Propagation of strong femtosecond hyper-Gaussian pulses in a cascade three-level molecular system is studied by solving numerically the Maxwell–Bloch equations by the iterative predictor-corrector finite-difference t...Propagation of strong femtosecond hyper-Gaussian pulses in a cascade three-level molecular system is studied by solving numerically the Maxwell–Bloch equations by the iterative predictor-corrector finite-difference time-domain method.Optical power limiting behavior induced by strong nonlinear two-photon absorption is observed for different orders of the femtosecond hyper-Gaussian pulses. Pulses of a higher order temporal profile are found to have a wider power range of optical limiting but a larger output saturation intensity. Both the output saturation value and the damage threshold of optical power limiting decrease with pulse duration increasing. The decrease of the pulse area along the pulse propagation is much slower than that obtained from the two-photon area theorem due to invalidity of the slowly varying amplitude approximation and the monochromatic field hypothesis.展开更多
By using the method of eigenvectors, the atomic populations and emission spectrum are investigated in a system that consists of a cascade three-level atom resonantly interacting with a single-mode tield in a Kerr-like...By using the method of eigenvectors, the atomic populations and emission spectrum are investigated in a system that consists of a cascade three-level atom resonantly interacting with a single-mode tield in a Kerr-like medium. The atom and the field are assumed to be initially in the upper atomic state and the Fock state, respectively. Results for models with intensity-dependent coupling and with intensity-independent coupling are compared. It is found that both population dynamics and emission spectrum show no indications of atom-field decoupling in the strong field limit if the intensity-dependent coupling is taken into account.展开更多
Gastric carcinoma(GC)is a malignancy with multifactorial involvement,multicellular regulation,and multistage evolution.The classic Correa's cascade of intestinal GC specifies a trilogy of malignant transformation ...Gastric carcinoma(GC)is a malignancy with multifactorial involvement,multicellular regulation,and multistage evolution.The classic Correa's cascade of intestinal GC specifies a trilogy of malignant transformation of the gastric mucosa,in which normal gastric mucosa gradually progresses from inactive or chronic active gastritis(Phase I)to gastric precancerous lesions(Phase II)and finally to GC(Phase III).Correa's cascade highlights the evolutionary pattern of GC and the importance of early intervention to prevent malignant transformation of the gastric mucosa.Intervening in early gastric mucosal lesions,i.e.,Phases I and II,will be the key strategy to prevent and treat GC.Natural products(NPs)have been an important source for drug development due to abundant sources,tremendous safety,and multiple pharmacodynamic mechanisms.This review is the first to investigate and summarize the multi-step effects and regulatory mechanisms of NPs on the Correa's cascade in gastric carcinogenesis.In Phase I,NPs modulate Helicobacter pylori urease activity,motility,adhesion,virulence factors,and drug resistance,thereby inhibiting H.pylori-induced gastric mucosal inflammation and oxidative stress,and facilitating ulcer healing.In Phase II,NPs modulate multiple pathways and mediators regulating gastric mucosal cell cycle,apoptosis,autophagy,and angiogenesis to reverse gastric precancerous lesions.In Phase III,NPs suppress cell proliferation,migration,invasion,angiogenesis,and cancer stem cells,induce apoptosis and autophagy,and enhance chemotherapeutic drug sensitivity for the treatment of GC.In contrast to existing work,we hope to uncover NPs with sequential therapeutic effects on multiple phases of GC development,providing new ideas for gastric cancer prevention,treatment,and drug development.展开更多
Broad area quantum cascade lasers(BA QCLs)have significant applications in many areas,but suffer from demanding pulse operating conditions and poor beam quality due to heat accumulation and generation of high order mo...Broad area quantum cascade lasers(BA QCLs)have significant applications in many areas,but suffer from demanding pulse operating conditions and poor beam quality due to heat accumulation and generation of high order modes.A structure of mini-array is adopted to improve the heat dissipation capacity and beam quality of BA QCLs.The active region is etched to form a multi-emitter and the channels are filled with In P:Fe,which acts as a lateral heat dissipation channel to improve the lateral heat dissipation efficiency.A device withλ~4.8μm,a peak output power of 122 W at 1.2%duty cycle with a pulse of 1.5μs is obtained in room temperature,with far-field single-lobed distribution.This result allows BA QCLs to obtain high peak power at wider pump pulse widths and higher duty cycle conditions,promotes the application of the mid-infrared laser operating in pulsed mode in th e field of standoff photoacoustic chemical detection,space optical communication,and so on.展开更多
