ronghly divided into two types, namely the lexical causatives and the productive ones. As far as lexical causatives are concerned, languages can be classified into Voice-bundling vs. Non-Voice-bundling ones according to whether the presence of an external argument （i.e, causer or cause） is obligatorily required in lexical causatives or not. English is Voice-bundling and Japanese is Non-Voice-bundling. Chinese stands as the third type of languages which may be called semi-Voice-bnndling language since lexical unaccusative causatives in Chinese are Non-Voice-bundling while action-result-compounds unaccusatives （resultative unaccusatives） are Voice-bundling. Causative heads of lexical cat, satires in these three languages are all root-selecting.展开更多
Hereditary spastic paraplegias(HSPs)refer to a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by the degeneration of motor neurons.To date,a significant number of patients ...Hereditary spastic paraplegias(HSPs)refer to a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by the degeneration of motor neurons.To date,a significant number of patients still have not received a definite genetic diagnosis.Therefore,identifying unreported causative genes continues to be of great importance.Here,we perform whole-exome sequencing in a cohort of Chinese HSP patients.Three homozygous variants(p.L604W,p.S517F,and p.T984A)within the sterol regulatory element-binding factor 2(SREBF2)gene are identified in one autosomal recessive family and two sporadic patients,respectively.Co-segregation is confirmed by Sanger sequencing in all available members.The three variants are rare in the public or in-house database and are predicted to be damaging.The biological impacts of variants in SREBF2 are examined by functional experiments in patient-derived fibroblasts and Drosophila.We find that the variants upregulate cellular cholesterol due to the overactivation of SREBP2,eventually impairing the autophagosomal and lysosomal functions.The overexpression of the mature form of SREBP2 leads to locomotion defects in Drosophila.Our findings identify SREBF2 as a causative gene for HSP and highlight the impairment of cholesterol as a critical pathway for HSP.展开更多
Monognnic diabetes is often misdiagnosed with type 2 diabetes due to overlapping characteristics. This study aimed to discover novel causative mutations of monogenic diabetes in patients with clinically diagnosed type...Monognnic diabetes is often misdiagnosed with type 2 diabetes due to overlapping characteristics. This study aimed to discover novel causative mutations of monogenic diabetes in patients with clinically diagnosed type 2 diabetes and to explore potential molecular mechanisms. Whole-exome sequencing was performed on 31 individuals clinically diagnosed with type 2 diabetes. One novel heterozygnus mutation （p^la2Thr） in INS was identified. It was further gnnotyped in an additional case-control population （6523 cases and 4635 controls）, and this variant was observed in 0.09% of cases. IntraceUular trafficking of insulin proteins was assessed in INSl-E and HEK293T cells, p.Ala2Thr preproinsuUn-GFP was markedly retained in the endoplasmic reticulum （ER） in INS1-E cells. Activation of the PERK-elF2a-ATF4, IREla-XBP1, and ATF6 pathways as well as upregulated ER chaperones were detected in INS1-E cells transfected with the p.Ala2Thr mutant. In conclusion, we identified a causative mutation in IN5 respon- sible for maturity-onset diabetes of the young 10 （MODYIO） in a Chinese population and demonstrated that this mutation affected 13 cell function by inducing ER stress.展开更多
Background: Maternal mortality remains a major public health problem worldwide. Objectives: Our study aims to present the results of an analysis of reviews of maternal deaths at HGOPY. Methodology: This was a descript...Background: Maternal mortality remains a major public health problem worldwide. Objectives: Our study aims to present the results of an analysis of reviews of maternal deaths at HGOPY. Methodology: This was a descriptive cross-sectional study with retrospective data collection from archived records and reviewed maternal death reports. Our study lasted 8 months, from October 1, 2023 to May 31, 2024. The study covered maternal death files at the HGOPY over an 8-year period, from 1st of January 2016 to the 31st of December 2023. Data were processed and analyzed using Statitical Paquage for Social Science (SPSS) version 26.0. Results: We counted a total of 160 maternal deaths, of which 97 had been reviewed. We excluded 61 deceased women reviewed and retained 33. We recorded a cumulative total of 160 maternal deaths and 19,651 live births. The peak in the proportion of maternal deaths at the Yaoundé Gynaeco-Obstetric and Paediatric Hospital was in 2021, with a proportion of 0.013. No maternal deaths had been reviewed between 2016 to 2017. Most deaths (64%) occurred between 37 and 40 weeks. The majority (30.5%) were aged between 30 and 35. The data show that 80.6% of maternal deaths were due to direct obstetric causes, while 19.4% were due to indirect causes. Most deaths (69.4%) were preventable. Only 8.3% were not preventable. Conclusion: Concerted efforts must be made to adapt maternal death prevention and management strategies to local contexts in order to significantly reduce these alarming figures.展开更多
