In the award-winning and widely-acclaimed fictional novel,The Vegetarian,the author,Han Kang,relates a compelling and dramatic story of inexorable psychotic deterioration from the perspective of a tragically affected ...In the award-winning and widely-acclaimed fictional novel,The Vegetarian,the author,Han Kang,relates a compelling and dramatic story of inexorable psychotic deterioration from the perspective of a tragically affected young woman and her close family members.Apart from a variety of interpretations of psychosis from historical,social,psychological,and feminist perspectives,the book also presents a detailed and realistic picture of objective psychotic symptoms that reveals insights into historic and nearly forgotten phenomenological concepts.In this literary case study,we analyze the symptoms remarkably described by the author and briefly review the medical literature on the phenomena of catatonia,schizophrenic autism,paragnomen and the praecox-feeling.展开更多
This paper deals with reduction of losses in electric power distribution system through a dynamic reconfiguration case study of a grid in the city of Mostar,Bosnia and Herzegovina.The proposed solution is based on a n...This paper deals with reduction of losses in electric power distribution system through a dynamic reconfiguration case study of a grid in the city of Mostar,Bosnia and Herzegovina.The proposed solution is based on a nonlinear model predictive control algorithm which determines the optimal switching operations of the distribution system.The goal of the control algorithm is to find the optimal radial network topology which minimizes cumulative active power losses and maximizes voltages across the network while simultaneously satisfying all system constraints.The optimization results are validated through multiple simulations(using real power demand data collected for a few characteristic days during winter and summer)which demonstrate the efficiency and usefulness of the developed control algorithm in reducing the grid losses by up to 14%.展开更多
Introductory courses in vocational education play a foundational role in orienting first-year students to their chosen major and initiating their professional formation.Such courses help newcomers establish a cognitiv...Introductory courses in vocational education play a foundational role in orienting first-year students to their chosen major and initiating their professional formation.Such courses help newcomers establish a cognitive map of the discipline,plan learning pathways,and cultivate identification with the profession,while also serving as a vehicle for integrating ideological-political education.In practice,however,many programs face persistent challenges in textbook development,faculty capacity,curriculum content,and alignment with industry standards,which limit the effectiveness of these courses.With the rollout of national policies such as the Implementation Plan for National Vocational Education Reform,the urgency of strengthening the construction of introductory courses has become increasingly evident.Using the textbook Introduction to Virtual Reality Applications:Cognition,Skills,and Career as a core case,this paper analyzes innovative practices in writing philosophy,course design,school-enterprise collaboration,resource integration,ideological-political infusion,and practical outcomes.Building on this analysis,the paper proposes strategies for reforming introductory courses and building coherent textbook systems in vocational education so as to improve course quality and better support students’professional development.展开更多
Coal bursts pose significant safety and operational challenges in deep mining environments,necessitating effective mitigation strategies to address high-stress concentrations and dynamic failure risks.This study evalu...Coal bursts pose significant safety and operational challenges in deep mining environments,necessitating effective mitigation strategies to address high-stress concentrations and dynamic failure risks.This study evaluated the efficacy of hydraulic fracturing as a preconditioning tool at a longwall face of the Mengcun coal mine with strong coal bursts,Shaanxi Province.The program involved the systematic creation of a fracture network through high-pressure fluid injection,monitored via microseismic arrays,stress measurements,and hydrological sensors.Results demonstrated that hydraulic fracturing effectively redistributed in-situ stresses,reducing high-stress concentrations by up to 30%,lowering the frequency of high-energy microseismic events,and enhancing the stability of fractured zones.However,the presence of unfractured blind spots and interactions with pre-existing faults highlighted the need for optimized well placement and adaptive fracturing designs.These findings underscore the potential of hydraulic fracturing as a critical preconditioning tool in high-stress mining operations,which could provide a framework for improving safety and efficiency in similar geological and operational settings.展开更多