In the process of power scaling large-area Quantum Cascade Lasers(QCLs),challenges such as degradation of beam quality and emission of multilobed far-field modes are frequently encountered.These issues become particul...In the process of power scaling large-area Quantum Cascade Lasers(QCLs),challenges such as degradation of beam quality and emission of multilobed far-field modes are frequently encountered.These issues become particularly pronounced with an increase in ridge width,resulting in multimode problems.To tackle this,an innovative multi ridge waveguide structure based on the principle of supersymmetry(SUSY)was proposed.This structure comprises a wider main waveguide in the center and two narrower auxiliary waveguides on either side.The high-order modes of the main waveguide are coupled with the modes of the auxiliary waveguides through mode-matching design,and the optical loss of the auxiliary waveguides suppresses these modes,thereby achieving fundamental mode lasing of the wider main waveguide.This paper employs the finite difference eigenmode(FDE)method to perform detailed structural modeling and simulation optimization of the 4.6μm wavelength quantum cascade laser,successfully achieving a single transverse mode QCL with a ridge width of 10μm.In comparison to the traditional single-mode QCL(with a ridge width of about 5μm),the MRW structure has the potential to increase the gain area of the laser by 100%.This offers a novel design concept and methodology for enhancing the single-mode luminous power of mid-infrared quantum cascade lasers,which is of considerable significance.展开更多
The cavity field spectrum of a cascade three-level atom interacting with single-mode field with Kerr-like medium in the cavity is investigated. The numerical results for the initial field in pure number state, coheren...The cavity field spectrum of a cascade three-level atom interacting with single-mode field with Kerr-like medium in the cavity is investigated. The numerical results for the initial field in pure number state, coherent state and squeezed vacuum state are calculated, respectively. It is found that the Kerr-like medium affects the spectral structure even though the initial field is in vacuum when the atom is in upper level. In the case of strong input field, the number state spectrum shows two peaks with different heights; and the superposition state spectrum shows a multipeak structure with an equal distance of two neighboring peaks. The spectral ＂central frequency＂ shifts away from the resonant frequency with the increasing of average photon number.展开更多
[Objective]The construction of weirs changes the hydraulic characteristics of rivers and affects the structure of phytoplankton communities and the health of aquatic ecosystems in the river.This study aims to explore ...[Objective]The construction of weirs changes the hydraulic characteristics of rivers and affects the structure of phytoplankton communities and the health of aquatic ecosystems in the river.This study aims to explore the nonlinear response relationship between phytoplankton community structure and its driving factors in spring and autumn in Furong Creek under the construction of cascade weirs.[Methods]The structure of phytoplankton communities and related environmental factors were investigated in Furong Creek from 2023 to 2024.This study focused on the analysis of the changes of nutrient concentrations and biomass of phytoplankton in autumn and spring within the same dry season in Furong Creek.Redundancy analysis was used to identify the key factors influencing the structure of phytoplankton communities.The MIKE 11 model was employed to simulate the hydrodynamic changes in the river.Combined with total nitrogen and permanganate index,a GAM model of phytoplankton diversity index and hydrodynamic factors was developed,and the change of phytoplankton diversity after the optimized layout of the cascade weirs was fitted.[Results]The result showed that the annual average value of Shannon-Wiener diversity index of phytoplankton in Furong Creek was 2.79,which was in a state of mild pollution.A total of 239 species from 95 genera in 8 phyla were identified.Among the phytoplankton,Chlorophyta was the dominant group throughout the year in Furong Creek,followed by Bacillariophyta and Cyanophyta.The cell abundance of phytoplankton ranged from 3.11 to 20.64 mg/L and from 0.23 to 6.31 mg/L in spring and autumn,which indicated a clear seasonal succession of phytoplankton community structure.Compared with autumn,the relative abundance of Cyanophyta significantly decreased in spring across the whole river section,while Chrysophyta and Dinophyta showed significant increase at some monitoring sites,leading to water bloom phenomenon and a noticeable decline in the diversity of phytoplankton.The dominant species in the water bodies throughout the year were Cyclotella catenata,Chlorella vulgaris,Scenedesmus bijuga,Scenedesmus quadricauda,Chroomonas acuta,Cryptomonas ovata,and Cryptomonas erosa.Redundancy analysis(RDA)showed that hydrodynamic factors(v,h)and water environmental factors(TN,COD_(Mn))were the main influencing factors of phytoplankton community structure.[Conclusion]The result show that the nutrient concentration,phytoplankton biomass,and density in Furong Creek in spring are significantly higher than in autumn.The GAM model,constructed by combining hydrodynamic and environmental factors,can effectively reflect the nonlinear relationship between phytoplankton diversity index and its driving factors.In spring,with an increase in nutrient concentration,the habitat conditions of low flow speed and high water depths formed by overflow weirs will lead to a decrease in the Shannon-Wiener index of phytoplankton and an intensified risk of eutrophication.However,a reasonable layout scheme of cascade weirs will improve the diversity of phytoplankton and reduce the risk of eutrophication in the river.The findings of this study can help deepen the understanding of the ecological and environmental effects of cascade weir construction in the river.展开更多