The increasing cost of infrastructure development risks stifling national investment plans.Many projects in Uganda have suffered because of the frequency and magnitude of claims made by parties involved especially the...The increasing cost of infrastructure development risks stifling national investment plans.Many projects in Uganda have suffered because of the frequency and magnitude of claims made by parties involved especially the contractors.As a result,the construction industry is plagued with claims which quite often lead to adversarial relationships.The major grounds for claims were identified through studying the contract documents where claims had been made.Increase in scope;change orders;errors in contract documents;inclement weather;inflation;delay in possessing the site;and change in the tax policy were the most prevalent grounds for making claims.Problems identified in claiming process include delays in getting approval;information on claims not reliable;hostility from the parties involved;pricing of claims;delays in effecting payment when approved;and overzealous contract interpretation leading to misunderstanding and delays Using a survey on project managers for 64 contractors and their corresponding clients or their representatives,the major ways in which it can be reduced were identified as being thoroughness during the design phase;providing for inflation;proper planning of works;using prequalified contractors;and proper documentation of records.Clients have a big role to play in reducing claims.展开更多
Author:Hu Yan.This book provides a comprehensive overview of the background,causes,process,and impact of the British invasion of Xizang from 1903 to 1904,offering an in-depth analysis of the nature and detrimental act...Author:Hu Yan.This book provides a comprehensive overview of the background,causes,process,and impact of the British invasion of Xizang from 1903 to 1904,offering an in-depth analysis of the nature and detrimental actions of imperialist aggression.展开更多
BACKGROUND Mediastinal lymph nodes(MLNs)can be enlarged due to various benign or malignant causes.Endoscopic ultrasound(EUS)is often employed for the acquisition of tissue specimens of the enlarged MLN(EMLN).AIM To de...BACKGROUND Mediastinal lymph nodes(MLNs)can be enlarged due to various benign or malignant causes.Endoscopic ultrasound(EUS)is often employed for the acquisition of tissue specimens of the enlarged MLN(EMLN).AIM To determine the causes,document the symptoms,and determine factors predicting good yield of EUS-guided EMLN biopsy.METHODS All patients having EMLN(>10 mm)on thoracic imaging and referred for EUSguided biopsy were included in this retrospective observational study.Adequacy of the tissue specimen was assessed by the endoscopist with macroscopic on-site evaluation(MOSE)and then sent to a histopathologist for final diagnosis.Analysis for factors predicting good biopsy yield was then performed.RESULTS Of the total 243 patients with EMLN,131(53.9%)were males.The mean age was 47.6(±14.7)and range 14-86 years.Commonest causes of EMLN were tuberculosis 82(33.7%),anthracosis 53(21.8%),neoplastic disease 43(17.7%)and sarcoidosis 14(5.8%).Among the 43 patients with neoplastic diseases:40 had metastatic disease(breast 9,lung 7,pancreatobiliary 6,esophagus 5,kidney 5,hepatocellular 2,neuroendocrine 2,gastrointestinal stromal 1,undetermined 3)and 3 had primary malignancies(lymphoproliferative disorder 2,Kaposi sarcoma 1).Chest related clinical symptoms were absent in more than half the patients with tuberculosis 51/82(62.2%),anthracosis 31/53(58.5%)and neoplastic disease 28/43(65.1%).Factors associated with good biopsy yield were:Subcarinal location of MLN(P=0.026),MLN size>12 mm(P<0.0001),use of fine-needle biopsy(vs fine-needle aspiration)(P=0.049)and satisfactory MOSE(P<0.0001)on univariate analysis;while MLN size>12 mm(P=0.005)and satisfactory MOSE(P<0.0001)on multivariate analysis.CONCLUSION Tuberculosis,anthracosis and metastatic disease were the commonest causes of EMLN.More than half the cases with EMLN had no chest-related symptoms.Large MLN size and satisfactory MOSE observation predicted a good biopsy yield.展开更多
Accurate fault root cause diagnosis is essential for ensuring stable industrial production. Traditional methods, which typically rely on the entire time series and overlook critical local features, can lead to biased ...Accurate fault root cause diagnosis is essential for ensuring stable industrial production. Traditional methods, which typically rely on the entire time series and overlook critical local features, can lead to biased inferences about causal relationships, thus hindering the accurate identification of root cause variables. This study proposed a shapelet-based state evolution graph for fault root cause diagnosis (SEG-RCD), which enables causal inference through the analysis of the important local features. First, the regularized autoencoder and fault contribution plot are used to identify the fault onset time and candidate root cause variables, respectively. Then, the most representative shapelets were extracted to construct a state evolution graph. Finally, the propagation path was extracted based on fault unit shapelets to pinpoint the fault root cause variable. The SEG-RCD can reduce the interference of noncausal information, enhancing the accuracy and interpretability of fault root cause diagnosis. The superiority of the proposed SEG-RCD was verified through experiments on a simulated penicillin fermentation process and an actual one.展开更多
文摘Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed.