As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article ...As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article introduces Professor Fang Gang’s experience in treating obesity-type polycystic ovary syndrome(PCOS)with modified Zhuang Medicine Mao Xia Yin.Professor Fang Gang proposes that the etiology and pathogenesis of obesity-type polycystic ovary syndrome(PCOS)primarily stem from spleen deficiency,which impairs the transport of water and dampness.This dysfunction leads to the accumulation of dampness that transforms into phlegm.Over time,the stagnation of phlegm and dampness generates internal heat,resulting in the formation of“dampness toxin,”“phlegm toxin,”and“heat toxin.”These pathological toxins obstruct the circulation of Qi and blood,causing stasis and the emergence of“stasis toxin.”The buildup of these toxins ultimately blocks the three channels and two pathways,disrupting the harmony among the three Qi of heaven,earth,and man.This disharmony culminates in impaired uterine gland function.Therefore,the treatment mainly focuses on tonifying deficiency,detoxifying,and regulating Qi.展开更多
BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group ...BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S.CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium.NS is crucial for early diagnosis and management,which ensures a better quality of life.AIM To report a case of the coexistence of sickle cell anemia(SCA)and CF and perform an integrative literature review.METHODS This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case.The authors identified only 5 cases of SCA associated with CF.No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.RESULTS Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin.The diagnosis of CF was confirmed by the Coulometry Sweat Test.The rarity of the co-occurrence of these two severe genetic pathologies(CF and SCA)is a challenge for medical science.CONCLUSION This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.展开更多
Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-indus...Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.展开更多
A cased well model consists of a coaxial tank and casing,which houses coaxially installed transmitting and receiving coils.The transmitting coil is excited by the current produced by the transmitting circuit,and trans...A cased well model consists of a coaxial tank and casing,which houses coaxially installed transmitting and receiving coils.The transmitting coil is excited by the current produced by the transmitting circuit,and transient electromagnetic responses occur in the casing,including direct coupling and casing responses.As the range between the transmitting and receiving coils increases,direct coupling responses decay rapidly,are less than the casing response at 0.3 m,and disappear at 0.7 m.By contrast,a casing response increases rapidly and then declines slowly after reaching a peak and changes little within a specifi c range.The peak decreases slowly with range.The continuous addition of water to the tank causes slight changes in transient electromagnetic responses,so the diff erence which are subtracted from the response without water is used.Moreover,the diff erences at the time of rapid increase in response and the time of rapid decrease in response are large,forming a peak and a trough.Given that the conductivity of water in a full tank changes after the addition of salt,the diff erence in the peak is linear with the increase in the conductivity of water.This result provides an experimental basis for the design of a transient electromagnetic logging instrument that measures the conductivity of formation in cased well.展开更多
BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex educat...BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex education started relatively late,yet there are many problems in the development of sex education in China;for example,college students lack knowledge of sexuality.AIM To explore the perception of sex education among medical college students.METHODS Students majoring in medicine in a medical school were selected as the survey subjects.Anonymous online questionnaires were used to conduct the survey,and the results were analyzed using GraphPad Prism,SPSS,Microsoft Excel,and other software.The questionnaire was administered to understand the source of sexual knowledge,sexual responsibility,mastery of sexual knowledge,and distress caused by sexual problems.RESULTS Most students majoring in medicine had no formal sex education,lacked sexual knowledge,or had a biased understanding of sexual responsibility.This study analyzed future research trends in sex education based on relevant achievements in the Chinese context and abroad to further realize the practical significance and value of sex education popularization in China and provide recommendations for parents and schools at different levels.CONCLUSION Sex education should be conducted among college students,and medical colleges and universities should strengthen scientific sex education.展开更多