A novel synthesis of C2-spiroindoline derivatives based on the cascade reaction of 2-aryl-3H-indoles with cyclo- propanols is presented. The formation of product involves Rh(III)-catalyzed aryl C(sp2)—H bond alkylati...A novel synthesis of C2-spiroindoline derivatives based on the cascade reaction of 2-aryl-3H-indoles with cyclo- propanols is presented. The formation of product involves Rh(III)-catalyzed aryl C(sp2)—H bond alkylation of 2-aryl- 3H-indole, which is followed by intramolecular spiroannulation. In this tandem process, cyclopropanol acts as not only an alkylating agent but also a masked nucleophile to take part in the construction of the spirocyclic scaffold. Meanwhile, air acts as an economical and sustainable oxidant to promote the regeneration of the active catalyst. By using this method, hybrid compounds containing the central scaffolds of some clinical drugs were prepared effectively. In general, this newly developed method has advantages such as easily obtainable substrates, concise synthetic procedure, excellent atom-economy, good compatibility with diverse functional groups and ready scalability.展开更多
Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using tw...Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using two rotating cascaded transmissive metasurfaces for adaptive aberration correction in focus scanning.The optimized phase profiles enable precise control of the focal position for scanning custom-curved surfaces.This concept was experimentally validated by two allsilicon meta-devices in the terahertz regime,paving the way for high-precision and compact optical devices in various applications.展开更多
Using molecular dynamics methods,simulations of collision cascades in polycrystalline tungsten(W)have been conducted in this study,including different primary-knock-on atom(PKA)directions,grain sizes,and PKA energies ...Using molecular dynamics methods,simulations of collision cascades in polycrystalline tungsten(W)have been conducted in this study,including different primary-knock-on atom(PKA)directions,grain sizes,and PKA energies between 1 keV and 150 keV.The results indicate that a smaller grain size leads to more defects forming in grain boundary regions during cascade processes.The impact of high-energy PKA may cause a certain degree of distortion of the grain boundaries,which has a higher probability in systems with smaller grain sizes and becomes more pronounced as the PKA energy increases.The direction of PKA can affect the formation and diffusion pathways of defects.When the PKA direction is perpendicular to the grain boundary,defects preferentially form near the grain boundary regions;by contrast,defects are more inclined to form in the interior of the grains.These results are of great significance for comprehending the changes in the performance of polycrystalline W under the high-energy fusion environments and can provide theoretical guidance for further optimization and application of W-based plasma materials.展开更多
This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-orde...This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-order error subsystems.A distributed consensus analysis for the corresponding error systems is conducted by employing recursive methods and virtual controllers,accompanied by a series of Lyapunov functions devised throughout the iterative process,which solves the leaderfollowing consensus problem of a class of nonlinear cascaded multi-agent systems.Specific simulation examples illustrate the effectiveness of the proposed control algorithm.展开更多
This study presents the design of an erbium-doped fiber laser(EDFL) featuring switchable wavelength intervals achieved through the implementation of cascaded and parallel Lyot filters. The proposed laser system utiliz...This study presents the design of an erbium-doped fiber laser(EDFL) featuring switchable wavelength intervals achieved through the implementation of cascaded and parallel Lyot filters. The proposed laser system utilizes a cascaded and parallel configuration of three Lyot filters, facilitated by a polarization beam splitter(PBS) for branch switching. The transmission properties of the filter are analyzed through theoretical modeling and experimental validation using the transmission matrix method. The experimental results are found to be consistent with the theoretical predictions, demonstrating the effectiveness of the proposed design. By adjusting the polarization controllers(PCs), the proposed laser can switch between wavelength spacings of 0.46 nm, 0.27 nm, and 0.76 nm, with a maximum optical signal-to-noise ratio(OSNR) of 38 d B. However, the stability of the laser with a 0.27 nm spacing is not high due to wavelength competition. Power fluctuation for 0.46 nm and 0.76 nm intervals is less than 0.93 d B and 0.78 d B in 1 h, with wavelength fluctuation less than 0.068 nm and 0.19 nm, respectively. This EDFL has the advantages of simple structure, great flexibility, and switchability, which can be applied to fiber optic sensing, wavelength division multiplexing(WDM) networks, and other fields that require a very flexible light source.展开更多
Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and pharmaceuticals.Artificial cascade biocatalysis represents an attractive method for the sy...Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and pharmaceuticals.Artificial cascade biocatalysis represents an attractive method for the synthesis of chiral molecules bearing multiple stereocenters from readily available materials.Here we reported an artificial cascade biocatalysis comprising an epoxide hydrolase,an alcohol dehydrogenase,and a reductive aminase or an amine dehydrogenase.It can be utilized to access all four stereoisomers of 2-aminocyclohexanol with two contiguous stereocenters in high yields(up to 95%)and excellent stereoselectivity(up to 98%de)starting from readily available cyclohexene oxide without isolation of the intermediates.Additionally,the biocatalytic cascade has been successfully extended to the production of structurally diverse 2-(alkylamino)cyclohexanols by replacing ammonia with different organic amines.展开更多
Herein,anthracene-pyridinium derivative(A1)is synthesized to assemble with amphiphilic sulfonatocalix[4]arene(SC4AD)with a porous cavity through electrostatic interaction,exhibiting enhanced fluorescence emission and ...Herein,anthracene-pyridinium derivative(A1)is synthesized to assemble with amphiphilic sulfonatocalix[4]arene(SC4AD)with a porous cavity through electrostatic interaction,exhibiting enhanced fluorescence emission and multipath fluorescence resonance energy transfer(FRET)with organic dyes(EY,Ni R or Cy5.5).In this nanoassembly,A1/SC4AD first transfers the energy to dye EY(first acceptor),and then delivers it to Ni R(second acceptor),which further transfers the energy to Cy5.5(third acceptor),accompanying with an emission ranging from 535 nm to 570 nm,then to 638 nm,and finally to near-infrared emission at 717 nm.Compared to one-step FRET(43.0%),the three-step FRET system shows higher energy transfer efficiency(FRET Ⅰ:84.9%,FRET Ⅱ:81.4%,FRET Ⅲ:66.9%).The donor/acceptor ratio is 3000(A1):20(EY):8(Ni R):5(Cy5.5),together with an antenna effect of 2.3.Additionally,diverse two-step cascade light-harvesting systems are successfully fabricated via tuning combination of dye acceptors.We believe that this multipath light-harvesting assembly will provide a direction for designing multiple sequential FRET and artificial light-harvesting systems.展开更多
Coal and gas outbursts constitute a critical hazard in underground mining operations,characterized by rapid transitions from localized instability to catastrophic failure.Understanding the relationship between initial...Coal and gas outbursts constitute a critical hazard in underground mining operations,characterized by rapid transitions from localized instability to catastrophic failure.Understanding the relationship between initial characteristics and final outburst scale remains a fundamental challenge in geomechanics.This study conceptualizes outbursts as deterministic cascade systems through integrated physical simulations combining high-sensitivity infrasound monitoring with energy analysis under controlled gas pressure(0.5–1.0 MPa)and confining stress(5–10 MPa)conditions.Our complementary analytical algorithms—the absolute amplitude integral and predominant period function—revealed characteristic step-wise patterns in outburst development.Quantitative analysis established a robust correlation(R2=0.91)between initial acoustic response and final outburst intensity.Energy analysis demonstrated that gas expansion dominates the outburst process(91.81%–99.09%of total energy),with desorption gas contributing 59.1%–77.7%.Time-frequency analysis showed systematic frequency migration from high(12–15 Hz)to low(4–8 Hz)bands during outburst progression,reflecting hierarchical spatial scale expansion.The concentrated energy release(>20%of total)within initial 0.2 s provides a mechanistic basis for the deterministic nature of outburst evolution.These mechanistic insights establish a quantitative framework for developing physics-based monitoring protocols and risk assessment methodologies applicable to underground coal mining operations.展开更多
Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition th...Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction.Concretely,the catalytic enzymes of glucose oxidase(GOx),lactate oxidase(LOx)and chloroperoxidase(CPO)are precrosslinked with bovine serum albumin(BSA)to construct nanozymes,which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC.Benefiting from the biomimetic camouflage with homologous cell membrane,m@BGLC inherit homotypic binding and immune escape abilities,facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery efficiency.Subsequently,under the cascade catalysis of nanozymes,m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation,and meanwhile,the resulting hyprochloric acid(HClO)causes an oxidative damage of cells to synergistically inhibit tumor growth.In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy.Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.11574082)the Fundamental Research Funds for the Central Universities,China(Grant No.2018MS050)
文摘Propagation of strong femtosecond hyper-Gaussian pulses in a cascade three-level molecular system is studied by solving numerically the Maxwell–Bloch equations by the iterative predictor-corrector finite-difference time-domain method.Optical power limiting behavior induced by strong nonlinear two-photon absorption is observed for different orders of the femtosecond hyper-Gaussian pulses. Pulses of a higher order temporal profile are found to have a wider power range of optical limiting but a larger output saturation intensity. Both the output saturation value and the damage threshold of optical power limiting decrease with pulse duration increasing. The decrease of the pulse area along the pulse propagation is much slower than that obtained from the two-photon area theorem due to invalidity of the slowly varying amplitude approximation and the monochromatic field hypothesis.