基金supported by Special Foundation for National Science and Technology Basic Research Program of China[2019FY101200]Beijing Key Clinical Specialty for Laboratory Medicine-Excellent Project[ZK201000].
文摘Objective To investigate the distribution and antimicrobial susceptibility of causative microorganisms recovered from patients with intra-abdominal infections(IAIs).Methods A total of 2,926 bacterial and fungal strains were identified in samples collected from 1,679 patients with IAIs at the Peking Union Medical College Hospital between 2011 and 2021.Pathogenic bacteria and fungi were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Antimicrobial susceptibility testing(AST)was performed using the VITEK 2 compact system and the Kirby–Bauer method.AST results were interpreted based on the M100-Ed31 clinical breakpoints of the Clinical and Laboratory Standards Institute.Results Of the 2,926 strains identified,49.2%,40.8%,and 9.5%were gram-negative bacteria,gram-positive bacteria,and fungi,respectively.Escherichia coli was the most prevalent pathogen in intensive care unit(ICU)and non-ICU patients;however,a significant decrease was observed in the isolation of E.coli between 2011 and 2021.Specifically,significant decreases were observed between 2011 and 2021 in the levels of extended-spectrumβ-lactamase(ESBL)-producing E.coli(from 76.9%to 14.3%)and Klebsiella pneumoniae(from 45.8%to 4.8%).Polymicrobial infections,particularly those involving co-infection with gram-positive and gram-negative bacteria,were commonly observed in IAI patients.Moreover,Candida albicans was more commonly isolated from hospital-associated IAI samples,while Staphylococcus epidermidis had a higher ratio in community-associated IAIs.Additionally,AST results revealed that most antimicrobial agents performed better in non-ESBL-producers than in ESBL-producers,while the overall resistance rates(56.9%–76.8%)of Acinetobacter baumanmii were higher against all antimicrobial agents than those of other common gram-negative bacteria.Indeed,Enterococcus faecium,Enterococcus faecalis,S.epidermidis,and S.aureus were consistently found to be susceptible to vancomycin,teicoplanin,and linezolid.Similarly,C.albicans exhibited high susceptibility to all the tested antifungal drugs.Conclusion The distribution and antimicrobial susceptibility of the causative microorganisms from patients with IAls were altered between 2011 and 2021.This finding is valuable for the implementation of evidence-based antimicrobial therapy and provides guidance for the control of hospital infections.
基金National Natural Science Foundation of China (40372086)"Short-term and Imminent Tracing Research of Moder-ate-strong Earthquakes in the SN Seismic Belt" by China Earthquake Administration and Scientific Key Foundation Item of Gansu Province (2GS054-A44-015).
文摘On the basis of the textual research on the historical earthquake data and the field investigation of Wudu earthquake occurred in 186 B.C., we suggest that the earthquake parameters drawn from the present earthquake catalogs are not definite and amendments should be made. The heavily-damaged area of this earthquake should be located between Jugan township of Wudu County and Pingding township of Zhouqu County. Its epicenter should be in the vicinity of Lianghekou in Wudu County with a magnitude of about 7-7 1/4 and an intensity of about IX-X. The major axis direction of the heavily-damaged area should be in the WNW direction that is approximately consistent with the strike of the middle-east segment of Diebu-Bailongjiang active fault zone, and the origin time should match up to that of the latest paleoearthquake event [before （83±46） B.C.] obtained by the trench investigation. Certain seismic rupture evidences are still preserved on this fault segment. Therefore, we propose on the basis of comprehensive analysis that the causative structure of the M 7-7 1/4 Wudu earthquake in 186 B.C. should be in the middle-east segment of Diebu-Bailongjiang active fault zone.