BACKGROUND Intraosseous lipoma of bone is one of the rarest benign bone tumors,which often involves the metaphysis of long tubular bones,especially the femur,tibia,fibula,and calcaneus.Bone lipoma can be characterized...BACKGROUND Intraosseous lipoma of bone is one of the rarest benign bone tumors,which often involves the metaphysis of long tubular bones,especially the femur,tibia,fibula,and calcaneus.Bone lipoma can be characterized by chronic dull pain but can also be asymptomatic most of the time.As a result,it is less likely to attract people’s attention and is occasionally diagnosed through imaging examination during routine physical health check-up.CASE SUMMARY We describe a clinical case of intraosseous lipoma in a 21-year-old patient with chronic pain in the left lower limb for four years without any significant physical findings apart from the minimal swelling and local tenderness over the median ankle.Computerized tomography suggested the possibility of a lipoma on the left distal tibia,but the pathological examination could make a definite diagnosis.The intraosseous lipoma of the left distal tibia was treated by surgical curettage,bone graft,and internal fixation with steel plate,since the conservative treatment is often ineffective.Postoperatively,the patient made an uneventful recovery and was able to do daily activities without any restrictions.In addition,local recur-rence of the intraosseous lipoma was not reported in subsequent reexamination.CONCLUSION Bone lipoma is very rare and often exhibits no characteristic clinical manifestation.The confirmative diagnosis of lipoma largely relies on a combination of imageo-logy and biopsy.Surgical intervention is often recommended as a conventional therapy for bone lipoma.Postoperatively,the patient makes an uneventful reco-very with a good prognosis,and the local recurrence of the tumor is also a low probability event.展开更多
Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be ...Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be used to access digital content,meet virtually,and perform several professional and leisure tasks.Among the numerous technologies supporting the metaverse,immersive Virtual Reality(VR)plays a primary role and offers highly interactive social experiences.Despite growing interest in this area,there are no clear design guidelines for creating environments tailored to the metaverse.Methods This study seeks to advance research in this area by moving from state-of-the-art studies on the design of immersive virtual environments in the context of metaverse and proposing how to integrate cutting-edge technologies within this context.Specifically,the best practices were identified by i)analyzing literature studies focused on human behavior in immersive virtual environments,ii)extracting common features of existing social VR platforms,and iii)conducting interviews with experts in a specific application domain.Specifically,this study considered the creation of a new virtual environment for MetaLibrary,a VR-based social platform aimed at integrating public libraries into metaverse.Several implementation challenges and additional requirements have been identified for the development of virtual environments(VEs).These elements were considered in the selection of specific cutting-edge technologies and their integration into the development process.A user study was also conducted to investigate some design aspects(namely lighting conditions and richness of the scene layout)for which deriving clear indications from the above analysis was not possible because different alternative configurations could be chosen.Results The work reported in this paper seeks to bridge the gap between existing VR platforms and related literature in the field,on the one hand,and requirements regarding immersive virtual environments for the metaverse,on the other hand,by reporting a set of best practices which were used to build a social virtual environment that meets users'expectations and needs.Conclusions Results suggest that carefully designed virtual environments can positively affect user experience and interaction within metaverse.The insights gained from this study offer valuable cues for developing immersive virtual environments for the metaverse to deliver more effective and engaging experiences.展开更多
A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative ...A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.展开更多
Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the pred...Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the prediction and prevention of AMS.Methods:A caseecontrol study was conducted to recruit participants who experienced or did not experience AMS after entering a plateau.The data was collected through online questionnaires for convenient sampling.Demographic characteristics,body constitution,and related states or behaviors were investigated before and after entering the plateau.The participants were divided into case and control groups based on the incidence of AMS.The distributions of relevant factors were compared.Binary logistic regression analysis was used to screen for risk and protective factors.Results:There were 167 participants who completed the questionnaire.A total of 54 cases were excluded,and 113 participants were included,including 52 in the case group and 61 in the control group.In the case group,37,13,and 2 patients had mild,moderate,and severe AMS,respectively.In terms of the Tibetan medicine constitution,the case group had the highest proportion of Bad-rlung(25.0%)and Rlung types(21.2%),whereas the control group had the highest proportion of Bad-rlung(29.5%)and Mkhrisbad types(24.6%).There was no significant difference in the distribution of the constitutional types between the two groups.Insomnia or insufficient sleep within the week prior to entering the plateau and fatigue after arrival were risk factors for AMS,with odds ratios(OR)and 95%confidence intervals(CI)of 5.012(1.871e13.426)and 3.387(1.393e8.236),respectively.A history of short-term plateau travel is a protective factor for AMS(OR:0.32,95%CI:0.129 to 0.792).Conclusion:Insomnia or lack of sleep before ascending to a plateau and fatigue after arrival are risk factors for AMS.The Rlung constitution might be related to the incidence of AMS;however,this still needs to be verified in large-sample observational studies.The risk factors identified in this study can provide a reference for the prevention practice and research of AMS.展开更多
This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural commu...This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural communication skills,in-depth regional and country knowledge,and practical expertise in ocean affairs.Additionally,the paper presents specific training pathways and policy recommendations for implementing this model.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus d...BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.展开更多
This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they...This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they had concomitant lung squamous cell carcinoma(LSCC)or not,to assess their connection with cancer susceptibility.By means of multivariate logistic regression analysis,the GSTM1 null genotype serves as a significant standalone risk factor for LSCC,in addition to variables like age,smoking history,emphysema,body mass index(BMI),albumin level,and neutrophil-to-lymphocyte ratio(NLR).A predictive model incorporating these factors demonstrated superior discriminative ability compared to the established COPD Lung Cancer Screening Score(COPD-LUCSS).展开更多
Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or g...Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or growing too slowly,or because the immune system has destroyed the tiny primary lesion.Most CUP patients receive only localized treatment or empirical systemic chemotherapy,leading to poor prognosis and shorter average overall survival.There is currently insufficient evidence-based medical support for the diagnosis and treatment of CUP.This study retrospectively analyzed clinical characteristics,diagnostic methods,treatment approaches,and prognostic outcomes of newly diagnosed CUP patients treated in our department.The findings aim to provide clinical guidance for diagnosis and treatment of CUP,with the goal of reducing diagnostic delays and improving patient outcomes.展开更多
AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(...AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.展开更多
文摘In the award-winning and widely-acclaimed fictional novel,The Vegetarian,the author,Han Kang,relates a compelling and dramatic story of inexorable psychotic deterioration from the perspective of a tragically affected young woman and her close family members.Apart from a variety of interpretations of psychosis from historical,social,psychological,and feminist perspectives,the book also presents a detailed and realistic picture of objective psychotic symptoms that reveals insights into historic and nearly forgotten phenomenological concepts.In this literary case study,we analyze the symptoms remarkably described by the author and briefly review the medical literature on the phenomena of catatonia,schizophrenic autism,paragnomen and the praecox-feeling.
基金supported in part by the European Regional Development Fund under Grant KK.01.1.1.01.0009(DATACROSS).
文摘This paper deals with reduction of losses in electric power distribution system through a dynamic reconfiguration case study of a grid in the city of Mostar,Bosnia and Herzegovina.The proposed solution is based on a nonlinear model predictive control algorithm which determines the optimal switching operations of the distribution system.The goal of the control algorithm is to find the optimal radial network topology which minimizes cumulative active power losses and maximizes voltages across the network while simultaneously satisfying all system constraints.The optimization results are validated through multiple simulations(using real power demand data collected for a few characteristic days during winter and summer)which demonstrate the efficiency and usefulness of the developed control algorithm in reducing the grid losses by up to 14%.