基金The project supported by the ‘Qing Lan＇ project of Jiangsu Province of China under Grant No. 2005SL002J
文摘By using the method of eigenvectors, the atomic populations and emission spectrum are investigated in a system that consists of a cascade three-level atom resonantly interacting with a single-mode tield in a Kerr-like medium. The atom and the field are assumed to be initially in the upper atomic state and the Fock state, respectively. Results for models with intensity-dependent coupling and with intensity-independent coupling are compared. It is found that both population dynamics and emission spectrum show no indications of atom-field decoupling in the strong field limit if the intensity-dependent coupling is taken into account.
基金supported by the Chengdu University of Traditional Chinese Medicine"Xinglin Scholars"Program,China(Grant No.:MPRC2023014).
文摘Gastric carcinoma(GC)is a malignancy with multifactorial involvement,multicellular regulation,and multistage evolution.The classic Correa's cascade of intestinal GC specifies a trilogy of malignant transformation of the gastric mucosa,in which normal gastric mucosa gradually progresses from inactive or chronic active gastritis(Phase I)to gastric precancerous lesions(Phase II)and finally to GC(Phase III).Correa's cascade highlights the evolutionary pattern of GC and the importance of early intervention to prevent malignant transformation of the gastric mucosa.Intervening in early gastric mucosal lesions,i.e.,Phases I and II,will be the key strategy to prevent and treat GC.Natural products(NPs)have been an important source for drug development due to abundant sources,tremendous safety,and multiple pharmacodynamic mechanisms.This review is the first to investigate and summarize the multi-step effects and regulatory mechanisms of NPs on the Correa's cascade in gastric carcinogenesis.In Phase I,NPs modulate Helicobacter pylori urease activity,motility,adhesion,virulence factors,and drug resistance,thereby inhibiting H.pylori-induced gastric mucosal inflammation and oxidative stress,and facilitating ulcer healing.In Phase II,NPs modulate multiple pathways and mediators regulating gastric mucosal cell cycle,apoptosis,autophagy,and angiogenesis to reverse gastric precancerous lesions.In Phase III,NPs suppress cell proliferation,migration,invasion,angiogenesis,and cancer stem cells,induce apoptosis and autophagy,and enhance chemotherapeutic drug sensitivity for the treatment of GC.In contrast to existing work,we hope to uncover NPs with sequential therapeutic effects on multiple phases of GC development,providing new ideas for gastric cancer prevention,treatment,and drug development.
文摘Broad area quantum cascade lasers(BA QCLs)have significant applications in many areas,but suffer from demanding pulse operating conditions and poor beam quality due to heat accumulation and generation of high order modes.A structure of mini-array is adopted to improve the heat dissipation capacity and beam quality of BA QCLs.The active region is etched to form a multi-emitter and the channels are filled with In P:Fe,which acts as a lateral heat dissipation channel to improve the lateral heat dissipation efficiency.A device withλ~4.8μm,a peak output power of 122 W at 1.2%duty cycle with a pulse of 1.5μs is obtained in room temperature,with far-field single-lobed distribution.This result allows BA QCLs to obtain high peak power at wider pump pulse widths and higher duty cycle conditions,promotes the application of the mid-infrared laser operating in pulsed mode in th e field of standoff photoacoustic chemical detection,space optical communication,and so on.