文摘The traditional Japanese grammar teaching often only pays attention to the interpretation of syntax and the integrity of grammar structure. This violates the cultivation of communicative competence, and is not in conformity with the society’s requirements of applied foreign language talents. Cognitive linguistics theory, which links language form with semantic concept, reveals the internal relation of man’s thinking and language. If we can subtly apply cognitive linguistic theory into Japanese grammar teaching to explore the cognitive process in the speakers’ brain while expressing, we can get a good understanding of diffi cult points and “special case”. This paper explores the introductory methods and efficacy of the cognitive linguistics theory applied in Japanese grammar teaching method, by lecturing causative sentences an example.
文摘This work interrogates why certain real-world events that meet criteria for being considered causative events cannot be expressed using Hupa’s morphological or syntactic causative constructions,but must be encoded using one of two periphrastic constructions in which the Causer or cause is not marked as an argument.Based on fieldwork with a native speaker,I probe into these two periphrastic constructions in depth,accounting for their distributions through an appeal to Næss’s(2007)account of semantic transitivity.
文摘This paper aims at investigating the morphophonological make-up of derived causatives in Moroccan Arabic within the framework of Optimality Theory (Prince &Smolensky, 2004). Causative verbs in MA are characterized by the systematic gemination of their medial consonants. However, it is not easy to determine the morphological nature of the causative morpheme involved in this derivation. Also, it is not clearly known why the causative morpheme gets realized exactly on the second segment of the base form.Therefore, we seek to achieve the following goals. First, we intend to determine the nature of the causative morpheme. Second, we aim to explain why the causative morpheme is realized on the second segment of the base form. In this respect, we show that the causative morpheme is represented by a featureless consonantal mora that targets the second segment of the base root, turning it into a geminate. We also show that the causative morpheme gets infixed thanks to the privileged status of root-initial segments.
文摘The main objective of this study is to give descriptions of formal and functional aspects of causative constructions in Afaan Oromoo.To achieve the objective,written texts,native speaker informants and introspections are predominantly used as sources of data.The findings reveal that the three structural aspects of causatives-morphological,lexical and syntactic-are used in the language.Morphological causatives are highly productive,and affixes with-s and-i in several combinations as well as-eess are employed for such purposes.Causative Morphemes are detected to derive causatives of basic verb stems of different semantic categories and to involve causations in word-class changing.There are also simple and complex causations in which there are several causatives suffixes,causers and micro-events indicated morphologically and syntactically.Semantically,direct,indirect,and assistive/cooperative causatives are identified.Pseudo-causatives are uncovered as peculiar futures of the language too.There are,even,structures with explicit causative affixes which are called subjectless causatives,but they do not show any causal relations between the participants in the structure.
文摘This paper explores the nature of the post-syntactic operations responsible for the representations of the linear order of terminal nodes.In particular,it argues in favor of a unified model of the morphosyntax and morphophonology,wherein the theory of Distributed Morphology and Optimality Theory operate in a single module.The testing ground is an investigation of the formation of morphological causatives in Moroccan Arabic.Herein,the process of realizing causatives is morphological gemination,whereby the second consonant of the root is doubled.Investigating the question of what triggers the infixal process,I argue against the linearization algorithm suggested in Embick&Noyer(2001),Embick&Marantz(2008),and Embick(2006,2010).Instead,the claim I defend here is that the onus of the linearization process falls on the prosody in Arabic,the central assumption being that the morphosyntactic structure,the output of the syntactic derivation,is the input to OT morphophonological constraints.These constraints are responsible for the linearization of the terminal nodes of the syntactic derivation.I show that adopting one theory over others misses important generalizations about the language.
文摘This paper will make an investigation on the properties of lexical causatives from the cross-linguistic perspective. Specifically, we shall contrast the lexical causatives in English, Japanese and Chinese. We adopt Pylkk^inen＇s （2008） minimalist model as the framework. According to this model, the similarity of cross-linguistic causatives is attributed to the presence of the functional head vCAUSE. Variations of causatives in different languages can be attributed to two parameters： （i） whether vCAUSE obligatorily requires the presence of an external argument or not; （ii） the complement of vCAUSE is root-selecting, verb-selecting or phase-selecting. Causatives in languages can be ronghly divided into two types, namely the lexical causatives and the productive ones. As far as lexical causatives are concerned, languages can be classified into Voice-bundling vs. Non-Voice-bundling ones according to whether the presence of an external argument （i.e, causer or cause） is obligatorily required in lexical causatives or not. English is Voice-bundling and Japanese is Non-Voice-bundling. Chinese stands as the third type of languages which may be called semi-Voice-bnndling language since lexical unaccusative causatives in Chinese are Non-Voice-bundling while action-result-compounds unaccusatives （resultative unaccusatives） are Voice-bundling. Causative heads of lexical cat, satires in these three languages are all root-selecting.