文摘Introductory courses in vocational education play a foundational role in orienting first-year students to their chosen major and initiating their professional formation.Such courses help newcomers establish a cognitive map of the discipline,plan learning pathways,and cultivate identification with the profession,while also serving as a vehicle for integrating ideological-political education.In practice,however,many programs face persistent challenges in textbook development,faculty capacity,curriculum content,and alignment with industry standards,which limit the effectiveness of these courses.With the rollout of national policies such as the Implementation Plan for National Vocational Education Reform,the urgency of strengthening the construction of introductory courses has become increasingly evident.Using the textbook Introduction to Virtual Reality Applications:Cognition,Skills,and Career as a core case,this paper analyzes innovative practices in writing philosophy,course design,school-enterprise collaboration,resource integration,ideological-political infusion,and practical outcomes.Building on this analysis,the paper proposes strategies for reforming introductory courses and building coherent textbook systems in vocational education so as to improve course quality and better support students’professional development.
基金supported by the National Natural Science Foundation of China(52274085).
文摘Coal bursts pose significant safety and operational challenges in deep mining environments,necessitating effective mitigation strategies to address high-stress concentrations and dynamic failure risks.This study evaluated the efficacy of hydraulic fracturing as a preconditioning tool at a longwall face of the Mengcun coal mine with strong coal bursts,Shaanxi Province.The program involved the systematic creation of a fracture network through high-pressure fluid injection,monitored via microseismic arrays,stress measurements,and hydrological sensors.Results demonstrated that hydraulic fracturing effectively redistributed in-situ stresses,reducing high-stress concentrations by up to 30%,lowering the frequency of high-energy microseismic events,and enhancing the stability of fractured zones.However,the presence of unfractured blind spots and interactions with pre-existing faults highlighted the need for optimized well placement and adaptive fracturing designs.These findings underscore the potential of hydraulic fracturing as a critical preconditioning tool in high-stress mining operations,which could provide a framework for improving safety and efficiency in similar geological and operational settings.
基金National Administration of Traditional Chinese Medicine high-level key discipline construction project on Ethnic Minority Medicine(Zhuang Medicine)(Project No.:zyyzdxk-2023164)Guangxi Higher Education Key Laboratory for Research on Toxin-related Diseases in Zhuang Medicine(Guijiao Keyan[2022]No.10).
文摘As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article introduces Professor Fang Gang’s experience in treating obesity-type polycystic ovary syndrome(PCOS)with modified Zhuang Medicine Mao Xia Yin.Professor Fang Gang proposes that the etiology and pathogenesis of obesity-type polycystic ovary syndrome(PCOS)primarily stem from spleen deficiency,which impairs the transport of water and dampness.This dysfunction leads to the accumulation of dampness that transforms into phlegm.Over time,the stagnation of phlegm and dampness generates internal heat,resulting in the formation of“dampness toxin,”“phlegm toxin,”and“heat toxin.”These pathological toxins obstruct the circulation of Qi and blood,causing stasis and the emergence of“stasis toxin.”The buildup of these toxins ultimately blocks the three channels and two pathways,disrupting the harmony among the three Qi of heaven,earth,and man.This disharmony culminates in impaired uterine gland function.Therefore,the treatment mainly focuses on tonifying deficiency,detoxifying,and regulating Qi.
文摘BACKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(CF),sickle cell disease,and other diseases.Sickle cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin S.CF is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface epithelium.NS is crucial for early diagnosis and management,which ensures a better quality of life.AIM To report a case of the coexistence of sickle cell anemia(SCA)and CF and perform an integrative literature review.METHODS This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical case.The authors identified only 5 cases of SCA associated with CF.No clinical trials or review articles were identified considering the rarity of the coexistence of these two pathologies.RESULTS Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with SCA with an alteration in the dosage of immunoreactive trypsin.The diagnosis of CF was confirmed by the Coulometry Sweat Test.The rarity of the co-occurrence of these two severe genetic pathologies(CF and SCA)is a challenge for medical science.CONCLUSION This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.
基金funded by the National Key Research and Development Program of China(No.2020YFC1909704)the Fundamental Research Funds for the Central Universities,China(Nos.N2301026,N2301017).