基金Supported by the National Natural Science Foundation of China(62105039)。
文摘In the process of power scaling large-area Quantum Cascade Lasers(QCLs),challenges such as degradation of beam quality and emission of multilobed far-field modes are frequently encountered.These issues become particularly pronounced with an increase in ridge width,resulting in multimode problems.To tackle this,an innovative multi ridge waveguide structure based on the principle of supersymmetry(SUSY)was proposed.This structure comprises a wider main waveguide in the center and two narrower auxiliary waveguides on either side.The high-order modes of the main waveguide are coupled with the modes of the auxiliary waveguides through mode-matching design,and the optical loss of the auxiliary waveguides suppresses these modes,thereby achieving fundamental mode lasing of the wider main waveguide.This paper employs the finite difference eigenmode(FDE)method to perform detailed structural modeling and simulation optimization of the 4.6μm wavelength quantum cascade laser,successfully achieving a single transverse mode QCL with a ridge width of 10μm.In comparison to the traditional single-mode QCL(with a ridge width of about 5μm),the MRW structure has the potential to increase the gain area of the laser by 100%.This offers a novel design concept and methodology for enhancing the single-mode luminous power of mid-infrared quantum cascade lasers,which is of considerable significance.
基金The project supported by the Natural Science Foundation of Shandong Province under Grant No. Y2004A09
文摘The cavity field spectrum of a cascade three-level atom interacting with single-mode field with Kerr-like medium in the cavity is investigated. The numerical results for the initial field in pure number state, coherent state and squeezed vacuum state are calculated, respectively. It is found that the Kerr-like medium affects the spectral structure even though the initial field is in vacuum when the atom is in upper level. In the case of strong input field, the number state spectrum shows two peaks with different heights; and the superposition state spectrum shows a multipeak structure with an equal distance of two neighboring peaks. The spectral ＂central frequency＂ shifts away from the resonant frequency with the increasing of average photon number.
文摘[Objective]The construction of weirs changes the hydraulic characteristics of rivers and affects the structure of phytoplankton communities and the health of aquatic ecosystems in the river.This study aims to explore the nonlinear response relationship between phytoplankton community structure and its driving factors in spring and autumn in Furong Creek under the construction of cascade weirs.[Methods]The structure of phytoplankton communities and related environmental factors were investigated in Furong Creek from 2023 to 2024.This study focused on the analysis of the changes of nutrient concentrations and biomass of phytoplankton in autumn and spring within the same dry season in Furong Creek.Redundancy analysis was used to identify the key factors influencing the structure of phytoplankton communities.The MIKE 11 model was employed to simulate the hydrodynamic changes in the river.Combined with total nitrogen and permanganate index,a GAM model of phytoplankton diversity index and hydrodynamic factors was developed,and the change of phytoplankton diversity after the optimized layout of the cascade weirs was fitted.[Results]The result showed that the annual average value of Shannon-Wiener diversity index of phytoplankton in Furong Creek was 2.79,which was in a state of mild pollution.A total of 239 species from 95 genera in 8 phyla were identified.Among the phytoplankton,Chlorophyta was the dominant group throughout the year in Furong Creek,followed by Bacillariophyta and Cyanophyta.The cell abundance of phytoplankton ranged from 3.11 to 20.64 mg/L and from 0.23 to 6.31 mg/L in spring and autumn,which indicated a clear seasonal succession of phytoplankton community structure.Compared with autumn,the relative abundance of Cyanophyta significantly decreased in spring across the whole river section,while Chrysophyta and Dinophyta showed significant increase at some monitoring sites,leading to water bloom phenomenon and a noticeable decline in the diversity of phytoplankton.The dominant species in the water bodies throughout the year were Cyclotella catenata,Chlorella vulgaris,Scenedesmus bijuga,Scenedesmus quadricauda,Chroomonas acuta,Cryptomonas ovata,and Cryptomonas erosa.Redundancy analysis(RDA)showed that hydrodynamic factors(v,h)and water environmental factors(TN,COD_(Mn))were the main influencing factors of phytoplankton community structure.[Conclusion]The result show that the nutrient concentration,phytoplankton biomass,and density in Furong Creek in spring are significantly higher than in autumn.The GAM model,constructed by combining hydrodynamic and environmental factors,can effectively reflect the nonlinear relationship between phytoplankton diversity index and its driving factors.In spring,with an increase in nutrient concentration,the habitat conditions of low flow speed and high water depths formed by overflow weirs will lead to a decrease in the Shannon-Wiener index of phytoplankton and an intensified risk of eutrophication.However,a reasonable layout scheme of cascade weirs will improve the diversity of phytoplankton and reduce the risk of eutrophication in the river.The findings of this study can help deepen the understanding of the ecological and environmental effects of cascade weir construction in the river.