基金supported by the grants from the National Natural Science Foundation of China to Zhi-Ying Wu(82230062,Beijing),Qiao Wei(82402156,Beijing),and Wanzhong Ge(31970668,Beijing)the research foundation for distinguished scholar of Zhejiang University(188020-193810101/089,Hangzhou)to Zhi-Ying Wu
文摘Hereditary spastic paraplegias(HSPs)refer to a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by the degeneration of motor neurons.To date,a significant number of patients still have not received a definite genetic diagnosis.Therefore,identifying unreported causative genes continues to be of great importance.Here,we perform whole-exome sequencing in a cohort of Chinese HSP patients.Three homozygous variants(p.L604W,p.S517F,and p.T984A)within the sterol regulatory element-binding factor 2(SREBF2)gene are identified in one autosomal recessive family and two sporadic patients,respectively.Co-segregation is confirmed by Sanger sequencing in all available members.The three variants are rare in the public or in-house database and are predicted to be damaging.The biological impacts of variants in SREBF2 are examined by functional experiments in patient-derived fibroblasts and Drosophila.We find that the variants upregulate cellular cholesterol due to the overactivation of SREBP2,eventually impairing the autophagosomal and lysosomal functions.The overexpression of the mature form of SREBP2 leads to locomotion defects in Drosophila.Our findings identify SREBF2 as a causative gene for HSP and highlight the impairment of cholesterol as a critical pathway for HSP.
文摘Monognnic diabetes is often misdiagnosed with type 2 diabetes due to overlapping characteristics. This study aimed to discover novel causative mutations of monogenic diabetes in patients with clinically diagnosed type 2 diabetes and to explore potential molecular mechanisms. Whole-exome sequencing was performed on 31 individuals clinically diagnosed with type 2 diabetes. One novel heterozygnus mutation （p^la2Thr） in INS was identified. It was further gnnotyped in an additional case-control population （6523 cases and 4635 controls）, and this variant was observed in 0.09% of cases. IntraceUular trafficking of insulin proteins was assessed in INSl-E and HEK293T cells, p.Ala2Thr preproinsuUn-GFP was markedly retained in the endoplasmic reticulum （ER） in INS1-E cells. Activation of the PERK-elF2a-ATF4, IREla-XBP1, and ATF6 pathways as well as upregulated ER chaperones were detected in INS1-E cells transfected with the p.Ala2Thr mutant. In conclusion, we identified a causative mutation in IN5 respon- sible for maturity-onset diabetes of the young 10 （MODYIO） in a Chinese population and demonstrated that this mutation affected 13 cell function by inducing ER stress.
文摘Background: Maternal mortality remains a major public health problem worldwide. Objectives: Our study aims to present the results of an analysis of reviews of maternal deaths at HGOPY. Methodology: This was a descriptive cross-sectional study with retrospective data collection from archived records and reviewed maternal death reports. Our study lasted 8 months, from October 1, 2023 to May 31, 2024. The study covered maternal death files at the HGOPY over an 8-year period, from 1st of January 2016 to the 31st of December 2023. Data were processed and analyzed using Statitical Paquage for Social Science (SPSS) version 26.0. Results: We counted a total of 160 maternal deaths, of which 97 had been reviewed. We excluded 61 deceased women reviewed and retained 33. We recorded a cumulative total of 160 maternal deaths and 19,651 live births. The peak in the proportion of maternal deaths at the Yaoundé Gynaeco-Obstetric and Paediatric Hospital was in 2021, with a proportion of 0.013. No maternal deaths had been reviewed between 2016 to 2017. Most deaths (64%) occurred between 37 and 40 weeks. The majority (30.5%) were aged between 30 and 35. The data show that 80.6% of maternal deaths were due to direct obstetric causes, while 19.4% were due to indirect causes. Most deaths (69.4%) were preventable. Only 8.3% were not preventable. Conclusion: Concerted efforts must be made to adapt maternal death prevention and management strategies to local contexts in order to significantly reduce these alarming figures.