文摘Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.
基金supported by the National Natural Science Foundation of China (grant nos. 42074137)。
文摘A cased well model consists of a coaxial tank and casing,which houses coaxially installed transmitting and receiving coils.The transmitting coil is excited by the current produced by the transmitting circuit,and transient electromagnetic responses occur in the casing,including direct coupling and casing responses.As the range between the transmitting and receiving coils increases,direct coupling responses decay rapidly,are less than the casing response at 0.3 m,and disappear at 0.7 m.By contrast,a casing response increases rapidly and then declines slowly after reaching a peak and changes little within a specifi c range.The peak decreases slowly with range.The continuous addition of water to the tank causes slight changes in transient electromagnetic responses,so the diff erence which are subtracted from the response without water is used.Moreover,the diff erences at the time of rapid increase in response and the time of rapid decrease in response are large,forming a peak and a trough.Given that the conductivity of water in a full tank changes after the addition of salt,the diff erence in the peak is linear with the increase in the conductivity of water.This result provides an experimental basis for the design of a transient electromagnetic logging instrument that measures the conductivity of formation in cased well.
基金Supported by Scientific Research Project of College Students in Liaoning Province,No.S202410164004.
文摘BACKGROUND Sex education was introduced early in foreign countries.For example,there is a more systematic sex education system abroad,which can better achieve the popularization of sex education.China's sex education started relatively late,yet there are many problems in the development of sex education in China;for example,college students lack knowledge of sexuality.AIM To explore the perception of sex education among medical college students.METHODS Students majoring in medicine in a medical school were selected as the survey subjects.Anonymous online questionnaires were used to conduct the survey,and the results were analyzed using GraphPad Prism,SPSS,Microsoft Excel,and other software.The questionnaire was administered to understand the source of sexual knowledge,sexual responsibility,mastery of sexual knowledge,and distress caused by sexual problems.RESULTS Most students majoring in medicine had no formal sex education,lacked sexual knowledge,or had a biased understanding of sexual responsibility.This study analyzed future research trends in sex education based on relevant achievements in the Chinese context and abroad to further realize the practical significance and value of sex education popularization in China and provide recommendations for parents and schools at different levels.CONCLUSION Sex education should be conducted among college students,and medical colleges and universities should strengthen scientific sex education.
基金Supported by the Lanzhou Science and Technology Plan,No.2023-2-11Lanzhou Talent Innovation and Entrepreneurship Project,No.2023-2-28+1 种基金Gansu University of Chinese Medicine Tutor Special Project,No.2023YXKY015Research Fund Project of 940th Hospital,No.2023YXKY014 and No.2023YXKY036.
文摘BACKGROUND Intraosseous lipoma of bone is one of the rarest benign bone tumors,which often involves the metaphysis of long tubular bones,especially the femur,tibia,fibula,and calcaneus.Bone lipoma can be characterized by chronic dull pain but can also be asymptomatic most of the time.As a result,it is less likely to attract people’s attention and is occasionally diagnosed through imaging examination during routine physical health check-up.CASE SUMMARY We describe a clinical case of intraosseous lipoma in a 21-year-old patient with chronic pain in the left lower limb for four years without any significant physical findings apart from the minimal swelling and local tenderness over the median ankle.Computerized tomography suggested the possibility of a lipoma on the left distal tibia,but the pathological examination could make a definite diagnosis.The intraosseous lipoma of the left distal tibia was treated by surgical curettage,bone graft,and internal fixation with steel plate,since the conservative treatment is often ineffective.Postoperatively,the patient made an uneventful recovery and was able to do daily activities without any restrictions.In addition,local recur-rence of the intraosseous lipoma was not reported in subsequent reexamination.CONCLUSION Bone lipoma is very rare and often exhibits no characteristic clinical manifestation.The confirmative diagnosis of lipoma largely relies on a combination of imageo-logy and biopsy.Surgical intervention is often recommended as a conventional therapy for bone lipoma.Postoperatively,the patient makes an uneventful reco-very with a good prognosis,and the local recurrence of the tumor is also a low probability event.