文摘A novel synthesis of C2-spiroindoline derivatives based on the cascade reaction of 2-aryl-3H-indoles with cyclo- propanols is presented. The formation of product involves Rh(III)-catalyzed aryl C(sp2)—H bond alkylation of 2-aryl- 3H-indole, which is followed by intramolecular spiroannulation. In this tandem process, cyclopropanol acts as not only an alkylating agent but also a masked nucleophile to take part in the construction of the spirocyclic scaffold. Meanwhile, air acts as an economical and sustainable oxidant to promote the regeneration of the active catalyst. By using this method, hybrid compounds containing the central scaffolds of some clinical drugs were prepared effectively. In general, this newly developed method has advantages such as easily obtainable substrates, concise synthetic procedure, excellent atom-economy, good compatibility with diverse functional groups and ready scalability.
文摘Aberration-corrected focus scanning is crucial for high-precision optics,but the conventional optical systems rely on bulky and complicated dynamic correctors.Recently,Shiyi Xiao's group proposed a method using two rotating cascaded transmissive metasurfaces for adaptive aberration correction in focus scanning.The optimized phase profiles enable precise control of the focal position for scanning custom-curved surfaces.This concept was experimentally validated by two allsilicon meta-devices in the terahertz regime,paving the way for high-precision and compact optical devices in various applications.
基金Project supported by the National MCF Energy Research and Development Program of China(Grant No.2018YFE0308101)the National Key Research and Development Program of China(Grant No.2018YFB0704000)+1 种基金the Suqian Science and Technology Program(Grant No.K202337)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.23KJD490001).
文摘Using molecular dynamics methods,simulations of collision cascades in polycrystalline tungsten(W)have been conducted in this study,including different primary-knock-on atom(PKA)directions,grain sizes,and PKA energies between 1 keV and 150 keV.The results indicate that a smaller grain size leads to more defects forming in grain boundary regions during cascade processes.The impact of high-energy PKA may cause a certain degree of distortion of the grain boundaries,which has a higher probability in systems with smaller grain sizes and becomes more pronounced as the PKA energy increases.The direction of PKA can affect the formation and diffusion pathways of defects.When the PKA direction is perpendicular to the grain boundary,defects preferentially form near the grain boundary regions;by contrast,defects are more inclined to form in the interior of the grains.These results are of great significance for comprehending the changes in the performance of polycrystalline W under the high-energy fusion environments and can provide theoretical guidance for further optimization and application of W-based plasma materials.
基金National Natural Science Foundation of China(No.12071370)。
文摘This paper focuses on the problem of leaderfollowing consensus for nonlinear cascaded multi-agent systems.The control strategies for these systems are transformed into successive control problem schemes for lower-order error subsystems.A distributed consensus analysis for the corresponding error systems is conducted by employing recursive methods and virtual controllers,accompanied by a series of Lyapunov functions devised throughout the iterative process,which solves the leaderfollowing consensus problem of a class of nonlinear cascaded multi-agent systems.Specific simulation examples illustrate the effectiveness of the proposed control algorithm.
基金supported by the Primary Research and Development Plan of Zhejiang Province (No.2023C03014)the Key Research and Development Program of Zhejiang Province (No.2022C03037)。
文摘This study presents the design of an erbium-doped fiber laser(EDFL) featuring switchable wavelength intervals achieved through the implementation of cascaded and parallel Lyot filters. The proposed laser system utilizes a cascaded and parallel configuration of three Lyot filters, facilitated by a polarization beam splitter(PBS) for branch switching. The transmission properties of the filter are analyzed through theoretical modeling and experimental validation using the transmission matrix method. The experimental results are found to be consistent with the theoretical predictions, demonstrating the effectiveness of the proposed design. By adjusting the polarization controllers(PCs), the proposed laser can switch between wavelength spacings of 0.46 nm, 0.27 nm, and 0.76 nm, with a maximum optical signal-to-noise ratio(OSNR) of 38 d B. However, the stability of the laser with a 0.27 nm spacing is not high due to wavelength competition. Power fluctuation for 0.46 nm and 0.76 nm intervals is less than 0.93 d B and 0.78 d B in 1 h, with wavelength fluctuation less than 0.068 nm and 0.19 nm, respectively. This EDFL has the advantages of simple structure, great flexibility, and switchability, which can be applied to fiber optic sensing, wavelength division multiplexing(WDM) networks, and other fields that require a very flexible light source.