文摘The increasing cost of infrastructure development risks stifling national investment plans.Many projects in Uganda have suffered because of the frequency and magnitude of claims made by parties involved especially the contractors.As a result,the construction industry is plagued with claims which quite often lead to adversarial relationships.The major grounds for claims were identified through studying the contract documents where claims had been made.Increase in scope;change orders;errors in contract documents;inclement weather;inflation;delay in possessing the site;and change in the tax policy were the most prevalent grounds for making claims.Problems identified in claiming process include delays in getting approval;information on claims not reliable;hostility from the parties involved;pricing of claims;delays in effecting payment when approved;and overzealous contract interpretation leading to misunderstanding and delays Using a survey on project managers for 64 contractors and their corresponding clients or their representatives,the major ways in which it can be reduced were identified as being thoroughness during the design phase;providing for inflation;proper planning of works;using prequalified contractors;and proper documentation of records.Clients have a big role to play in reducing claims.
文摘Author:Hu Yan.This book provides a comprehensive overview of the background,causes,process,and impact of the British invasion of Xizang from 1903 to 1904,offering an in-depth analysis of the nature and detrimental actions of imperialist aggression.
文摘BACKGROUND Mediastinal lymph nodes(MLNs)can be enlarged due to various benign or malignant causes.Endoscopic ultrasound(EUS)is often employed for the acquisition of tissue specimens of the enlarged MLN(EMLN).AIM To determine the causes,document the symptoms,and determine factors predicting good yield of EUS-guided EMLN biopsy.METHODS All patients having EMLN(>10 mm)on thoracic imaging and referred for EUSguided biopsy were included in this retrospective observational study.Adequacy of the tissue specimen was assessed by the endoscopist with macroscopic on-site evaluation(MOSE)and then sent to a histopathologist for final diagnosis.Analysis for factors predicting good biopsy yield was then performed.RESULTS Of the total 243 patients with EMLN,131(53.9%)were males.The mean age was 47.6(±14.7)and range 14-86 years.Commonest causes of EMLN were tuberculosis 82(33.7%),anthracosis 53(21.8%),neoplastic disease 43(17.7%)and sarcoidosis 14(5.8%).Among the 43 patients with neoplastic diseases:40 had metastatic disease(breast 9,lung 7,pancreatobiliary 6,esophagus 5,kidney 5,hepatocellular 2,neuroendocrine 2,gastrointestinal stromal 1,undetermined 3)and 3 had primary malignancies(lymphoproliferative disorder 2,Kaposi sarcoma 1).Chest related clinical symptoms were absent in more than half the patients with tuberculosis 51/82(62.2%),anthracosis 31/53(58.5%)and neoplastic disease 28/43(65.1%).Factors associated with good biopsy yield were:Subcarinal location of MLN(P=0.026),MLN size>12 mm(P<0.0001),use of fine-needle biopsy(vs fine-needle aspiration)(P=0.049)and satisfactory MOSE(P<0.0001)on univariate analysis;while MLN size>12 mm(P=0.005)and satisfactory MOSE(P<0.0001)on multivariate analysis.CONCLUSION Tuberculosis,anthracosis and metastatic disease were the commonest causes of EMLN.More than half the cases with EMLN had no chest-related symptoms.Large MLN size and satisfactory MOSE observation predicted a good biopsy yield.
基金support from the following foundations:the National Natural Science Foundation of China(62322309,62433004)Shanghai Science and Technology Innovation Action Plan(23S41900500)Shanghai Pilot Program for Basic Research(22TQ1400100-16).
文摘Accurate fault root cause diagnosis is essential for ensuring stable industrial production. Traditional methods, which typically rely on the entire time series and overlook critical local features, can lead to biased inferences about causal relationships, thus hindering the accurate identification of root cause variables. This study proposed a shapelet-based state evolution graph for fault root cause diagnosis (SEG-RCD), which enables causal inference through the analysis of the important local features. First, the regularized autoencoder and fault contribution plot are used to identify the fault onset time and candidate root cause variables, respectively. Then, the most representative shapelets were extracted to construct a state evolution graph. Finally, the propagation path was extracted based on fault unit shapelets to pinpoint the fault root cause variable. The SEG-RCD can reduce the interference of noncausal information, enhancing the accuracy and interpretability of fault root cause diagnosis. The superiority of the proposed SEG-RCD was verified through experiments on a simulated penicillin fermentation process and an actual one.