基金Supported by Fondazione TIM in the context of the “Facciamola Facile” initiativeby Programma Operativo Nazionale (PON)“Ricerca e Innovazione” 2014-2020-DM 1062/2021 funds
文摘Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be used to access digital content,meet virtually,and perform several professional and leisure tasks.Among the numerous technologies supporting the metaverse,immersive Virtual Reality(VR)plays a primary role and offers highly interactive social experiences.Despite growing interest in this area,there are no clear design guidelines for creating environments tailored to the metaverse.Methods This study seeks to advance research in this area by moving from state-of-the-art studies on the design of immersive virtual environments in the context of metaverse and proposing how to integrate cutting-edge technologies within this context.Specifically,the best practices were identified by i)analyzing literature studies focused on human behavior in immersive virtual environments,ii)extracting common features of existing social VR platforms,and iii)conducting interviews with experts in a specific application domain.Specifically,this study considered the creation of a new virtual environment for MetaLibrary,a VR-based social platform aimed at integrating public libraries into metaverse.Several implementation challenges and additional requirements have been identified for the development of virtual environments(VEs).These elements were considered in the selection of specific cutting-edge technologies and their integration into the development process.A user study was also conducted to investigate some design aspects(namely lighting conditions and richness of the scene layout)for which deriving clear indications from the above analysis was not possible because different alternative configurations could be chosen.Results The work reported in this paper seeks to bridge the gap between existing VR platforms and related literature in the field,on the one hand,and requirements regarding immersive virtual environments for the metaverse,on the other hand,by reporting a set of best practices which were used to build a social virtual environment that meets users'expectations and needs.Conclusions Results suggest that carefully designed virtual environments can positively affect user experience and interaction within metaverse.The insights gained from this study offer valuable cues for developing immersive virtual environments for the metaverse to deliver more effective and engaging experiences.
基金Sponsored by Vocational Education Teaching Reform Research Project of Shandong Province“Research on Digital New-Form Curriculum Development Based on AI Knowledge Maps in the Context of Industry-Education Integration”(2023352)Vocational Education Teaching Reform Research Project of Shandong Province“Innovation and Practice in the Development Model of Vocational College Master Craftsman Studios under the Perspective of Industry-Education Integration”(2024375).
文摘A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.
基金funded by the institutional program of China Tibetology Research Center(CTRC20236JS08).
文摘Objective:This study aimed to determine the correlation between the incidence of acute mountain sickness(AMS)and the body constitution of Tibetan medicine and other relevant factors to provide a reference for the prediction and prevention of AMS.Methods:A caseecontrol study was conducted to recruit participants who experienced or did not experience AMS after entering a plateau.The data was collected through online questionnaires for convenient sampling.Demographic characteristics,body constitution,and related states or behaviors were investigated before and after entering the plateau.The participants were divided into case and control groups based on the incidence of AMS.The distributions of relevant factors were compared.Binary logistic regression analysis was used to screen for risk and protective factors.Results:There were 167 participants who completed the questionnaire.A total of 54 cases were excluded,and 113 participants were included,including 52 in the case group and 61 in the control group.In the case group,37,13,and 2 patients had mild,moderate,and severe AMS,respectively.In terms of the Tibetan medicine constitution,the case group had the highest proportion of Bad-rlung(25.0%)and Rlung types(21.2%),whereas the control group had the highest proportion of Bad-rlung(29.5%)and Mkhrisbad types(24.6%).There was no significant difference in the distribution of the constitutional types between the two groups.Insomnia or insufficient sleep within the week prior to entering the plateau and fatigue after arrival were risk factors for AMS,with odds ratios(OR)and 95%confidence intervals(CI)of 5.012(1.871e13.426)and 3.387(1.393e8.236),respectively.A history of short-term plateau travel is a protective factor for AMS(OR:0.32,95%CI:0.129 to 0.792).Conclusion:Insomnia or lack of sleep before ascending to a plateau and fatigue after arrival are risk factors for AMS.The Rlung constitution might be related to the incidence of AMS;however,this still needs to be verified in large-sample observational studies.The risk factors identified in this study can provide a reference for the prevention practice and research of AMS.