文摘Chiral cyclic amino alcohols with contiguous stereocenters are key building blocks in the synthesis of bioactive molecules and pharmaceuticals.Artificial cascade biocatalysis represents an attractive method for the synthesis of chiral molecules bearing multiple stereocenters from readily available materials.Here we reported an artificial cascade biocatalysis comprising an epoxide hydrolase,an alcohol dehydrogenase,and a reductive aminase or an amine dehydrogenase.It can be utilized to access all four stereoisomers of 2-aminocyclohexanol with two contiguous stereocenters in high yields(up to 95%)and excellent stereoselectivity(up to 98%de)starting from readily available cyclohexene oxide without isolation of the intermediates.Additionally,the biocatalytic cascade has been successfully extended to the production of structurally diverse 2-(alkylamino)cyclohexanols by replacing ammonia with different organic amines.
基金financially supported by the National Natural Science Foundation of China(No.22131008)。
文摘Herein,anthracene-pyridinium derivative(A1)is synthesized to assemble with amphiphilic sulfonatocalix[4]arene(SC4AD)with a porous cavity through electrostatic interaction,exhibiting enhanced fluorescence emission and multipath fluorescence resonance energy transfer(FRET)with organic dyes(EY,Ni R or Cy5.5).In this nanoassembly,A1/SC4AD first transfers the energy to dye EY(first acceptor),and then delivers it to Ni R(second acceptor),which further transfers the energy to Cy5.5(third acceptor),accompanying with an emission ranging from 535 nm to 570 nm,then to 638 nm,and finally to near-infrared emission at 717 nm.Compared to one-step FRET(43.0%),the three-step FRET system shows higher energy transfer efficiency(FRET Ⅰ:84.9%,FRET Ⅱ:81.4%,FRET Ⅲ:66.9%).The donor/acceptor ratio is 3000(A1):20(EY):8(Ni R):5(Cy5.5),together with an antenna effect of 2.3.Additionally,diverse two-step cascade light-harvesting systems are successfully fabricated via tuning combination of dye acceptors.We believe that this multipath light-harvesting assembly will provide a direction for designing multiple sequential FRET and artificial light-harvesting systems.
基金funded by the National Natural Science Foundation of China(No.52464016)the Guizhou Provincial Foundation Research Project(No.QKHJC-[2024]Youth 141)+1 种基金the Guizhou Provincial Basic Research Program(No.MS[2025]632)the Young Researcher Growth Project of Guizhou Provincial Department of Education(No.QJJ-[2024]25).
文摘Coal and gas outbursts constitute a critical hazard in underground mining operations,characterized by rapid transitions from localized instability to catastrophic failure.Understanding the relationship between initial characteristics and final outburst scale remains a fundamental challenge in geomechanics.This study conceptualizes outbursts as deterministic cascade systems through integrated physical simulations combining high-sensitivity infrasound monitoring with energy analysis under controlled gas pressure(0.5–1.0 MPa)and confining stress(5–10 MPa)conditions.Our complementary analytical algorithms—the absolute amplitude integral and predominant period function—revealed characteristic step-wise patterns in outburst development.Quantitative analysis established a robust correlation(R2=0.91)between initial acoustic response and final outburst intensity.Energy analysis demonstrated that gas expansion dominates the outburst process(91.81%–99.09%of total energy),with desorption gas contributing 59.1%–77.7%.Time-frequency analysis showed systematic frequency migration from high(12–15 Hz)to low(4–8 Hz)bands during outburst progression,reflecting hierarchical spatial scale expansion.The concentrated energy release(>20%of total)within initial 0.2 s provides a mechanistic basis for the deterministic nature of outburst evolution.These mechanistic insights establish a quantitative framework for developing physics-based monitoring protocols and risk assessment methodologies applicable to underground coal mining operations.
基金financial support of Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020095)National Natural Science Foundation of China(No.52073140)。
文摘Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction.Concretely,the catalytic enzymes of glucose oxidase(GOx),lactate oxidase(LOx)and chloroperoxidase(CPO)are precrosslinked with bovine serum albumin(BSA)to construct nanozymes,which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC.Benefiting from the biomimetic camouflage with homologous cell membrane,m@BGLC inherit homotypic binding and immune escape abilities,facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery efficiency.Subsequently,under the cascade catalysis of nanozymes,m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation,and meanwhile,the resulting hyprochloric acid(HClO)causes an oxidative damage of cells to synergistically inhibit tumor growth.In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy.Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.