基金supported by“Dalian Maritime University Teaching Reform Research Fund 2022 Annual Project”(Fund No.XJG2022-96).
文摘This paper proposes an interdisciplinary talent training model that combines foreign language education with area studies.The model aims to cultivate international ocean affairs professionals with cross-cultural communication skills,in-depth regional and country knowledge,and practical expertise in ocean affairs.Additionally,the paper presents specific training pathways and policy recommendations for implementing this model.
文摘BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.
基金Anhui Province’s Clinical Medical Research Transformation Special Initiative(Project No.:202204295107020016)。
文摘This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they had concomitant lung squamous cell carcinoma(LSCC)or not,to assess their connection with cancer susceptibility.By means of multivariate logistic regression analysis,the GSTM1 null genotype serves as a significant standalone risk factor for LSCC,in addition to variables like age,smoking history,emphysema,body mass index(BMI),albumin level,and neutrophil-to-lymphocyte ratio(NLR).A predictive model incorporating these factors demonstrated superior discriminative ability compared to the established COPD Lung Cancer Screening Score(COPD-LUCSS).
文摘Primary of Unknown Origin Cancer(CUP)is a metastatic tumor whose origin remains undetermined.The reason for this ambiguity in identifying the primary site remains unclear,possibly due to the tumor being too small or growing too slowly,or because the immune system has destroyed the tiny primary lesion.Most CUP patients receive only localized treatment or empirical systemic chemotherapy,leading to poor prognosis and shorter average overall survival.There is currently insufficient evidence-based medical support for the diagnosis and treatment of CUP.This study retrospectively analyzed clinical characteristics,diagnostic methods,treatment approaches,and prognostic outcomes of newly diagnosed CUP patients treated in our department.The findings aim to provide clinical guidance for diagnosis and treatment of CUP,with the goal of reducing diagnostic delays and improving patient outcomes.
文摘AIM:To report and analyze cases of sterile intraocular inflammation(IOI)following intravitreal faricimab injections in patients treated for neovascular age-related macular degeneration(nAMD)and diabetic macular edema(DME).METHODS:This double-center case series included nine eyes of six patients who developed uveitis after faricimab therapy.Comprehensive clinical evaluation was performed,including slit-lamp examination,intraocular pressure(IOP)measurement,fluorescein and indocyanine green angiography(ICGA),and laboratory tests.Inflammatory responses were treated with topical or systemic corticosteroids,and patients were monitored for visual acuity and inflammatory activity.RESULTS:The incidence of IOI was 0.8%per patient(Innsbruck)and 0.23%(Czechia),with inflammation typically occurring between the third and sixth injection(mean interval:10d post-injection).Inflammator y presentations ranged from anterior uveitis to posterior segment involvement.One notable case demonstrated novel choroidal hypofluorescent lesions on angiography,suggesting deeper ocular involvement.The mean patient age was 76y;five of six affected patients were female.All cases responded to local and systemic corticosteroids,with full recovery of initial visual acuity.CONCLUSION:Sterile IOI after faricimab appears to be a rare but relevant adverse event.Although the incidence falls within expected ranges for anti-vascular endothelial growth factor(anti-VEGF)agents,the observed choroidal involvement represents a potentially new safety signal.Prompt diagnosis and corticosteroid therapy are effective in all cases.Our findings support the need for vigilant post-marketing surveillance and further studies to better understand the underlying mechanisms and risk factors of faricimab-associated inflammation.
